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Protein

SWI/SNF chromatin-remodeling complex subunit SNF5

Gene

SNF5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD

GO - Biological processi

  • ATP-dependent chromatin remodeling Source: GO_Central
  • carbon catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  • chromatin remodeling Source: SGD
  • double-strand break repair via homologous recombination Source: SGD
  • nucleosome disassembly Source: GO_Central
  • positive regulation of invasive growth in response to glucose limitation Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter Source: SGD
  • sucrose catabolic process Source: SGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF chromatin-remodeling complex subunit SNF5
Alternative name(s):
SWI/SNF complex subunit SNF5
Transcription factor TYE4
Transcription regulatory protein SNF5
Gene namesi
Name:SNF5
Synonyms:SWI10, TYE4
Ordered Locus Names:YBR289W
ORF Names:YBR2036
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR289W.
SGDiS000000493. SNF5.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • nuclear chromosome Source: InterPro
  • nucleus Source: SGD
  • RSC complex Source: GO_Central
  • SWI/SNF complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059551 – 905SWI/SNF chromatin-remodeling complex subunit SNF5Add BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei818PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP18480.
PRIDEiP18480.

PTM databases

iPTMnetiP18480.

Interactioni

Subunit structurei

Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF14P351892EBI-17546,EBI-18920

GO - Molecular functioni

  • RNA polymerase II activating transcription factor binding Source: SGD

Protein-protein interaction databases

BioGridi32983. 160 interactors.
DIPiDIP-2364N.
IntActiP18480. 46 interactors.
MINTiMINT-424303.

Structurei

3D structure databases

ProteinModelPortaliP18480.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 270Gln-richAdd BLAST240
Compositional biasi72 – 132Pro-richAdd BLAST61
Compositional biasi272 – 324Pro-richAdd BLAST53
Compositional biasi489 – 588Asp/Glu-rich (acidic)Add BLAST100
Compositional biasi714 – 882Pro-richAdd BLAST169
Compositional biasi755 – 798Arg/Lys-rich (basic)Add BLAST44

Sequence similaritiesi

Belongs to the SNF5 family.Curated

Phylogenomic databases

GeneTreeiENSGT00440000038585.
InParanoidiP18480.
KOiK11648.
OMAiFIMENIN.
OrthoDBiEOG092C06MM.

Family and domain databases

InterProiIPR006939. SNF5.
[Graphical view]
PANTHERiPTHR10019. PTHR10019. 1 hit.
PfamiPF04855. SNF5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18480-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQPQGTNS VPNSIGNIFS NIGTPSFNMA QIPQQLYQSL TPQQLQMIQQ
60 70 80 90 100
RHQQLLRSRL QQQQQQQQQT SPPPQTHQSP PPPPQQSQPI ANQSATSTPP
110 120 130 140 150
PPPAPHNLHP QIGQVPLAPA PINLPPQIAQ LPLATQQQVL NKLRQQAIAK
160 170 180 190 200
NNPQVVNAIT VAQQQVQRQI EQQKGQQTAQ TQLEQQRQLL VQQQQQQQLR
210 220 230 240 250
NQIQRQQQQQ FRHHVQIQQQ QQKQQQQQQQ HQQQQQQQQQ QQQQQQQQQQ
260 270 280 290 300
QQQQQQQQQQ QQQQQQQQGQ IPQSQQVPQV RSMSGQPPTN VQPTIGQLPQ
310 320 330 340 350
LPKLNLPKYQ TIQYDPPETK LPYPTYWSDK KADTDTLLYE QIIQRDKINK
360 370 380 390 400
YSLIRETNGY DPFSIYGFSN KEYISRLWHT LKYYQDLKNT RMKSITSTSQ
410 420 430 440 450
KIPSASIWGN GYSGYGNGIT NTTTRVIPQV EVGNRKHYLE DKLKVYKQAM
460 470 480 490 500
NETSEQLVPI RLEFDQDRDR FFLRDTLLWN KNDKLIKIED FVDDMLRDYR
510 520 530 540 550
FEDATREQHI DTICQSIQEQ IQEFQGNPYI ELNQDRLGGD DLRIRIKLDI
560 570 580 590 600
VVGQNQLIDQ FEWDISNSDN CPEEFAESMC QELELPGEFV TAIAHSIREQ
610 620 630 640 650
VHMYHKSLAL LGYNFDGSAI EDDDIRSRML PTITLDDVYR PAAESKIFTP
660 670 680 690 700
NLLQISAAEL ERLDKDKDRD TRRKRRQGRS NRRGMLALSG TSASNTSMNG
710 720 730 740 750
VHNTVAAGNA SSLPPGEILL PDIADIPRTF RTPVPSTLMP GGVDVGPSVE
760 770 780 790 800
SYELRNTTTY KSRPDRPKPV SPPCYIIDHI PGHSLLLSIK LPGKVNTKEE
810 820 830 840 850
FAAAPNDTSS GTNAMLPSPE SLKTKLNSNI RAGVTIPSIP NPIANHTVTN
860 870 880 890 900
SPNPTLQPVI PGGAASKSVP TPSLPIAPPV APHDSEATLL TNSNNGSSNN

NTQNT
Length:905
Mass (Da):102,543
Last modified:July 27, 2011 - v3
Checksum:iF6D31A57E6D6DA94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti564D → E in CAA53652 (PubMed:8091861).Curated1
Sequence conflicti564D → E in CAA85254 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36482 Genomic DNA. Translation: AAA35062.1.
X76053 Genomic DNA. Translation: CAA53652.1.
Z36158 Genomic DNA. Translation: CAA85254.1.
BK006936 Genomic DNA. Translation: DAA07404.2.
PIRiS44551. RGBYS5.
RefSeqiNP_009848.4. NM_001178637.4.

Genome annotation databases

EnsemblFungiiYBR289W; YBR289W; YBR289W.
GeneIDi852592.
KEGGisce:YBR289W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36482 Genomic DNA. Translation: AAA35062.1.
X76053 Genomic DNA. Translation: CAA53652.1.
Z36158 Genomic DNA. Translation: CAA85254.1.
BK006936 Genomic DNA. Translation: DAA07404.2.
PIRiS44551. RGBYS5.
RefSeqiNP_009848.4. NM_001178637.4.

3D structure databases

ProteinModelPortaliP18480.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32983. 160 interactors.
DIPiDIP-2364N.
IntActiP18480. 46 interactors.
MINTiMINT-424303.

PTM databases

iPTMnetiP18480.

Proteomic databases

MaxQBiP18480.
PRIDEiP18480.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR289W; YBR289W; YBR289W.
GeneIDi852592.
KEGGisce:YBR289W.

Organism-specific databases

EuPathDBiFungiDB:YBR289W.
SGDiS000000493. SNF5.

Phylogenomic databases

GeneTreeiENSGT00440000038585.
InParanoidiP18480.
KOiK11648.
OMAiFIMENIN.
OrthoDBiEOG092C06MM.

Enzyme and pathway databases

BioCyciYEAST:G3O-29208-MONOMER.

Miscellaneous databases

PROiP18480.

Family and domain databases

InterProiIPR006939. SNF5.
[Graphical view]
PANTHERiPTHR10019. PTHR10019. 1 hit.
PfamiPF04855. SNF5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNF5_YEAST
AccessioniPrimary (citable) accession number: P18480
Secondary accession number(s): D6VQT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.