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P18483

- TRPG_ASPAW

UniProt

P18483 - TRPG_ASPAW

Protein

Multifunctional tryptophan biosynthesis protein

Gene

trpC

Organism
Aspergillus awamori (Black koji mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    • Comment

    Functioni

    Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.
    Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021For GATase activityBy similarity
    Active sitei197 – 1971For GATase activityBy similarity
    Active sitei199 – 1991For GATase activityBy similarity

    GO - Molecular functioni

    1. anthranilate synthase activity Source: UniProtKB-EC
    2. indole-3-glycerol-phosphate synthase activity Source: UniProtKB-EC
    3. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC
    4. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-KW
    2. tryptophan biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00040.
    UPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multifunctional tryptophan biosynthesis protein
    Including the following 3 domains:
    Anthranilate synthase component 2 (EC:4.1.3.27)
    Short name:
    AS
    Alternative name(s):
    Anthranilate synthase, glutamine amidotransferase component
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpC
    OrganismiAspergillus awamori (Black koji mold)
    Taxonomic identifieri105351 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 768768Multifunctional tryptophan biosynthesis proteinPRO_0000056854Add
    BLAST

    Proteomic databases

    PRIDEiP18483.

    Structurei

    3D structure databases

    ProteinModelPortaliP18483.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 223199Glutamine amidotransferase type-1Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 517265Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni533 – 768236N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Glutamine amidotransferase

    Family and domain databases

    Gene3Di3.20.20.70. 3 hits.
    3.40.50.880. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR016302. Anthranilate_synth_II.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    IPR006221. TrpG/PapA_dom.
    [Graphical view]
    PfamiPF00117. GATase. 1 hit.
    PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001382. TrpG-trpC-trpF. 1 hit.
    SUPFAMiSSF51366. SSF51366. 3 hits.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsiTIGR00566. trpG_papA. 1 hit.
    PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
    PS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18483-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSGLVDHS PHHPTKAAQL NTASNVILID NYDSFTWNVY LVLEGATVNV    50
    FRNDQITLEE LIAKKPTQLV ISPGPGHPET DAGISSAAIQ YFSGKIPIFG 100
    VCMGQQCIIT CFGGKVDVTG EILHGKTSAL KHDGKGAYEG LPDSLALTRY 150
    HSLAGTHATI PDCLEVSSSV QLTDDSNKDV IMGVRHKKLA VEGVQFHPES 200
    ILTEYGRTMF RNFLKLTAGT WEGNGKHFDE QSNTTKATVS SNTAPKTDKK 250
    LSILERIYDH RRAAVAVQKT IPSQRPADLQ AAYDLNLAPP QVPFPARLRQ 300
    SPYPLSLMAE IKRASPSKGM IAENACAPAQ ARQYAKAGAS VISVLTEPEW 350
    FKGSIDDLRA VRQSLEGLTN RPAILRKEFV FDEYQILEAR LAGADTVLLI 400
    VKMLSVELLT RLYHYSRSLG MEPLVEVNTP EEMKIAVDLG AEVIGVNNRD 450
    LTSFEVDLGT TSRLMDQVPS STIVCALSGI SGPKDVEAYK KEGVKAILVG 500
    EALMRAADTA AFIAELLGGS SQNVSKESRS SPLVKICGTR SEEAARAAIE 550
    AGADLIGIIM VQGRTRCVPD DVALRISQVV KSIPKPAGQT PPTSRGTPAA 600
    ASVEYFDHSA RILRHPSRAL LVGVFQNQPL DYILSQQQKL GLDVVQLHGS 650
    EPLEWAKLIP VPVIRKFGLD EPAIARRAYH SLPLLDSGVG GTGELLDQSR 700
    VQNVLDKDSG LRVILAGGLD PTNVAGIVQK LGESGRKVVG VDVSSGVESD 750
    GAQDLGKIRA FVQAVRGL 768
    Length:768
    Mass (Da):82,657
    Last modified:November 1, 1990 - v1
    Checksum:iE3C0DB1AB10225CE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53576 Genomic DNA. Translation: CAA37640.1.
    PIRiS11161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53576 Genomic DNA. Translation: CAA37640.1 .
    PIRi S11161.

    3D structure databases

    ProteinModelPortali P18483.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P18483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00040 .
    UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .

    Family and domain databases

    Gene3Di 3.20.20.70. 3 hits.
    3.40.50.880. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR016302. Anthranilate_synth_II.
    IPR029062. Class_I_gatase-like.
    IPR017926. GATASE.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    IPR006221. TrpG/PapA_dom.
    [Graphical view ]
    Pfami PF00117. GATase. 1 hit.
    PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001382. TrpG-trpC-trpF. 1 hit.
    SUPFAMi SSF51366. SSF51366. 3 hits.
    SSF52317. SSF52317. 1 hit.
    TIGRFAMsi TIGR00566. trpG_papA. 1 hit.
    PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
    PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence encoding trpC from Aspergillus niger var. awamori."
      Adams R.R., Royer T.
      Nucleic Acids Res. 18:4931-4931(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 22342 / NRRL 3112.

    Entry informationi

    Entry nameiTRPG_ASPAW
    AccessioniPrimary (citable) accession number: P18483
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3