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P18502

- PTC_DROME

UniProt

P18502 - PTC_DROME

Protein

Protein patched

Gene

ptc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (02 Nov 2001)
      Previous versions | rss
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    Functioni

    Segmentation polarity protein. Acts as a receptor for the hedgehog protein (HH). Associates with the smoothened protein (SMO) to transduce the hedgehog signal leading to the activation of wingless, decapentaplegic and patched itself. Participates in cell interactions that establish pattern within the segment and the imaginal disks during development. In the absence of HH, represses the constitutive signaling activity of smo through fused (FU).

    GO - Molecular functioni

    1. hedgehog receptor activity Source: FlyBase
    2. lipoprotein particle receptor activity Source: FlyBase
    3. protein binding Source: FlyBase
    4. transmembrane signaling receptor activity Source: FlyBase

    GO - Biological processi

    1. anterior/posterior lineage restriction, imaginal disc Source: FlyBase
    2. anterior/posterior pattern specification Source: FlyBase
    3. axon guidance Source: FlyBase
    4. Bolwig's organ morphogenesis Source: FlyBase
    5. dephosphorylation Source: FlyBase
    6. determination of genital disc primordium Source: FlyBase
    7. embryonic pattern specification Source: FlyBase
    8. eye-antennal disc morphogenesis Source: FlyBase
    9. germ-line stem cell division Source: FlyBase
    10. gonad development Source: FlyBase
    11. imaginal disc-derived wing morphogenesis Source: FlyBase
    12. lipid homeostasis Source: FlyBase
    13. negative regulation of smoothened signaling pathway Source: FlyBase
    14. oogenesis Source: FlyBase
    15. ovarian follicle cell development Source: FlyBase
    16. peripheral nervous system development Source: FlyBase
    17. proteolysis Source: FlyBase
    18. receptor-mediated endocytosis Source: GOC
    19. regulation of apoptotic process Source: FlyBase
    20. regulation of mitotic cell cycle Source: FlyBase
    21. regulation of protein import into nucleus Source: FlyBase
    22. segment polarity determination Source: UniProtKB-KW
    23. smoothened signaling pathway Source: FlyBase
    24. somatic stem cell division Source: FlyBase
    25. wing disc anterior/posterior pattern formation Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Receptor, Segmentation polarity protein

    Enzyme and pathway databases

    SignaLinkiP18502.

    Protein family/group databases

    TCDBi2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein patched
    Alternative name(s):
    Hedgehog receptor
    Gene namesi
    Name:ptc
    ORF Names:CG2411
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0003892. ptc.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. endocytic vesicle Source: FlyBase
    3. integral component of membrane Source: FlyBase
    4. integral component of plasma membrane Source: FlyBase
    5. perinuclear region of cytoplasm Source: FlyBase
    6. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12861286Protein patchedPRO_0000205973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi807 – 8071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP18502.

    Expressioni

    Gene expression databases

    BgeeiP18502.

    Interactioni

    Protein-protein interaction databases

    BioGridi61701. 130 interactions.
    DIPiDIP-634N.

    Structurei

    3D structure databases

    ProteinModelPortaliP18502.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 427335ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini449 – 46517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini487 – 4926ExtracellularSequence Analysis
    Topological domaini512 – 53221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini554 – 5629ExtracellularSequence Analysis
    Topological domaini584 – 67794CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini700 – 931232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini953 – 9553CytoplasmicSequence Analysis
    Topological domaini977 – 100731ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1029 – 105628CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1078 – 10825ExtracellularSequence Analysis
    Topological domaini1104 – 1286183CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9216HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei533 – 55321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei563 – 58321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei678 – 69922HelicalSequence AnalysisAdd
    BLAST
    Transmembranei932 – 95221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei956 – 97621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1008 – 102821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1057 – 107721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1083 – 110321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini428 – 583156SSDPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1227 – 12326Poly-Pro

    Sequence similaritiesi

    Belongs to the patched family.Curated
    Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG313603.
    GeneTreeiENSGT00680000099777.
    HOGENOMiHOG000228313.
    InParanoidiP18502.
    KOiK06225.
    OMAiPDRDYLH.
    OrthoDBiEOG7HMS06.
    PhylomeDBiP18502.

    Family and domain databases

    InterProiIPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view]
    PfamiPF02460. Patched. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00918. 2A060602. 1 hit.
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18502-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR     50
    TAIYLRSVFQ SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK 100
    VHQLWIQEGG RLEAELAYTQ KTIGEDESAT HQLLIQTTHD PNASVLHPQA 150
    LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN MPSTPSFEGI YYIEQILRHL 200
    IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN PASVMQYMKQ 250
    KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST 300
    QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV 350
    QLMTEKEMYD QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ 400
    SRIATNYDIY VFSSAALDDI LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW 450
    RDPVRGQSSV GVAGVLLMCF STAAGLGLSA LLGIVFNAAS TQVVPFLALG 500
    LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST AGSFFAAAFI 550
    PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF 600
    PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI 650
    PGSSHSLASF SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR 700
    LQDGLDIIDL VPKDSNEHKF LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL 750
    RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS EWLGNLQKIF DEEYRDGRLT 800
    KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV NSDGIINQRA 850
    FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA 900
    QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM 950
    TLRSSLAMIL ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT 1000
    LLGIKLSAIP AVILILSVGM MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS 1050
    LGPLVHGMLT SGVAVFMLST SPFEFVIRHF CWLLLVVLCV GACNSLLVFP 1100
    ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV VQGSRSSRGS 1150
    CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA 1200
    SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV 1250
    ETTHSDSNTT KVTATANIKV ELAMPGRAVR SYNFTS 1286
    Length:1,286
    Mass (Da):142,831
    Last modified:November 2, 2001 - v2
    Checksum:i5F22A956F8BE0EC6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1111R → G in CAA35591. (PubMed:2797178)Curated
    Sequence conflicti274 – 2741G → A in CAA35591. (PubMed:2797178)Curated
    Sequence conflicti332 – 3321A → R in AAA28696. (PubMed:2582494)Curated
    Sequence conflicti636 – 6361P → A in CAA35591. (PubMed:2797178)Curated
    Sequence conflicti862 – 8643DVF → ASSPTELLRANCIRNR(PubMed:2797178)Curated
    Sequence conflicti866 – 8661Y → N(PubMed:2797178)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28999, M28418 Genomic DNA. Translation: AAA28696.1.
    X17558 mRNA. Translation: CAA35591.1.
    AE013599 Genomic DNA. Translation: AAF59062.1.
    PIRiS06119.
    RefSeqiNP_523661.2. NM_078937.3.
    UniGeneiDm.2630.

    Genome annotation databases

    EnsemblMetazoaiFBtr0089427; FBpp0088443; FBgn0003892.
    GeneIDi35851.
    KEGGidme:Dmel_CG2411.
    UCSCiCG2411-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28999 , M28418 Genomic DNA. Translation: AAA28696.1 .
    X17558 mRNA. Translation: CAA35591.1 .
    AE013599 Genomic DNA. Translation: AAF59062.1 .
    PIRi S06119.
    RefSeqi NP_523661.2. NM_078937.3.
    UniGenei Dm.2630.

    3D structure databases

    ProteinModelPortali P18502.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61701. 130 interactions.
    DIPi DIP-634N.

    Protein family/group databases

    TCDBi 2.A.6.6.2. the resistance-nodulation-cell division (rnd) superfamily.

    Proteomic databases

    PaxDbi P18502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0089427 ; FBpp0088443 ; FBgn0003892 .
    GeneIDi 35851.
    KEGGi dme:Dmel_CG2411.
    UCSCi CG2411-RA. d. melanogaster.

    Organism-specific databases

    CTDi 35851.
    FlyBasei FBgn0003892. ptc.

    Phylogenomic databases

    eggNOGi NOG313603.
    GeneTreei ENSGT00680000099777.
    HOGENOMi HOG000228313.
    InParanoidi P18502.
    KOi K06225.
    OMAi PDRDYLH.
    OrthoDBi EOG7HMS06.
    PhylomeDBi P18502.

    Enzyme and pathway databases

    SignaLinki P18502.

    Miscellaneous databases

    GenomeRNAii 35851.
    NextBioi 795513.
    PROi P18502.

    Gene expression databases

    Bgeei P18502.

    Family and domain databases

    InterProi IPR003392. Patched.
    IPR000731. SSD.
    IPR004766. TM_rcpt_patched.
    [Graphical view ]
    Pfami PF02460. Patched. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00918. 2A060602. 1 hit.
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila patched gene encodes a putative membrane protein required for segmental patterning."
      Hooper J.E., Scott M.P.
      Cell 59:751-765(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched."
      Nakano Y., Guerrero I., Hidalgo A., Taylor A., Whittle J.R.S., Ingham P.W.
      Nature 341:508-513(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.

    Entry informationi

    Entry nameiPTC_DROME
    AccessioniPrimary (citable) accession number: P18502
    Secondary accession number(s): Q9V4W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 2, 2001
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3