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P18502

- PTC_DROME

UniProt

P18502 - PTC_DROME

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Protein
Protein patched
Gene
ptc, CG2411
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).

GO - Molecular functioni

  1. hedgehog receptor activity Source: FlyBase
  2. lipoprotein particle receptor activity Source: FlyBase
  3. protein binding Source: FlyBase
  4. transmembrane signaling receptor activity Source: FlyBase
Complete GO annotation...

GO - Biological processi

  1. Bolwig's organ morphogenesis Source: FlyBase
  2. anterior/posterior lineage restriction, imaginal disc Source: FlyBase
  3. anterior/posterior pattern specification Source: FlyBase
  4. axon guidance Source: FlyBase
  5. dephosphorylation Source: FlyBase
  6. determination of genital disc primordium Source: FlyBase
  7. embryonic pattern specification Source: FlyBase
  8. eye-antennal disc morphogenesis Source: FlyBase
  9. germ-line stem cell division Source: FlyBase
  10. gonad development Source: FlyBase
  11. imaginal disc-derived wing morphogenesis Source: FlyBase
  12. lipid homeostasis Source: FlyBase
  13. negative regulation of smoothened signaling pathway Source: FlyBase
  14. oogenesis Source: FlyBase
  15. ovarian follicle cell development Source: FlyBase
  16. peripheral nervous system development Source: FlyBase
  17. proteolysis Source: FlyBase
  18. receptor-mediated endocytosis Source: GOC
  19. regulation of apoptotic process Source: FlyBase
  20. regulation of mitotic cell cycle Source: FlyBase
  21. regulation of protein import into nucleus Source: FlyBase
  22. segment polarity determination Source: UniProtKB-KW
  23. smoothened signaling pathway Source: FlyBase
  24. somatic stem cell division Source: FlyBase
  25. wing disc anterior/posterior pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor, Segmentation polarity protein

Enzyme and pathway databases

SignaLinkiP18502.

Protein family/group databases

TCDBi2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched
Alternative name(s):
Hedgehog receptor
Gene namesi
Name:ptc
ORF Names:CG2411
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003892. ptc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei77 – 9216Helical; Reviewed prediction
Add
BLAST
Topological domaini93 – 427335Extracellular Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Reviewed prediction
Add
BLAST
Topological domaini449 – 46517Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei466 – 48621Helical; Reviewed prediction
Add
BLAST
Topological domaini487 – 4926Extracellular Reviewed prediction
Transmembranei493 – 51119Helical; Reviewed prediction
Add
BLAST
Topological domaini512 – 53221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei533 – 55321Helical; Reviewed prediction
Add
BLAST
Topological domaini554 – 5629Extracellular Reviewed prediction
Transmembranei563 – 58321Helical; Reviewed prediction
Add
BLAST
Topological domaini584 – 67794Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei678 – 69922Helical; Reviewed prediction
Add
BLAST
Topological domaini700 – 931232Extracellular Reviewed prediction
Add
BLAST
Transmembranei932 – 95221Helical; Reviewed prediction
Add
BLAST
Topological domaini953 – 9553Cytoplasmic Reviewed prediction
Transmembranei956 – 97621Helical; Reviewed prediction
Add
BLAST
Topological domaini977 – 100731Extracellular Reviewed prediction
Add
BLAST
Transmembranei1008 – 102821Helical; Reviewed prediction
Add
BLAST
Topological domaini1029 – 105628Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1057 – 107721Helical; Reviewed prediction
Add
BLAST
Topological domaini1078 – 10825Extracellular Reviewed prediction
Transmembranei1083 – 110321Helical; Reviewed prediction
Add
BLAST
Topological domaini1104 – 1286183Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. endocytic vesicle Source: FlyBase
  3. integral component of membrane Source: FlyBase
  4. integral component of plasma membrane Source: FlyBase
  5. perinuclear region of cytoplasm Source: FlyBase
  6. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12861286Protein patched
PRO_0000205973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi388 – 3881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi807 – 8071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP18502.

Expressioni

Gene expression databases

BgeeiP18502.

Interactioni

Protein-protein interaction databases

BioGridi61701. 130 interactions.
DIPiDIP-634N.

Structurei

3D structure databases

ProteinModelPortaliP18502.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini428 – 583156SSD
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1227 – 12326Poly-Pro

Sequence similaritiesi

Belongs to the patched family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313603.
GeneTreeiENSGT00680000099777.
HOGENOMiHOG000228313.
InParanoidiP18502.
KOiK06225.
OMAiPDRDYLH.
OrthoDBiEOG7HMS06.
PhylomeDBiP18502.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18502-1 [UniParc]FASTAAdd to Basket

« Hide

MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR     50
TAIYLRSVFQ SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK 100
VHQLWIQEGG RLEAELAYTQ KTIGEDESAT HQLLIQTTHD PNASVLHPQA 150
LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN MPSTPSFEGI YYIEQILRHL 200
IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN PASVMQYMKQ 250
KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST 300
QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV 350
QLMTEKEMYD QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ 400
SRIATNYDIY VFSSAALDDI LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW 450
RDPVRGQSSV GVAGVLLMCF STAAGLGLSA LLGIVFNAAS TQVVPFLALG 500
LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST AGSFFAAAFI 550
PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF 600
PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI 650
PGSSHSLASF SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR 700
LQDGLDIIDL VPKDSNEHKF LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL 750
RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS EWLGNLQKIF DEEYRDGRLT 800
KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV NSDGIINQRA 850
FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA 900
QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM 950
TLRSSLAMIL ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT 1000
LLGIKLSAIP AVILILSVGM MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS 1050
LGPLVHGMLT SGVAVFMLST SPFEFVIRHF CWLLLVVLCV GACNSLLVFP 1100
ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV VQGSRSSRGS 1150
CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA 1200
SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV 1250
ETTHSDSNTT KVTATANIKV ELAMPGRAVR SYNFTS 1286
Length:1,286
Mass (Da):142,831
Last modified:November 2, 2001 - v2
Checksum:i5F22A956F8BE0EC6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111R → G in CAA35591. 1 Publication
Sequence conflicti274 – 2741G → A in CAA35591. 1 Publication
Sequence conflicti332 – 3321A → R in AAA28696. 1 Publication
Sequence conflicti636 – 6361P → A in CAA35591. 1 Publication
Sequence conflicti862 – 8643DVF → ASSPTELLRANCIRNR1 Publication
Sequence conflicti866 – 8661Y → N1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28999, M28418 Genomic DNA. Translation: AAA28696.1.
X17558 mRNA. Translation: CAA35591.1.
AE013599 Genomic DNA. Translation: AAF59062.1.
PIRiS06119.
RefSeqiNP_523661.2. NM_078937.3.
UniGeneiDm.2630.

Genome annotation databases

EnsemblMetazoaiFBtr0089427; FBpp0088443; FBgn0003892.
GeneIDi35851.
KEGGidme:Dmel_CG2411.
UCSCiCG2411-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28999 , M28418 Genomic DNA. Translation: AAA28696.1 .
X17558 mRNA. Translation: CAA35591.1 .
AE013599 Genomic DNA. Translation: AAF59062.1 .
PIRi S06119.
RefSeqi NP_523661.2. NM_078937.3.
UniGenei Dm.2630.

3D structure databases

ProteinModelPortali P18502.
ModBasei Search...

Protein-protein interaction databases

BioGridi 61701. 130 interactions.
DIPi DIP-634N.

Protein family/group databases

TCDBi 2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Proteomic databases

PaxDbi P18502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0089427 ; FBpp0088443 ; FBgn0003892 .
GeneIDi 35851.
KEGGi dme:Dmel_CG2411.
UCSCi CG2411-RA. d. melanogaster.

Organism-specific databases

CTDi 35851.
FlyBasei FBgn0003892. ptc.

Phylogenomic databases

eggNOGi NOG313603.
GeneTreei ENSGT00680000099777.
HOGENOMi HOG000228313.
InParanoidi P18502.
KOi K06225.
OMAi PDRDYLH.
OrthoDBi EOG7HMS06.
PhylomeDBi P18502.

Enzyme and pathway databases

SignaLinki P18502.

Miscellaneous databases

GenomeRNAii 35851.
NextBioi 795513.
PROi P18502.

Gene expression databases

Bgeei P18502.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view ]
Pfami PF02460. Patched. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00918. 2A060602. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning."
    Hooper J.E., Scott M.P.
    Cell 59:751-765(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched."
    Nakano Y., Guerrero I., Hidalgo A., Taylor A., Whittle J.R.S., Ingham P.W.
    Nature 341:508-513(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiPTC_DROME
AccessioniPrimary (citable) accession number: P18502
Secondary accession number(s): Q9V4W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2001
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi