Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P18502

- PTC_DROME

UniProt

P18502 - PTC_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein patched

Gene

ptc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).

GO - Molecular functioni

  1. hedgehog receptor activity Source: FlyBase
  2. lipoprotein particle receptor activity Source: FlyBase
  3. transmembrane signaling receptor activity Source: FlyBase

GO - Biological processi

  1. anterior/posterior lineage restriction, imaginal disc Source: FlyBase
  2. anterior/posterior pattern specification Source: FlyBase
  3. axon guidance Source: FlyBase
  4. Bolwig's organ morphogenesis Source: FlyBase
  5. dephosphorylation Source: FlyBase
  6. determination of genital disc primordium Source: FlyBase
  7. embryonic pattern specification Source: FlyBase
  8. eye-antennal disc morphogenesis Source: FlyBase
  9. germ-line stem cell division Source: FlyBase
  10. gonad development Source: FlyBase
  11. imaginal disc-derived wing morphogenesis Source: FlyBase
  12. lipid homeostasis Source: FlyBase
  13. negative regulation of smoothened signaling pathway Source: FlyBase
  14. oogenesis Source: FlyBase
  15. ovarian follicle cell development Source: FlyBase
  16. peripheral nervous system development Source: FlyBase
  17. proteolysis Source: FlyBase
  18. receptor-mediated endocytosis Source: GOC
  19. regulation of apoptotic process Source: FlyBase
  20. regulation of epithelial cell migration, open tracheal system Source: FlyBase
  21. regulation of mitotic cell cycle Source: FlyBase
  22. regulation of protein import into nucleus Source: FlyBase
  23. segment polarity determination Source: UniProtKB-KW
  24. smoothened signaling pathway Source: FlyBase
  25. somatic stem cell division Source: FlyBase
  26. wing disc anterior/posterior pattern formation Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor, Segmentation polarity protein

Enzyme and pathway databases

ReactomeiREACT_253948. Class B/2 (Secretin family receptors).
REACT_271202. Hedgehog 'off' state.
SignaLinkiP18502.

Protein family/group databases

TCDBi2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein patched
Alternative name(s):
Hedgehog receptor
Gene namesi
Name:ptc
ORF Names:CG2411
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003892. ptc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei77 – 9216HelicalSequence AnalysisAdd
BLAST
Topological domaini93 – 427335ExtracellularSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST
Topological domaini449 – 46517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Topological domaini487 – 4926ExtracellularSequence Analysis
Transmembranei493 – 51119HelicalSequence AnalysisAdd
BLAST
Topological domaini512 – 53221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence AnalysisAdd
BLAST
Topological domaini554 – 5629ExtracellularSequence Analysis
Transmembranei563 – 58321HelicalSequence AnalysisAdd
BLAST
Topological domaini584 – 67794CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei678 – 69922HelicalSequence AnalysisAdd
BLAST
Topological domaini700 – 931232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei932 – 95221HelicalSequence AnalysisAdd
BLAST
Topological domaini953 – 9553CytoplasmicSequence Analysis
Transmembranei956 – 97621HelicalSequence AnalysisAdd
BLAST
Topological domaini977 – 100731ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1008 – 102821HelicalSequence AnalysisAdd
BLAST
Topological domaini1029 – 105628CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1057 – 107721HelicalSequence AnalysisAdd
BLAST
Topological domaini1078 – 10825ExtracellularSequence Analysis
Transmembranei1083 – 110321HelicalSequence AnalysisAdd
BLAST
Topological domaini1104 – 1286183CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. endocytic vesicle Source: FlyBase
  3. integral component of membrane Source: FlyBase
  4. integral component of plasma membrane Source: FlyBase
  5. perinuclear region of cytoplasm Source: FlyBase
  6. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12861286Protein patchedPRO_0000205973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP18502.

Expressioni

Gene expression databases

BgeeiP18502.

Interactioni

Protein-protein interaction databases

BioGridi61701. 130 interactions.
DIPiDIP-634N.

Structurei

3D structure databases

ProteinModelPortaliP18502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini428 – 583156SSDPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1227 – 12326Poly-Pro

Sequence similaritiesi

Belongs to the patched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG313603.
GeneTreeiENSGT00760000119174.
HOGENOMiHOG000228313.
InParanoidiP18502.
KOiK06225.
OMAiPDRDYLH.
OrthoDBiEOG7HMS06.
PhylomeDBiP18502.

Family and domain databases

InterProiIPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00918. 2A060602. 1 hit.
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18502-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR
60 70 80 90 100
TAIYLRSVFQ SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK
110 120 130 140 150
VHQLWIQEGG RLEAELAYTQ KTIGEDESAT HQLLIQTTHD PNASVLHPQA
160 170 180 190 200
LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN MPSTPSFEGI YYIEQILRHL
210 220 230 240 250
IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN PASVMQYMKQ
260 270 280 290 300
KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST
310 320 330 340 350
QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV
360 370 380 390 400
QLMTEKEMYD QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ
410 420 430 440 450
SRIATNYDIY VFSSAALDDI LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW
460 470 480 490 500
RDPVRGQSSV GVAGVLLMCF STAAGLGLSA LLGIVFNAAS TQVVPFLALG
510 520 530 540 550
LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST AGSFFAAAFI
560 570 580 590 600
PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF
610 620 630 640 650
PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI
660 670 680 690 700
PGSSHSLASF SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR
710 720 730 740 750
LQDGLDIIDL VPKDSNEHKF LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL
760 770 780 790 800
RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS EWLGNLQKIF DEEYRDGRLT
810 820 830 840 850
KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV NSDGIINQRA
860 870 880 890 900
FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA
910 920 930 940 950
QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM
960 970 980 990 1000
TLRSSLAMIL ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT
1010 1020 1030 1040 1050
LLGIKLSAIP AVILILSVGM MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS
1060 1070 1080 1090 1100
LGPLVHGMLT SGVAVFMLST SPFEFVIRHF CWLLLVVLCV GACNSLLVFP
1110 1120 1130 1140 1150
ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV VQGSRSSRGS
1160 1170 1180 1190 1200
CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA
1210 1220 1230 1240 1250
SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV
1260 1270 1280
ETTHSDSNTT KVTATANIKV ELAMPGRAVR SYNFTS
Length:1,286
Mass (Da):142,831
Last modified:November 2, 2001 - v2
Checksum:i5F22A956F8BE0EC6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111R → G in CAA35591. (PubMed:2797178)Curated
Sequence conflicti274 – 2741G → A in CAA35591. (PubMed:2797178)Curated
Sequence conflicti332 – 3321A → R in AAA28696. (PubMed:2582494)Curated
Sequence conflicti636 – 6361P → A in CAA35591. (PubMed:2797178)Curated
Sequence conflicti862 – 8643DVF → ASSPTELLRANCIRNR(PubMed:2797178)Curated
Sequence conflicti866 – 8661Y → N(PubMed:2797178)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28999, M28418 Genomic DNA. Translation: AAA28696.1.
X17558 mRNA. Translation: CAA35591.1.
AE013599 Genomic DNA. Translation: AAF59062.1.
PIRiS06119.
RefSeqiNP_523661.2. NM_078937.4.

Genome annotation databases

EnsemblMetazoaiFBtr0089427; FBpp0088443; FBgn0003892.
GeneIDi35851.
KEGGidme:Dmel_CG2411.
UCSCiCG2411-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28999 , M28418 Genomic DNA. Translation: AAA28696.1 .
X17558 mRNA. Translation: CAA35591.1 .
AE013599 Genomic DNA. Translation: AAF59062.1 .
PIRi S06119.
RefSeqi NP_523661.2. NM_078937.4.

3D structure databases

ProteinModelPortali P18502.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61701. 130 interactions.
DIPi DIP-634N.

Protein family/group databases

TCDBi 2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

Proteomic databases

PaxDbi P18502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0089427 ; FBpp0088443 ; FBgn0003892 .
GeneIDi 35851.
KEGGi dme:Dmel_CG2411.
UCSCi CG2411-RA. d. melanogaster.

Organism-specific databases

CTDi 35851.
FlyBasei FBgn0003892. ptc.

Phylogenomic databases

eggNOGi NOG313603.
GeneTreei ENSGT00760000119174.
HOGENOMi HOG000228313.
InParanoidi P18502.
KOi K06225.
OMAi PDRDYLH.
OrthoDBi EOG7HMS06.
PhylomeDBi P18502.

Enzyme and pathway databases

Reactomei REACT_253948. Class B/2 (Secretin family receptors).
REACT_271202. Hedgehog 'off' state.
SignaLinki P18502.

Miscellaneous databases

GenomeRNAii 35851.
NextBioi 795513.
PROi P18502.

Gene expression databases

Bgeei P18502.

Family and domain databases

InterProi IPR003392. Patched.
IPR000731. SSD.
IPR004766. TM_rcpt_patched.
[Graphical view ]
Pfami PF02460. Patched. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00918. 2A060602. 1 hit.
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning."
    Hooper J.E., Scott M.P.
    Cell 59:751-765(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched."
    Nakano Y., Guerrero I., Hidalgo A., Taylor A., Whittle J.R.S., Ingham P.W.
    Nature 341:508-513(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.

Entry informationi

Entry nameiPTC_DROME
AccessioniPrimary (citable) accession number: P18502
Secondary accession number(s): Q9V4W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 2, 2001
Last modified: November 26, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3