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P18465 (1B57_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-57 alpha chain
Alternative name(s):
Bw-57
MHC class I antigen B*57
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence shown is that of B*57:01.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi apparatus

Inferred from sequence or structural similarity. Source: UniProt

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProt

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-57 alpha chain
PRO_0000018860

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36230Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 Ref.8
Disulfide bond227 ↔ 283 Ref.8

Natural variations

Natural variant1211V → R in allele B*57:05; requires 2 nucleotide substitutions.
VAR_016669
Natural variant1271V → L in allele B*57:05.
VAR_016670
Natural variant1371H → Y in allele B*57:05.
VAR_016671
Natural variant1381D → N in allele B*57:02, allele B*57:03 and allele B*57:05.
VAR_016495
Natural variant1401S → Y in allele B*57:02, allele B*57:03 and allele B*57:05. Ref.9
VAR_016496
Natural variant1801L → R in allele B*57:02 and allele B*57:05.
VAR_016497
Natural variant3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056416
Natural variant3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056417
Natural variant3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061431
Natural variant3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061432

Secondary structure

................................................. 362
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18465 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: C1EFCF089096AFF9

FASTA36240,224
        10         20         30         40         50         60 
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE NLRIALRYYN QSEAGSHIIQ 

       130        140        150        160        170        180 
VMYGCDVGPD GRLLRGHDQS AYDGKDYIAL NEDLSSWTAA DTAAQITQRK WEAARVAEQL 

       190        200        210        220        230        240 
RAYLEGLCVE WLRRYLENGK ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
Ennis P.D., Zemmour J., Salter R.D., Parham P.
Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:01).
[2]"Nucleotide sequence of an HLA-Bw57 gene."
Isamat M., Girdlestone J., Milstein C.
Nucleic Acids Res. 18:6702-6702(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*57:01).
[3]"Confirmation of B*5701."
Cox S.T.
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Distinctive HLA-A,B antigens of black populations formed by interallelic conversion."
Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., Martell R.W., du Toit E.D., Parham P.
J. Immunol. 149:3411-3415(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:02).
[5]"Molecular diversity of HLA-B."
Petersdorf E.
Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:03).
Tissue: Blood.
[6]"The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi population from Equatorial Guinea."
Vilches C., Bunce M., de Pablo R., Moreno M.E., Puente S., Sanz L., Kreisler M.
Tissue Antigens 49:644-648(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:03).
[7]"Twenty-nine new HLA-B alleles associated with antigens in the 5C CREG."
Steiner N.K., Kosman C., Jones P.F., Gans C.P., Rodriguez-Marino S.G., Rizzuto G., Baldassarre L.A., Edson S., Koester R., Sese D., Mitton W., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 57:481-485(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:05).
[8]"Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression."
Stewart-Jones G.B., Gillespie G., Overton I.M., Kaul R., Roche P., McMichael A.J., Rowland-Jones S., Jones E.Y.
J. Immunol. 175:2459-2468(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 25-300 (ALLELE B*57:03) IN COMPLEX WITH HIV-1 PEPTIDES, DISULFIDE BONDS.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32318 mRNA. Translation: AAA36231.1.
X55711 Genomic DNA. Translation: CAA39244.1.
AJ458991 Genomic DNA. Translation: CAD30339.1.
X61707 mRNA. Translation: CAA43876.1.
U18790 mRNA. Translation: AAB60361.1.
Y09157 mRNA. Translation: CAA70355.1.
AH006370 Genomic DNA. Translation: AAC32568.1.
PIRD35997.
UniGeneHs.654404.
Hs.77961.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BVOX-ray1.65A25-300[»]
2BVPX-ray1.35A25-300[»]
2BVQX-ray2.00A25-300[»]
2HJLX-ray1.50A25-298[»]
2RFXX-ray2.50A25-299[»]
2YPKX-ray1.95A25-298[»]
2YPLX-ray2.40A25-298[»]
3UPRX-ray2.00A/C25-300[»]
3VH8X-ray1.80A/D25-299[»]
3VRIX-ray1.60A25-300[»]
3VRJX-ray1.90A25-300[»]
ProteinModelPortalP18465.
SMRP18465. Positions 25-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP18465. 1 interaction.

Polymorphism databases

DMDM122174.

Proteomic databases

PRIDEP18465.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000435618; ENSP00000405178; ENSG00000224608.

Organism-specific databases

GeneCardsGC06M031321.
GC06Ml31364.
HGNCHGNC:4932. HLA-B.
MIM142830. gene.
neXtProtNX_P18465.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG016709.
InParanoidP18465.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-B.
GenevestigatorP18465.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
EvolutionaryTraceP18465.
SOURCESearch...

Entry information

Entry name1B57_HUMAN
AccessionPrimary (citable) accession number: P18465
Secondary accession number(s): O62917 expand/collapse secondary AC list , P30497, P79496, Q29679, Q5QT24
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM