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P18539 (AMPC_SERMA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Cephalosporinase
Gene names
Name:ampC
OrganismSerratia marcescens
Taxonomic identifier615 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSerratia

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the class-C beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentPeriplasm
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Chain22 – 376355Beta-lactamase
PRO_0000016965

Regions

Region328 – 3303Substrate binding By similarity

Sites

Active site791Acyl-ester intermediate By similarity
Active site1641Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
P18539 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 890CEE7C27925150

FASTA37641,096
        10         20         30         40         50         60 
MTKMNRCAAL IAALILPTAH AAQQQDIDAV IQPLMKKYGV PGMAIAVSVD GKQQIYPYGV 

        70         80         90        100        110        120 
ASKQTGKPIT EQTLFEVGSL SKTFTATLAV YAQQQSKLSF KDPASHYLPD VRGSAFDGVS 

       130        140        150        160        170        180 
LLNLATHTSG LPLFVPDDVT NNAQLMAYYR AWQPKHPAGS YRVYSNLGIG MLGMIAAKSL 

       190        200        210        220        230        240 
DQPFIQAMEQ GMLPALGMSH TYVQVPAAQM ANYAQGYSKD DKPVRVNPGP LDAESYGIKS 

       250        260        270        280        290        300 
NARDLIRYLD ANLQQVKVAS VARRWPRRTS VITSAGAFTQ DLMWENYPYP VKLSRLIEGN 

       310        320        330        340        350        360 
NAGMIMNGTP ATAITPPQPE LRAGWYNKTG STGGFSTYAV FIPAKNIAVE MLANKWFPND 

       370 
DRVEAAYHII QALEKR 

« Hide

References

[1]"Nucleotide sequence of the Serratia marcescens SR50 chromosomal ampC beta-lactamase gene."
Nomura K., Yoshida T.
FEMS Microbiol. Lett. 58:295-299(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sr50.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X52964 Genomic DNA. Translation: CAA37137.1.
PIRQKSE. A48176.

3D structure databases

ProteinModelPortalP18539.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL5693.

Protein family/group databases

MEROPSS12.006.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP18539.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00336. BETA_LACTAMASE_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAMPC_SERMA
AccessionPrimary (citable) accession number: P18539
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 11, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families