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P18465

- 1B57_HUMAN

UniProt

P18465 - 1B57_HUMAN

Protein

HLA class I histocompatibility antigen, B-57 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro
    8. regulation of immune response Source: Reactome
    9. type I interferon signaling pathway Source: Reactome
    10. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-57 alpha chain
    Alternative name(s):
    Bw-57
    MHC class I antigen B*57
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. MHC class I protein complex Source: UniProt
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-57 alpha chainPRO_0000018860Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 1881 PublicationPROSITE-ProRule annotation
    Disulfide bondi227 ↔ 2831 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiP18465.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-B.
    GenevestigatoriP18465.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Protein-protein interaction databases

    IntActiP18465. 1 interaction.

    Structurei

    Secondary structure

    1
    362
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi41 – 433
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Helixi74 – 763
    Helixi81 – 10828
    Beta strandi118 – 12710
    Beta strandi133 – 14210
    Beta strandi145 – 1506
    Beta strandi157 – 1615
    Helixi162 – 17312
    Helixi176 – 18510
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 21910
    Beta strandi222 – 23514
    Beta strandi238 – 2436
    Helixi249 – 2513
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BVOX-ray1.65A25-300[»]
    2BVPX-ray1.35A25-300[»]
    2BVQX-ray2.00A25-300[»]
    2HJLX-ray1.50A25-298[»]
    2RFXX-ray2.50A25-299[»]
    2YPKX-ray1.95A25-298[»]
    2YPLX-ray2.40A25-298[»]
    3UPRX-ray2.00A/C25-300[»]
    3VH8X-ray1.80A/D25-299[»]
    3VRIX-ray1.60A25-300[»]
    3VRJX-ray1.90A25-300[»]
    3WUWX-ray2.00A25-299[»]
    ProteinModelPortaliP18465.
    SMRiP18465. Positions 25-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP18465.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    InParanoidiP18465.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18465-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG    50
    YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE 100
    NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHDQS AYDGKDYIAL 150
    NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK 200
    ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,224
    Last modified:November 1, 1990 - v1
    Checksum:iC1EFCF089096AFF9
    GO

    Polymorphismi

    The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence shown is that of B*57:01.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211V → R in allele B*57:05; requires 2 nucleotide substitutions.
    VAR_016669
    Natural varianti127 – 1271V → L in allele B*57:05.
    VAR_016670
    Natural varianti137 – 1371H → Y in allele B*57:05.
    VAR_016671
    Natural varianti138 – 1381D → N in allele B*57:02, allele B*57:03 and allele B*57:05.
    VAR_016495
    Natural varianti140 – 1401S → Y in allele B*57:02, allele B*57:03 and allele B*57:05. 1 Publication
    VAR_016496
    Natural varianti180 – 1801L → R in allele B*57:02 and allele B*57:05.
    VAR_016497
    Natural varianti306 – 3061V → I.
    Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
    VAR_056416
    Natural varianti329 – 3291A → T.
    Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
    VAR_056417
    Natural varianti349 – 3491C → S.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061431
    Natural varianti349 – 3491C → Y.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061432

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32318 mRNA. Translation: AAA36231.1.
    X55711 Genomic DNA. Translation: CAA39244.1.
    AJ458991 Genomic DNA. Translation: CAD30339.1.
    X61707 mRNA. Translation: CAA43876.1.
    U18790 mRNA. Translation: AAB60361.1.
    Y09157 mRNA. Translation: CAA70355.1.
    AH006370 Genomic DNA. Translation: AAC32568.1.
    PIRiD35997.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000435618; ENSP00000405178; ENSG00000224608.

    Polymorphism databases

    DMDMi122174.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32318 mRNA. Translation: AAA36231.1 .
    X55711 Genomic DNA. Translation: CAA39244.1 .
    AJ458991 Genomic DNA. Translation: CAD30339.1 .
    X61707 mRNA. Translation: CAA43876.1 .
    U18790 mRNA. Translation: AAB60361.1 .
    Y09157 mRNA. Translation: CAA70355.1 .
    AH006370 Genomic DNA. Translation: AAC32568.1 .
    PIRi D35997.
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BVO X-ray 1.65 A 25-300 [» ]
    2BVP X-ray 1.35 A 25-300 [» ]
    2BVQ X-ray 2.00 A 25-300 [» ]
    2HJL X-ray 1.50 A 25-298 [» ]
    2RFX X-ray 2.50 A 25-299 [» ]
    2YPK X-ray 1.95 A 25-298 [» ]
    2YPL X-ray 2.40 A 25-298 [» ]
    3UPR X-ray 2.00 A/C 25-300 [» ]
    3VH8 X-ray 1.80 A/D 25-299 [» ]
    3VRI X-ray 1.60 A 25-300 [» ]
    3VRJ X-ray 1.90 A 25-300 [» ]
    3WUW X-ray 2.00 A 25-299 [» ]
    ProteinModelPortali P18465.
    SMRi P18465. Positions 25-298.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P18465. 1 interaction.

    Polymorphism databases

    DMDMi 122174.

    Proteomic databases

    PRIDEi P18465.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435618 ; ENSP00000405178 ; ENSG00000224608 .

    Organism-specific databases

    GeneCardsi GC06M031321.
    GC06Ml31364.
    HGNCi HGNC:4932. HLA-B.
    MIMi 142830. gene.
    neXtProti NX_P18465.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    InParanoidi P18465.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    EvolutionaryTracei P18465.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-B.
    Genevestigatori P18465.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
      Ennis P.D., Zemmour J., Salter R.D., Parham P.
      Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:01).
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*57:01).
    3. "Confirmation of B*5701."
      Cox S.T.
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion."
      Madrigal J.A., Belich M.P., Hildebrand W.H., Benjamin R.J., Little A.-M., Zemmour J., Ennis P.D., Ward F.E., Petzl-Erler M.L., Martell R.W., du Toit E.D., Parham P.
      J. Immunol. 149:3411-3415(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:02).
    5. "Molecular diversity of HLA-B."
      Petersdorf E.
      Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:03).
      Tissue: Blood.
    6. "The novel HLA-Cw*1802 allele is associated with B*5703 in the Bubi population from Equatorial Guinea."
      Vilches C., Bunce M., de Pablo R., Moreno M.E., Puente S., Sanz L., Kreisler M.
      Tissue Antigens 49:644-648(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*57:03).
    7. Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE B*57:05).
    8. "Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression."
      Stewart-Jones G.B., Gillespie G., Overton I.M., Kaul R., Roche P., McMichael A.J., Rowland-Jones S., Jones E.Y.
      J. Immunol. 175:2459-2468(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 25-300 (ALLELE B*57:03) IN COMPLEX WITH HIV-1 PEPTIDES, DISULFIDE BONDS.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] TYR-140, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1B57_HUMAN
    AccessioniPrimary (citable) accession number: P18465
    Secondary accession number(s): O62917
    , P30497, P79496, Q29679, Q5QT24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3