P18459 (TY3H_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 118.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine 3-monooxygenase EC=1.14.16.2 Alternative name(s): Protein Pale Tyrosine 3-hydroxylase Short name=TH | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora |
Protein attributes
| Sequence length | 579 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Plays an important role in the physiology of adrenergic neurons. |
| Catalytic activity | L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. |
| Cofactor | Fe2+ ion. |
| Pathway | Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2. |
| Sequence similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform Neuronal (identifier: P18459-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Hypodermal (identifier: P18459-2) The sequence of this isoform differs from the canonical sequence as follows: 60-130: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 579 | 579 | Tyrosine 3-monooxygenase | PRO_0000205566 | |||||
Sites | |||||||||
| Metal binding | 409 | 1 | Iron By similarity | ||||||
| Metal binding | 414 | 1 | Iron By similarity | ||||||
| Metal binding | 454 | 1 | Iron By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 60 – 130 | 71 | Missing in isoform Hypodermal. | VSP_000545 | |||||
Experimental info | |||||||||
| Sequence conflict | 264 | 1 | P → L in AAL49320. Ref.4 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U14395 Genomic DNA. Translation: AAA62876.1. U14395 Genomic DNA. Translation: AAA62877.1. X76209 mRNA. Translation: CAA53802.1. AE014296 Genomic DNA. Translation: AAN12080.1. AE014296 Genomic DNA. Translation: AAF50648.1. AY071698 mRNA. Translation: AAL49320.1. |
| PIR | A55369. |
| RefSeq | NP_476897.1. NM_057549.2. NP_476898.1. NM_057550.3. |
| UniGene | Dm.3463. |
3D structure databases | |
| ProteinModelPortal | P18459. |
| SMR | P18459. Positions 145-575. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-17399N. |
| IntAct | P18459. 2 interactions. |
| MINT | MINT-293430. |
| STRING | P18459. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0076957; FBpp0076666; FBgn0005626. |
| GeneID | 38746. |
| KEGG | dme:Dmel_CG10118. |
| NMPDR | fig|7227.3.peg.8571. |
Organism-specific databases | |
| CTD | 18809. |
| FlyBase | FBgn0005626. ple. |
Phylogenomic databases | |
| eggNOG | inNOG07305. |
| GeneTree | EMGT00050000016900. |
| InParanoid | P18459. |
| OMA | RFETIVV. |
| OrthoDB | EOG41C5BG. |
| PhylomeDB | P18459. |
Gene expression databases | |
| ArrayExpress | P18459. |
| Bgee | P18459. |
| GermOnline | CG10118. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005962. Tyr_3_mOase. [Graphical view] |
| Gene3D | G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit. |
| KO | K00501. |
| PANTHER | PTHR11473. Aaa_hydroxylase. 1 hit. |
| Pfam | PF00351. Biopterin_H. 1 hit. [Graphical view] |
| PRINTS | PR00372. FYWHYDRXLASE. |
| SUPFAM | SSF56534. Aaa_hydroxylase. 1 hit. |
| TIGRFAMs | TIGR01269. Tyr_3_monoox. 1 hit. |
| PROSITE | PS00367. BH4_AAA_HYDROXYL_1. 1 hit. PS51410. BH4_AAA_HYDROXYL_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 810172. |
Entry information
| Entry name | TY3H_DROME | ||||||||
| Accession | Primary (citable) accession number: P18459 Secondary accession number(s): Q24000, Q8SY95 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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