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Protein

H-2 class II histocompatibility antigen, I-A beta chain

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: BHF-UCL
  • response to interferon-gamma Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, I-A beta chain
Gene namesi
Name:H2-Eb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95901. H2-Eb1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 225ExtracellularSequence analysisAdd BLAST194
Transmembranei226 – 248HelicalSequence analysisAdd BLAST23
Topological domaini249 – 264CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Add BLAST31
ChainiPRO_000001900332 – 264H-2 class II histocompatibility antigen, I-A beta chainAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 106PROSITE-ProRule annotation1 Publication
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 200PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP18468.
PaxDbiP18468.
PRIDEiP18468.

PTM databases

iPTMnetiP18468.
PhosphoSitePlusiP18468.

Expressioni

Gene expression databases

CleanExiMM_H2-EB1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi34 – 45Combined sources12
Helixi47 – 49Combined sources3
Beta strandi50 – 59Combined sources10
Beta strandi62 – 68Combined sources7
Turni69 – 71Combined sources3
Beta strandi73 – 78Combined sources6
Helixi79 – 81Combined sources3
Helixi82 – 89Combined sources8
Helixi92 – 104Combined sources13
Helixi106 – 113Combined sources8
Turni114 – 116Combined sources3
Beta strandi125 – 131Combined sources7
Beta strandi133 – 135Combined sources3
Beta strandi141 – 152Combined sources12
Beta strandi155 – 160Combined sources6
Beta strandi167 – 171Combined sources5
Beta strandi178 – 180Combined sources3
Beta strandi182 – 189Combined sources8
Beta strandi198 – 203Combined sources6
Beta strandi211 – 215Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R5VX-ray2.50B/D32-215[»]
ProteinModelPortaliP18468.
SMRiP18468.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18468.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 214Ig-like C1-typeAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni32 – 121Beta-1Add BLAST90
Regioni122 – 215Beta-2Add BLAST94
Regioni216 – 225Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
HOVERGENiHBG012730.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWLPRVPCV AAVILLLTVL SPPVALVRDS RPWFLEYCKS ECHFYNGTQR
60 70 80 90 100
VRFLKRYFYN LEENLRFDSD VGEFRAVTEL GRPDAENWNS QPEILDEKRA
110 120 130 140 150
AVDTYCRHNY EIFDNFLVPR RVEPTVTVYP TKTQPLEHHN LLVCSVSDFY
160 170 180 190 200
PGNIEVRWFR NGKEEKTGIV STGLVRNGDW TFQTLVMLET VPQSGEVYTC
210 220 230 240 250
QVEHPSLTDP VTVEWKAQST SAQNKMLSGV GGFVLGLLFL RAGLFIYFRN
260
QKGQSGLQPT GLLS
Length:264
Mass (Da):30,232
Last modified:November 1, 1990 - v1
Checksum:i04529F5E2E527D7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52641 mRNA. Translation: CAA36863.1.
PIRiI48224. S11650.
UniGeneiMm.22564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52641 mRNA. Translation: CAA36863.1.
PIRiI48224. S11650.
UniGeneiMm.22564.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R5VX-ray2.50B/D32-215[»]
ProteinModelPortaliP18468.
SMRiP18468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074143.

PTM databases

iPTMnetiP18468.
PhosphoSitePlusiP18468.

Proteomic databases

MaxQBiP18468.
PaxDbiP18468.
PRIDEiP18468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95901. H2-Eb1.

Phylogenomic databases

eggNOGiENOG410IWG3. Eukaryota.
ENOG410YI0S. LUCA.
HOVERGENiHBG012730.

Miscellaneous databases

EvolutionaryTraceiP18468.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-EB1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHB2I_MOUSE
AccessioniPrimary (citable) accession number: P18468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.