Gamma-aminobutyric acid receptor subunit gamma-2 precursor

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P18508 (GBRG2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-2

Alternative name(s):
GABA(A) receptor subunit gamma-2

Gene names

Name:

Gabrg2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit structure	Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular location	Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Post-translational modification	Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability By similarity.
Miscellaneous	This subunit carries the benzodiazepine binding site.
Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Signal Transmembrane Transmembrane helix
Ligand	Chloride
Molecular function	Chloride channel Ionic channel
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gamma-aminobutyric acid signaling pathway Traceable author statement. Source: RGD
Cellular component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW chloride channel complex Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from direct assay. Source: RGD dendrite membrane Inferred from direct assay. Source: BHF-UCL postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GABA-A receptor activity Inferred from direct assay Ref.1. Source: RGD chloride channel activity Inferred from direct assay Ref.1. Source: RGD inhibitory extracellular ligand-gated ion channel activity Traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 38

Potential

Chain

39 – 466

428

Gamma-aminobutyric acid receptor subunit gamma-2

PRO_0000000479

Regions

Topological domain

39 – 272

234

Extracellular Probable

Transmembrane

273 – 295

Helical; Probable

Transmembrane

299 – 321

Helical; Probable

Transmembrane

333 – 355

Helical; Probable

Topological domain

356 – 442

Cytoplasmic Probable

Transmembrane

443 – 465

Helical; Probable

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

128

N-linked (GlcNAc...) Potential

Glycosylation

246

N-linked (GlcNAc...) Potential

Disulfide bond

189 ↔ 203

By similarity

Experimental info

Sequence conflict

M → I no nucleotide entry Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P18508 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 3C60B66E0D23072F
Show »

FASTA

466

54,077

        10         20         30         40         50         60 
MSSPNTWSTG STVYSPVFSQ KMTLWILLLL SLYPGFTSQK SDDDYEDYAS NKTWVLTPKV 

        70         80         90        100        110        120 
PEGDVTVILN NLLEGYDNKL RPDIGVKPTL IHTDMYVNSI GPVNAINMEY TIDIFFAQTW 

       130        140        150        160        170        180 
YDRRLKFNST IKVLRLNSNM VGKIWIPDTF FRNSKKADAH WITTPNRMLR IWNDGRVLYT 

       190        200        210        220        230        240 
LRLTIDAECQ LQLHNFPMDE HSCPLEFSSY GYPREEIVYQ WKRSSVEVGD TRSWRLYQFS 

       250        260        270        280        290        300 
FVGLRNTTEV VKTTSGDYVV MSVYFDLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV 

       310        320        330        340        350        360 
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV EYGTLHYFVS 

       370        380        390        400        410        420 
NRKPSKDKDK KKKNPAPTID IRPRSATIQM NNATHLQERD EEYGYECLDG KDCASFFCCF 

       430        440        450        460 
EDCRTGAWRH GRIHIRIAKM DSYARIFFPT AFCLFNLVYW VSYLYL

« Hide

References

[1]	"Two novel GABAA receptor subunits exist in distinct neuronal subpopulations." Shivers B.D., Killisch I., Sprengel R., Sontheimer H., Koehler M., Schofield P.R., Seeburg P.H. Neuron 3:327-337(1989) [PubMed: 2561970] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[2]	"Functional characteristics and sites of gene expression of the alpha 1, beta 1, gamma 2-isoform of the rat GABAA receptor." Malherbe P., Sigel E., Baur R., Persohn E., Richards J.G., Mohler H. J. Neurosci. 10:2330-2337(1990) [PubMed: 2165521] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L08497 Genomic DNA. Translation: AAC42036.1.

IPI

IPI00192646.

PIR

JQ0077.

RefSeq

NP_899156.1. NM_183327.1.

UniGene

Rn.159942.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2PR9	X-ray	2.51	P	400-409	[»]

ProteinModelPortal

P18508.

SMR

P18508. Positions 300-357.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-3371576.

STRING

P18508.

Proteomic databases

PRIDE

P18508.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSRNOT00000004619; ENSRNOP00000004619; ENSRNOG00000003241.

GeneID

29709.

KEGG

rno:29709.

UCSC

AY574252. rat.

Organism-specific databases

CTD

2566.

RGD

61966. Gabrg2.

Phylogenomic databases

eggNOG

roNOG07684.

GeneTree

ENSGT00540000070314.

HOVERGEN

HBG051707.

Gene expression databases

ArrayExpress

P18508.

Genevestigator

P18508.

GermOnline

ENSRNOG00000003241. Rattus norvegicus.

Family and domain databases

InterPro

IPR006028. GABAA_rcpt.
IPR005439. GABBAg2_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]

Gene3D

G3DSA:2.70.170.10. Neur_chan_lig_bd. 1 hit.

K05186.

PANTHER

PTHR18945. Neur_channel. 1 hit.

Pfam

PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]

PRINTS

PR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01622. GABAARGAMMA2.
PR00252. NRIONCHANNEL.

SUPFAM

SSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.

TIGRFAMs

TIGR00860. LIC. 1 hit.

PROSITE

PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

610135.

Entry information

Entry name

GBRG2_RAT

Accession

Primary (citable) accession number: P18508

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	December 14, 2011
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents