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P18440

- ARY1_HUMAN

UniProt

P18440 - ARY1_HUMAN

Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

    Catalytic activityi

    Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Acyl-thioester intermediate
    Binding sitei103 – 1031Coenzyme ABy similarity
    Binding sitei104 – 1041Coenzyme A; via amide nitrogenBy similarity
    Active sitei107 – 1071
    Active sitei122 – 1221
    Binding sitei208 – 2081Coenzyme ABy similarity
    Binding sitei214 – 2141Coenzyme ABy similarity

    GO - Molecular functioni

    1. arylamine N-acetyltransferase activity Source: ProtInc

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.3.1.5. 2681.
    ReactomeiREACT_6732. Acetylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
    Alternative name(s):
    Arylamide acetylase 1
    Monomorphic arylamine N-acetyltransferase
    Short name:
    MNAT
    N-acetyltransferase type 1
    Short name:
    NAT-1
    Gene namesi
    Name:NAT1
    Synonyms:AAC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:7645. NAT1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi64 – 641R → A, M, Q or K: Reduced enzymatic activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA17.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Arylamine N-acetyltransferase 1PRO_0000107904Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP18440.
    PaxDbiP18440.
    PRIDEiP18440.

    PTM databases

    PhosphoSiteiP18440.

    Expressioni

    Gene expression databases

    ArrayExpressiP18440.
    BgeeiP18440.
    CleanExiHS_NAT1.
    GenevestigatoriP18440.

    Organism-specific databases

    HPAiCAB017782.
    HPA043704.

    Interactioni

    Protein-protein interaction databases

    BioGridi106527. 2 interactions.
    IntActiP18440. 1 interaction.
    STRINGi9606.ENSP00000307218.

    Structurei

    Secondary structure

    1
    290
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 98
    Helixi21 – 3414
    Helixi42 – 443
    Helixi52 – 609
    Helixi68 – 8215
    Beta strandi85 – 9511
    Turni96 – 994
    Beta strandi107 – 1148
    Beta strandi117 – 1215
    Beta strandi123 – 1253
    Helixi127 – 1293
    Beta strandi142 – 1443
    Beta strandi149 – 1557
    Beta strandi158 – 1647
    Beta strandi167 – 1693
    Helixi173 – 1753
    Beta strandi185 – 1928
    Helixi199 – 2024
    Helixi203 – 2119
    Helixi216 – 2194
    Beta strandi222 – 2265
    Beta strandi228 – 2358
    Beta strandi238 – 2436
    Beta strandi247 – 25711
    Helixi260 – 27112

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DSSmodel-@1-290[»]
    2GWUmodel-A1-290[»]
    2IJAX-ray1.70A2-290[»]
    2PQTX-ray1.78A2-290[»]
    ProteinModelPortaliP18440.
    SMRiP18440. Positions 2-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP18440.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni106 – 1072Substrate binding

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2162.
    HOGENOMiHOG000205435.
    HOVERGENiHBG000165.
    InParanoidiP18440.
    KOiK00622.
    OrthoDBiEOG7BP83H.
    PhylomeDBiP18440.

    Family and domain databases

    InterProiIPR001447. Arylamine_N-AcTrfase.
    [Graphical view]
    PANTHERiPTHR11786. PTHR11786. 1 hit.
    PfamiPF00797. Acetyltransf_2. 1 hit.
    [Graphical view]
    PRINTSiPR01543. ANATRNSFRASE.

    Sequencei

    Sequence statusi: Complete.

    P18440-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL    50
    GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK 100
    YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF 150
    RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE 200
    DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT 250
    DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI 290
    Length:290
    Mass (Da):33,899
    Last modified:February 1, 1991 - v2
    Checksum:iC015F7F3D4830107
    GO

    Polymorphismi

    N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 Publication
    Corresponds to variant rs56379106 [ dbSNP | Ensembl ].
    VAR_004606
    Natural varianti117 – 1171R → T in allele NAT1*5. 1 Publication
    Corresponds to variant rs55641436 [ dbSNP | Ensembl ].
    VAR_009510
    Natural varianti149 – 1491V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 Publications
    Corresponds to variant rs4987076 [ dbSNP | Ensembl ].
    VAR_004607
    Natural varianti166 – 1672RE → TQ in allele NAT1*5.
    VAR_009511
    Natural varianti187 – 1871R → Q in allele NAT1*14; a slow acetylator. 2 Publications
    Corresponds to variant rs4986782 [ dbSNP | Ensembl ].
    VAR_009069
    Natural varianti205 – 2051M → V in allele NAT1*21.
    VAR_009070
    Natural varianti207 – 2071T → I.
    Corresponds to variant rs4987195 [ dbSNP | Ensembl ].
    VAR_020384
    Natural varianti214 – 2141S → A in allele NAT1*11. 5 Publications
    Corresponds to variant rs4986783 [ dbSNP | Ensembl ].
    VAR_009071
    Natural varianti251 – 2511D → V in allele NAT1*22.
    Corresponds to variant rs56172717 [ dbSNP | Ensembl ].
    VAR_009072
    Natural varianti261 – 2611E → K in allele NAT1*24.
    VAR_009073
    Natural varianti263 – 2631I → V in allele NAT1*25.
    VAR_009074

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17059 Genomic DNA. Translation: CAA34905.1.
    D90041 mRNA. Translation: BAA14095.1.
    AF032677 Genomic DNA. Translation: AAB86878.1.
    AF032678 Genomic DNA. Translation: AAB86879.1.
    U80835 Genomic DNA. Translation: AAB62398.1.
    AF008204 Genomic DNA. Translation: AAB84384.1.
    AF071552 Genomic DNA. Translation: AAC24712.1.
    AF067408 Genomic DNA. Translation: AAC24707.1.
    AF082903 Genomic DNA. Translation: AAD13343.1.
    AF082904 Genomic DNA. Translation: AAC32388.1.
    AJ278017 Genomic DNA. Translation: CAC01128.1.
    AJ307007 Genomic DNA. Translation: CAC38345.1.
    DQ305816 Genomic DNA. Translation: ABC26192.1.
    DQ305817 Genomic DNA. Translation: ABC26193.1.
    DQ305818 Genomic DNA. Translation: ABC26194.1.
    DQ305819 Genomic DNA. Translation: ABC26195.1.
    DQ305820 Genomic DNA. Translation: ABC26196.1.
    DQ305821 Genomic DNA. Translation: ABC26197.1.
    DQ305822 Genomic DNA. Translation: ABC26198.1.
    DQ305823 Genomic DNA. Translation: ABC26199.1.
    DQ305824 Genomic DNA. Translation: ABC26200.1.
    DQ305825 Genomic DNA. Translation: ABC26201.1.
    DQ305826 Genomic DNA. Translation: ABC26202.1.
    DQ305827 Genomic DNA. Translation: ABC26203.1.
    DQ305828 Genomic DNA. Translation: ABC26204.1.
    DQ305829 Genomic DNA. Translation: ABC26205.1.
    DQ305830 Genomic DNA. Translation: ABC26206.1.
    DQ305831 Genomic DNA. Translation: ABC26207.1.
    DQ305832 Genomic DNA. Translation: ABC26208.1.
    DQ305833 Genomic DNA. Translation: ABC26209.1.
    DQ305834 Genomic DNA. Translation: ABC26210.1.
    DQ305835 Genomic DNA. Translation: ABC26211.1.
    DQ305836 Genomic DNA. Translation: ABC26212.1.
    DQ305837 Genomic DNA. Translation: ABC26213.1.
    DQ305838 Genomic DNA. Translation: ABC26214.1.
    DQ305839 Genomic DNA. Translation: ABC26215.1.
    DQ305840 Genomic DNA. Translation: ABC26216.1.
    DQ305841 Genomic DNA. Translation: ABC26217.1.
    DQ305842 Genomic DNA. Translation: ABC26218.1.
    DQ305843 Genomic DNA. Translation: ABC26219.1.
    DQ305844 Genomic DNA. Translation: ABC26220.1.
    DQ305845 Genomic DNA. Translation: ABC26221.1.
    DQ305846 Genomic DNA. Translation: ABC26222.1.
    DQ305847 Genomic DNA. Translation: ABC26223.1.
    DQ305848 Genomic DNA. Translation: ABC26224.1.
    DQ305849 Genomic DNA. Translation: ABC26225.1.
    DQ305850 Genomic DNA. Translation: ABC26226.1.
    DQ305851 Genomic DNA. Translation: ABC26227.1.
    DQ305852 Genomic DNA. Translation: ABC26228.1.
    DQ305853 Genomic DNA. Translation: ABC26229.1.
    DQ305854 Genomic DNA. Translation: ABC26230.1.
    DQ305855 Genomic DNA. Translation: ABC26231.1.
    DQ305856 Genomic DNA. Translation: ABC26232.1.
    DQ305857 Genomic DNA. Translation: ABC26233.1.
    DQ305858 Genomic DNA. Translation: ABC26234.1.
    DQ305859 Genomic DNA. Translation: ABC26235.1.
    DQ305860 Genomic DNA. Translation: ABC26236.1.
    DQ305861 Genomic DNA. Translation: ABC26237.1.
    DQ305862 Genomic DNA. Translation: ABC26238.1.
    DQ305863 Genomic DNA. Translation: ABC26239.1.
    DQ305864 Genomic DNA. Translation: ABC26240.1.
    DQ305865 Genomic DNA. Translation: ABC26241.1.
    DQ305866 Genomic DNA. Translation: ABC26242.1.
    DQ305867 Genomic DNA. Translation: ABC26243.1.
    DQ305868 Genomic DNA. Translation: ABC26244.1.
    DQ305869 Genomic DNA. Translation: ABC26245.1.
    DQ305870 Genomic DNA. Translation: ABC26246.1.
    DQ305871 Genomic DNA. Translation: ABC26247.1.
    DQ305872 Genomic DNA. Translation: ABC26248.1.
    DQ305873 Genomic DNA. Translation: ABC26249.1.
    DQ305874 Genomic DNA. Translation: ABC26250.1.
    DQ305875 Genomic DNA. Translation: ABC26251.1.
    DQ305876 Genomic DNA. Translation: ABC26252.1.
    DQ305877 Genomic DNA. Translation: ABC26253.1.
    DQ305878 Genomic DNA. Translation: ABC26254.1.
    DQ305879 Genomic DNA. Translation: ABC26255.1.
    DQ305880 Genomic DNA. Translation: ABC26256.1.
    DQ305881 Genomic DNA. Translation: ABC26257.1.
    DQ305882 Genomic DNA. Translation: ABC26258.1.
    DQ305883 Genomic DNA. Translation: ABC26259.1.
    DQ305884 Genomic DNA. Translation: ABC26260.1.
    DQ305885 Genomic DNA. Translation: ABC26261.1.
    DQ305886 Genomic DNA. Translation: ABC26262.1.
    DQ305887 Genomic DNA. Translation: ABC26263.1.
    DQ305888 Genomic DNA. Translation: ABC26264.1.
    DQ305889 Genomic DNA. Translation: ABC26265.1.
    DQ305890 Genomic DNA. Translation: ABC26266.1.
    DQ305891 Genomic DNA. Translation: ABC26267.1.
    DQ305892 Genomic DNA. Translation: ABC26268.1.
    DQ305893 Genomic DNA. Translation: ABC26269.1.
    DQ305894 Genomic DNA. Translation: ABC26270.1.
    DQ305895 Genomic DNA. Translation: ABC26271.1.
    DQ305896 Genomic DNA. Translation: ABC26272.1.
    DQ305897 Genomic DNA. Translation: ABC26273.1.
    DQ305898 Genomic DNA. Translation: ABC26274.1.
    DQ305899 Genomic DNA. Translation: ABC26275.1.
    DQ305900 Genomic DNA. Translation: ABC26276.1.
    DQ305901 Genomic DNA. Translation: ABC26277.1.
    DQ305902 Genomic DNA. Translation: ABC26278.1.
    DQ305903 Genomic DNA. Translation: ABC26279.1.
    DQ305904 Genomic DNA. Translation: ABC26280.1.
    DQ305905 Genomic DNA. Translation: ABC26281.1.
    DQ305906 Genomic DNA. Translation: ABC26282.1.
    DQ305907 Genomic DNA. Translation: ABC26283.1.
    DQ305908 Genomic DNA. Translation: ABC26284.1.
    DQ305909 Genomic DNA. Translation: ABC26285.1.
    DQ305910 Genomic DNA. Translation: ABC26286.1.
    DQ305911 Genomic DNA. Translation: ABC26287.1.
    DQ305912 Genomic DNA. Translation: ABC26288.1.
    DQ305913 Genomic DNA. Translation: ABC26289.1.
    DQ305914 Genomic DNA. Translation: ABC26290.1.
    DQ305915 Genomic DNA. Translation: ABC26291.1.
    DQ305916 Genomic DNA. Translation: ABC26292.1.
    DQ305917 Genomic DNA. Translation: ABC26293.1.
    DQ305918 Genomic DNA. Translation: ABC26294.1.
    DQ305919 Genomic DNA. Translation: ABC26295.1.
    DQ305920 Genomic DNA. Translation: ABC26296.1.
    DQ305921 Genomic DNA. Translation: ABC26297.1.
    DQ305922 Genomic DNA. Translation: ABC26298.1.
    DQ305923 Genomic DNA. Translation: ABC26299.1.
    DQ305924 Genomic DNA. Translation: ABC26300.1.
    DQ305925 Genomic DNA. Translation: ABC26301.1.
    DQ305926 Genomic DNA. Translation: ABC26302.1.
    DQ305927 Genomic DNA. Translation: ABC26303.1.
    DQ305928 Genomic DNA. Translation: ABC26304.1.
    DQ305929 Genomic DNA. Translation: ABC26305.1.
    DQ305930 Genomic DNA. Translation: ABC26306.1.
    DQ305931 Genomic DNA. Translation: ABC26307.1.
    DQ305932 Genomic DNA. Translation: ABC26308.1.
    DQ305933 Genomic DNA. Translation: ABC26309.1.
    DQ305934 Genomic DNA. Translation: ABC26310.1.
    DQ305935 Genomic DNA. Translation: ABC26311.1.
    DQ305936 Genomic DNA. Translation: ABC26312.1.
    DQ305937 Genomic DNA. Translation: ABC26313.1.
    DQ305938 Genomic DNA. Translation: ABC26314.1.
    DQ305939 Genomic DNA. Translation: ABC26315.1.
    DQ305940 Genomic DNA. Translation: ABC26316.1.
    DQ305941 Genomic DNA. Translation: ABC26317.1.
    DQ305942 Genomic DNA. Translation: ABC26318.1.
    DQ305943 Genomic DNA. Translation: ABC26319.1.
    DQ305944 Genomic DNA. Translation: ABC26320.1.
    DQ305945 Genomic DNA. Translation: ABC26321.1.
    DQ305946 Genomic DNA. Translation: ABC26322.1.
    DQ305947 Genomic DNA. Translation: ABC26323.1.
    DQ305948 Genomic DNA. Translation: ABC26324.1.
    DQ305949 Genomic DNA. Translation: ABC26325.1.
    DQ305950 Genomic DNA. Translation: ABC26326.1.
    DQ305951 Genomic DNA. Translation: ABC26327.1.
    DQ305952 Genomic DNA. Translation: ABC26328.1.
    DQ305953 Genomic DNA. Translation: ABC26329.1.
    DQ305954 Genomic DNA. Translation: ABC26330.1.
    DQ305955 Genomic DNA. Translation: ABC26331.1.
    DQ305956 Genomic DNA. Translation: ABC26332.1.
    DQ305957 Genomic DNA. Translation: ABC26333.1.
    DQ305958 Genomic DNA. Translation: ABC26334.1.
    DQ305959 Genomic DNA. Translation: ABC26335.1.
    DQ305960 Genomic DNA. Translation: ABC26336.1.
    DQ305961 Genomic DNA. Translation: ABC26337.1.
    DQ305962 Genomic DNA. Translation: ABC26338.1.
    DQ305963 Genomic DNA. Translation: ABC26339.1.
    DQ305964 Genomic DNA. Translation: ABC26340.1.
    DQ305965 Genomic DNA. Translation: ABC26341.1.
    DQ305966 Genomic DNA. Translation: ABC26342.1.
    DQ305967 Genomic DNA. Translation: ABC26343.1.
    DQ305968 Genomic DNA. Translation: ABC26344.1.
    DQ305969 Genomic DNA. Translation: ABC26345.1.
    DQ305970 Genomic DNA. Translation: ABC26346.1.
    DQ305971 Genomic DNA. Translation: ABC26347.1.
    DQ305972 Genomic DNA. Translation: ABC26348.1.
    DQ305973 Genomic DNA. Translation: ABC26349.1.
    DQ305974 Genomic DNA. Translation: ABC26350.1.
    DQ305975 Genomic DNA. Translation: ABC26351.1.
    AK290912 mRNA. Translation: BAF83601.1.
    AY338489 Genomic DNA. Translation: AAP88036.1.
    AY800271 Genomic DNA. Translation: AAV50002.1.
    BC047666 mRNA. Translation: AAH47666.1.
    M75164 Genomic DNA. Translation: AAA59905.1.
    CCDSiCCDS6007.1.
    PIRiA34585.
    RefSeqiNP_000653.3. NM_000662.7.
    NP_001153642.1. NM_001160170.3.
    NP_001153643.1. NM_001160171.3.
    NP_001153644.1. NM_001160172.3.
    NP_001153645.1. NM_001160173.3.
    NP_001153646.1. NM_001160174.2.
    NP_001153651.1. NM_001160179.2.
    XP_006716473.1. XM_006716410.1.
    UniGeneiHs.2.
    Hs.591847.

    Genome annotation databases

    EnsembliENST00000307719; ENSP00000307218; ENSG00000171428.
    ENST00000517492; ENSP00000429407; ENSG00000171428.
    ENST00000518029; ENSP00000428270; ENSG00000171428.
    ENST00000520546; ENSP00000429341; ENSG00000171428.
    ENST00000541942; ENSP00000440900; ENSG00000171428.
    GeneIDi9.
    KEGGihsa:9.
    UCSCiuc003wyq.3. human.

    Polymorphism databases

    DMDMi114234.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NAT

    NAT alleles

    NIEHS-SNPs
    SHMPD

    The Singapore human mutation and polymorphism database

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17059 Genomic DNA. Translation: CAA34905.1 .
    D90041 mRNA. Translation: BAA14095.1 .
    AF032677 Genomic DNA. Translation: AAB86878.1 .
    AF032678 Genomic DNA. Translation: AAB86879.1 .
    U80835 Genomic DNA. Translation: AAB62398.1 .
    AF008204 Genomic DNA. Translation: AAB84384.1 .
    AF071552 Genomic DNA. Translation: AAC24712.1 .
    AF067408 Genomic DNA. Translation: AAC24707.1 .
    AF082903 Genomic DNA. Translation: AAD13343.1 .
    AF082904 Genomic DNA. Translation: AAC32388.1 .
    AJ278017 Genomic DNA. Translation: CAC01128.1 .
    AJ307007 Genomic DNA. Translation: CAC38345.1 .
    DQ305816 Genomic DNA. Translation: ABC26192.1 .
    DQ305817 Genomic DNA. Translation: ABC26193.1 .
    DQ305818 Genomic DNA. Translation: ABC26194.1 .
    DQ305819 Genomic DNA. Translation: ABC26195.1 .
    DQ305820 Genomic DNA. Translation: ABC26196.1 .
    DQ305821 Genomic DNA. Translation: ABC26197.1 .
    DQ305822 Genomic DNA. Translation: ABC26198.1 .
    DQ305823 Genomic DNA. Translation: ABC26199.1 .
    DQ305824 Genomic DNA. Translation: ABC26200.1 .
    DQ305825 Genomic DNA. Translation: ABC26201.1 .
    DQ305826 Genomic DNA. Translation: ABC26202.1 .
    DQ305827 Genomic DNA. Translation: ABC26203.1 .
    DQ305828 Genomic DNA. Translation: ABC26204.1 .
    DQ305829 Genomic DNA. Translation: ABC26205.1 .
    DQ305830 Genomic DNA. Translation: ABC26206.1 .
    DQ305831 Genomic DNA. Translation: ABC26207.1 .
    DQ305832 Genomic DNA. Translation: ABC26208.1 .
    DQ305833 Genomic DNA. Translation: ABC26209.1 .
    DQ305834 Genomic DNA. Translation: ABC26210.1 .
    DQ305835 Genomic DNA. Translation: ABC26211.1 .
    DQ305836 Genomic DNA. Translation: ABC26212.1 .
    DQ305837 Genomic DNA. Translation: ABC26213.1 .
    DQ305838 Genomic DNA. Translation: ABC26214.1 .
    DQ305839 Genomic DNA. Translation: ABC26215.1 .
    DQ305840 Genomic DNA. Translation: ABC26216.1 .
    DQ305841 Genomic DNA. Translation: ABC26217.1 .
    DQ305842 Genomic DNA. Translation: ABC26218.1 .
    DQ305843 Genomic DNA. Translation: ABC26219.1 .
    DQ305844 Genomic DNA. Translation: ABC26220.1 .
    DQ305845 Genomic DNA. Translation: ABC26221.1 .
    DQ305846 Genomic DNA. Translation: ABC26222.1 .
    DQ305847 Genomic DNA. Translation: ABC26223.1 .
    DQ305848 Genomic DNA. Translation: ABC26224.1 .
    DQ305849 Genomic DNA. Translation: ABC26225.1 .
    DQ305850 Genomic DNA. Translation: ABC26226.1 .
    DQ305851 Genomic DNA. Translation: ABC26227.1 .
    DQ305852 Genomic DNA. Translation: ABC26228.1 .
    DQ305853 Genomic DNA. Translation: ABC26229.1 .
    DQ305854 Genomic DNA. Translation: ABC26230.1 .
    DQ305855 Genomic DNA. Translation: ABC26231.1 .
    DQ305856 Genomic DNA. Translation: ABC26232.1 .
    DQ305857 Genomic DNA. Translation: ABC26233.1 .
    DQ305858 Genomic DNA. Translation: ABC26234.1 .
    DQ305859 Genomic DNA. Translation: ABC26235.1 .
    DQ305860 Genomic DNA. Translation: ABC26236.1 .
    DQ305861 Genomic DNA. Translation: ABC26237.1 .
    DQ305862 Genomic DNA. Translation: ABC26238.1 .
    DQ305863 Genomic DNA. Translation: ABC26239.1 .
    DQ305864 Genomic DNA. Translation: ABC26240.1 .
    DQ305865 Genomic DNA. Translation: ABC26241.1 .
    DQ305866 Genomic DNA. Translation: ABC26242.1 .
    DQ305867 Genomic DNA. Translation: ABC26243.1 .
    DQ305868 Genomic DNA. Translation: ABC26244.1 .
    DQ305869 Genomic DNA. Translation: ABC26245.1 .
    DQ305870 Genomic DNA. Translation: ABC26246.1 .
    DQ305871 Genomic DNA. Translation: ABC26247.1 .
    DQ305872 Genomic DNA. Translation: ABC26248.1 .
    DQ305873 Genomic DNA. Translation: ABC26249.1 .
    DQ305874 Genomic DNA. Translation: ABC26250.1 .
    DQ305875 Genomic DNA. Translation: ABC26251.1 .
    DQ305876 Genomic DNA. Translation: ABC26252.1 .
    DQ305877 Genomic DNA. Translation: ABC26253.1 .
    DQ305878 Genomic DNA. Translation: ABC26254.1 .
    DQ305879 Genomic DNA. Translation: ABC26255.1 .
    DQ305880 Genomic DNA. Translation: ABC26256.1 .
    DQ305881 Genomic DNA. Translation: ABC26257.1 .
    DQ305882 Genomic DNA. Translation: ABC26258.1 .
    DQ305883 Genomic DNA. Translation: ABC26259.1 .
    DQ305884 Genomic DNA. Translation: ABC26260.1 .
    DQ305885 Genomic DNA. Translation: ABC26261.1 .
    DQ305886 Genomic DNA. Translation: ABC26262.1 .
    DQ305887 Genomic DNA. Translation: ABC26263.1 .
    DQ305888 Genomic DNA. Translation: ABC26264.1 .
    DQ305889 Genomic DNA. Translation: ABC26265.1 .
    DQ305890 Genomic DNA. Translation: ABC26266.1 .
    DQ305891 Genomic DNA. Translation: ABC26267.1 .
    DQ305892 Genomic DNA. Translation: ABC26268.1 .
    DQ305893 Genomic DNA. Translation: ABC26269.1 .
    DQ305894 Genomic DNA. Translation: ABC26270.1 .
    DQ305895 Genomic DNA. Translation: ABC26271.1 .
    DQ305896 Genomic DNA. Translation: ABC26272.1 .
    DQ305897 Genomic DNA. Translation: ABC26273.1 .
    DQ305898 Genomic DNA. Translation: ABC26274.1 .
    DQ305899 Genomic DNA. Translation: ABC26275.1 .
    DQ305900 Genomic DNA. Translation: ABC26276.1 .
    DQ305901 Genomic DNA. Translation: ABC26277.1 .
    DQ305902 Genomic DNA. Translation: ABC26278.1 .
    DQ305903 Genomic DNA. Translation: ABC26279.1 .
    DQ305904 Genomic DNA. Translation: ABC26280.1 .
    DQ305905 Genomic DNA. Translation: ABC26281.1 .
    DQ305906 Genomic DNA. Translation: ABC26282.1 .
    DQ305907 Genomic DNA. Translation: ABC26283.1 .
    DQ305908 Genomic DNA. Translation: ABC26284.1 .
    DQ305909 Genomic DNA. Translation: ABC26285.1 .
    DQ305910 Genomic DNA. Translation: ABC26286.1 .
    DQ305911 Genomic DNA. Translation: ABC26287.1 .
    DQ305912 Genomic DNA. Translation: ABC26288.1 .
    DQ305913 Genomic DNA. Translation: ABC26289.1 .
    DQ305914 Genomic DNA. Translation: ABC26290.1 .
    DQ305915 Genomic DNA. Translation: ABC26291.1 .
    DQ305916 Genomic DNA. Translation: ABC26292.1 .
    DQ305917 Genomic DNA. Translation: ABC26293.1 .
    DQ305918 Genomic DNA. Translation: ABC26294.1 .
    DQ305919 Genomic DNA. Translation: ABC26295.1 .
    DQ305920 Genomic DNA. Translation: ABC26296.1 .
    DQ305921 Genomic DNA. Translation: ABC26297.1 .
    DQ305922 Genomic DNA. Translation: ABC26298.1 .
    DQ305923 Genomic DNA. Translation: ABC26299.1 .
    DQ305924 Genomic DNA. Translation: ABC26300.1 .
    DQ305925 Genomic DNA. Translation: ABC26301.1 .
    DQ305926 Genomic DNA. Translation: ABC26302.1 .
    DQ305927 Genomic DNA. Translation: ABC26303.1 .
    DQ305928 Genomic DNA. Translation: ABC26304.1 .
    DQ305929 Genomic DNA. Translation: ABC26305.1 .
    DQ305930 Genomic DNA. Translation: ABC26306.1 .
    DQ305931 Genomic DNA. Translation: ABC26307.1 .
    DQ305932 Genomic DNA. Translation: ABC26308.1 .
    DQ305933 Genomic DNA. Translation: ABC26309.1 .
    DQ305934 Genomic DNA. Translation: ABC26310.1 .
    DQ305935 Genomic DNA. Translation: ABC26311.1 .
    DQ305936 Genomic DNA. Translation: ABC26312.1 .
    DQ305937 Genomic DNA. Translation: ABC26313.1 .
    DQ305938 Genomic DNA. Translation: ABC26314.1 .
    DQ305939 Genomic DNA. Translation: ABC26315.1 .
    DQ305940 Genomic DNA. Translation: ABC26316.1 .
    DQ305941 Genomic DNA. Translation: ABC26317.1 .
    DQ305942 Genomic DNA. Translation: ABC26318.1 .
    DQ305943 Genomic DNA. Translation: ABC26319.1 .
    DQ305944 Genomic DNA. Translation: ABC26320.1 .
    DQ305945 Genomic DNA. Translation: ABC26321.1 .
    DQ305946 Genomic DNA. Translation: ABC26322.1 .
    DQ305947 Genomic DNA. Translation: ABC26323.1 .
    DQ305948 Genomic DNA. Translation: ABC26324.1 .
    DQ305949 Genomic DNA. Translation: ABC26325.1 .
    DQ305950 Genomic DNA. Translation: ABC26326.1 .
    DQ305951 Genomic DNA. Translation: ABC26327.1 .
    DQ305952 Genomic DNA. Translation: ABC26328.1 .
    DQ305953 Genomic DNA. Translation: ABC26329.1 .
    DQ305954 Genomic DNA. Translation: ABC26330.1 .
    DQ305955 Genomic DNA. Translation: ABC26331.1 .
    DQ305956 Genomic DNA. Translation: ABC26332.1 .
    DQ305957 Genomic DNA. Translation: ABC26333.1 .
    DQ305958 Genomic DNA. Translation: ABC26334.1 .
    DQ305959 Genomic DNA. Translation: ABC26335.1 .
    DQ305960 Genomic DNA. Translation: ABC26336.1 .
    DQ305961 Genomic DNA. Translation: ABC26337.1 .
    DQ305962 Genomic DNA. Translation: ABC26338.1 .
    DQ305963 Genomic DNA. Translation: ABC26339.1 .
    DQ305964 Genomic DNA. Translation: ABC26340.1 .
    DQ305965 Genomic DNA. Translation: ABC26341.1 .
    DQ305966 Genomic DNA. Translation: ABC26342.1 .
    DQ305967 Genomic DNA. Translation: ABC26343.1 .
    DQ305968 Genomic DNA. Translation: ABC26344.1 .
    DQ305969 Genomic DNA. Translation: ABC26345.1 .
    DQ305970 Genomic DNA. Translation: ABC26346.1 .
    DQ305971 Genomic DNA. Translation: ABC26347.1 .
    DQ305972 Genomic DNA. Translation: ABC26348.1 .
    DQ305973 Genomic DNA. Translation: ABC26349.1 .
    DQ305974 Genomic DNA. Translation: ABC26350.1 .
    DQ305975 Genomic DNA. Translation: ABC26351.1 .
    AK290912 mRNA. Translation: BAF83601.1 .
    AY338489 Genomic DNA. Translation: AAP88036.1 .
    AY800271 Genomic DNA. Translation: AAV50002.1 .
    BC047666 mRNA. Translation: AAH47666.1 .
    M75164 Genomic DNA. Translation: AAA59905.1 .
    CCDSi CCDS6007.1.
    PIRi A34585.
    RefSeqi NP_000653.3. NM_000662.7.
    NP_001153642.1. NM_001160170.3.
    NP_001153643.1. NM_001160171.3.
    NP_001153644.1. NM_001160172.3.
    NP_001153645.1. NM_001160173.3.
    NP_001153646.1. NM_001160174.2.
    NP_001153651.1. NM_001160179.2.
    XP_006716473.1. XM_006716410.1.
    UniGenei Hs.2.
    Hs.591847.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DSS model - @ 1-290 [» ]
    2GWU model - A 1-290 [» ]
    2IJA X-ray 1.70 A 2-290 [» ]
    2PQT X-ray 1.78 A 2-290 [» ]
    ProteinModelPortali P18440.
    SMRi P18440. Positions 2-290.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106527. 2 interactions.
    IntActi P18440. 1 interaction.
    STRINGi 9606.ENSP00000307218.

    Chemistry

    BindingDBi P18440.
    ChEMBLi CHEMBL5101.

    PTM databases

    PhosphoSitei P18440.

    Polymorphism databases

    DMDMi 114234.

    Proteomic databases

    MaxQBi P18440.
    PaxDbi P18440.
    PRIDEi P18440.

    Protocols and materials databases

    DNASUi 9.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307719 ; ENSP00000307218 ; ENSG00000171428 .
    ENST00000517492 ; ENSP00000429407 ; ENSG00000171428 .
    ENST00000518029 ; ENSP00000428270 ; ENSG00000171428 .
    ENST00000520546 ; ENSP00000429341 ; ENSG00000171428 .
    ENST00000541942 ; ENSP00000440900 ; ENSG00000171428 .
    GeneIDi 9.
    KEGGi hsa:9.
    UCSCi uc003wyq.3. human.

    Organism-specific databases

    CTDi 9.
    GeneCardsi GC08P018031.
    HGNCi HGNC:7645. NAT1.
    HPAi CAB017782.
    HPA043704.
    MIMi 108345. gene.
    neXtProti NX_P18440.
    PharmGKBi PA17.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2162.
    HOGENOMi HOG000205435.
    HOVERGENi HBG000165.
    InParanoidi P18440.
    KOi K00622.
    OrthoDBi EOG7BP83H.
    PhylomeDBi P18440.

    Enzyme and pathway databases

    BRENDAi 2.3.1.5. 2681.
    Reactomei REACT_6732. Acetylation.

    Miscellaneous databases

    EvolutionaryTracei P18440.
    GeneWikii N-acetyltransferase_1.
    GenomeRNAii 9.
    NextBioi 11.
    PROi P18440.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18440.
    Bgeei P18440.
    CleanExi HS_NAT1.
    Genevestigatori P18440.

    Family and domain databases

    InterProi IPR001447. Arylamine_N-AcTrfase.
    [Graphical view ]
    PANTHERi PTHR11786. PTHR11786. 1 hit.
    Pfami PF00797. Acetyltransf_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01543. ANATRNSFRASE.
    ProtoNeti Search...

    Publicationsi

    1. "Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."
      Blum M., Grant D.M., McBride W., Heim M., Meyer U.A.
      DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
      Tissue: Leukocyte.
    2. "Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."
      Ohsako S., Deguchi T.
      J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS NAT1*5 THR-117 AND 166-THR-GLN-167.
      Tissue: Liver.
    3. "Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus."
      Vatsis K.P., Weber W.W.
      Arch. Biochem. Biophys. 301:71-76(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
    4. "Identification of a novel allele at the human NAT1 acetyltransferase locus."
      Doll M.A., Jiang W., Deitz A.C., Rustan T.D., Hein D.W.
      Biochem. Biophys. Res. Commun. 233:584-591(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
      Tissue: Blood.
    5. "Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations."
      Butcher N.J., Ilett K.F., Minchin R.F.
      Pharmacogenetics 8:67-72(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*17 TRP-64 AND NAT1*14 GLN-187.
    6. "Homo sapiens N-acetyltransferase-1 (NAT1) gene complete cds."
      Deitz A.C., Fretland A.J., Leff M.A., Doll M.A., Hein D.W.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay."
      Lo-Guidice J.-M., Allorge D., Chevalier D., Debuysere H., Fazio F., Lafitte J.-J., Broly F.
      Pharmacogenetics 10:293-300(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, allele NAT1*11B."
      Johnson N., Sim E.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
    9. "Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, NAT1*4 allele."
      Johnson N., Sim E.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
    10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
    11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    12. NIEHS SNPs program
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-149 AND ALA-214.
    13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    14. "Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."
      Ebisawa T., Deguchi T.
      Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
      Tissue: Liver.
    15. "Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis."
      Delomenie C., Goodfellow G.H., Krishnamoorthy R., Grant D.M., Dupret J.-M.
      Biochem. J. 323:207-215(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF ARG-64.
    16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."
      Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N.
      J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF WILD-TYPE IN COMPLEX WITH 2-BROMOACETANILIDE AND OF MUTANT SER-125, IDENTIFICATION BY MASS SPECTROMETRY.
    18. "Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe."
      Hughes N.C., Janezic S.A., McQueen K.L., Jewett M.A., Castranio T., Bell D.A., Grant D.M.
      Pharmacogenetics 8:55-66(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NAT1*14 GLN-187.
    19. "Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas."
      Lin H.J., Probst-Hensch N.M., Hughes N.C., Sakamoto G.T., Louie A.D., Kau I.H., Lin B.K., Lee D.B., Lin J., Frankl H.D., Lee E.R., Hardy S., Grant D.M., Haile R.W.
      Pharmacogenetics 8:269-281(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS NAT1*17; NAT1*21; NAT1*22; NAT1*24 AND NAT1*25.

    Entry informationi

    Entry nameiARY1_HUMAN
    AccessioniPrimary (citable) accession number: P18440
    Secondary accession number(s): A8K4E7
    , O15159, O15300, Q546N1, Q96TE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

    Caution

    The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3