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Protein

Ig heavy chain V region 345

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region 345
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 11798Ig heavy chain V region 345PRO_0000015238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP18526.
PeptideAtlasiP18526.
PRIDEiP18526.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi23 – 264Combined sources
Beta strandi37 – 437Combined sources
Helixi48 – 503Combined sources
Beta strandi53 – 586Combined sources
Beta strandi64 – 663Combined sources
Turni81 – 866Combined sources
Beta strandi87 – 893Combined sources
Turni93 – 964Combined sources
Beta strandi97 – 1026Combined sources
Helixi107 – 1093Combined sources
Beta strandi111 – 1177Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QFWX-ray3.50I21-117[»]
ProteinModelPortaliP18526.
SMRiP18526. Positions 20-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 4930Framework-1Add
BLAST
Regioni50 – 545Complementarity-determining-1
Regioni55 – 6814Framework-2Add
BLAST
Regioni69 – 8517Complementarity-determining-2Add
BLAST
Regioni86 – 11732Framework-3Add
BLAST

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFGLRLIFL VLTLKGVKCE VQLVESGGGL VKPGGSLKLS CAASGFAFSS
60 70 80 90 100
YDMSWVRQTP EKRLEWVAYI SSGGGSTYYP DTVKGRFTIS RDNAKNTLYL
110
QMSSLKSEDT AMYYCAR
Length:117
Mass (Da):12,902
Last modified:November 1, 1990 - v1
Checksum:i49380E4627ACA99A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei117 – 1171

Sequence databases

PIRiJT0502. HVMS34.

Cross-referencesi

Sequence databases

PIRiJT0502. HVMS34.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QFWX-ray3.50I21-117[»]
ProteinModelPortaliP18526.
SMRiP18526. Positions 20-117.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP18526.
PeptideAtlasiP18526.
PRIDEiP18526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response."
    Levy N.S., Malipiero U.V., Lebecque S.G., Gearhart P.J.
    J. Exp. Med. 169:2007-2019(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cJ.

Entry informationi

Entry nameiHVM55_MOUSE
AccessioniPrimary (citable) accession number: P18526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This sequence belongs to the VH7183 subfamily.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.