P18532 (HVM61_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Ig heavy chain V region 1B43
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous

This sequence belongs to the VH3660 subfamily.

Ontologies

Keywords
Domain	Immunoglobulin V region Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

18

Chain

19 – 116

98

Ig heavy chain V region 1B43

PRO_0000015242

Regions

Region

19 – 48

30

Framework-1

Region

49 – 53

5

Complementarity-determining-1

Region

54 – 67

14

Framework-2

Region

68 – 84

17

Complementarity-determining-2

Region

85 – 116

32

Framework-3

Amino acid modifications

Disulfide bond

40 ↔ 114

By similarity

Experimental info

Non-terminal residue

116

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

116

Helix Strand Turn

Details...

Beta strand

28 – 30

3

Beta strand

36 – 45

10

Turn

47 – 49

3

Beta strand

50 – 58

9

Beta strand

64 – 71

8

Beta strand

76 – 78

3

Turn

80 – 85

6

Beta strand

86 – 91

6

Turn

92 – 95

4

Beta strand

96 – 101

6

Helix

106 – 108

3

Sequences

	Sequence		Length	Mass (Da)
	P18532 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 1CB547253681FF74	FASTA	116	13,158
	10 20 30 40 50 60 MRVLILLCLF TAFPGILSDV QLQESGPDLV KPSQSLSLTC TVTGYSITSG YSWHWIRQFP 70 80 90 100 110 GNKLEWMGYI HYSGNTSYNP SLKSRISITR DTSKNQFFLQ LNSVTTEDTA TYYCAR

References

[1]	"Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response." Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J. J. Exp. Med. 169:2007-2019(1989) [PubMed: 2499654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/cJ.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00828881.

PIR

HVMS1B. JT0508.

UniGene

Mm.342177.
Mm.458003.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KCS	X-ray	2.50	H	25-116	[»]
1KCV	X-ray	1.80	H	25-116	[»]
2EXP	model	-	H	19-114	[»]
2EXQ	model	-	H	19-114	[»]
2F58	X-ray	2.80	H	19-116	[»]
3F58	X-ray	2.80	H	19-116	[»]

ProteinModelPortal

P18532.

SMR

P18532. Positions 19-116.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG018013.

Gene expression databases

Genevestigator

P18532.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

HVM61_MOUSE

Accession

Primary (citable) accession number: P18532

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	September 21, 2011
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program