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Protein

Gamma-aminobutyric acid receptor subunit delta

Gene

Gabrd

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

GO - Molecular functioni

GO - Biological processi

  • signal transduction Source: GOC
  • synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit delta
Alternative name(s):
GABA(A) receptor subunit delta
Gene namesi
Name:Gabrd
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61901. Gabrd.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 248232ExtracellularCuratedAdd
BLAST
Transmembranei249 – 27123HelicalCuratedAdd
BLAST
Transmembranei275 – 29723HelicalCuratedAdd
BLAST
Transmembranei309 – 33123HelicalCuratedAdd
BLAST
Topological domaini332 – 42695CytoplasmicCuratedAdd
BLAST
Transmembranei427 – 44923HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1907607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Add
BLAST
Chaini17 – 449433Gamma-aminobutyric acid receptor subunit deltaPRO_0000000470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence analysis
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi164 ↔ 178By similarity
Modified residuei390 – 3901PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18506.

PTM databases

iPTMnetiP18506.

Expressioni

Gene expression databases

GenevisibleiP18506. RN.

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

IntActiP18506. 1 interaction.
STRINGi10116.ENSRNOP00000022246.

Structurei

3D structure databases

ProteinModelPortaliP18506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP18506.
KOiK05184.
OMAiIVYHWSE.
OrthoDBiEOG712TVZ.
PhylomeDBiP18506.
TreeFamiTF315453.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG
60 70 80 90 100
YARNFRPGIG GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL
110 120 130 140 150
SYNHTNETLG LDSRFVDKLW LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG
160 170 180 190 200
VILYSIRITS TVACDMDLAK YPMDEQECML DLESYGYSSE DIVYYWSENQ
210 220 230 240 250
EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH FQLRRNRGVY
260 270 280 290 300
IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
310 320 330 340 350
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP
360 370 380 390 400
RAEMDVRNAI VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK
410 420 430 440
EGGSRPGGPG GIRSRLKPID ADTIDIYARA VFPAAFAAVN IIYWAAYTM
Length:449
Mass (Da):50,566
Last modified:June 1, 1994 - v2
Checksum:i64BDBCDEEB2C70AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08496 Genomic DNA. Translation: AAC42035.1.
BC087714 mRNA. Translation: AAH87714.1.
M35162 mRNA. Translation: AAA41182.1.
PIRiA34625.
RefSeqiNP_058985.1. NM_017289.1.
UniGeneiRn.10927.

Genome annotation databases

EnsembliENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385.
GeneIDi29689.
KEGGirno:29689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08496 Genomic DNA. Translation: AAC42035.1.
BC087714 mRNA. Translation: AAH87714.1.
M35162 mRNA. Translation: AAA41182.1.
PIRiA34625.
RefSeqiNP_058985.1. NM_017289.1.
UniGeneiRn.10927.

3D structure databases

ProteinModelPortaliP18506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18506. 1 interaction.
STRINGi10116.ENSRNOP00000022246.

Chemistry

ChEMBLiCHEMBL1907607.

PTM databases

iPTMnetiP18506.

Proteomic databases

PaxDbiP18506.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385.
GeneIDi29689.
KEGGirno:29689.

Organism-specific databases

CTDi2563.
RGDi61901. Gabrd.

Phylogenomic databases

eggNOGiKOG3643. Eukaryota.
ENOG410XPWH. LUCA.
GeneTreeiENSGT00760000118821.
HOGENOMiHOG000231335.
HOVERGENiHBG051707.
InParanoidiP18506.
KOiK05184.
OMAiIVYHWSE.
OrthoDBiEOG712TVZ.
PhylomeDBiP18506.
TreeFamiTF315453.

Miscellaneous databases

PROiP18506.

Gene expression databases

GenevisibleiP18506. RN.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008098. GABAAd_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR01722. GABAARDELTA.
PR00253. GABAARECEPTR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel GABAA receptor subunits exist in distinct neuronal subpopulations."
    Shivers B.D., Killisch I., Sprengel R., Sontheimer H., Koehler M., Schofield P.R., Seeburg P.H.
    Neuron 3:327-337(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  2. "Isolation of distantly related members in a multigene family using the polymerase chain reaction technique."
    Zhao Z.Y., Joho R.H.
    Biochem. Biophys. Res. Commun. 167:174-182(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Brain.
  3. Erratum
    Zhao Z.Y., Joho R.H.
    Biochem. Biophys. Res. Commun. 168:887-887(1990)
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "BSF1, a novel brain-specific DNA-binding protein recognizing a tandemly repeated purine DNA element in the GABAA receptor delta subunit gene."
    Motejlek K., Hauselmann R., Leitgeb S., Luescher B.
    J. Biol. Chem. 269:15265-15273(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-22.
    Strain: Sprague-Dawley.
    Tissue: Testis.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGBRD_RAT
AccessioniPrimary (citable) accession number: P18506
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: June 1, 1994
Last modified: June 8, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.