P18519 (TNR16_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor receptor superfamily member 16

Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name=NGF receptor
p75 ICD

Gene names

Name:	NGFR
Synonyms:	TNFRSF16

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells By similarity.
Subunit structure	Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 By similarity. Interacts with LINGO1 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	N- and O-glycosylated. Phosphorylated on serine residues.
Sequence similarities	Contains 1 death domain. Contains 4 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis Differentiation Neurogenesis
Cellular component	Membrane
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW axon guidance Inferred from electronic annotation. Source: Compara central nervous system development Inferred from electronic annotation. Source: Compara detection of temperature stimulus Inferred from electronic annotation. Source: Compara hair follicle morphogenesis Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from electronic annotation. Source: Compara negative regulation of fibroblast growth factor receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of hair follicle development Inferred from electronic annotation. Source: Compara nerve development Inferred from electronic annotation. Source: Compara positive regulation of fibroblast proliferation Inferred from electronic annotation. Source: Compara positive regulation of odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara regulation of gene expression Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	death receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 416	397	Tumor necrosis factor receptor superfamily member 16		PRO_0000034594
Regions
	Topological domain	29 – 239	211	Extracellular Potential
	Transmembrane	240 – 261	22	Helical; Potential
	Topological domain	262 – 416	155	Cytoplasmic Potential
	Repeat	23 – 57	35	TNFR-Cys 1
	Repeat	58 – 99	42	TNFR-Cys 2
	Repeat	100 – 138	39	TNFR-Cys 3
	Repeat	140 – 180	41	TNFR-Cys 4
	Domain	333 – 410	78	Death
	Compositional bias	188 – 236	49	Ser/Thr-rich
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Disulfide bond	24 ↔ 35		By similarity
	Disulfide bond	36 ↔ 49		By similarity
	Disulfide bond	39 ↔ 56		By similarity
	Disulfide bond	59 ↔ 75		By similarity
	Disulfide bond	78 ↔ 91		By similarity
	Disulfide bond	81 ↔ 99		By similarity
	Disulfide bond	101 ↔ 114		By similarity
	Disulfide bond	117 ↔ 130		By similarity
	Disulfide bond	120 ↔ 138		By similarity
	Disulfide bond	141 ↔ 156		By similarity
	Disulfide bond	159 ↔ 172		By similarity
	Disulfide bond	162 ↔ 180		By similarity
Experimental info
	Sequence conflict	36	1	C → Y Ref.2
	Sequence conflict	173	1	T → K Ref.2
	Sequence conflict	276	1	N → S Ref.2
	Sequence conflict	396	1	K → R Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P18519 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 6BCEAAB54F4D2D56	FASTA	416	44,654
	10 20 30 40 50 60 MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG VNQTVCEPCL 70 80 90 100 110 120 DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR CAYGYFQDEL SGSCKECSIC 130 140 150 160 170 180 EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA NFVDPCLPCT ICEENEVMVK ECTATSDAEC 190 200 210 220 230 240 RDLHPRWTTH TPSLAGSDSP EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL 250 260 270 280 290 300 IPVYCSILAA VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS 310 320 330 340 350 360 QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ LAGELGYKED 370 380 390 400 410 LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG DIAESLYSES TATSPV

References

[1]	"Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system." Large T.H., Weskamp G., Helder J.C., Radeke M.J., Misko T.P., Shooter E.M., Reichardt L.F. Neuron 2:1123-1134(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain.
[2]	"Structure and developmental expression of the chicken NGF receptor." Heuer J.G., Fatemie-Nainie S., Wheeler E.F., Bothwell M. Dev. Biol. 137:287-304(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 21-416.

Cross-references

Sequence databases
IPI	IPI00572450.
PIR	JN0006.
UniGene	Gga.39799.
3D structure databases
ProteinModelPortal	P18519.
SMR	P18519. Positions 322-409.
ModBase	Search...
Proteomic databases
PaxDb	P18519.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG39106.
HOGENOM	HOG000059587.
HOVERGEN	HBG060431.
InParanoid	P18519.
OrthoDB	EOG4ZKJM8.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR001368. TNFR/NGFR_Cys_rich_reg. IPR022325. TNFR_16. [Graphical view]
Pfam	PF00531. Death. 1 hit. PF00020. TNFR_c6. 3 hits. [Graphical view]
PRINTS	PR01966. TNFACTORR16.
SMART	SM00005. DEATH. 1 hit. SM00208. TNFR. 4 hits. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 3 hits. PS50050. TNFR_NGFR_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TNR16_CHICK

Accession

Primary (citable) accession number: P18519

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program