P18462 (1A25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-25 alpha chain

Alternative name(s):
HLA class I histocompatibility antigen, A-10 alpha chain
MHC class I antigen A*25

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of A-25 are known: A*25:01 A*25:02 and A*25:03. The sequence shown is that of A*25:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 365	341	HLA class I histocompatibility antigen, A-25 alpha chain		PRO_0000018819
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 365	33	Cytoplasmic Potential
	Domain	209 – 295	87	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	125 ↔ 188		By similarity
	Disulfide bond	227 ↔ 283		By similarity
Natural variations
	Natural variant	33	1	Y → F in allele A*25:03. Corresponds to variant rs2075684 [ dbSNP | Ensembl ].		VAR_016737
	Natural variant	94	1	H → Q in allele A*25:02.		VAR_004361
	Natural variant	151	1	N → K. Corresponds to variant rs1059509 [ dbSNP | Ensembl ].		VAR_056264
	Natural variant	166	1	I → T. Corresponds to variant rs1059516 [ dbSNP | Ensembl ].		VAR_056265

Sequences

	Sequence		Length	Mass (Da)
	P18462 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 00F71BD2F97C3620	FASTA	365	41,218
	10 20 30 40 50 60 MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAHSQTDRE SLRIALRYYN QSEDGSHTIQ 130 140 150 160 170 180 RMYGCDVGPD GRFLRGYQQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WETAHEAEQW 190 200 210 220 230 240 RAYLEGRCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLFGA VIAGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification." Ennis P.D., Zemmour J., Salter R.D., Parham P. Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed: 2320591] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*25:01).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE A*25:01). Tissue: Brain.
[3]	"Identification of a new HLA-A allele (A*2502) by PCR-SSP." Krausa P., Young D.M., Gotch F. Immunogenetics 45:84-85(1996) [PubMed: 8881046] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*25:02). Tissue: Hematopoietic.
[4]	"Sequence confirmation of HLA-A*2502." Guttridge M.G. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*25:02).
[5]	"Seventeen more novel HLA-A locus alleles." Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:369-373(2000) [PubMed: 10852390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*25:03).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32321 mRNA. Translation: AAA36234.1. BC008611 mRNA. Translation: AAH08611.1. X97802 mRNA. Translation: CAA66389.1. AJ238524 Genomic DNA. Translation: CAB41888.1. AF137076, AF137075 Genomic DNA. Translation: AAD33737.1. AF148898, AF148897 Genomic DNA. Translation: AAD34010.1.
IPI	IPI00785070.
PIR	A35997.
UniGene	Hs.181244. Hs.713441.
3D structure databases
ProteinModelPortal	P18462.
SMR	P18462. Positions 25-299.
ModBase	Search...
Protein-protein interaction databases
STRING	P18462.
Polymorphism databases
DMDM	122158.
Proteomic databases
PRIDE	P18462.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383605; ENSP00000373100; ENSG00000206505. ENST00000383617; ENSP00000373112; ENSG00000206505.
Organism-specific databases
GeneCards	GC06P029921. GC06Pn29898.
HGNC	HGNC:4931. HLA-A.
MIM	142800. gene.
neXtProt	NX_P18462.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
OrthoDB	EOG4NZTV0.
Gene expression databases
CleanEx	HS_HLA-A.
Genevestigator	P18462.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

1A25_HUMAN

Accession

Primary (citable) accession number: P18462
Secondary accession number(s): Q95362 , Q9TQE8, Q9TQG0, Q9UQU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	December 14, 2011
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.