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Protein

HLA class I histocompatibility antigen, B-51 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-51 alpha chain
Alternative name(s):
MHC class I antigen B*51
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36230CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi122172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-51 alpha chainPRO_0000018854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP18464.
PRIDEiP18464.

PTM databases

SwissPalmiP18464.

Expressioni

Gene expression databases

CleanExiHS_HLA-B.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

DIPiDIP-6150N.
MINTiMINT-144207.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Turni39 – 413Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Helixi74 – 785Combined sources
Helixi81 – 10828Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E27X-ray2.20A25-300[»]
1E28X-ray3.00A25-300[»]
4MJIX-ray2.99A/F25-300[»]
ProteinModelPortaliP18464.
SMRiP18464. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18464-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVTAPRTVL LLLWGAVALT ETWAGSHSMR YFYTAMSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRTE PRAPWIEQEG PEYWDRNTQI FKTNTQTYRE
110 120 130 140 150
NLRIALRYYN QSEAGSHTWQ TMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLSSWTAA DTAAQITQRK WEAAREAEQL RAYLEGLCVE WLRRHLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPVSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLAV VVIGAVVATV MCRRKSSGGK GGSYSQAASS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,566
Last modified:November 1, 1990 - v1
Checksum:iD104163B4CC71F92
GO

Polymorphismi

The following alleles of B-51 are known: B*51:01, B*51:03, B*51:04, B*51:08 and B*51:24. The sequence shown is that of B*51:01.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1214TWQT → IIQR in allele B*51:04.
VAR_016478
Natural varianti155 – 1551S → R in allele B*51:24.
VAR_017442
Natural varianti176 – 1761E → V in allele B*51:08.
VAR_016479
Natural varianti180 – 1801L → D in allele B*51:08; requires 2 nucleotide substitutions.
VAR_016480
Natural varianti191 – 1911W → G in allele B*51:03.
VAR_016481
Natural varianti195 – 1951H → Y in allele B*51:02.
VAR_016482

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32319 mRNA. Translation: AAA36232.1.
M22792
, M22786, M22787, M22788, M22789, M22790, M22791 Genomic DNA. Translation: AAA59620.1. Sequence problems.
L41087, L41086 Genomic DNA. Translation: AAA64513.1.
Z15143 mRNA. Translation: CAA78849.1.
M80670 Genomic DNA. Translation: AAA52661.1.
L41925 mRNA. Translation: AAC41979.1.
Y08994 mRNA. Translation: CAA70198.1.
AB056860 Genomic DNA. Translation: BAB64902.1.
AB056862 Genomic DNA. Translation: BAB64904.1.
AB056863 Genomic DNA. Translation: BAB64905.1.
AB056864 Genomic DNA. Translation: BAB64906.1.
AB056865 Genomic DNA. Translation: BAB64907.1.
AJ278903 Genomic DNA. Translation: CAC05371.1.
BC007243 mRNA. Translation: AAH07243.1.
AJ276995 Genomic DNA. Translation: CAB86196.1.
Z46808 mRNA. Translation: CAA86838.1.
PIRiA30345.
I37120.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32319 mRNA. Translation: AAA36232.1.
M22792
, M22786, M22787, M22788, M22789, M22790, M22791 Genomic DNA. Translation: AAA59620.1. Sequence problems.
L41087, L41086 Genomic DNA. Translation: AAA64513.1.
Z15143 mRNA. Translation: CAA78849.1.
M80670 Genomic DNA. Translation: AAA52661.1.
L41925 mRNA. Translation: AAC41979.1.
Y08994 mRNA. Translation: CAA70198.1.
AB056860 Genomic DNA. Translation: BAB64902.1.
AB056862 Genomic DNA. Translation: BAB64904.1.
AB056863 Genomic DNA. Translation: BAB64905.1.
AB056864 Genomic DNA. Translation: BAB64906.1.
AB056865 Genomic DNA. Translation: BAB64907.1.
AJ278903 Genomic DNA. Translation: CAC05371.1.
BC007243 mRNA. Translation: AAH07243.1.
AJ276995 Genomic DNA. Translation: CAB86196.1.
Z46808 mRNA. Translation: CAA86838.1.
PIRiA30345.
I37120.
UniGeneiHs.654404.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E27X-ray2.20A25-300[»]
1E28X-ray3.00A25-300[»]
4MJIX-ray2.99A/F25-300[»]
ProteinModelPortaliP18464.
SMRiP18464. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6150N.
MINTiMINT-144207.

PTM databases

SwissPalmiP18464.

Polymorphism and mutation databases

DMDMi122172.

Proteomic databases

EPDiP18464.
PRIDEiP18464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359635; ENSP00000352656; ENSG00000206450.

Organism-specific databases

GeneCardsiHLA-B.
H-InvDBHIX0005715.
HGNCiHGNC:4932. HLA-B.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P18464.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
EvolutionaryTraceiP18464.
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
    Ennis P.D., Zemmour J., Salter R.D., Parham P.
    Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:01).
  2. "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain."
    Hayashi H., Ennis P.D., Ariga H., Salter R.D., Parham P., Kano K., Takiguchi M.
    J. Immunol. 142:306-311(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:01).
  3. "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles."
    Pohla H., Kuon W., Tabaczewski P., Doerner C., Weiss E.H.
    Immunogenetics 29:297-307(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*51:01).
  4. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*51:04).
  5. "A single amino acid substitution at residue 167 forms a novel HLA-B51 subtype."
    Kawaguchi G., Nakayama S., Nagao T., Takiguchi M.
    Tissue Antigens 42:39-41(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:03).
    Tissue: Peripheral blood.
  6. "Novel alleles HLA-B*7802 and B*51022: evidence for convergency in the HLA-B5 family."
    Prilliman K., Steiner N.K., Ellexson M., Stewart D., Lau M., Terasaki P., Hurley C.K., Hildebrand W.H.
    Tissue Antigens 47:49-57(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:02).
  7. "Complete coding regions of two novel HLA-B alleles detected by phototyping (PCR-SSP) in the British Caucasoid population: B*5108 and B*5002."
    Vilches C., Bunce M., de Pablo R., Murray A.K., McIntyre C.A., Kreisler M.
    Tissue Antigens 50:38-41(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*51:08).
  8. "The absence of disease-specific polymorphisms within the HLA-B51 gene that is the susceptible locus for Behcet's disease."
    Sano K., Yabuki K., Imagawa Y., Shiina T., Mizuki N., Ohno S., Kulski J.K., Inoko H.
    Tissue Antigens 58:77-82(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*51:01).
  9. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*51:01).
  10. "HLA class I alleles of LCL 721 and 174 x CEM.T2 (T2)."
    Steinle A., Schendel D.J.
    Tissue Antigens 44:268-270(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-206 (ALLELE B*51:01).
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-362 (ALLELE B*51:01).
    Tissue: Lymph.
  12. "Three newly identified HLA-B alleles: B*5124, B*5306, B*5307 and confirmation of B*0809 and B*5606."
    Anholts J.D.H., Kemps-Mols B., Verduijn W., Oudshoorn M., Schreuder G.M.T.
    Tissue Antigens 58:38-41(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*51:24).
    Tissue: Peripheral blood.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes."
    Maenaka K., Maenaka T., Tomiyama H., Takiguchi M., Stuart D.I., Jones E.Y.
    J. Immunol. 165:3260-3267(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 25-300 (B*51:01).
  16. "New insights into the pathogenesis and therapy of Behcet's disease."
    Arayssi T., Hamdan A.
    Curr. Opin. Pharmacol. 4:183-188(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN BEHCET DISEASE.

Entry informationi

Entry namei1B51_HUMAN
AccessioniPrimary (citable) accession number: P18464
Secondary accession number(s): O19675
, O78173, P30489, Q29851, Q29857, Q96IT9, Q9MY43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There is evidence that HLA-B51 is associated with susceptibility to Behcet disease. However, it is not certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. The world distribution of HLA-B51 in healthy people corresponds to the global distribution of Behcet disease; in Southern hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B51 in healthy people is low or null, corresponding to a low prevalence of Behcet disease. The wide variation that exists in the relative risk of HLA-B51 would support other nongenetic risk factors.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.