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P18492

- GSA_HORVU

UniProt

P18492 - GSA_HORVU

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic

Gene
GSA
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:GSA
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP18492.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: EnsemblPlants/Gramene
  2. chloroplast envelope Source: EnsemblPlants/Gramene
  3. chloroplast stroma Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434ChloroplastUniRule annotationAdd
BLAST
Chaini35 – 469435Glutamate-1-semialdehyde 2,1-aminomutase, chloroplasticUniRule annotationPRO_0000001258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiP18492.

Expressioni

Gene expression databases

GenevestigatoriP18492.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP18492.
SMRiP18492. Positions 47-466.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18492-1 [UniParc]FASTAAdd to Basket

« Hide

MAGAAAAVAS GISIRPVAAP KISRAPRSRS VVRAAVSIDE KAYTVQKSEE    50
IFNAAKELMP GGVNSPVRAF KSVGGQPIVF DSVKGSHMWD VDGNEYIDYV 100
GSWGPAIIGH ADDKVNAALI ETLKKGTSFG APCALENVLA QMVISAVPSI 150
EMVRFVNSGT EACMGALRLV RAFTGREKIL KFEGCYHGHA DSFLVKAGSG 200
VATLGLPDSP GVPKGATVGT LTAPYNDADA VKKLFEDNKG EIAAVFLEPV 250
VGNAGFIPPQ PAFLNALREV TKQDGALLVF DEVMTGFRLA YGGAQEYFGI 300
TPDVTTLGKI IGGGLPVGAY GGRKDIMEMV APAGPMYQAG TLSGNPLAMT 350
AGIHTLKRLM EPGTYEYLDK VTGELVRGIL DVGAKTGHEM CGGHIRGMFG 400
FFFAGGPVHN FDDAKKSDTA KFGRFHRGML GEGVYLAPSQ FEAGFTSLAH 450
TTQDIEKTVE AAEKVLRWI 469
Length:469
Mass (Da):49,494
Last modified:November 1, 1995 - v3
Checksum:i78BF03C14A3C1448
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091K → Q AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31545 mRNA. Translation: AAB59330.1.
PIRiA35789.
UniGeneiHv.186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M31545 mRNA. Translation: AAB59330.1 .
PIRi A35789.
UniGenei Hv.186.

3D structure databases

ProteinModelPortali P18492.
SMRi P18492. Positions 47-466.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P18492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P18492.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .

Gene expression databases

Genevestigatori P18492.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of a key enzyme in plant tetrapyrrole synthesis: glutamate 1-semialdehyde aminotransferase."
    Grimm B.
    Proc. Natl. Acad. Sci. U.S.A. 87:4169-4173(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Bonus.
    Tissue: Seedling.
  2. "Purification and partial amino acid sequence of the glutamate 1-semialdehyde aminotransferase of barley and synechococcus."
    Grimm B., Bull A., Welinder K.G., Gough S.P., Kannangara C.G.
    Carlsberg Res. Commun. 54:67-79(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.

Entry informationi

Entry nameiGSA_HORVU
AccessioniPrimary (citable) accession number: P18492
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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