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P18480

- SNF5_YEAST

UniProt

P18480 - SNF5_YEAST

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Protein

SWI/SNF chromatin-remodeling complex subunit SNF5

Gene

SNF5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

GO - Molecular functioni

  1. RNA polymerase II activating transcription factor binding Source: SGD

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. carbon catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  3. chromatin remodeling Source: SGD
  4. double-strand break repair via homologous recombination Source: SGD
  5. positive regulation of transcription from RNA polymerase II promoter Source: SGD
  6. sucrose catabolic process Source: SGD
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF chromatin-remodeling complex subunit SNF5
Alternative name(s):
SWI/SNF complex subunit SNF5
Transcription factor TYE4
Transcription regulatory protein SNF5
Gene namesi
Name:SNF5
Synonyms:SWI10, TYE4
Ordered Locus Names:YBR289W
ORF Names:YBR2036
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR289w.
SGDiS000000493. SNF5.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. nuclear chromosome Source: InterPro
  3. nucleus Source: SGD
  4. SWI/SNF complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905SWI/SNF chromatin-remodeling complex subunit SNF5PRO_0000205955Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei818 – 8181Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP18480.
PaxDbiP18480.
PeptideAtlasiP18480.
PRIDEiP18480.

Expressioni

Gene expression databases

GenevestigatoriP18480.

Interactioni

Subunit structurei

Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF14P351892EBI-17546,EBI-18920

Protein-protein interaction databases

BioGridi32983. 158 interactions.
DIPiDIP-2364N.
IntActiP18480. 45 interactions.
MINTiMINT-424303.
STRINGi4932.YBR289W.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi31 – 270240Gln-richAdd
BLAST
Compositional biasi72 – 13261Pro-richAdd
BLAST
Compositional biasi272 – 32453Pro-richAdd
BLAST
Compositional biasi489 – 588100Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi714 – 882169Pro-richAdd
BLAST
Compositional biasi755 – 79844Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the SNF5 family.Curated

Phylogenomic databases

eggNOGiNOG291299.
GeneTreeiENSGT00440000038585.
InParanoidiP18480.
KOiK11648.
OMAiIREQVHM.
OrthoDBiEOG79W9DR.

Family and domain databases

InterProiIPR006939. SNF5.
[Graphical view]
PANTHERiPTHR10019. PTHR10019. 1 hit.
PfamiPF04855. SNF5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18480-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQPQGTNS VPNSIGNIFS NIGTPSFNMA QIPQQLYQSL TPQQLQMIQQ
60 70 80 90 100
RHQQLLRSRL QQQQQQQQQT SPPPQTHQSP PPPPQQSQPI ANQSATSTPP
110 120 130 140 150
PPPAPHNLHP QIGQVPLAPA PINLPPQIAQ LPLATQQQVL NKLRQQAIAK
160 170 180 190 200
NNPQVVNAIT VAQQQVQRQI EQQKGQQTAQ TQLEQQRQLL VQQQQQQQLR
210 220 230 240 250
NQIQRQQQQQ FRHHVQIQQQ QQKQQQQQQQ HQQQQQQQQQ QQQQQQQQQQ
260 270 280 290 300
QQQQQQQQQQ QQQQQQQQGQ IPQSQQVPQV RSMSGQPPTN VQPTIGQLPQ
310 320 330 340 350
LPKLNLPKYQ TIQYDPPETK LPYPTYWSDK KADTDTLLYE QIIQRDKINK
360 370 380 390 400
YSLIRETNGY DPFSIYGFSN KEYISRLWHT LKYYQDLKNT RMKSITSTSQ
410 420 430 440 450
KIPSASIWGN GYSGYGNGIT NTTTRVIPQV EVGNRKHYLE DKLKVYKQAM
460 470 480 490 500
NETSEQLVPI RLEFDQDRDR FFLRDTLLWN KNDKLIKIED FVDDMLRDYR
510 520 530 540 550
FEDATREQHI DTICQSIQEQ IQEFQGNPYI ELNQDRLGGD DLRIRIKLDI
560 570 580 590 600
VVGQNQLIDQ FEWDISNSDN CPEEFAESMC QELELPGEFV TAIAHSIREQ
610 620 630 640 650
VHMYHKSLAL LGYNFDGSAI EDDDIRSRML PTITLDDVYR PAAESKIFTP
660 670 680 690 700
NLLQISAAEL ERLDKDKDRD TRRKRRQGRS NRRGMLALSG TSASNTSMNG
710 720 730 740 750
VHNTVAAGNA SSLPPGEILL PDIADIPRTF RTPVPSTLMP GGVDVGPSVE
760 770 780 790 800
SYELRNTTTY KSRPDRPKPV SPPCYIIDHI PGHSLLLSIK LPGKVNTKEE
810 820 830 840 850
FAAAPNDTSS GTNAMLPSPE SLKTKLNSNI RAGVTIPSIP NPIANHTVTN
860 870 880 890 900
SPNPTLQPVI PGGAASKSVP TPSLPIAPPV APHDSEATLL TNSNNGSSNN

NTQNT
Length:905
Mass (Da):102,543
Last modified:July 27, 2011 - v3
Checksum:iF6D31A57E6D6DA94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti564 – 5641D → E in CAA53652. (PubMed:8091861)Curated
Sequence conflicti564 – 5641D → E in CAA85254. (PubMed:7813418)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36482 Genomic DNA. Translation: AAA35062.1.
X76053 Genomic DNA. Translation: CAA53652.1.
Z36158 Genomic DNA. Translation: CAA85254.1.
BK006936 Genomic DNA. Translation: DAA07404.2.
PIRiS44551. RGBYS5.
RefSeqiNP_009848.4. NM_001178637.4.

Genome annotation databases

EnsemblFungiiYBR289W; YBR289W; YBR289W.
GeneIDi852592.
KEGGisce:YBR289W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36482 Genomic DNA. Translation: AAA35062.1 .
X76053 Genomic DNA. Translation: CAA53652.1 .
Z36158 Genomic DNA. Translation: CAA85254.1 .
BK006936 Genomic DNA. Translation: DAA07404.2 .
PIRi S44551. RGBYS5.
RefSeqi NP_009848.4. NM_001178637.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32983. 158 interactions.
DIPi DIP-2364N.
IntActi P18480. 45 interactions.
MINTi MINT-424303.
STRINGi 4932.YBR289W.

Proteomic databases

MaxQBi P18480.
PaxDbi P18480.
PeptideAtlasi P18480.
PRIDEi P18480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR289W ; YBR289W ; YBR289W .
GeneIDi 852592.
KEGGi sce:YBR289W.

Organism-specific databases

CYGDi YBR289w.
SGDi S000000493. SNF5.

Phylogenomic databases

eggNOGi NOG291299.
GeneTreei ENSGT00440000038585.
InParanoidi P18480.
KOi K11648.
OMAi IREQVHM.
OrthoDBi EOG79W9DR.

Enzyme and pathway databases

BioCyci YEAST:G3O-29208-MONOMER.

Miscellaneous databases

NextBioi 971757.
PROi P18480.

Gene expression databases

Genevestigatori P18480.

Family and domain databases

InterProi IPR006939. SNF5.
[Graphical view ]
PANTHERi PTHR10019. PTHR10019. 1 hit.
Pfami PF04855. SNF5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes."
    Laurent B.C., Treitel M.A., Carlson M.
    Mol. Cell. Biol. 10:5616-5625(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MCY.
  2. "The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae."
    Holmstroem K., Brandt T., Kallesoe T.
    Yeast 10:S47-S62(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 564.
    Strain: ATCC 204508 / S288c.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
    Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
    Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.

Entry informationi

Entry nameiSNF5_YEAST
AccessioniPrimary (citable) accession number: P18480
Secondary accession number(s): D6VQT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 217 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3