Reviewed,
UniProtKB/Swiss-Prot P18459 (TY3H_DROME)
Last modified
June 16, 2009.
Version 93.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Tyrosine 3-monooxygenase EC=1.14.16.2 Alternative name(s): Tyrosine 3-hydroxylase Short name=TH Protein Pale | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 579 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays an important role in the physiology of adrenergic neurons. |
| Catalytic activity | L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. |
| Cofactor | Fe2+ ion. |
| Pathway | Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. |
| Sequence similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| MED19 | Q9VVL6 | 1 | EBI-198251,EBI-125442 | |
| Sdc | P49415 | 1 | EBI-198251,EBI-198254 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Neuronal (identifier: P18459-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Hypodermal (identifier: P18459-2) The sequence of this isoform differs from the canonical sequence as follows: 60-130: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 579 | 579 | Tyrosine 3-monooxygenase | PRO_0000205566 | |||||
Sites | |||||||||
| Metal binding | 409 | 1 | Iron By similarity | ||||||
| Metal binding | 414 | 1 | Iron By similarity | ||||||
| Metal binding | 454 | 1 | Iron By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 60 – 130 | 71 | Missing in isoform Hypodermal. | VSP_000545 | |||||
Experimental info | |||||||||
| Sequence conflict | 264 | 1 | P → L in AAL49320. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| U14395 Genomic DNA. Translation: AAA62876.1. U14395 Genomic DNA. Translation: AAA62877.1. X76209 mRNA. Translation: CAA53802.1. AE014296 Genomic DNA. Translation: AAN12080.1. AE014296 Genomic DNA. Translation: AAF50648.1. AY071698 mRNA. Translation: AAL49320.1. | |
| PIR | A55369. |
| RefSeq | NP_476897.1. NP_476898.1. |
| UniGene | Dm.3463 |
3D structure databases | |
| HSSP | HSSP built from PDB template 2TOH based on UniProtKB P04177. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:17399N. |
| IntAct | P18459. 22 interactions. |
Genome annotation databases | |
| Ensembl | FBgn0005626. Drosophila melanogaster. [Contig view] |
| GeneID | 38746. |
| KEGG | dme:Dmel_CG10118. |
| NMPDR | fig|7227.3.peg.8571. |
Organism-specific databases | |
| FlyBase | FBgn0005626. ple. |
Phylogenomic databases | |
| HOGENOM | P18459. |
| OMA | P18459. YSIENGY. |
Enzyme and pathway databases | |
| BioCyc | DMEL-XXX-02:DMEL-XXX-02-015478-MON. |
| BRENDA | 1.14.16.2. 48. |
Gene expression databases | |
| ArrayExpress | P18459. |
| GermOnline | CG10118. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005962. Tyr_3_mOase. [Graphical view] |
| Gene3D | G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit. |
| PANTHER | PTHR11473. Aaa_hydroxylase. 1 hit. |
| Pfam | PF00351. Biopterin_H. 1 hit. [Graphical view] |
| PRINTS | PR00372. FYWHYDRXLASE. |
| ProDom | PD002559. Aaa_hydroxylase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01269. Tyr_3_monoox. 1 hit. |
| PROSITE | PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 810172. |
Entry information
| Entry name | TY3H_DROME | ||||||||
| Accession | Primary (citable) accession number: P18459 Secondary accession number(s): Q24000, Q8SY95 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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