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Protein

Beta-lactamase

Gene

ampC

Organism
Serratia marcescens
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei164Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP18539.

Protein family/group databases

MEROPSiS12.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001696522 – 376Beta-lactamaseAdd BLAST355

Structurei

3D structure databases

ProteinModelPortaliP18539.
SMRiP18539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni328 – 330Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18539-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKMNRCAAL IAALILPTAH AAQQQDIDAV IQPLMKKYGV PGMAIAVSVD
60 70 80 90 100
GKQQIYPYGV ASKQTGKPIT EQTLFEVGSL SKTFTATLAV YAQQQSKLSF
110 120 130 140 150
KDPASHYLPD VRGSAFDGVS LLNLATHTSG LPLFVPDDVT NNAQLMAYYR
160 170 180 190 200
AWQPKHPAGS YRVYSNLGIG MLGMIAAKSL DQPFIQAMEQ GMLPALGMSH
210 220 230 240 250
TYVQVPAAQM ANYAQGYSKD DKPVRVNPGP LDAESYGIKS NARDLIRYLD
260 270 280 290 300
ANLQQVKVAS VARRWPRRTS VITSAGAFTQ DLMWENYPYP VKLSRLIEGN
310 320 330 340 350
NAGMIMNGTP ATAITPPQPE LRAGWYNKTG STGGFSTYAV FIPAKNIAVE
360 370
MLANKWFPND DRVEAAYHII QALEKR
Length:376
Mass (Da):41,096
Last modified:November 1, 1990 - v1
Checksum:i890CEE7C27925150
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52964 Genomic DNA. Translation: CAA37137.1.
PIRiA48176. QKSE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52964 Genomic DNA. Translation: CAA37137.1.
PIRiA48176. QKSE.

3D structure databases

ProteinModelPortaliP18539.
SMRiP18539.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL5693.

Protein family/group databases

MEROPSiS12.006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP18539.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMPC_SERMA
AccessioniPrimary (citable) accession number: P18539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.