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P18519 (TNR16_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name=NGF receptor
p75 ICD
Gene names
Name:NGFR
Synonyms:TNFRSF16
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells By similarity.

Subunit structure

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 By similarity. Interacts with LINGO1 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

N- and O-glycosylated.

Phosphorylated on serine residues.

Sequence similarities

Contains 1 death domain.

Contains 4 TNFR-Cys repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 416397Tumor necrosis factor receptor superfamily member 16
PRO_0000034594

Regions

Topological domain29 – 239211Extracellular Potential
Transmembrane240 – 26122Helical; Potential
Topological domain262 – 416155Cytoplasmic Potential
Repeat23 – 5735TNFR-Cys 1
Repeat58 – 9942TNFR-Cys 2
Repeat100 – 13839TNFR-Cys 3
Repeat140 – 18041TNFR-Cys 4
Domain333 – 41078Death
Compositional bias188 – 23649Ser/Thr-rich

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 35 By similarity
Disulfide bond36 ↔ 49 By similarity
Disulfide bond39 ↔ 56 By similarity
Disulfide bond59 ↔ 75 By similarity
Disulfide bond78 ↔ 91 By similarity
Disulfide bond81 ↔ 99 By similarity
Disulfide bond101 ↔ 114 By similarity
Disulfide bond117 ↔ 130 By similarity
Disulfide bond120 ↔ 138 By similarity
Disulfide bond141 ↔ 156 By similarity
Disulfide bond159 ↔ 172 By similarity
Disulfide bond162 ↔ 180 By similarity

Experimental info

Sequence conflict361C → Y Ref.2
Sequence conflict1731T → K Ref.2
Sequence conflict2761N → S Ref.2
Sequence conflict3961K → R Ref.2

Sequences

Sequence LengthMass (Da)Tools
P18519 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 6BCEAAB54F4D2D56

FASTA41644,654
        10         20         30         40         50         60 
MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG VNQTVCEPCL 

        70         80         90        100        110        120 
DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR CAYGYFQDEL SGSCKECSIC 

       130        140        150        160        170        180 
EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA NFVDPCLPCT ICEENEVMVK ECTATSDAEC 

       190        200        210        220        230        240 
RDLHPRWTTH TPSLAGSDSP EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL 

       250        260        270        280        290        300 
IPVYCSILAA VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS 

       310        320        330        340        350        360 
QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ LAGELGYKED 

       370        380        390        400        410 
LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG DIAESLYSES TATSPV 

« Hide

References

[1]"Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system."
Large T.H., Weskamp G., Helder J.C., Radeke M.J., Misko T.P., Shooter E.M., Reichardt L.F.
Neuron 2:1123-1134(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain.
[2]"Structure and developmental expression of the chicken NGF receptor."
Heuer J.G., Fatemie-Nainie S., Wheeler E.F., Bothwell M.
Dev. Biol. 137:287-304(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 21-416.

Cross-references

Sequence databases

PIRJN0006.
UniGeneGga.39799.

3D structure databases

ProteinModelPortalP18519.
SMRP18519. Positions 322-409.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP18519.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG39106.
HOGENOMHOG000059587.
HOVERGENHBG060431.
InParanoidP18519.
PhylomeDBP18519.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSPR01966. TNFACTORR16.
SMARTSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTNR16_CHICK
AccessionPrimary (citable) accession number: P18519
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families