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P18440 (ARY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arylamine N-acetyltransferase 1

EC=2.3.1.5
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name=MNAT
N-acetyltransferase type 1
Short name=NAT-1
Gene names
Name:NAT1
Synonyms:AAC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activity

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Subcellular location

Cytoplasm.

Polymorphism

N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder.

Miscellaneous

NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

Sequence similarities

Belongs to the arylamine N-acetyltransferase family.

Caution

The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Molecular functionAcyltransferase
Transferase
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsmall molecule metabolic process

Traceable author statement. Source: Reactome

xenobiotic metabolic process

Traceable author statement. Source: Reactome

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

   Molecular_functionarylamine N-acetyltransferase activity

Traceable author statement PubMed 10908296. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Arylamine N-acetyltransferase 1
PRO_0000107904

Regions

Region106 – 1072Substrate binding

Sites

Active site681Acyl-thioester intermediate
Active site1071
Active site1221
Binding site1031Coenzyme A By similarity
Binding site1041Coenzyme A; via amide nitrogen By similarity
Binding site2081Coenzyme A By similarity
Binding site2141Coenzyme A By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.16

Natural variations

Natural variant641R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. Ref.5
Corresponds to variant rs56379106 [ dbSNP | Ensembl ].
VAR_004606
Natural variant1171R → T in allele NAT1*5. Ref.2
Corresponds to variant rs55641436 [ dbSNP | Ensembl ].
VAR_009510
Natural variant1491V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. Ref.3 Ref.4 Ref.8 Ref.10 Ref.12
Corresponds to variant rs4987076 [ dbSNP | Ensembl ].
VAR_004607
Natural variant166 – 1672RE → TQ in allele NAT1*5.
VAR_009511
Natural variant1871R → Q in allele NAT1*14; a slow acetylator. Ref.5 Ref.18
Corresponds to variant rs4986782 [ dbSNP | Ensembl ].
VAR_009069
Natural variant2051M → V in allele NAT1*21.
VAR_009070
Natural variant2071T → I.
Corresponds to variant rs4987195 [ dbSNP | Ensembl ].
VAR_020384
Natural variant2141S → A in allele NAT1*11. Ref.3 Ref.4 Ref.8 Ref.10 Ref.12
Corresponds to variant rs4986783 [ dbSNP | Ensembl ].
VAR_009071
Natural variant2511D → V in allele NAT1*22.
Corresponds to variant rs56172717 [ dbSNP | Ensembl ].
VAR_009072
Natural variant2611E → K in allele NAT1*24.
VAR_009073
Natural variant2631I → V in allele NAT1*25.
VAR_009074

Experimental info

Mutagenesis641R → A, M, Q or K: Reduced enzymatic activity. Ref.15

Secondary structure

................................................. 290
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18440 [UniParc].

Last modified February 1, 1991. Version 2.
Checksum: C015F7F3D4830107

FASTA29033,899
        10         20         30         40         50         60 
MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL GLEAIFDQVV 

        70         80         90        100        110        120 
RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK YSTGMIHLLL QVTIDGRNYI 

       130        140        150        160        170        180 
VDAGFGRSYQ MWQPLELISG KDQPQVPCVF RLTEENGFWY LDQIRREQYI PNEEFLHSDL 

       190        200        210        220        230        240 
LEDSKYRKIY SFTLKPRTIE DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT 

       250        260        270        280        290 
HRRFNYKDNT DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI 

« Hide

References

« Hide 'large scale' references
[1]"Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."
Blum M., Grant D.M., McBride W., Heim M., Meyer U.A.
DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
Tissue: Leukocyte.
[2]"Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."
Ohsako S., Deguchi T.
J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS NAT1*5 THR-117 AND 166-THR-GLN-167.
Tissue: Liver.
[3]"Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus."
Vatsis K.P., Weber W.W.
Arch. Biochem. Biophys. 301:71-76(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[4]"Identification of a novel allele at the human NAT1 acetyltransferase locus."
Doll M.A., Jiang W., Deitz A.C., Rustan T.D., Hein D.W.
Biochem. Biophys. Res. Commun. 233:584-591(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
Tissue: Blood.
[5]"Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations."
Butcher N.J., Ilett K.F., Minchin R.F.
Pharmacogenetics 8:67-72(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*17 TRP-64 AND NAT1*14 GLN-187.
[6]"Homo sapiens N-acetyltransferase-1 (NAT1) gene complete cds."
Deitz A.C., Fretland A.J., Leff M.A., Doll M.A., Hein D.W.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay."
Lo-Guidice J.-M., Allorge D., Chevalier D., Debuysere H., Fazio F., Lafitte J.-J., Broly F.
Pharmacogenetics 10:293-300(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]"Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, allele NAT1*11B."
Johnson N., Sim E.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[9]"Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, NAT1*4 allele."
Johnson N., Sim E.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
[10]"Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes."
Patin E., Barreiro L.B., Sabeti P.C., Austerlitz F., Luca F., Sajantila A., Behar D.M., Semino O., Sakuntabhai A., Guiso N., Gicquel B., McElreavey K., Harding R.M., Heyer E., Quintana-Murci L.
Am. J. Hum. Genet. 78:423-436(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[11]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[12]NIEHS SNPs program
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-149 AND ALA-214.
[13]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[14]"Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."
Ebisawa T., Deguchi T.
Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
Tissue: Liver.
[15]"Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis."
Delomenie C., Goodfellow G.H., Krishnamoorthy R., Grant D.M., Dupret J.-M.
Biochem. J. 323:207-215(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF ARG-64.
[16]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."
Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N.
J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF WILD-TYPE IN COMPLEX WITH 2-BROMOACETANILIDE AND OF MUTANT SER-125, IDENTIFICATION BY MASS SPECTROMETRY.
[18]"Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe."
Hughes N.C., Janezic S.A., McQueen K.L., Jewett M.A., Castranio T., Bell D.A., Grant D.M.
Pharmacogenetics 8:55-66(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT NAT1*14 GLN-187.
[19]"Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas."
Lin H.J., Probst-Hensch N.M., Hughes N.C., Sakamoto G.T., Louie A.D., Kau I.H., Lin B.K., Lee D.B., Lin J., Frankl H.D., Lee E.R., Hardy S., Grant D.M., Haile R.W.
Pharmacogenetics 8:269-281(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS NAT1*17; NAT1*21; NAT1*22; NAT1*24 AND NAT1*25.
+Additional computationally mapped references.

Web resources

NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17059 Genomic DNA. Translation: CAA34905.1.
D90041 mRNA. Translation: BAA14095.1.
AF032677 Genomic DNA. Translation: AAB86878.1.
AF032678 Genomic DNA. Translation: AAB86879.1.
U80835 Genomic DNA. Translation: AAB62398.1.
AF008204 Genomic DNA. Translation: AAB84384.1.
AF071552 Genomic DNA. Translation: AAC24712.1.
AF067408 Genomic DNA. Translation: AAC24707.1.
AF082903 Genomic DNA. Translation: AAD13343.1.
AF082904 Genomic DNA. Translation: AAC32388.1.
AJ278017 Genomic DNA. Translation: CAC01128.1.
AJ307007 Genomic DNA. Translation: CAC38345.1.
DQ305816 Genomic DNA. Translation: ABC26192.1.
DQ305817 Genomic DNA. Translation: ABC26193.1.
DQ305818 Genomic DNA. Translation: ABC26194.1.
DQ305819 Genomic DNA. Translation: ABC26195.1.
DQ305820 Genomic DNA. Translation: ABC26196.1.
DQ305821 Genomic DNA. Translation: ABC26197.1.
DQ305822 Genomic DNA. Translation: ABC26198.1.
DQ305823 Genomic DNA. Translation: ABC26199.1.
DQ305824 Genomic DNA. Translation: ABC26200.1.
DQ305825 Genomic DNA. Translation: ABC26201.1.
DQ305826 Genomic DNA. Translation: ABC26202.1.
DQ305827 Genomic DNA. Translation: ABC26203.1.
DQ305828 Genomic DNA. Translation: ABC26204.1.
DQ305829 Genomic DNA. Translation: ABC26205.1.
DQ305830 Genomic DNA. Translation: ABC26206.1.
DQ305831 Genomic DNA. Translation: ABC26207.1.
DQ305832 Genomic DNA. Translation: ABC26208.1.
DQ305833 Genomic DNA. Translation: ABC26209.1.
DQ305834 Genomic DNA. Translation: ABC26210.1.
DQ305835 Genomic DNA. Translation: ABC26211.1.
DQ305836 Genomic DNA. Translation: ABC26212.1.
DQ305837 Genomic DNA. Translation: ABC26213.1.
DQ305838 Genomic DNA. Translation: ABC26214.1.
DQ305839 Genomic DNA. Translation: ABC26215.1.
DQ305840 Genomic DNA. Translation: ABC26216.1.
DQ305841 Genomic DNA. Translation: ABC26217.1.
DQ305842 Genomic DNA. Translation: ABC26218.1.
DQ305843 Genomic DNA. Translation: ABC26219.1.
DQ305844 Genomic DNA. Translation: ABC26220.1.
DQ305845 Genomic DNA. Translation: ABC26221.1.
DQ305846 Genomic DNA. Translation: ABC26222.1.
DQ305847 Genomic DNA. Translation: ABC26223.1.
DQ305848 Genomic DNA. Translation: ABC26224.1.
DQ305849 Genomic DNA. Translation: ABC26225.1.
DQ305850 Genomic DNA. Translation: ABC26226.1.
DQ305851 Genomic DNA. Translation: ABC26227.1.
DQ305852 Genomic DNA. Translation: ABC26228.1.
DQ305853 Genomic DNA. Translation: ABC26229.1.
DQ305854 Genomic DNA. Translation: ABC26230.1.
DQ305855 Genomic DNA. Translation: ABC26231.1.
DQ305856 Genomic DNA. Translation: ABC26232.1.
DQ305857 Genomic DNA. Translation: ABC26233.1.
DQ305858 Genomic DNA. Translation: ABC26234.1.
DQ305859 Genomic DNA. Translation: ABC26235.1.
DQ305860 Genomic DNA. Translation: ABC26236.1.
DQ305861 Genomic DNA. Translation: ABC26237.1.
DQ305862 Genomic DNA. Translation: ABC26238.1.
DQ305863 Genomic DNA. Translation: ABC26239.1.
DQ305864 Genomic DNA. Translation: ABC26240.1.
DQ305865 Genomic DNA. Translation: ABC26241.1.
DQ305866 Genomic DNA. Translation: ABC26242.1.
DQ305867 Genomic DNA. Translation: ABC26243.1.
DQ305868 Genomic DNA. Translation: ABC26244.1.
DQ305869 Genomic DNA. Translation: ABC26245.1.
DQ305870 Genomic DNA. Translation: ABC26246.1.
DQ305871 Genomic DNA. Translation: ABC26247.1.
DQ305872 Genomic DNA. Translation: ABC26248.1.
DQ305873 Genomic DNA. Translation: ABC26249.1.
DQ305874 Genomic DNA. Translation: ABC26250.1.
DQ305875 Genomic DNA. Translation: ABC26251.1.
DQ305876 Genomic DNA. Translation: ABC26252.1.
DQ305877 Genomic DNA. Translation: ABC26253.1.
DQ305878 Genomic DNA. Translation: ABC26254.1.
DQ305879 Genomic DNA. Translation: ABC26255.1.
DQ305880 Genomic DNA. Translation: ABC26256.1.
DQ305881 Genomic DNA. Translation: ABC26257.1.
DQ305882 Genomic DNA. Translation: ABC26258.1.
DQ305883 Genomic DNA. Translation: ABC26259.1.
DQ305884 Genomic DNA. Translation: ABC26260.1.
DQ305885 Genomic DNA. Translation: ABC26261.1.
DQ305886 Genomic DNA. Translation: ABC26262.1.
DQ305887 Genomic DNA. Translation: ABC26263.1.
DQ305888 Genomic DNA. Translation: ABC26264.1.
DQ305889 Genomic DNA. Translation: ABC26265.1.
DQ305890 Genomic DNA. Translation: ABC26266.1.
DQ305891 Genomic DNA. Translation: ABC26267.1.
DQ305892 Genomic DNA. Translation: ABC26268.1.
DQ305893 Genomic DNA. Translation: ABC26269.1.
DQ305894 Genomic DNA. Translation: ABC26270.1.
DQ305895 Genomic DNA. Translation: ABC26271.1.
DQ305896 Genomic DNA. Translation: ABC26272.1.
DQ305897 Genomic DNA. Translation: ABC26273.1.
DQ305898 Genomic DNA. Translation: ABC26274.1.
DQ305899 Genomic DNA. Translation: ABC26275.1.
DQ305900 Genomic DNA. Translation: ABC26276.1.
DQ305901 Genomic DNA. Translation: ABC26277.1.
DQ305902 Genomic DNA. Translation: ABC26278.1.
DQ305903 Genomic DNA. Translation: ABC26279.1.
DQ305904 Genomic DNA. Translation: ABC26280.1.
DQ305905 Genomic DNA. Translation: ABC26281.1.
DQ305906 Genomic DNA. Translation: ABC26282.1.
DQ305907 Genomic DNA. Translation: ABC26283.1.
DQ305908 Genomic DNA. Translation: ABC26284.1.
DQ305909 Genomic DNA. Translation: ABC26285.1.
DQ305910 Genomic DNA. Translation: ABC26286.1.
DQ305911 Genomic DNA. Translation: ABC26287.1.
DQ305912 Genomic DNA. Translation: ABC26288.1.
DQ305913 Genomic DNA. Translation: ABC26289.1.
DQ305914 Genomic DNA. Translation: ABC26290.1.
DQ305915 Genomic DNA. Translation: ABC26291.1.
DQ305916 Genomic DNA. Translation: ABC26292.1.
DQ305917 Genomic DNA. Translation: ABC26293.1.
DQ305918 Genomic DNA. Translation: ABC26294.1.
DQ305919 Genomic DNA. Translation: ABC26295.1.
DQ305920 Genomic DNA. Translation: ABC26296.1.
DQ305921 Genomic DNA. Translation: ABC26297.1.
DQ305922 Genomic DNA. Translation: ABC26298.1.
DQ305923 Genomic DNA. Translation: ABC26299.1.
DQ305924 Genomic DNA. Translation: ABC26300.1.
DQ305925 Genomic DNA. Translation: ABC26301.1.
DQ305926 Genomic DNA. Translation: ABC26302.1.
DQ305927 Genomic DNA. Translation: ABC26303.1.
DQ305928 Genomic DNA. Translation: ABC26304.1.
DQ305929 Genomic DNA. Translation: ABC26305.1.
DQ305930 Genomic DNA. Translation: ABC26306.1.
DQ305931 Genomic DNA. Translation: ABC26307.1.
DQ305932 Genomic DNA. Translation: ABC26308.1.
DQ305933 Genomic DNA. Translation: ABC26309.1.
DQ305934 Genomic DNA. Translation: ABC26310.1.
DQ305935 Genomic DNA. Translation: ABC26311.1.
DQ305936 Genomic DNA. Translation: ABC26312.1.
DQ305937 Genomic DNA. Translation: ABC26313.1.
DQ305938 Genomic DNA. Translation: ABC26314.1.
DQ305939 Genomic DNA. Translation: ABC26315.1.
DQ305940 Genomic DNA. Translation: ABC26316.1.
DQ305941 Genomic DNA. Translation: ABC26317.1.
DQ305942 Genomic DNA. Translation: ABC26318.1.
DQ305943 Genomic DNA. Translation: ABC26319.1.
DQ305944 Genomic DNA. Translation: ABC26320.1.
DQ305945 Genomic DNA. Translation: ABC26321.1.
DQ305946 Genomic DNA. Translation: ABC26322.1.
DQ305947 Genomic DNA. Translation: ABC26323.1.
DQ305948 Genomic DNA. Translation: ABC26324.1.
DQ305949 Genomic DNA. Translation: ABC26325.1.
DQ305950 Genomic DNA. Translation: ABC26326.1.
DQ305951 Genomic DNA. Translation: ABC26327.1.
DQ305952 Genomic DNA. Translation: ABC26328.1.
DQ305953 Genomic DNA. Translation: ABC26329.1.
DQ305954 Genomic DNA. Translation: ABC26330.1.
DQ305955 Genomic DNA. Translation: ABC26331.1.
DQ305956 Genomic DNA. Translation: ABC26332.1.
DQ305957 Genomic DNA. Translation: ABC26333.1.
DQ305958 Genomic DNA. Translation: ABC26334.1.
DQ305959 Genomic DNA. Translation: ABC26335.1.
DQ305960 Genomic DNA. Translation: ABC26336.1.
DQ305961 Genomic DNA. Translation: ABC26337.1.
DQ305962 Genomic DNA. Translation: ABC26338.1.
DQ305963 Genomic DNA. Translation: ABC26339.1.
DQ305964 Genomic DNA. Translation: ABC26340.1.
DQ305965 Genomic DNA. Translation: ABC26341.1.
DQ305966 Genomic DNA. Translation: ABC26342.1.
DQ305967 Genomic DNA. Translation: ABC26343.1.
DQ305968 Genomic DNA. Translation: ABC26344.1.
DQ305969 Genomic DNA. Translation: ABC26345.1.
DQ305970 Genomic DNA. Translation: ABC26346.1.
DQ305971 Genomic DNA. Translation: ABC26347.1.
DQ305972 Genomic DNA. Translation: ABC26348.1.
DQ305973 Genomic DNA. Translation: ABC26349.1.
DQ305974 Genomic DNA. Translation: ABC26350.1.
DQ305975 Genomic DNA. Translation: ABC26351.1.
AK290912 mRNA. Translation: BAF83601.1.
AY338489 Genomic DNA. Translation: AAP88036.1.
AY800271 Genomic DNA. Translation: AAV50002.1.
BC047666 mRNA. Translation: AAH47666.1.
M75164 Genomic DNA. Translation: AAA59905.1.
CCDSCCDS6007.1.
PIRA34585.
RefSeqNP_000653.3. NM_000662.7.
NP_001153642.1. NM_001160170.3.
NP_001153643.1. NM_001160171.3.
NP_001153644.1. NM_001160172.3.
NP_001153645.1. NM_001160173.3.
NP_001153646.1. NM_001160174.2.
NP_001153651.1. NM_001160179.2.
XP_006716473.1. XM_006716410.1.
UniGeneHs.2.
Hs.591847.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSSmodel-@1-290[»]
2GWUmodel-A1-290[»]
2IJAX-ray1.70A2-290[»]
2PQTX-ray1.78A2-290[»]
ProteinModelPortalP18440.
SMRP18440. Positions 2-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106527. 2 interactions.
STRING9606.ENSP00000307218.

Chemistry

BindingDBP18440.
ChEMBLCHEMBL5101.

PTM databases

PhosphoSiteP18440.

Polymorphism databases

DMDM114234.

Proteomic databases

MaxQBP18440.
PaxDbP18440.
PRIDEP18440.

Protocols and materials databases

DNASU9.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307719; ENSP00000307218; ENSG00000171428.
ENST00000517492; ENSP00000429407; ENSG00000171428.
ENST00000518029; ENSP00000428270; ENSG00000171428.
ENST00000520546; ENSP00000429341; ENSG00000171428.
ENST00000535084; ENSP00000444609; ENSG00000171428.
ENST00000539092; ENSP00000440434; ENSG00000171428.
ENST00000541942; ENSP00000440900; ENSG00000171428.
GeneID9.
KEGGhsa:9.
UCSCuc003wyq.3. human.

Organism-specific databases

CTD9.
GeneCardsGC08P018031.
HGNCHGNC:7645. NAT1.
HPACAB017782.
HPA043704.
MIM108345. gene.
neXtProtNX_P18440.
PharmGKBPA17.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2162.
HOGENOMHOG000205435.
HOVERGENHBG000165.
InParanoidP18440.
KOK00622.
OrthoDBEOG7BP83H.
PhylomeDBP18440.

Enzyme and pathway databases

BRENDA2.3.1.5. 2681.
ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP18440.
BgeeP18440.
CleanExHS_NAT1.
GenevestigatorP18440.

Family and domain databases

InterProIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERPTHR11786. PTHR11786. 1 hit.
PfamPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSPR01543. ANATRNSFRASE.
ProtoNetSearch...

Other

EvolutionaryTraceP18440.
GeneWikiN-acetyltransferase_1.
GenomeRNAi9.
NextBio11.
PROP18440.
SOURCESearch...

Entry information

Entry nameARY1_HUMAN
AccessionPrimary (citable) accession number: P18440
Secondary accession number(s): A8K4E7 expand/collapse secondary AC list , O15159, O15300, Q546N1, Q96TE9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM