Reviewed,
UniProtKB/Swiss-Prot P18510 (IL1RA_HUMAN)
Last modified
January 19, 2010.
Version 127.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Interleukin-1 receptor antagonist protein Short name=IL-1ra Short name=IL-1RN Short name=IRAP Alternative name(s): IL1 inhibitor ICIL-1RA INN=Anakinra | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 177 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity. |
| Subcellular location | Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm. |
| Tissue specificity | The intracellular form of IL1RN is predominantly expressed in epithelial cells. |
| Involvement in disease | Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function. |
| Pharmaceutical use | Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Secreted |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Pharmaceutical |
| Gene Ontology (GO) | |
| Biological process | immune response Ref.7 Non-traceable author statement. Source: UniProtKB inflammatory responseInferred from direct assay. Source: UniProtKB response to glucocorticoid stimulusInferred from direct assay. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from direct assay. Source: HPA extracellular space Ref.4Inferred from direct assay. Source: UniProtKB |
| Molecular function | cytokine activity Non-traceable author statement. Source: UniProtKB interleukin-1 receptor antagonist activity Ref.1 Ref.7Traceable author statement. Source: UniProtKB |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P18510-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P18510-2) Also known as: icIL-1ra; The sequence of this isoform differs from the canonical sequence as follows: 1-21: MEICRGLRSHLITLLLFLFHS → MAL | ||||||
| Isoform 3 (identifier: P18510-3) Also known as: icIL-1ra type II; The sequence of this isoform differs from the canonical sequence as follows: 1-21: MEICRGLRSHLITLLLFLFHS → MALADLYEEGGGGGGEGEDNADSK | ||||||
| Isoform 4 (identifier: P18510-4) The sequence of this isoform differs from the canonical sequence as follows: 1-34: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Ref.12 Ref.13 | |||||||||||||||||||||||||||||||||||||
| Chain | 26 – 177 | 152 | Interleukin-1 receptor antagonist protein Ref.1 | PRO_0000015328 | ||||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 109 | 1 | N-linked (GlcNAc...) Ref.12 Ref.16 | |||||||||||||||||||||||||||||||||||||
| Disulfide bond | 91 ↔ 141 | |||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 34 | 34 | Missing in isoform 4. | VSP_002651 | ||||||||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 21 | 21 | MEICR…FLFHS → MAL in isoform 2. | VSP_002649 | ||||||||||||||||||||||||||||||||||||
| Alternative sequence | 1 – 21 | 21 | MEICR…FLFHS → MALADLYEEGGGGGGEGEDN ADSK in isoform 3. | VSP_002650 | ||||||||||||||||||||||||||||||||||||
| Natural variant | 124 | 1 | A → T: dbSNP rs45507693. Ref.23 | VAR_049573 | ||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||
| Beta strand | 36 – 42 | 7 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 47 – 51 | 5 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 54 – 58 | 5 | ||||||||||||||||||||||||||||||||||||||
| Helix | 62 – 67 | 6 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 71 – 76 | 6 | ||||||||||||||||||||||||||||||||||||||
| Turn | 77 – 79 | 3 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 80 – 85 | 6 | ||||||||||||||||||||||||||||||||||||||
| Turn | 86 – 89 | 4 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 90 – 97 | 8 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 100 – 106 | 7 | ||||||||||||||||||||||||||||||||||||||
| Helix | 110 – 112 | 3 | ||||||||||||||||||||||||||||||||||||||
| Helix | 118 – 123 | 6 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 124 – 130 | 7 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 133 – 141 | 9 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 145 – 151 | 7 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 157 – 160 | 4 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 162 – 168 | 7 | ||||||||||||||||||||||||||||||||||||||
| Beta strand | 171 – 175 | 5 | ||||||||||||||||||||||||||||||||||||||
Sequences
| ||||||||||||||||||||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein." Carter D.B., Deibel M.R. Jr., Dunn C.J., Tomich C.S.C., Laborde A.L., Slightom J.L., Berger A.E., Bienkowski M.J., Sun F.F., McEwan R.N., Harris P.K.W., Yem A.W., Waszak G.A., Chosay J.G., Sieu L.C., Hardee M.M., Zurcher-Neely H.A., Reardon I.M. Tracey D.E.Nature 344:633-638(1990) [PubMed: 2139180] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [2] | "Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist." Eisenberg S.P., Evans R.J., Arend W.P., Verderber E., Brewer M.T., Hannum C.H., Thompson R.C. Nature 343:341-346(1990) [PubMed: 2137201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). |
| [3] | "Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism." Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P., Brandhuber B.J., Thompson R.C. Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991) [PubMed: 1828896] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). |
| [4] | "Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene." Lennard A., Gorman P., Carrier M., Griffiths S., Scotney H., Sheer D., Solari R. Cytokine 4:83-89(1992) [PubMed: 1385987] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). |
| [5] | "Intracellular IL-1 receptor antagonist promoter: cell type-specific and inducible regulatory regions." Jenkins J.K., Drong R.F., Shuck M.E., Bienkowski M.J., Slightom J.L., Arend W.P., Smith M.F. Jr. J. Immunol. 158:748-755(1997) [PubMed: 8992991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3). |
| [6] | "cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium." Haskill S., Martin G., van Le L., Morris J., Peace A., Bigler C.F., Jaffe G.J., Hammerberg C., Sporn S.A., Fong S., Arend W.P., Ralph P. Proc. Natl. Acad. Sci. U.S.A. 88:3681-3685(1991) [PubMed: 1827201] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). |
| [7] | "Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist." Muzio M., Polentarutti N., Sironi M., Poli G., De Gioia L., Introna M., Mantovani A., Colotta F. J. Exp. Med. 182:623-628(1995) [PubMed: 7629520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). |
| [8] | SeattleSNPs variation discovery resource Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [9] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). |
| [10] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [11] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Pancreas. |
| [12] | "Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor." Hannum C.H., Wilcox C.J., Arend W.P., Joslin F.G., Dripps D.J., Heimdal P.L., Armes L.G., Sommer A., Eisenberg S.P., Thompson R.C. Nature 343:336-340(1990) [PubMed: 2137200] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-45, GLYCOSYLATION AT ASN-109. |
| [13] | "Purification and characterization of interleukin 1 receptor level antagonist proteins from THP-1 cells." Bienkowski M.J., Eessalu T.E., Berger A.E., Truesdell S.E., Shelly J.A., Laborde A.L., Zurcher-Neely H.A., Reardon I.M., Heinrikson R.L., Chosay J.G., Tracey D.E. J. Biol. Chem. 265:14505-14511(1990) [PubMed: 2143761] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-52. |
| [14] | "Detection of an interleukin-1 intracellular receptor antagonist mRNA variant." Weissbach L., Tran K., Colquhoun S.A., Champliaud M.-F., Towle C.A. Biochem. Biophys. Res. Commun. 244:91-95(1998) [PubMed: 9514884] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-177 (ISOFORM 4). |
| [15] | "A sequence-based map of the nine genes of the human interleukin-1 cluster." Nicklin M.J.H., Barton J.L., Nguyen M., Fitzgerald M.G., Duff W.G., Kornman K. Genomics 79:718-725(2002) [PubMed: 11991722] [Abstract] Cited for: IDENTIFICATION (ISOFORM 2). |
| [16] | "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed: 16335952] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109, MASS SPECTROMETRY. Tissue: Plasma. |
| [17] | "Secondary structure and topology of interleukin-1 receptor antagonist protein determined by heteronuclear three-dimensional NMR spectroscopy." Stockman B.J., Scahill T.A., Roy M., Ulrich E.L., Strakalaitis N.A., Brunner D.P., Yem A.W., Deibel M.R. Jr. Biochemistry 31:5237-5244(1992) [PubMed: 1534997] [Abstract] Cited for: STRUCTURE BY NMR. |
| [18] | "Solution structure of human interleukin-1 receptor antagonist protein." Stockman B.J., Scahill T.A., Strakalaitis N.A., Brunner D.P., Yem A.W., Deibel M.R. Jr. FEBS Lett. 349:79-83(1994) [PubMed: 8045306] [Abstract] Cited for: STRUCTURE BY NMR. |
| [19] | "X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution." Vigers G.P.A., Caffes P., Evans R.J., Thompson R.C., Eisenberg S.P., Brandhuber B.J. J. Biol. Chem. 269:12874-12879(1994) [PubMed: 8175703] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS). |
| [20] | "Refined crystal structure of the interleukin-1 receptor antagonist. Presence of a disulfide link and a cis-proline." Schreuder H.A., Rondeau J.-M., Tardif C., Soffientini A., Sarubbi E., Akeson A., Bowlin T.L., Yanofsky S., Barrett R.W. Eur. J. Biochem. 227:838-847(1995) [PubMed: 7867645] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS). |
| [21] | "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist." Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W. Nature 386:194-200(1997) [PubMed: 9062194] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 32-177 IN COMPLEX WITH IL1R. |
| [22] | "Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus." Blakemore A.I.F., Cox A., Gonzalez A.-M., Maskil J.K., Hughes M.E., Wilson R.M., Ward J.D., Duff G.W. Hum. Genet. 97:369-374(1996) [PubMed: 8786086] [Abstract] Cited for: INVOLVEMENT IN DIABETIC NEPHROPATHY SUSCEPTIBILITY. |
| [23] | "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome." Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. Wilson R.K.Nature 456:66-72(2008) [PubMed: 18987736] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-124. |
| + | Additional computationally mapped references. |
Web resources
| R&D Systems' cytokine source book: IL-1ra |
| Wikipedia Interleukin-1 entry |
| SeattleSNPs |
| SHMPD The Singapore human mutation and polymorphism database |
| Kineret professional medical information" |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X53296 mRNA. Translation: CAA37386.1. X52015 mRNA. Translation: CAA36262.1. M63099 Genomic DNA. Translation: AAB41943.1. X64532 Genomic DNA. Translation: CAA45832.1. U65590 Genomic DNA. Translation: AAB92270.1. U65590 Genomic DNA. Translation: AAB92268.1. U65590 Genomic DNA. Translation: AAB92269.1. M55646 mRNA. Translation: AAA59138.1. X84348 mRNA. Translation: CAA59087.1. AY196903 Genomic DNA. Translation: AAN87150.1. AK290926 mRNA. Translation: BAF83615.1. CH471217 Genomic DNA. Translation: EAW73625.1. BC009745 mRNA. Translation: AAH09745.1. AF043143 mRNA. Translation: AAC39672.1. BN000002 Genomic DNA. Translation: CAD29879.1. | ||||||||||||||||||||||||||||||||||||||||||
| IPI | IPI00000045. IPI00174541. IPI00175024. IPI00218573. | ||||||||||||||||||||||||||||||||||||||||||
| PIR | A30368. A40956. A39386. I37893. | ||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NP_000568.1. NP_776213.1. NP_776214.1. NP_776215.1. | ||||||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.81134 | ||||||||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||||||||
| DIP | DIP-3513N. | ||||||||||||||||||||||||||||||||||||||||||
| IntAct | P18510. 1 interaction. | ||||||||||||||||||||||||||||||||||||||||||
| STRING | P18510. | ||||||||||||||||||||||||||||||||||||||||||
2-D gel databases | |||||||||||||||||||||||||||||||||||||||||||
| Aarhus/Ghent-2DPAGE | 7104. IEF. 7105. IEF. | ||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||||||||
| PRIDE | P18510. | ||||||||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||||||||
| Ensembl | ENST00000409930; ENSP00000387173; ENSG00000136689; Homo sapiens. [Genome view] | ||||||||||||||||||||||||||||||||||||||||||
| GeneID | 3557. | ||||||||||||||||||||||||||||||||||||||||||
| KEGG | hsa:3557. | ||||||||||||||||||||||||||||||||||||||||||
| UCSC | uc002tiy.1. human. uc002tjb.1. human. | ||||||||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||||||||
| CTD | 3557. | ||||||||||||||||||||||||||||||||||||||||||
| GeneCards | GC02P113591. | ||||||||||||||||||||||||||||||||||||||||||
| H-InvDB | HIX0002389. | ||||||||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:6000. IL1RN. | ||||||||||||||||||||||||||||||||||||||||||
| HPA | CAB009633. HPA001482. | ||||||||||||||||||||||||||||||||||||||||||
| MIM | 147679. gene. 612628. phenotype. | ||||||||||||||||||||||||||||||||||||||||||
| Orphanet | 210115. Autoinflammatory disease due to interleukin-1 receptor antagonist deficiency. | ||||||||||||||||||||||||||||||||||||||||||
| PharmGKB | PA29816. | ||||||||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||||||||
| eggNOG | prNOG14050. | ||||||||||||||||||||||||||||||||||||||||||
| HOVERGEN | P18510. | ||||||||||||||||||||||||||||||||||||||||||
| OMA | TFIRSDS. | ||||||||||||||||||||||||||||||||||||||||||
Enzyme and pathway databases | |||||||||||||||||||||||||||||||||||||||||||
| Pathway_Interaction_DB | il1pathway. IL1-mediated signaling events. | ||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||||||||
| ArrayExpress | P18510. | ||||||||||||||||||||||||||||||||||||||||||
| Bgee | P18510. | ||||||||||||||||||||||||||||||||||||||||||
| CleanEx | HS_IL1RN. | ||||||||||||||||||||||||||||||||||||||||||
| Genevestigator | P18510. | ||||||||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000136689. Homo sapiens. | ||||||||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||||||||
| InterPro | IPR008996. Cytokine_IL1-like. IPR003297. IL_rcpt_IL1RA. IPR020877. Interleukin-1_CS. IPR000975. Interleukin_1. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| Pfam | PF00340. IL1. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| PRINTS | PR00264. INTERLEUKIN1. PR01360. INTRLEUKIN1X. | ||||||||||||||||||||||||||||||||||||||||||
| SMART | SM00125. IL1. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| PROSITE | PS00253. INTERLEUKIN_1. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||||||||||||||
| DrugBank | DB00026. Anakinra. | ||||||||||||||||||||||||||||||||||||||||||
| NextBio | 13886. | ||||||||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | IL1RA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P18510 Secondary accession number(s): A8K4G1 Q9UPC0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |

Clusters with


