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Protein

Tyrosine-protein kinase receptor torso

Gene

tor

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo (PubMed:2927509, PubMed:8423783). During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth (PubMed:19965758). Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity).By similarity3 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei502ATPPROSITE-ProRule annotation1
Active sitei741Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi481 – 489ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • protein tyrosine kinase activity Source: FlyBase
  • transmembrane receptor protein tyrosine kinase activity Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: FlyBase
  • cell fate determination Source: FlyBase
  • chorion-containing eggshell pattern formation Source: FlyBase
  • gastrulation Source: FlyBase
  • Malpighian tubule morphogenesis Source: FlyBase
  • metamorphosis Source: FlyBase
  • negative phototaxis Source: FlyBase
  • negative regulation of multicellular organism growth Source: FlyBase
  • peptidyl-tyrosine autophosphorylation Source: FlyBase
  • pole cell migration Source: FlyBase
  • protein autophosphorylation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • terminal region determination Source: FlyBase
  • torso signaling pathway Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
ReactomeiR-DME-210993. Tie2 Signaling.
R-DME-5673001. RAF/MAP kinase cascade.
SignaLinkiP18475.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptor torso (EC:2.7.10.1)
Gene namesi
Name:tor
ORF Names:CG1389
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003733. tor.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 399ExtracellularSequence analysisAdd BLAST379
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 923CytoplasmicSequence analysisAdd BLAST503

GO - Cellular componenti

  • integral component of plasma membrane Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage. In addition, pupal size and, to a lesser extent, PG cell size are increased.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002447721 – 923Tyrosine-protein kinase receptor torsoAdd BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi314N-linked (GlcNAc...)Sequence analysis1
Glycosylationi326N-linked (GlcNAc...)Sequence analysis1
Glycosylationi342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi348N-linked (GlcNAc...)Sequence analysis1
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Modified residuei608Phosphoserine1 Publication1

Post-translational modificationi

May be auto-phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18475.
PRIDEiP18475.

PTM databases

iPTMnetiP18475.

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed throughout the embryo but is activated specifically at the poles (PubMed:2927509, PubMed:8423783, PubMed:19965758). Expressed in the prothoracic gland in wandering L3 larvae (PubMed:19965758).3 Publications

Gene expression databases

BgeeiFBgn0003733.
GenevisibleiP18475. DM.

Interactioni

Protein-protein interaction databases

BioGridi61589. 28 interactors.
IntActiP18475. 2 interactors.
MINTiMINT-755149.
STRINGi7227.FBpp0111751.

Structurei

3D structure databases

ProteinModelPortaliP18475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini475 – 874Protein kinasePROSITE-ProRule annotationAdd BLAST400

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.
InParanoidiP18475.
KOiK12378.
OMAiREEWKFR.
OrthoDBiEOG091G0CQZ.
PhylomeDBiP18475.

Family and domain databases

InterProiIPR003961. FN3_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform AImported (identifier: P18475-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLIFYAKYAF IFWFFVGSNQ GEMLLMDKIS HDKTLLNVTA CTQNCLEKGQ
60 70 80 90 100
MDFRSCLKDC RINGTFPGAL RKVQENYQMN MICRTESEIV FQIDWVQHSR
110 120 130 140 150
GTEPAPNATY IIRVDAVKDD NKETALYLSD DNFLILPGLE SNSTHNITAL
160 170 180 190 200
AMHGDGSYSL IAKDQTFATL IRGYQPSKMG AVNLLRFVPQ PDDLHHIAAE
210 220 230 240 250
IEWKPSAESN CYFDMVSYST NSVNMDEPLE VQFRDRKKLY RHTVDNLEFD
260 270 280 290 300
KQYHVGVRTV NIMNRLESDL QWLPIAVPSC LDWYPYNYTL CPPHKPENLT
310 320 330 340 350
VTQKQYLPNI LALNITWARP RYLPDNYTLH IFDLFKGGTE LNYTLDQNRS
360 370 380 390 400
HFYVPKITVL GSHFEVHLVA QSAGGKNVSG LTLDKVHRGV LLSEGNMVKL
410 420 430 440 450
VLFIIVPICC ILMLCSLTFC RRNRSEVQAL QMDAKDAKAS EFHLSLMDSS
460 470 480 490 500
GLLVTLSANE SLEVMDELEV EPHSVLLQDV LGEGAFGLVR RGVYKKRQVA
510 520 530 540 550
VKLLKDEPND EDVYAFKCEI QMLKAVGKHP NIVGIVGYST RFSNQMMLLI
560 570 580 590 600
EYCSLGSLQN FLREEWKFRQ EQNAIGLKKN LEQNVDNRRF NRLPRNSIHD
610 620 630 640 650
RIEDINNSML STVEEESESD QTHSSRCETY TLTRITNAAD NKGYGLEDIE
660 670 680 690 700
NIGGSYIPKT AEAPKDRPKR KLKPQPKKDS KQDFKSDNKK RIFENKEYFD
710 720 730 740 750
CLDSSDTKPR IPLKYADLLD IAQQVAVGME FLAQNKVVHR DLAARNVLIS
760 770 780 790 800
VDRSIKIADF GLSRDVYHEN VYRKSGGSGK LPIKWLALES LTHQVYTSQS
810 820 830 840 850
DVWSFGVLLY EITTLGGMPY PSVSPSDLLQ LLRQGHRMKR PEGCTQEMFS
860 870 880 890 900
LMESCWSSVP SHRPTFSALK HRLGGMILAT NDVPERLKQL QAATESKLKS
910 920
CDGLNSKVEQ VPCEEELYLE PLN
Length:923
Mass (Da):105,201
Last modified:August 30, 2005 - v2
Checksum:i746F46E1A4277ACF
GO
Isoform DImported (identifier: P18475-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-393: Missing.

Note: No experimental confirmation available.
Show »
Length:918
Mass (Da):104,732
Checksum:i3E34A91BF45665BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125A → T in CAA33247 (PubMed:2927509).Curated1
Sequence conflicti387H → P in CAA33247 (PubMed:2927509).Curated1
Sequence conflicti667R → Q in CAA33247 (PubMed:2927509).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058212389 – 393Missing in isoform D. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15150 Genomic DNA. Translation: CAA33247.1.
AE013599 Genomic DNA. Translation: AAF59203.1.
AE013599 Genomic DNA. Translation: ABV53713.1.
AE013599 Genomic DNA. Translation: ABV53714.2.
AY071403 mRNA. Translation: AAL49025.1.
PIRiS03900.
RefSeqiNP_001097212.2. NM_001103742.2. [P18475-3]
NP_476762.1. NM_057414.4. [P18475-1]
UniGeneiDm.512.

Genome annotation databases

EnsemblMetazoaiFBtr0088938; FBpp0088012; FBgn0003733. [P18475-1]
GeneIDi35717.
KEGGidme:Dmel_CG1389.
UCSCiCG1389-RA. d. melanogaster. [P18475-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15150 Genomic DNA. Translation: CAA33247.1.
AE013599 Genomic DNA. Translation: AAF59203.1.
AE013599 Genomic DNA. Translation: ABV53713.1.
AE013599 Genomic DNA. Translation: ABV53714.2.
AY071403 mRNA. Translation: AAL49025.1.
PIRiS03900.
RefSeqiNP_001097212.2. NM_001103742.2. [P18475-3]
NP_476762.1. NM_057414.4. [P18475-1]
UniGeneiDm.512.

3D structure databases

ProteinModelPortaliP18475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61589. 28 interactors.
IntActiP18475. 2 interactors.
MINTiMINT-755149.
STRINGi7227.FBpp0111751.

PTM databases

iPTMnetiP18475.

Proteomic databases

PaxDbiP18475.
PRIDEiP18475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0088938; FBpp0088012; FBgn0003733. [P18475-1]
GeneIDi35717.
KEGGidme:Dmel_CG1389.
UCSCiCG1389-RA. d. melanogaster. [P18475-1]

Organism-specific databases

CTDi21977.
FlyBaseiFBgn0003733. tor.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00810000125384.
InParanoidiP18475.
KOiK12378.
OMAiREEWKFR.
OrthoDBiEOG091G0CQZ.
PhylomeDBiP18475.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
ReactomeiR-DME-210993. Tie2 Signaling.
R-DME-5673001. RAF/MAP kinase cascade.
SignaLinkiP18475.

Miscellaneous databases

GenomeRNAii35717.
PROiP18475.

Gene expression databases

BgeeiFBgn0003733.
GenevisibleiP18475. DM.

Family and domain databases

InterProiIPR003961. FN3_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTORSO_DROME
AccessioniPrimary (citable) accession number: P18475
Secondary accession number(s): A8DY54, A8DY56, Q9V4R2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: August 30, 2005
Last modified: November 30, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.