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P18519

- TNR16_CHICK

UniProt

P18519 - TNR16_CHICK

Protein

Tumor necrosis factor receptor superfamily member 16

Gene

NGFR

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes and the genes involved in glucose and lipid metabolism By similarity.By similarity

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. circadian regulation of gene expression Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis, Biological rhythms, Differentiation, Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 16
    Alternative name(s):
    Gp80-LNGFR
    Low affinity neurotrophin receptor p75NTR
    Low-affinity nerve growth factor receptor
    Short name:
    NGF receptor
    p75 ICD
    Gene namesi
    Name:NGFR
    Synonyms:TNFRSF16
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 416397Tumor necrosis factor receptor superfamily member 16PRO_0000034594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 35PROSITE-ProRule annotation
    Disulfide bondi36 ↔ 49PROSITE-ProRule annotation
    Disulfide bondi39 ↔ 56PROSITE-ProRule annotation
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
    Disulfide bondi78 ↔ 91PROSITE-ProRule annotation
    Disulfide bondi81 ↔ 99PROSITE-ProRule annotation
    Disulfide bondi101 ↔ 114PROSITE-ProRule annotation
    Disulfide bondi117 ↔ 130PROSITE-ProRule annotation
    Disulfide bondi120 ↔ 138PROSITE-ProRule annotation
    Disulfide bondi141 ↔ 156PROSITE-ProRule annotation
    Disulfide bondi159 ↔ 172PROSITE-ProRule annotation
    Disulfide bondi162 ↔ 180PROSITE-ProRule annotation

    Post-translational modificationi

    N- and O-glycosylated.
    Phosphorylated on serine residues.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP18519.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6 and PTPN13 By similarity. Interacts with LINGO1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP18519.
    SMRiP18519. Positions 322-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 239211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini262 – 416155CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei240 – 26122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati23 – 5735TNFR-Cys 1Add
    BLAST
    Repeati58 – 9942TNFR-Cys 2Add
    BLAST
    Repeati100 – 13839TNFR-Cys 3Add
    BLAST
    Repeati140 – 18041TNFR-Cys 4Add
    BLAST
    Domaini333 – 41078DeathPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi188 – 23649Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39106.
    HOGENOMiHOG000059587.
    HOVERGENiHBG060431.
    InParanoidiP18519.
    PhylomeDBiP18519.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01966. TNFACTORR16.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18519-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGFVPLLLL LLPAGPTWGS KEKCLTKMYT TSGECCKACN LGEGVVQPCG    50
    VNQTVCEPCL DSVTYSDTVS ATEPCKPCTQ CVGLHSMSAP CVESDDAVCR 100
    CAYGYFQDEL SGSCKECSIC EVGFGLMFPC RDSQDTVCEE CPEGTFSDEA 150
    NFVDPCLPCT ICEENEVMVK ECTATSDAEC RDLHPRWTTH TPSLAGSDSP 200
    EPITRDPFNT EGMATTLADI VTTVMGSSQP VVSRGTADNL IPVYCSILAA 250
    VVVGLVAYIA FKRWNSCKQN KQGANNRPVN QTPSPEGEKL HSDSGISVDS 300
    QSLHDQQPPN QSTQGPAPKG DGSLYASLPP SKQEEVEKLL SSSAEETWRQ 350
    LAGELGYKED LIDCFTREES PARALLADWS AKETATLDAL LVALRKIQRG 400
    DIAESLYSES TATSPV 416
    Length:416
    Mass (Da):44,654
    Last modified:November 1, 1990 - v1
    Checksum:i6BCEAAB54F4D2D56
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361C → Y(PubMed:2154393)Curated
    Sequence conflicti173 – 1731T → K(PubMed:2154393)Curated
    Sequence conflicti276 – 2761N → S(PubMed:2154393)Curated
    Sequence conflicti396 – 3961K → R(PubMed:2154393)Curated

    Sequence databases

    PIRiJN0006.
    UniGeneiGga.39799.

    Cross-referencesi

    Sequence databases

    PIRi JN0006.
    UniGenei Gga.39799.

    3D structure databases

    ProteinModelPortali P18519.
    SMRi P18519. Positions 322-409.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P18519.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG39106.
    HOGENOMi HOG000059587.
    HOVERGENi HBG060431.
    InParanoidi P18519.
    PhylomeDBi P18519.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022325. TNFR_16.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01966. TNFACTORR16.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system."
      Large T.H., Weskamp G., Helder J.C., Radeke M.J., Misko T.P., Shooter E.M., Reichardt L.F.
      Neuron 2:1123-1134(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Brain.
    2. "Structure and developmental expression of the chicken NGF receptor."
      Heuer J.G., Fatemie-Nainie S., Wheeler E.F., Bothwell M.
      Dev. Biol. 137:287-304(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 21-416.

    Entry informationi

    Entry nameiTNR16_CHICK
    AccessioniPrimary (citable) accession number: P18519
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3