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P18539

- AMPC_SERMA

UniProt

P18539 - AMPC_SERMA

Protein

Beta-lactamase

Gene

ampC

Organism
Serratia marcescens
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    • Comment

    Functioni

    This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei79 – 791Acyl-ester intermediatePROSITE-ProRule annotation
    Active sitei164 – 1641Proton acceptorBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKP18539.

    Protein family/group databases

    MEROPSiS12.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase (EC:3.5.2.6)
    Alternative name(s):
    Cephalosporinase
    Gene namesi
    Name:ampC
    OrganismiSerratia marcescens
    Taxonomic identifieri615 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

    Subcellular locationi

    Periplasm By similarity

    GO - Cellular componenti

    1. outer membrane-bounded periplasmic space Source: InterPro

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Add
    BLAST
    Chaini22 – 376355Beta-lactamasePRO_0000016965Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP18539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni328 – 3303Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-C beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view]
    PfamiPF00144. Beta-lactamase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18539-1 [UniParc]FASTAAdd to Basket

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    MTKMNRCAAL IAALILPTAH AAQQQDIDAV IQPLMKKYGV PGMAIAVSVD    50
    GKQQIYPYGV ASKQTGKPIT EQTLFEVGSL SKTFTATLAV YAQQQSKLSF 100
    KDPASHYLPD VRGSAFDGVS LLNLATHTSG LPLFVPDDVT NNAQLMAYYR 150
    AWQPKHPAGS YRVYSNLGIG MLGMIAAKSL DQPFIQAMEQ GMLPALGMSH 200
    TYVQVPAAQM ANYAQGYSKD DKPVRVNPGP LDAESYGIKS NARDLIRYLD 250
    ANLQQVKVAS VARRWPRRTS VITSAGAFTQ DLMWENYPYP VKLSRLIEGN 300
    NAGMIMNGTP ATAITPPQPE LRAGWYNKTG STGGFSTYAV FIPAKNIAVE 350
    MLANKWFPND DRVEAAYHII QALEKR 376
    Length:376
    Mass (Da):41,096
    Last modified:November 1, 1990 - v1
    Checksum:i890CEE7C27925150
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52964 Genomic DNA. Translation: CAA37137.1.
    PIRiA48176. QKSE.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52964 Genomic DNA. Translation: CAA37137.1 .
    PIRi A48176. QKSE.

    3D structure databases

    ProteinModelPortali P18539.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL5693.

    Protein family/group databases

    MEROPSi S12.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P18539.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR001466. Beta-lactam-related.
    IPR012338. Beta-lactam/transpept-like.
    IPR001586. Beta-lactam_class-C_AS.
    [Graphical view ]
    Pfami PF00144. Beta-lactamase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00336. BETA_LACTAMASE_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the Serratia marcescens SR50 chromosomal ampC beta-lactamase gene."
      Nomura K., Yoshida T.
      FEMS Microbiol. Lett. 58:295-299(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sr50.

    Entry informationi

    Entry nameiAMPC_SERMA
    AccessioniPrimary (citable) accession number: P18539
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3