Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 16

Gene

NGFR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes and the genes involved in glucose and lipid metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis, Biological rhythms, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor
p75 ICD
Gene namesi
Name:NGFR
Synonyms:TNFRSF16
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 239ExtracellularSequence analysisAdd BLAST211
Transmembranei240 – 261HelicalSequence analysisAdd BLAST22
Topological domaini262 – 416CytoplasmicSequence analysisAdd BLAST155

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003459420 – 416Tumor necrosis factor receptor superfamily member 16Add BLAST397

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 35PROSITE-ProRule annotation
Disulfide bondi36 ↔ 49PROSITE-ProRule annotation
Disulfide bondi39 ↔ 56PROSITE-ProRule annotation
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Disulfide bondi78 ↔ 91PROSITE-ProRule annotation
Disulfide bondi81 ↔ 99PROSITE-ProRule annotation
Disulfide bondi101 ↔ 114PROSITE-ProRule annotation
Disulfide bondi117 ↔ 130PROSITE-ProRule annotation
Disulfide bondi120 ↔ 138PROSITE-ProRule annotation
Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
Disulfide bondi159 ↔ 172PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.
Phosphorylated on serine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18519.

PTM databases

iPTMnetiP18519.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 (By similarity). Interacts with LINGO1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020402.

Structurei

3D structure databases

ProteinModelPortaliP18519.
SMRiP18519.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 57TNFR-Cys 1Add BLAST35
Repeati58 – 99TNFR-Cys 2Add BLAST42
Repeati100 – 138TNFR-Cys 3Add BLAST39
Repeati140 – 180TNFR-Cys 4Add BLAST41
Domaini333 – 410DeathPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi188 – 236Ser/Thr-richAdd BLAST49

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
InParanoidiP18519.
PhylomeDBiP18519.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18519-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG
60 70 80 90 100
VNQTVCEPCL DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR
110 120 130 140 150
CAYGYFQDEL SGSCKECSIC EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA
160 170 180 190 200
NFVDPCLPCT ICEENEVMVK ECTATSDAEC RDLHPRWTTH TPSLAGSDSP
210 220 230 240 250
EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL IPVYCSILAA
260 270 280 290 300
VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS
310 320 330 340 350
QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ
360 370 380 390 400
LAGELGYKED LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG
410
DIAESLYSES TATSPV
Length:416
Mass (Da):44,654
Last modified:November 1, 1990 - v1
Checksum:i6BCEAAB54F4D2D56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36C → Y (PubMed:2154393).Curated1
Sequence conflicti173T → K (PubMed:2154393).Curated1
Sequence conflicti276N → S (PubMed:2154393).Curated1
Sequence conflicti396K → R (PubMed:2154393).Curated1

Sequence databases

PIRiJN0006.
UniGeneiGga.39799.

Genome annotation databases

EnsembliENSGALT00000046359; ENSGALP00000046489; ENSGALG00000035950.

Cross-referencesi

Sequence databases

PIRiJN0006.
UniGeneiGga.39799.

3D structure databases

ProteinModelPortaliP18519.
SMRiP18519.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020402.

PTM databases

iPTMnetiP18519.

Proteomic databases

PaxDbiP18519.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000046359; ENSGALP00000046489; ENSGALG00000035950.

Phylogenomic databases

eggNOGiENOG410IQFC. Eukaryota.
ENOG4111F3C. LUCA.
GeneTreeiENSGT00730000110974.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
InParanoidiP18519.
PhylomeDBiP18519.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR16_CHICK
AccessioniPrimary (citable) accession number: P18519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.