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P18475

- TORSO_DROME

UniProt

P18475 - TORSO_DROME

Protein

Tyrosine-protein kinase receptor torso

Gene

tor

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 2 (30 Aug 2005)
      Previous versions | rss
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    Functioni

    Probable receptor with tyrosine-protein kinase activity. Required for determination of anterior and posterior terminal structures in the Drosophila embryo. The ligand of torso seems to be TSL.2 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei502 – 5021ATPPROSITE-ProRule annotation
    Active sitei741 – 7411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi481 – 4899ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein tyrosine kinase activity Source: FlyBase
    3. transmembrane receptor protein tyrosine kinase activity Source: FlyBase

    GO - Biological processi

    1. anterior/posterior axis specification, embryo Source: FlyBase
    2. cell fate determination Source: FlyBase
    3. chorion-containing eggshell pattern formation Source: FlyBase
    4. gastrulation Source: FlyBase
    5. Malpighian tubule morphogenesis Source: FlyBase
    6. metamorphosis Source: FlyBase
    7. negative phototaxis Source: FlyBase
    8. negative regulation of multicellular organism growth Source: FlyBase
    9. peptidyl-tyrosine phosphorylation Source: GOC
    10. pole cell migration Source: FlyBase
    11. protein autophosphorylation Source: FlyBase
    12. protein phosphorylation Source: FlyBase
    13. regulation of transcription, DNA-templated Source: FlyBase
    14. terminal region determination Source: FlyBase
    15. torso signaling pathway Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.1. 1994.
    SignaLinkiP18475.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase receptor torso (EC:2.7.10.1)
    Gene namesi
    Name:tor
    ORF Names:CG1389
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2R

    Organism-specific databases

    FlyBaseiFBgn0003733. tor.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 923903Tyrosine-protein kinase receptor torsoPRO_0000024477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi326 – 3261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi348 – 3481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis
    Modified residuei608 – 6081Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP18475.

    Expressioni

    Tissue specificityi

    Expressed throughout the embryo but is activated specifically at the poles.2 Publications

    Developmental stagei

    Expressed both maternally and zygotically.2 Publications

    Gene expression databases

    BgeeiP18475.

    Interactioni

    Protein-protein interaction databases

    BioGridi61589. 28 interactions.
    IntActiP18475. 1 interaction.
    MINTiMINT-755149.

    Structurei

    3D structure databases

    ProteinModelPortaliP18475.
    SMRiP18475. Positions 449-898.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 399379ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini421 – 923503CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei400 – 42021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini475 – 874400Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117500.
    InParanoidiP18475.
    KOiK12378.
    OMAiRDVYHEN.
    OrthoDBiEOG7BZVTF.
    PhylomeDBiP18475.

    Family and domain databases

    InterProiIPR003961. Fibronectin_type3.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: P18475-1) [UniParc]FASTAAdd to Basket

    Also known as: C

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLIFYAKYAF IFWFFVGSNQ GEMLLMDKIS HDKTLLNVTA CTQNCLEKGQ    50
    MDFRSCLKDC RINGTFPGAL RKVQENYQMN MICRTESEIV FQIDWVQHSR 100
    GTEPAPNATY IIRVDAVKDD NKETALYLSD DNFLILPGLE SNSTHNITAL 150
    AMHGDGSYSL IAKDQTFATL IRGYQPSKMG AVNLLRFVPQ PDDLHHIAAE 200
    IEWKPSAESN CYFDMVSYST NSVNMDEPLE VQFRDRKKLY RHTVDNLEFD 250
    KQYHVGVRTV NIMNRLESDL QWLPIAVPSC LDWYPYNYTL CPPHKPENLT 300
    VTQKQYLPNI LALNITWARP RYLPDNYTLH IFDLFKGGTE LNYTLDQNRS 350
    HFYVPKITVL GSHFEVHLVA QSAGGKNVSG LTLDKVHRGV LLSEGNMVKL 400
    VLFIIVPICC ILMLCSLTFC RRNRSEVQAL QMDAKDAKAS EFHLSLMDSS 450
    GLLVTLSANE SLEVMDELEV EPHSVLLQDV LGEGAFGLVR RGVYKKRQVA 500
    VKLLKDEPND EDVYAFKCEI QMLKAVGKHP NIVGIVGYST RFSNQMMLLI 550
    EYCSLGSLQN FLREEWKFRQ EQNAIGLKKN LEQNVDNRRF NRLPRNSIHD 600
    RIEDINNSML STVEEESESD QTHSSRCETY TLTRITNAAD NKGYGLEDIE 650
    NIGGSYIPKT AEAPKDRPKR KLKPQPKKDS KQDFKSDNKK RIFENKEYFD 700
    CLDSSDTKPR IPLKYADLLD IAQQVAVGME FLAQNKVVHR DLAARNVLIS 750
    VDRSIKIADF GLSRDVYHEN VYRKSGGSGK LPIKWLALES LTHQVYTSQS 800
    DVWSFGVLLY EITTLGGMPY PSVSPSDLLQ LLRQGHRMKR PEGCTQEMFS 850
    LMESCWSSVP SHRPTFSALK HRLGGMILAT NDVPERLKQL QAATESKLKS 900
    CDGLNSKVEQ VPCEEELYLE PLN 923
    Length:923
    Mass (Da):105,201
    Last modified:August 30, 2005 - v2
    Checksum:i746F46E1A4277ACF
    GO
    Isoform B (identifier: P18475-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         907-923: KVEQVPCEEELYLEPLN → IGLRISAK

    Note: No experimental confirmation available.

    Show »
    Length:914
    Mass (Da):104,026
    Checksum:iE56B6FB1098131DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti125 – 1251A → T in CAA33247. (PubMed:2927509)Curated
    Sequence conflicti387 – 3871H → P in CAA33247. (PubMed:2927509)Curated
    Sequence conflicti667 – 6671R → Q in CAA33247. (PubMed:2927509)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei907 – 92317KVEQV…LEPLN → IGLRISAK in isoform B. CuratedVSP_034011Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15150 Genomic DNA. Translation: CAA33247.1.
    AE013599 Genomic DNA. Translation: AAF59203.1.
    AE013599 Genomic DNA. Translation: ABV53713.1.
    AE013599 Genomic DNA. Translation: ABV53714.1.
    AY071403 mRNA. Translation: AAL49025.1.
    PIRiS03900.
    RefSeqiNP_001097211.1. NM_001103741.1. [P18475-2]
    NP_001097212.1. NM_001103742.1. [P18475-1]
    NP_476762.1. NM_057414.3. [P18475-1]
    UniGeneiDm.512.

    Genome annotation databases

    EnsemblMetazoaiFBtr0088938; FBpp0088012; FBgn0003733. [P18475-1]
    FBtr0112838; FBpp0111751; FBgn0003733. [P18475-1]
    GeneIDi35717.
    KEGGidme:Dmel_CG1389.
    UCSCiCG1389-RA. d. melanogaster. [P18475-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15150 Genomic DNA. Translation: CAA33247.1 .
    AE013599 Genomic DNA. Translation: AAF59203.1 .
    AE013599 Genomic DNA. Translation: ABV53713.1 .
    AE013599 Genomic DNA. Translation: ABV53714.1 .
    AY071403 mRNA. Translation: AAL49025.1 .
    PIRi S03900.
    RefSeqi NP_001097211.1. NM_001103741.1. [P18475-2 ]
    NP_001097212.1. NM_001103742.1. [P18475-1 ]
    NP_476762.1. NM_057414.3. [P18475-1 ]
    UniGenei Dm.512.

    3D structure databases

    ProteinModelPortali P18475.
    SMRi P18475. Positions 449-898.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 61589. 28 interactions.
    IntActi P18475. 1 interaction.
    MINTi MINT-755149.

    Proteomic databases

    PaxDbi P18475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0088938 ; FBpp0088012 ; FBgn0003733 . [P18475-1 ]
    FBtr0112838 ; FBpp0111751 ; FBgn0003733 . [P18475-1 ]
    GeneIDi 35717.
    KEGGi dme:Dmel_CG1389.
    UCSCi CG1389-RA. d. melanogaster. [P18475-1 ]

    Organism-specific databases

    CTDi 21977.
    FlyBasei FBgn0003733. tor.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117500.
    InParanoidi P18475.
    KOi K12378.
    OMAi RDVYHEN.
    OrthoDBi EOG7BZVTF.
    PhylomeDBi P18475.

    Enzyme and pathway databases

    BRENDAi 2.7.10.1. 1994.
    SignaLinki P18475.

    Miscellaneous databases

    GenomeRNAii 35717.
    NextBioi 794882.

    Gene expression databases

    Bgeei P18475.

    Family and domain databases

    InterProi IPR003961. Fibronectin_type3.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila gene torso encodes a putative receptor tyrosine kinase."
      Sprenger F., Stevens L.M., Nuesslein-Volhard C.
      Nature 338:478-483(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: Berkeley.
      Tissue: Embryo.
    5. "Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction."
      Sprenger F., Torsoclair M.M., Morrison D.K.
      Mol. Cell. Biol. 13:1163-1172(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiTORSO_DROME
    AccessioniPrimary (citable) accession number: P18475
    Secondary accession number(s): A8DY54, A8DY56, Q9V4R2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: August 30, 2005
    Last modified: October 1, 2014
    This is version 143 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3