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P18480

- SNF5_YEAST

UniProt

P18480 - SNF5_YEAST

Protein

SWI/SNF chromatin-remodeling complex subunit SNF5

Gene

SNF5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II activating transcription factor binding Source: SGD

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. carbon catabolite activation of transcription from RNA polymerase II promoter Source: SGD
    3. chromatin remodeling Source: SGD
    4. double-strand break repair via homologous recombination Source: SGD
    5. positive regulation of transcription from RNA polymerase II promoter Source: SGD
    6. sucrose catabolic process Source: SGD
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29208-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SWI/SNF chromatin-remodeling complex subunit SNF5
    Alternative name(s):
    SWI/SNF complex subunit SNF5
    Transcription factor TYE4
    Transcription regulatory protein SNF5
    Gene namesi
    Name:SNF5
    Synonyms:SWI10, TYE4
    Ordered Locus Names:YBR289W
    ORF Names:YBR2036
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome II

    Organism-specific databases

    CYGDiYBR289w.
    SGDiS000000493. SNF5.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. nuclear chromosome Source: InterPro
    3. nucleus Source: SGD
    4. SWI/SNF complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 905905SWI/SNF chromatin-remodeling complex subunit SNF5PRO_0000205955Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei818 – 8181Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP18480.
    PaxDbiP18480.
    PeptideAtlasiP18480.
    PRIDEiP18480.

    Expressioni

    Gene expression databases

    GenevestigatoriP18480.

    Interactioni

    Subunit structurei

    Component of the SWI/SNF global transcription activator complex. The 1.14 MDa SWI/SNF complex is composed of 11 different subunits: one copy each of SWI1, SNF2/SWI2, SNF5, SNF12/SWP73, ARP7/SWP61, ARP9/SWP59; two copies each of SWI3, SNF6, SNF11, SWP82; and three copies of TAF14/SWP29.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TAF14P351892EBI-17546,EBI-18920

    Protein-protein interaction databases

    BioGridi32983. 158 interactions.
    DIPiDIP-2364N.
    IntActiP18480. 45 interactions.
    MINTiMINT-424303.
    STRINGi4932.YBR289W.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi31 – 270240Gln-richAdd
    BLAST
    Compositional biasi72 – 13261Pro-richAdd
    BLAST
    Compositional biasi272 – 32453Pro-richAdd
    BLAST
    Compositional biasi489 – 588100Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi714 – 882169Pro-richAdd
    BLAST
    Compositional biasi755 – 79844Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the SNF5 family.Curated

    Phylogenomic databases

    eggNOGiNOG291299.
    GeneTreeiENSGT00440000038585.
    KOiK11648.
    OMAiIREQVHM.
    OrthoDBiEOG79W9DR.

    Family and domain databases

    InterProiIPR006939. SNF5.
    [Graphical view]
    PANTHERiPTHR10019. PTHR10019. 1 hit.
    PfamiPF04855. SNF5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18480-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQPQGTNS VPNSIGNIFS NIGTPSFNMA QIPQQLYQSL TPQQLQMIQQ    50
    RHQQLLRSRL QQQQQQQQQT SPPPQTHQSP PPPPQQSQPI ANQSATSTPP 100
    PPPAPHNLHP QIGQVPLAPA PINLPPQIAQ LPLATQQQVL NKLRQQAIAK 150
    NNPQVVNAIT VAQQQVQRQI EQQKGQQTAQ TQLEQQRQLL VQQQQQQQLR 200
    NQIQRQQQQQ FRHHVQIQQQ QQKQQQQQQQ HQQQQQQQQQ QQQQQQQQQQ 250
    QQQQQQQQQQ QQQQQQQQGQ IPQSQQVPQV RSMSGQPPTN VQPTIGQLPQ 300
    LPKLNLPKYQ TIQYDPPETK LPYPTYWSDK KADTDTLLYE QIIQRDKINK 350
    YSLIRETNGY DPFSIYGFSN KEYISRLWHT LKYYQDLKNT RMKSITSTSQ 400
    KIPSASIWGN GYSGYGNGIT NTTTRVIPQV EVGNRKHYLE DKLKVYKQAM 450
    NETSEQLVPI RLEFDQDRDR FFLRDTLLWN KNDKLIKIED FVDDMLRDYR 500
    FEDATREQHI DTICQSIQEQ IQEFQGNPYI ELNQDRLGGD DLRIRIKLDI 550
    VVGQNQLIDQ FEWDISNSDN CPEEFAESMC QELELPGEFV TAIAHSIREQ 600
    VHMYHKSLAL LGYNFDGSAI EDDDIRSRML PTITLDDVYR PAAESKIFTP 650
    NLLQISAAEL ERLDKDKDRD TRRKRRQGRS NRRGMLALSG TSASNTSMNG 700
    VHNTVAAGNA SSLPPGEILL PDIADIPRTF RTPVPSTLMP GGVDVGPSVE 750
    SYELRNTTTY KSRPDRPKPV SPPCYIIDHI PGHSLLLSIK LPGKVNTKEE 800
    FAAAPNDTSS GTNAMLPSPE SLKTKLNSNI RAGVTIPSIP NPIANHTVTN 850
    SPNPTLQPVI PGGAASKSVP TPSLPIAPPV APHDSEATLL TNSNNGSSNN 900
    NTQNT 905
    Length:905
    Mass (Da):102,543
    Last modified:July 27, 2011 - v3
    Checksum:iF6D31A57E6D6DA94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti564 – 5641D → E in CAA53652. (PubMed:8091861)Curated
    Sequence conflicti564 – 5641D → E in CAA85254. (PubMed:7813418)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36482 Genomic DNA. Translation: AAA35062.1.
    X76053 Genomic DNA. Translation: CAA53652.1.
    Z36158 Genomic DNA. Translation: CAA85254.1.
    BK006936 Genomic DNA. Translation: DAA07404.2.
    PIRiS44551. RGBYS5.
    RefSeqiNP_009848.4. NM_001178637.4.

    Genome annotation databases

    EnsemblFungiiYBR289W; YBR289W; YBR289W.
    GeneIDi852592.
    KEGGisce:YBR289W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36482 Genomic DNA. Translation: AAA35062.1 .
    X76053 Genomic DNA. Translation: CAA53652.1 .
    Z36158 Genomic DNA. Translation: CAA85254.1 .
    BK006936 Genomic DNA. Translation: DAA07404.2 .
    PIRi S44551. RGBYS5.
    RefSeqi NP_009848.4. NM_001178637.4.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32983. 158 interactions.
    DIPi DIP-2364N.
    IntActi P18480. 45 interactions.
    MINTi MINT-424303.
    STRINGi 4932.YBR289W.

    Proteomic databases

    MaxQBi P18480.
    PaxDbi P18480.
    PeptideAtlasi P18480.
    PRIDEi P18480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YBR289W ; YBR289W ; YBR289W .
    GeneIDi 852592.
    KEGGi sce:YBR289W.

    Organism-specific databases

    CYGDi YBR289w.
    SGDi S000000493. SNF5.

    Phylogenomic databases

    eggNOGi NOG291299.
    GeneTreei ENSGT00440000038585.
    KOi K11648.
    OMAi IREQVHM.
    OrthoDBi EOG79W9DR.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29208-MONOMER.

    Miscellaneous databases

    NextBioi 971757.
    PROi P18480.

    Gene expression databases

    Genevestigatori P18480.

    Family and domain databases

    InterProi IPR006939. SNF5.
    [Graphical view ]
    PANTHERi PTHR10019. PTHR10019. 1 hit.
    Pfami PF04855. SNF5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes."
      Laurent B.C., Treitel M.A., Carlson M.
      Mol. Cell. Biol. 10:5616-5625(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MCY.
    2. "The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae."
      Holmstroem K., Brandt T., Kallesoe T.
      Yeast 10:S47-S62(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "Complete DNA sequence of yeast chromosome II."
      Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
      , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
      EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION, SEQUENCE REVISION TO 564.
      Strain: ATCC 204508 / S288c.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-818, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Structural analysis of the yeast SWI/SNF chromatin remodeling complex."
      Smith C.L., Horowitz-Scherer R., Flanagan J.F., Woodcock C.L., Peterson C.L.
      Nat. Struct. Biol. 10:141-145(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF THE SWI/SNF COMPLEX, ELECTRON MICROSCOPY OF THE SWI/SNF COMPLEX.

    Entry informationi

    Entry nameiSNF5_YEAST
    AccessioniPrimary (citable) accession number: P18480
    Secondary accession number(s): D6VQT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 217 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome II
      Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

    External Data

    Dasty 3