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P18519

- TNR16_CHICK

UniProt

P18519 - TNR16_CHICK

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Protein
Tumor necrosis factor receptor superfamily member 16
Gene
NGFR, TNFRSF16
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes and the genes involved in glucose and lipid metabolism By similarity.

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. circadian regulation of gene expression Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis, Biological rhythms, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor
p75 ICD
Gene namesi
Name:NGFR
Synonyms:TNFRSF16
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 239211Extracellular Reviewed prediction
Add
BLAST
Transmembranei240 – 26122Helical; Reviewed prediction
Add
BLAST
Topological domaini262 – 416155Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 416397Tumor necrosis factor receptor superfamily member 16
PRO_0000034594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 35 By similarity
Disulfide bondi36 ↔ 49 By similarity
Disulfide bondi39 ↔ 56 By similarity
Glycosylationi52 – 521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi59 ↔ 75 By similarity
Disulfide bondi78 ↔ 91 By similarity
Disulfide bondi81 ↔ 99 By similarity
Disulfide bondi101 ↔ 114 By similarity
Disulfide bondi117 ↔ 130 By similarity
Disulfide bondi120 ↔ 138 By similarity
Disulfide bondi141 ↔ 156 By similarity
Disulfide bondi159 ↔ 172 By similarity
Disulfide bondi162 ↔ 180 By similarity

Post-translational modificationi

N- and O-glycosylated.
Phosphorylated on serine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18519.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 By similarity. Interacts with LINGO1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP18519.
SMRiP18519. Positions 322-409.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 5735TNFR-Cys 1
Add
BLAST
Repeati58 – 9942TNFR-Cys 2
Add
BLAST
Repeati100 – 13839TNFR-Cys 3
Add
BLAST
Repeati140 – 18041TNFR-Cys 4
Add
BLAST
Domaini333 – 41078Death
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 23649Ser/Thr-rich
Add
BLAST

Sequence similaritiesi

Contains 1 death domain.
Contains 4 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39106.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
InParanoidiP18519.
PhylomeDBiP18519.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18519-1 [UniParc]FASTAAdd to Basket

« Hide

MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG    50
VNQTVCEPCL DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR 100
CAYGYFQDEL SGSCKECSIC EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA 150
NFVDPCLPCT ICEENEVMVK ECTATSDAEC RDLHPRWTTH TPSLAGSDSP 200
EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL IPVYCSILAA 250
VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS 300
QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ 350
LAGELGYKED LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG 400
DIAESLYSES TATSPV 416
Length:416
Mass (Da):44,654
Last modified:November 1, 1990 - v1
Checksum:i6BCEAAB54F4D2D56
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361C → Y1 Publication
Sequence conflicti173 – 1731T → K1 Publication
Sequence conflicti276 – 2761N → S1 Publication
Sequence conflicti396 – 3961K → R1 Publication

Sequence databases

PIRiJN0006.
UniGeneiGga.39799.

Cross-referencesi

Sequence databases

PIRi JN0006.
UniGenei Gga.39799.

3D structure databases

ProteinModelPortali P18519.
SMRi P18519. Positions 322-409.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P18519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG39106.
HOGENOMi HOG000059587.
HOVERGENi HBG060431.
InParanoidi P18519.
PhylomeDBi P18519.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view ]
PRINTSi PR01966. TNFACTORR16.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system."
    Large T.H., Weskamp G., Helder J.C., Radeke M.J., Misko T.P., Shooter E.M., Reichardt L.F.
    Neuron 2:1123-1134(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. "Structure and developmental expression of the chicken NGF receptor."
    Heuer J.G., Fatemie-Nainie S., Wheeler E.F., Bothwell M.
    Dev. Biol. 137:287-304(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 21-416.

Entry informationi

Entry nameiTNR16_CHICK
AccessioniPrimary (citable) accession number: P18519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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