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Protein

Protein patched

Gene

ptc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).

GO - Molecular functioni

  • hedgehog receptor activity Source: FlyBase
  • lipoprotein particle receptor activity Source: FlyBase
  • transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  • anterior/posterior lineage restriction, imaginal disc Source: FlyBase
  • anterior/posterior pattern specification Source: FlyBase
  • axon guidance Source: FlyBase
  • Bolwig's organ morphogenesis Source: FlyBase
  • dephosphorylation Source: FlyBase
  • determination of genital disc primordium Source: FlyBase
  • embryonic pattern specification Source: FlyBase
  • eye-antennal disc morphogenesis Source: FlyBase
  • germ-line stem cell division Source: FlyBase
  • gonad development Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • negative regulation of smoothened signaling pathway Source: FlyBase
  • oogenesis Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • proteolysis Source: FlyBase
  • regulation of apoptotic process Source: FlyBase
  • regulation of epithelial cell migration, open tracheal system Source: FlyBase
  • regulation of mitotic cell cycle Source: FlyBase
  • regulation of protein import into nucleus Source: FlyBase
  • segment polarity determination Source: UniProtKB-KW
  • smoothened signaling pathway Source: FlyBase
  • somatic stem cell division Source: FlyBase
  • wing disc anterior/posterior pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor, Segmentation polarity protein

Enzyme and pathway databases

ReactomeiR-DME-5610787. Hedgehog 'off' state.
R-DME-5632681. Ligand-receptor interactions.
R-DME-5632684. Hedgehog 'on' state.
SignaLinkiP18502.

Protein family/group databases

TCDBi2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched
Alternative name(s):
Hedgehog receptor
Gene namesi
Name:ptc
ORF Names:CG2411
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003892. ptc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 92HelicalSequence analysisAdd BLAST16
Topological domaini93 – 427ExtracellularSequence analysisAdd BLAST335
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 465CytoplasmicSequence analysisAdd BLAST17
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 492ExtracellularSequence analysis6
Transmembranei493 – 511HelicalSequence analysisAdd BLAST19
Topological domaini512 – 532CytoplasmicSequence analysisAdd BLAST21
Transmembranei533 – 553HelicalSequence analysisAdd BLAST21
Topological domaini554 – 562ExtracellularSequence analysis9
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 677CytoplasmicSequence analysisAdd BLAST94
Transmembranei678 – 699HelicalSequence analysisAdd BLAST22
Topological domaini700 – 931ExtracellularSequence analysisAdd BLAST232
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Topological domaini953 – 955CytoplasmicSequence analysis3
Transmembranei956 – 976HelicalSequence analysisAdd BLAST21
Topological domaini977 – 1007ExtracellularSequence analysisAdd BLAST31
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Topological domaini1029 – 1056CytoplasmicSequence analysisAdd BLAST28
Transmembranei1057 – 1077HelicalSequence analysisAdd BLAST21
Topological domaini1078 – 1082ExtracellularSequence analysis5
Transmembranei1083 – 1103HelicalSequence analysisAdd BLAST21
Topological domaini1104 – 1286CytoplasmicSequence analysisAdd BLAST183

GO - Cellular componenti

  • cilium Source: FlyBase
  • cytoplasm Source: FlyBase
  • endocytic vesicle Source: FlyBase
  • integral component of membrane Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • perinuclear region of cytoplasm Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059731 – 1286Protein patchedAdd BLAST1286

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi335N-linked (GlcNAc...)Sequence analysis1
Glycosylationi388N-linked (GlcNAc...)Sequence analysis1
Glycosylationi807N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP18502.
PRIDEiP18502.

Expressioni

Gene expression databases

BgeeiFBgn0003892.
GenevisibleiP18502. DM.

Interactioni

Protein-protein interaction databases

BioGridi61701. 130 interactors.
DIPiDIP-634N.
IntActiP18502. 1 interactor.
STRINGi7227.FBpp0088443.

Structurei

3D structure databases

ProteinModelPortaliP18502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 583SSDPROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1227 – 1232Poly-Pro6

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1935. Eukaryota.
ENOG410XRKU. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000228313.
InParanoidiP18502.
KOiK06225.
OMAiHVIKNDN.
OrthoDBiEOG091G0LGQ.
PhylomeDBiP18502.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR
60 70 80 90 100
TAIYLRSVFQ SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK
110 120 130 140 150
VHQLWIQEGG RLEAELAYTQ KTIGEDESAT HQLLIQTTHD PNASVLHPQA
160 170 180 190 200
LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN MPSTPSFEGI YYIEQILRHL
210 220 230 240 250
IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN PASVMQYMKQ
260 270 280 290 300
KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST
310 320 330 340 350
QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV
360 370 380 390 400
QLMTEKEMYD QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ
410 420 430 440 450
SRIATNYDIY VFSSAALDDI LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW
460 470 480 490 500
RDPVRGQSSV GVAGVLLMCF STAAGLGLSA LLGIVFNAAS TQVVPFLALG
510 520 530 540 550
LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST AGSFFAAAFI
560 570 580 590 600
PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF
610 620 630 640 650
PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI
660 670 680 690 700
PGSSHSLASF SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR
710 720 730 740 750
LQDGLDIIDL VPKDSNEHKF LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL
760 770 780 790 800
RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS EWLGNLQKIF DEEYRDGRLT
810 820 830 840 850
KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV NSDGIINQRA
860 870 880 890 900
FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA
910 920 930 940 950
QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM
960 970 980 990 1000
TLRSSLAMIL ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT
1010 1020 1030 1040 1050
LLGIKLSAIP AVILILSVGM MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS
1060 1070 1080 1090 1100
LGPLVHGMLT SGVAVFMLST SPFEFVIRHF CWLLLVVLCV GACNSLLVFP
1110 1120 1130 1140 1150
ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV VQGSRSSRGS
1160 1170 1180 1190 1200
CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA
1210 1220 1230 1240 1250
SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV
1260 1270 1280
ETTHSDSNTT KVTATANIKV ELAMPGRAVR SYNFTS
Length:1,286
Mass (Da):142,831
Last modified:November 2, 2001 - v2
Checksum:i5F22A956F8BE0EC6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111R → G in CAA35591 (PubMed:2797178).Curated1
Sequence conflicti274G → A in CAA35591 (PubMed:2797178).Curated1
Sequence conflicti332A → R in AAA28696 (PubMed:2582494).Curated1
Sequence conflicti636P → A in CAA35591 (PubMed:2797178).Curated1
Sequence conflicti862 – 864DVF → ASSPTELLRANCIRNR (PubMed:2797178).Curated3
Sequence conflicti866Y → N (PubMed:2797178).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28999, M28418 Genomic DNA. Translation: AAA28696.1.
X17558 mRNA. Translation: CAA35591.1.
AE013599 Genomic DNA. Translation: AAF59062.1.
PIRiS06119.
RefSeqiNP_523661.2. NM_078937.4.

Genome annotation databases

EnsemblMetazoaiFBtr0089427; FBpp0088443; FBgn0003892.
GeneIDi35851.
KEGGidme:Dmel_CG2411.
UCSCiCG2411-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28999, M28418 Genomic DNA. Translation: AAA28696.1.
X17558 mRNA. Translation: CAA35591.1.
AE013599 Genomic DNA. Translation: AAF59062.1.
PIRiS06119.
RefSeqiNP_523661.2. NM_078937.4.

3D structure databases

ProteinModelPortaliP18502.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61701. 130 interactors.
DIPiDIP-634N.
IntActiP18502. 1 interactor.
STRINGi7227.FBpp0088443.

Protein family/group databases

TCDBi2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Proteomic databases

PaxDbiP18502.
PRIDEiP18502.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089427; FBpp0088443; FBgn0003892.
GeneIDi35851.
KEGGidme:Dmel_CG2411.
UCSCiCG2411-RA. d. melanogaster.

Organism-specific databases

CTDi35851.
FlyBaseiFBgn0003892. ptc.

Phylogenomic databases

eggNOGiKOG1935. Eukaryota.
ENOG410XRKU. LUCA.
GeneTreeiENSGT00800000124043.
HOGENOMiHOG000228313.
InParanoidiP18502.
KOiK06225.
OMAiHVIKNDN.
OrthoDBiEOG091G0LGQ.
PhylomeDBiP18502.

Enzyme and pathway databases

ReactomeiR-DME-5610787. Hedgehog 'off' state.
R-DME-5632681. Ligand-receptor interactions.
R-DME-5632684. Hedgehog 'on' state.
SignaLinkiP18502.

Miscellaneous databases

GenomeRNAii35851.
PROiP18502.

Gene expression databases

BgeeiFBgn0003892.
GenevisibleiP18502. DM.

Family and domain databases

InterProiIPR003392. Ptc/Disp.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTC_DROME
AccessioniPrimary (citable) accession number: P18502
Secondary accession number(s): Q9V4W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2001
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.