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Protein

HLA class I histocompatibility antigen, B-57 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-57 alpha chain
Alternative name(s):
Bw-57
MHC class I antigen B*57
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi122174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001886025 – 362HLA class I histocompatibility antigen, B-57 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP18465.
PeptideAtlasiP18465.
PRIDEiP18465.

PTM databases

SwissPalmiP18465.

Expressioni

Gene expression databases

BgeeiENSG00000224608.
CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiP18465. 1 interactor.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 219Combined sources10
Beta strandi222 – 235Combined sources14
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BVOX-ray1.65A25-300[»]
2BVPX-ray1.35A25-300[»]
2BVQX-ray2.00A25-300[»]
2HJLX-ray1.50A25-298[»]
2RFXX-ray2.50A25-299[»]
2YPKX-ray1.95A25-298[»]
2YPLX-ray2.40A25-298[»]
3UPRX-ray2.00A/C25-300[»]
3VH8X-ray1.80A/D25-299[»]
3VRIX-ray1.60A25-300[»]
3VRJX-ray1.90A25-300[»]
3WUWX-ray2.00A25-299[»]
3X11X-ray2.15A25-300[»]
3X12X-ray1.80A25-300[»]
5B38X-ray2.30A25-300[»]
5B39X-ray2.50A25-300[»]
ProteinModelPortaliP18465.
SMRiP18465.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18465.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRMA PRAPWIEQEG PEYWDGETRN MKASAQTYRE
110 120 130 140 150
NLRIALRYYN QSEAGSHIIQ VMYGCDVGPD GRLLRGHDQS AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAARVAEQL RAYLEGLCVE WLRRYLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,224
Last modified:November 1, 1990 - v1
Checksum:iC1EFCF089096AFF9
GO

Polymorphismi

The following alleles of B-57 are known: B*57:01, B*57:02 (Bw57.2), B*57:03 (B-57SAU) and B*57:05. The sequence shown is that of B*57:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016669121V → R in allele B*57:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_016670127V → L in allele B*57:05. 1
Natural variantiVAR_016671137H → Y in allele B*57:05. 1
Natural variantiVAR_016495138D → N in allele B*57:02, allele B*57:03 and allele B*57:05. 1
Natural variantiVAR_016496140S → Y in allele B*57:02, allele B*57:03 and allele B*57:05. Combined sources1
Natural variantiVAR_016497180L → R in allele B*57:02 and allele B*57:05. 1
Natural variantiVAR_056416306V → I.Corresponds to variant rs1131500dbSNPEnsembl.1
Natural variantiVAR_056417329A → T.Corresponds to variant rs1051488dbSNPEnsembl.1
Natural variantiVAR_061431349C → S.Corresponds to variant rs2308655dbSNPEnsembl.1
Natural variantiVAR_061432349C → Y.Corresponds to variant rs2308655dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32318 mRNA. Translation: AAA36231.1.
X55711 Genomic DNA. Translation: CAA39244.1.
AJ458991 Genomic DNA. Translation: CAD30339.1.
X61707 mRNA. Translation: CAA43876.1.
U18790 mRNA. Translation: AAB60361.1.
Y09157 mRNA. Translation: CAA70355.1.
AH006370 Genomic DNA. Translation: AAC32568.1.
PIRiD35997.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32318 mRNA. Translation: AAA36231.1.
X55711 Genomic DNA. Translation: CAA39244.1.
AJ458991 Genomic DNA. Translation: CAD30339.1.
X61707 mRNA. Translation: CAA43876.1.
U18790 mRNA. Translation: AAB60361.1.
Y09157 mRNA. Translation: CAA70355.1.
AH006370 Genomic DNA. Translation: AAC32568.1.
PIRiD35997.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BVOX-ray1.65A25-300[»]
2BVPX-ray1.35A25-300[»]
2BVQX-ray2.00A25-300[»]
2HJLX-ray1.50A25-298[»]
2RFXX-ray2.50A25-299[»]
2YPKX-ray1.95A25-298[»]
2YPLX-ray2.40A25-298[»]
3UPRX-ray2.00A/C25-300[»]
3VH8X-ray1.80A/D25-299[»]
3VRIX-ray1.60A25-300[»]
3VRJX-ray1.90A25-300[»]
3WUWX-ray2.00A25-299[»]
3X11X-ray2.15A25-300[»]
3X12X-ray1.80A25-300[»]
5B38X-ray2.30A25-300[»]
5B39X-ray2.50A25-300[»]
ProteinModelPortaliP18465.
SMRiP18465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18465. 1 interactor.

PTM databases

SwissPalmiP18465.

Polymorphism and mutation databases

DMDMi122174.

Proteomic databases

MaxQBiP18465.
PeptideAtlasiP18465.
PRIDEiP18465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435618; ENSP00000405178; ENSG00000224608.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P18465.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
EvolutionaryTraceiP18465.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000224608.
CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B57_HUMAN
AccessioniPrimary (citable) accession number: P18465
Secondary accession number(s): O62917
, P30497, P79496, Q29679, Q5QT24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.