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P18539

- AMPC_SERMA

UniProt

P18539 - AMPC_SERMA

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Protein
Beta-lactamase
Gene
ampC
Organism
Serratia marcescens
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Acyl-ester intermediate By similarity
Active sitei164 – 1641Proton acceptor By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP18539.

Protein family/group databases

MEROPSiS12.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Cephalosporinase
Gene namesi
Name:ampC
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Subcellular locationi

Periplasm By similarity

GO - Cellular componenti

  1. outer membrane-bounded periplasmic space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121
Add
BLAST
Chaini22 – 376355Beta-lactamase
PRO_0000016965Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP18539.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni328 – 3303Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18539-1 [UniParc]FASTAAdd to Basket

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MTKMNRCAAL IAALILPTAH AAQQQDIDAV IQPLMKKYGV PGMAIAVSVD    50
GKQQIYPYGV ASKQTGKPIT EQTLFEVGSL SKTFTATLAV YAQQQSKLSF 100
KDPASHYLPD VRGSAFDGVS LLNLATHTSG LPLFVPDDVT NNAQLMAYYR 150
AWQPKHPAGS YRVYSNLGIG MLGMIAAKSL DQPFIQAMEQ GMLPALGMSH 200
TYVQVPAAQM ANYAQGYSKD DKPVRVNPGP LDAESYGIKS NARDLIRYLD 250
ANLQQVKVAS VARRWPRRTS VITSAGAFTQ DLMWENYPYP VKLSRLIEGN 300
NAGMIMNGTP ATAITPPQPE LRAGWYNKTG STGGFSTYAV FIPAKNIAVE 350
MLANKWFPND DRVEAAYHII QALEKR 376
Length:376
Mass (Da):41,096
Last modified:November 1, 1990 - v1
Checksum:i890CEE7C27925150
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52964 Genomic DNA. Translation: CAA37137.1.
PIRiA48176. QKSE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52964 Genomic DNA. Translation: CAA37137.1 .
PIRi A48176. QKSE.

3D structure databases

ProteinModelPortali P18539.
ModBasei Search...

Chemistry

ChEMBLi CHEMBL5693.

Protein family/group databases

MEROPSi S12.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P18539.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Serratia marcescens SR50 chromosomal ampC beta-lactamase gene."
    Nomura K., Yoshida T.
    FEMS Microbiol. Lett. 58:295-299(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sr50.

Entry informationi

Entry nameiAMPC_SERMA
AccessioniPrimary (citable) accession number: P18539
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 11, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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