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P18460

- FGFR3_CHICK

UniProt

P18460 - FGFR3_CHICK

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Protein
Fibroblast growth factor receptor 3
Gene
FGFR3, CEK2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Enzyme regulationi

Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei502 – 5021ATP By similarity
Active sitei611 – 6111Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi472 – 4809ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fibroblast growth factor-activated receptor activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. positive regulation of cell proliferation Source: InterPro
  3. skeletal system development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptor 3 (EC:2.7.10.1)
Short name:
FGFR-3
Alternative name(s):
Tyrosine kinase receptor CEK2
Gene namesi
Name:FGFR3
Synonyms:CEK2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 364345Extracellular Reviewed prediction
Add
BLAST
Transmembranei365 – 38925Helical; Reviewed prediction
Add
BLAST
Topological domaini390 – 806417Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 806787Fibroblast growth factor receptor 3
PRO_0000016790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 107 By similarity
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi96 – 961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi170 ↔ 222 By similarity
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi269 ↔ 333 By similarity
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi309 – 3091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi322 – 3221N-linked (GlcNAc...) Reviewed prediction
Modified residuei641 – 6411Phosphotyrosine; by autocatalysis By similarity
Modified residuei642 – 6421Phosphotyrosine; by autocatalysis By similarity
Modified residuei718 – 7181Phosphotyrosine; by autocatalysis By similarity
Modified residuei754 – 7541Phosphotyrosine; by autocatalysis By similarity

Post-translational modificationi

Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18460.

Interactioni

Subunit structurei

Monomer. Homodimer after ligand binding By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001710.

Structurei

3D structure databases

ProteinModelPortaliP18460.
SMRiP18460. Positions 145-355, 453-750.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 124101Ig-like C2-type 1
Add
BLAST
Domaini150 – 23889Ig-like C2-type 2
Add
BLAST
Domaini247 – 349103Ig-like C2-type 3
Add
BLAST
Domaini466 – 755290Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi131 – 14111Asp/Glu-rich (highly acidic)
Add
BLAST

Domaini

The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans By similarity.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000263410.
HOVERGENiHBG000345.
InParanoidiP18460.
KOiK05094.
PhylomeDBiP18460.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24416:SF128. PTHR24416:SF128. 1 hit.
PfamiPF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18460-1 [UniParc]FASTAAdd to Basket

« Hide

MRAAWGSVWC LCLAAAVGAL PAARRRGAER SGGQAAEYLR SETAFLEELV    50
FGSGDTIELS CNTQSSSVSV FWFKDGIGIA PSNRTHIGQK LLKIINVSYD 100
DSGLYSCKPR HSNEVLGNFT VRVTDSPSSG DDEDDDDESE DTGVPFWTRP 150
DKMEKKLLAV PAANTVRFRC PAGGNPTPTI YWLKNGKEFK GEHRIGGIKL 200
RHQQWSLVME SVVPSDRGNY TCVVENKYGN IRHTYQLDVL ERSPHRPILQ 250
AGLPANQTVV VGSNVEFHCK VYSDAQPHIQ WLKHVEVNGS KYGPDGTPYV 300
TVLKTAGVNT TDKELEILYL RNVTFEDAGE YTCLAGNSIG FSHHSAWLTV 350
LPAEELMEMD DSGSVYAGIL SYGTGLVLFI LVLVIVIICR MKMPNKKAMN 400
TTTVQKVSKF PLKRQQVSLE SNSSMNSNTP LVRITRLSSS DGPMLANVSE 450
LELPPDPKWE LARSRLTLGK PLGEGCFGQV VMAEAIGIDK DKPNKAITVA 500
VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QDGPLYVLVE 550
YASKGNLREY LRARRPPGMD YSFDTCKLPE EQLTFKDLVS CAYQVARGME 600
YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNID YYKKTTNGRL 650
PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL 700
LKEGHRMDKP ANCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRVLTMTS 750
TDEYLDLSVP FEQYSPAGQD THSTCSSGDD SVFAHDLLPD EPCLPKHVPC 800
NGVIRT 806
Length:806
Mass (Da):89,730
Last modified:November 1, 1990 - v1
Checksum:iB38B3C6D5F2314B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35195 mRNA. Translation: AAA48664.1.
PIRiA35963.
RefSeqiNP_990840.2. NM_205509.2.
UniGeneiGga.14066.

Genome annotation databases

GeneIDi396515.
KEGGigga:396515.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M35195 mRNA. Translation: AAA48664.1 .
PIRi A35963.
RefSeqi NP_990840.2. NM_205509.2.
UniGenei Gga.14066.

3D structure databases

ProteinModelPortali P18460.
SMRi P18460. Positions 145-355, 453-750.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000001710.

Proteomic databases

PaxDbi P18460.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396515.
KEGGi gga:396515.

Organism-specific databases

CTDi 2261.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000263410.
HOVERGENi HBG000345.
InParanoidi P18460.
KOi K05094.
PhylomeDBi P18460.

Enzyme and pathway databases

BRENDAi 2.7.10.1. 1306.

Miscellaneous databases

NextBioi 20816552.
PROi P18460.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
PANTHERi PTHR24416:SF128. PTHR24416:SF128. 1 hit.
Pfami PF07679. I-set. 2 hits.
PF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000628. FGFR. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A distinctive family of embryonic protein-tyrosine kinase receptors."
    Pasquale E.B.
    Proc. Natl. Acad. Sci. U.S.A. 87:5812-5816(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFGFR3_CHICK
AccessioniPrimary (citable) accession number: P18460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi