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P18475 (TORSO_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor torso

EC=2.7.10.1
Gene names
Name:tor
ORF Names:CG1389
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length923 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable receptor with tyrosine-protein kinase activity. Required for determination of anterior and posterior terminal structures in the Drosophila embryo. The ligand of torso seems to be TSL. Ref.1 Ref.5

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed throughout the embryo but is activated specifically at the poles. Ref.1 Ref.5

Developmental stage

Expressed both maternally and zygotically. Ref.1 Ref.5

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMalpighian tubule morphogenesis

Traceable author statement PubMed 10512197. Source: FlyBase

anterior/posterior axis specification, embryo

Traceable author statement PubMed 10494038. Source: FlyBase

cell fate determination

Traceable author statement PubMed 9631645. Source: FlyBase

chorion-containing eggshell pattern formation

Inferred from mutant phenotype PubMed 1783295. Source: FlyBase

gastrulation

Inferred from mutant phenotype PubMed 14602078. Source: FlyBase

metamorphosis

Inferred from mutant phenotype PubMed 19965758. Source: FlyBase

negative phototaxis

Inferred from mutant phenotype PubMed 24009394. Source: FlyBase

negative regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 23959885. Source: FlyBase

peptidyl-tyrosine phosphorylation

Inferred from direct assay Ref.5. Source: GOC

pole cell migration

Inferred from mutant phenotype PubMed 14602078. Source: FlyBase

protein autophosphorylation

Inferred from direct assay Ref.5. Source: FlyBase

protein phosphorylation

Non-traceable author statement PubMed 10494038PubMed 10908587. Source: FlyBase

regulation of transcription, DNA-templated

Inferred from mutant phenotype PubMed 19959668. Source: FlyBase

terminal region determination

Inferred from mutant phenotype PubMed 10652276Ref.1. Source: FlyBase

torso signaling pathway

Traceable author statement PubMed 10494038. Source: FlyBase

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Non-traceable author statement PubMed 10512197. Source: FlyBase

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from direct assay Ref.5. Source: FlyBase

transmembrane receptor protein tyrosine kinase activity

Inferred from sequence or structural similarity Ref.1. Source: FlyBase

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P18475-1)

Also known as: C;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P18475-2)

The sequence of this isoform differs from the canonical sequence as follows:
     907-923: KVEQVPCEEELYLEPLN → IGLRISAK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 923903Tyrosine-protein kinase receptor torso
PRO_0000024477

Regions

Topological domain21 – 399379Extracellular Potential
Transmembrane400 – 42021Helical; Potential
Topological domain421 – 923503Cytoplasmic Potential
Domain475 – 874400Protein kinase
Nucleotide binding481 – 4899ATP By similarity

Sites

Active site7411Proton acceptor By similarity
Binding site5021ATP By similarity

Amino acid modifications

Modified residue6081Phosphoserine Ref.6
Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation3261N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation3481N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence907 – 92317KVEQV…LEPLN → IGLRISAK in isoform B.
VSP_034011

Experimental info

Sequence conflict1251A → T in CAA33247. Ref.1
Sequence conflict3871H → P in CAA33247. Ref.1
Sequence conflict6671R → Q in CAA33247. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform A (C) [UniParc].

Last modified August 30, 2005. Version 2.
Checksum: 746F46E1A4277ACF

FASTA923105,201
        10         20         30         40         50         60 
MLIFYAKYAF IFWFFVGSNQ GEMLLMDKIS HDKTLLNVTA CTQNCLEKGQ MDFRSCLKDC 

        70         80         90        100        110        120 
RINGTFPGAL RKVQENYQMN MICRTESEIV FQIDWVQHSR GTEPAPNATY IIRVDAVKDD 

       130        140        150        160        170        180 
NKETALYLSD DNFLILPGLE SNSTHNITAL AMHGDGSYSL IAKDQTFATL IRGYQPSKMG 

       190        200        210        220        230        240 
AVNLLRFVPQ PDDLHHIAAE IEWKPSAESN CYFDMVSYST NSVNMDEPLE VQFRDRKKLY 

       250        260        270        280        290        300 
RHTVDNLEFD KQYHVGVRTV NIMNRLESDL QWLPIAVPSC LDWYPYNYTL CPPHKPENLT 

       310        320        330        340        350        360 
VTQKQYLPNI LALNITWARP RYLPDNYTLH IFDLFKGGTE LNYTLDQNRS HFYVPKITVL 

       370        380        390        400        410        420 
GSHFEVHLVA QSAGGKNVSG LTLDKVHRGV LLSEGNMVKL VLFIIVPICC ILMLCSLTFC 

       430        440        450        460        470        480 
RRNRSEVQAL QMDAKDAKAS EFHLSLMDSS GLLVTLSANE SLEVMDELEV EPHSVLLQDV 

       490        500        510        520        530        540 
LGEGAFGLVR RGVYKKRQVA VKLLKDEPND EDVYAFKCEI QMLKAVGKHP NIVGIVGYST 

       550        560        570        580        590        600 
RFSNQMMLLI EYCSLGSLQN FLREEWKFRQ EQNAIGLKKN LEQNVDNRRF NRLPRNSIHD 

       610        620        630        640        650        660 
RIEDINNSML STVEEESESD QTHSSRCETY TLTRITNAAD NKGYGLEDIE NIGGSYIPKT 

       670        680        690        700        710        720 
AEAPKDRPKR KLKPQPKKDS KQDFKSDNKK RIFENKEYFD CLDSSDTKPR IPLKYADLLD 

       730        740        750        760        770        780 
IAQQVAVGME FLAQNKVVHR DLAARNVLIS VDRSIKIADF GLSRDVYHEN VYRKSGGSGK 

       790        800        810        820        830        840 
LPIKWLALES LTHQVYTSQS DVWSFGVLLY EITTLGGMPY PSVSPSDLLQ LLRQGHRMKR 

       850        860        870        880        890        900 
PEGCTQEMFS LMESCWSSVP SHRPTFSALK HRLGGMILAT NDVPERLKQL QAATESKLKS 

       910        920 
CDGLNSKVEQ VPCEEELYLE PLN 

« Hide

Isoform B [UniParc].

Checksum: E56B6FB1098131DB
Show »

FASTA914104,026

References

« Hide 'large scale' references
[1]"The Drosophila gene torso encodes a putative receptor tyrosine kinase."
Sprenger F., Stevens L.M., Nuesslein-Volhard C.
Nature 338:478-483(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
Strain: Berkeley.
Tissue: Embryo.
[5]"Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction."
Sprenger F., Torsoclair M.M., Morrison D.K.
Mol. Cell. Biol. 13:1163-1172(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15150 Genomic DNA. Translation: CAA33247.1.
AE013599 Genomic DNA. Translation: AAF59203.1.
AE013599 Genomic DNA. Translation: ABV53713.1.
AE013599 Genomic DNA. Translation: ABV53714.1.
AY071403 mRNA. Translation: AAL49025.1.
PIRS03900.
RefSeqNP_001097211.1. NM_001103741.1. [P18475-2]
NP_001097212.1. NM_001103742.1. [P18475-1]
NP_476762.1. NM_057414.3. [P18475-1]
UniGeneDm.512.

3D structure databases

ProteinModelPortalP18475.
SMRP18475. Positions 449-898.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid61589. 28 interactions.
IntActP18475. 1 interaction.
MINTMINT-755149.

Proteomic databases

PaxDbP18475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0088938; FBpp0088012; FBgn0003733. [P18475-1]
FBtr0112838; FBpp0111751; FBgn0003733. [P18475-1]
GeneID35717.
KEGGdme:Dmel_CG1389.
UCSCCG1389-RA. d. melanogaster. [P18475-1]

Organism-specific databases

CTD21977.
FlyBaseFBgn0003733. tor.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117500.
InParanoidP18475.
KOK12378.
OMARDVYHEN.
OrthoDBEOG7BZVTF.
PhylomeDBP18475.

Enzyme and pathway databases

BRENDA2.7.10.1. 1994.
SignaLinkP18475.

Gene expression databases

BgeeP18475.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi35717.
NextBio794882.

Entry information

Entry nameTORSO_DROME
AccessionPrimary (citable) accession number: P18475
Secondary accession number(s): A8DY54, A8DY56, Q9V4R2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 30, 2005
Last modified: July 9, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase