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P18519

- TNR16_CHICK

UniProt

P18519 - TNR16_CHICK

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Protein

Tumor necrosis factor receptor superfamily member 16

Gene

NGFR

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes and the genes involved in glucose and lipid metabolism (By similarity).By similarity

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. cell differentiation Source: UniProtKB-KW
  3. circadian regulation of gene expression Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis, Biological rhythms, Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor
p75 ICD
Gene namesi
Name:NGFR
Synonyms:TNFRSF16
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 239211ExtracellularSequence AnalysisAdd
BLAST
Transmembranei240 – 26122HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 416155CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 416397Tumor necrosis factor receptor superfamily member 16PRO_0000034594Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 35PROSITE-ProRule annotation
Disulfide bondi36 ↔ 49PROSITE-ProRule annotation
Disulfide bondi39 ↔ 56PROSITE-ProRule annotation
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Disulfide bondi78 ↔ 91PROSITE-ProRule annotation
Disulfide bondi81 ↔ 99PROSITE-ProRule annotation
Disulfide bondi101 ↔ 114PROSITE-ProRule annotation
Disulfide bondi117 ↔ 130PROSITE-ProRule annotation
Disulfide bondi120 ↔ 138PROSITE-ProRule annotation
Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
Disulfide bondi159 ↔ 172PROSITE-ProRule annotation
Disulfide bondi162 ↔ 180PROSITE-ProRule annotation

Post-translational modificationi

N- and O-glycosylated.
Phosphorylated on serine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18519.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 (By similarity). Interacts with LINGO1 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP18519.
SMRiP18519. Positions 322-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 5735TNFR-Cys 1Add
BLAST
Repeati58 – 9942TNFR-Cys 2Add
BLAST
Repeati100 – 13839TNFR-Cys 3Add
BLAST
Repeati140 – 18041TNFR-Cys 4Add
BLAST
Domaini333 – 41078DeathPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 23649Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39106.
HOGENOMiHOG000059587.
HOVERGENiHBG060431.
InParanoidiP18519.
PhylomeDBiP18519.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01966. TNFACTORR16.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18519-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG
60 70 80 90 100
VNQTVCEPCL DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR
110 120 130 140 150
CAYGYFQDEL SGSCKECSIC EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA
160 170 180 190 200
NFVDPCLPCT ICEENEVMVK ECTATSDAEC RDLHPRWTTH TPSLAGSDSP
210 220 230 240 250
EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL IPVYCSILAA
260 270 280 290 300
VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS
310 320 330 340 350
QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ
360 370 380 390 400
LAGELGYKED LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG
410
DIAESLYSES TATSPV
Length:416
Mass (Da):44,654
Last modified:November 1, 1990 - v1
Checksum:i6BCEAAB54F4D2D56
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361C → Y(PubMed:2154393)Curated
Sequence conflicti173 – 1731T → K(PubMed:2154393)Curated
Sequence conflicti276 – 2761N → S(PubMed:2154393)Curated
Sequence conflicti396 – 3961K → R(PubMed:2154393)Curated

Sequence databases

PIRiJN0006.
UniGeneiGga.39799.

Cross-referencesi

Sequence databases

PIRi JN0006.
UniGenei Gga.39799.

3D structure databases

ProteinModelPortali P18519.
SMRi P18519. Positions 322-409.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P18519.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG39106.
HOGENOMi HOG000059587.
HOVERGENi HBG060431.
InParanoidi P18519.
PhylomeDBi P18519.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022325. TNFR_16.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view ]
PRINTSi PR01966. TNFACTORR16.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system."
    Large T.H., Weskamp G., Helder J.C., Radeke M.J., Misko T.P., Shooter E.M., Reichardt L.F.
    Neuron 2:1123-1134(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. "Structure and developmental expression of the chicken NGF receptor."
    Heuer J.G., Fatemie-Nainie S., Wheeler E.F., Bothwell M.
    Dev. Biol. 137:287-304(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 21-416.

Entry informationi

Entry nameiTNR16_CHICK
AccessioniPrimary (citable) accession number: P18519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3