Reviewed, UniProtKB/Swiss-Prot P18440 (ARY1_HUMAN)

Names and origin

Protein names

Recommended name:
    Arylamine N-acetyltransferase 1
    EC=2.3.1.5
Alternative name(s):
    Arylamide acetylase 1
    Monomorphic arylamine N-acetyltransferase
      Short name=MNAT
    N-acetyltransferase type 1
      Short name=NAT-1

Gene names

Name:	NAT1
Synonyms:	AAC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subcellular location	Cytoplasm.
Polymorphism	N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder.
Miscellaneous	NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.
Caution	The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature commitee.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from Experiment. Source: Reactome
Molecular function	arylamine N-acetyltransferase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 290

290

Arylamine N-acetyltransferase 1

PRO_0000107904

Regions

Region

106 – 107

2

Substrate binding

Sites

Active site

68

1

Acyl-thioester intermediate

Active site

107

1

Active site

122

1

Binding site

103

1

Coenzyme A By similarity

Binding site

104

1

Coenzyme A; via amide nitrogen By similarity

Binding site

208

1

Coenzyme A By similarity

Binding site

214

1

Coenzyme A By similarity

Natural variations

Natural variant

64

1

R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. dbSNP rs56379106. Ref.5

VAR_004606

Natural variant

117

1

R → T in allele NAT1*5. dbSNP rs55641436. Ref.2

VAR_009510

Natural variant

149

1

V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. dbSNP rs4987076. Ref.3 Ref.4 Ref.8 Ref.10

VAR_004607

Natural variant

166 – 167

2

RE → TQ in allele NAT1*5.

VAR_009511

Natural variant

187

1

R → Q in allele NAT1*14; a slow acetylator. dbSNP rs4986782. Ref.5 Ref.18

VAR_009069

Natural variant

205

1

M → V in allele NAT1*21.

VAR_009070

Natural variant

207

1

T → I: dbSNP rs4987195.

VAR_020384

Natural variant

214

1

S → A in allele NAT1*11. dbSNP rs4986783. Ref.3 Ref.4 Ref.8 Ref.10

VAR_009071

Natural variant

251

1

D → V in allele NAT1*22. dbSNP rs56172717.

VAR_009072

Natural variant

261

1

E → K in allele NAT1*24.

VAR_009073

Natural variant

263

1

I → V in allele NAT1*25.

VAR_009074

Experimental info

Mutagenesis

64

1

R → A, M, Q or K: Reduced enzymatic activity. Ref.15

Secondary structure

1

.

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.

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290

Helix Strand Turn

Details...

Helix

2 – 9

8

Helix

21 – 34

14

Helix

42 – 44

3

Helix

52 – 60

9

Helix

68 – 82

15

Beta strand

85 – 95

11

Turn

96 – 99

4

Beta strand

107 – 114

8

Beta strand

117 – 121

5

Helix

127 – 129

3

Beta strand

142 – 144

3

Beta strand

149 – 155

7

Beta strand

158 – 164

7

Beta strand

167 – 169

3

Helix

173 – 175

3

Beta strand

185 – 192

8

Helix

199 – 202

4

Helix

203 – 211

9

Helix

216 – 219

4

Beta strand

222 – 226

5

Beta strand

228 – 235

8

Beta strand

238 – 243

6

Beta strand

247 – 257

11

Helix

260 – 271

12

Sequences

	Sequence		Length	Mass (Da)
	P18440-1 [UniParc]. Last modified February 1, 1991. Version 2. Checksum: C015F7F3D4830107	FASTA	290	33,899
	10 20 30 40 50 60 MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL GLEAIFDQVV 70 80 90 100 110 120 RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK YSTGMIHLLL QVTIDGRNYI 130 140 150 160 170 180 VDAGFGRSYQ MWQPLELISG KDQPQVPCVF RLTEENGFWY LDQIRREQYI PNEEFLHSDL 190 200 210 220 230 240 LEDSKYRKIY SFTLKPRTIE DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT 250 260 270 280 290 HRRFNYKDNT DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression." Blum M., Grant D.M., McBride W., Heim M., Meyer U.A. DNA Cell Biol. 9:193-203(1990) [PubMed: 2340091] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (NAT1*4). Tissue: Leukocyte.
[2]	"Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver." Ohsako S., Deguchi T. J. Biol. Chem. 265:4630-4634(1990) [PubMed: 1968463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS NAT1*5 THR-117 AND 166-THR-GLN-167. Tissue: Liver.
[3]	"Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus." Vatsis K.P., Weber W.W. Arch. Biochem. Biophys. 301:71-76(1993) [PubMed: 8442668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[4]	"Identification of a novel allele at the human NAT1 acetyltransferase locus." Doll M.A., Jiang W., Deitz A.C., Rustan T.D., Hein D.W. Biochem. Biophys. Res. Commun. 233:584-591(1997) [PubMed: 9168895] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214. Tissue: Blood.
[5]	"Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations." Butcher N.J., Ilett K.F., Minchin R.F. Pharmacogenetics 8:67-72(1998) [PubMed: 9511183] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*17 TRP-64 AND NAT1*14 GLN-187.
[6]	"Homo sapiens N-acetyltransferase-1 (NAT1) gene complete cds." Deitz A.C., Fretland A.J., Leff M.A., Doll M.A., Hein D.W. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay." Lo-Guidice J.-M., Allorge D., Chevalier D., Debuysere H., Fazio F., Lafitte J.-J., Broly F. Pharmacogenetics 10:293-300(2000) [PubMed: 10862520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, allele NAT1*11B." Johnson N., Sim E. Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[9]	"Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, NAT1*4 allele." Johnson N., Sim E. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (NAT1*4).
[10]	"Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes." Patin E., Barreiro L.B., Sabeti P.C., Austerlitz F., Luca F., Sajantila A., Behar D.M., Semino O., Sakuntabhai A., Guiso N., Gicquel B., McElreavey K., Harding R.M., Heyer E., Quintana-Murci L. Am. J. Hum. Genet. 78:423-436(2006) [PubMed: 16416399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
[11]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[12]	NIEHS SNPs program Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-149 AND ALA-214.
[13]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[14]	"Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases." Ebisawa T., Deguchi T. Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed: 1676262] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22. Tissue: Liver.
[15]	"Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis." Delomenie C., Goodfellow G.H., Krishnamoorthy R., Grant D.M., Dupret J.-M. Biochem. J. 323:207-215(1997) [PubMed: 9173883] [Abstract] Cited for: MUTAGENESIS OF ARG-64.
[16]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[17]	"Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases." Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N. J. Biol. Chem. 282:30189-30197(2007) [PubMed: 17656365] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF WILD-TYPE IN COMPLEX WITH 2-BROMOACETANILIDE AND OF MUTANT SER-125, MASS SPECTROMETRY.
[18]	"Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe." Hughes N.C., Janezic S.A., McQueen K.L., Jewett M.A., Castranio T., Bell D.A., Grant D.M. Pharmacogenetics 8:55-66(1998) [PubMed: 9511182] [Abstract] Cited for: VARIANT NAT1*14 GLN-187.
[19]	"Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas." Lin H.J., Probst-Hensch N.M., Hughes N.C., Sakamoto G.T., Louie A.D., Kau I.H., Lin B.K., Lee D.B., Lin J., Frankl H.D., Lee E.R., Hardy S., Grant D.M., Haile R.W. Pharmacogenetics 8:269-281(1998) [PubMed: 9682272] [Abstract] Cited for: VARIANTS NAT1*17; NAT1*21; NAT1*22; NAT1*24 AND NAT1*25.
+	Additional computationally mapped references.

Web resources

NAT

NAT alleles

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Cross-references

Sequence databases

EMBLGenBankDDBJ

X17059 Genomic DNA. Translation: CAA34905.1.
D90041 mRNA. Translation: BAA14095.1.
AF032677 Genomic DNA. Translation: AAB86878.1.
AF032678 Genomic DNA. Translation: AAB86879.1.
U80835 Genomic DNA. Translation: AAB62398.1.
AF008204 Genomic DNA. Translation: AAB84384.1.
AF071552 Genomic DNA. Translation: AAC24712.1.
AF067408 Genomic DNA. Translation: AAC24707.1.
AF082903 Genomic DNA. Translation: AAD13343.1.
AF082904 Genomic DNA. Translation: AAC32388.1.
AJ278017 Genomic DNA. Translation: CAC01128.1.
AJ307007 Genomic DNA. Translation: CAC38345.1.
DQ305816 Genomic DNA. Translation: ABC26192.1.
DQ305817 Genomic DNA. Translation: ABC26193.1.
DQ305818 Genomic DNA. Translation: ABC26194.1.
DQ305819 Genomic DNA. Translation: ABC26195.1.
DQ305820 Genomic DNA. Translation: ABC26196.1.
DQ305821 Genomic DNA. Translation: ABC26197.1.
DQ305822 Genomic DNA. Translation: ABC26198.1.
DQ305823 Genomic DNA. Translation: ABC26199.1.
DQ305824 Genomic DNA. Translation: ABC26200.1.
DQ305825 Genomic DNA. Translation: ABC26201.1.
DQ305826 Genomic DNA. Translation: ABC26202.1.
DQ305827 Genomic DNA. Translation: ABC26203.1.
DQ305828 Genomic DNA. Translation: ABC26204.1.
DQ305829 Genomic DNA. Translation: ABC26205.1.
DQ305830 Genomic DNA. Translation: ABC26206.1.
DQ305831 Genomic DNA. Translation: ABC26207.1.
DQ305832 Genomic DNA. Translation: ABC26208.1.
DQ305833 Genomic DNA. Translation: ABC26209.1.
DQ305834 Genomic DNA. Translation: ABC26210.1.
DQ305835 Genomic DNA. Translation: ABC26211.1.
DQ305836 Genomic DNA. Translation: ABC26212.1.
DQ305837 Genomic DNA. Translation: ABC26213.1.
DQ305838 Genomic DNA. Translation: ABC26214.1.
DQ305839 Genomic DNA. Translation: ABC26215.1.
DQ305840 Genomic DNA. Translation: ABC26216.1.
DQ305841 Genomic DNA. Translation: ABC26217.1.
DQ305842 Genomic DNA. Translation: ABC26218.1.
DQ305843 Genomic DNA. Translation: ABC26219.1.
DQ305844 Genomic DNA. Translation: ABC26220.1.
DQ305845 Genomic DNA. Translation: ABC26221.1.
DQ305846 Genomic DNA. Translation: ABC26222.1.
DQ305847 Genomic DNA. Translation: ABC26223.1.
DQ305848 Genomic DNA. Translation: ABC26224.1.
DQ305849 Genomic DNA. Translation: ABC26225.1.
DQ305850 Genomic DNA. Translation: ABC26226.1.
DQ305851 Genomic DNA. Translation: ABC26227.1.
DQ305852 Genomic DNA. Translation: ABC26228.1.
DQ305853 Genomic DNA. Translation: ABC26229.1.
DQ305854 Genomic DNA. Translation: ABC26230.1.
DQ305855 Genomic DNA. Translation: ABC26231.1.
DQ305856 Genomic DNA. Translation: ABC26232.1.
DQ305857 Genomic DNA. Translation: ABC26233.1.
DQ305858 Genomic DNA. Translation: ABC26234.1.
DQ305859 Genomic DNA. Translation: ABC26235.1.
DQ305860 Genomic DNA. Translation: ABC26236.1.
DQ305861 Genomic DNA. Translation: ABC26237.1.
DQ305862 Genomic DNA. Translation: ABC26238.1.
DQ305863 Genomic DNA. Translation: ABC26239.1.
DQ305864 Genomic DNA. Translation: ABC26240.1.
DQ305865 Genomic DNA. Translation: ABC26241.1.
DQ305866 Genomic DNA. Translation: ABC26242.1.
DQ305867 Genomic DNA. Translation: ABC26243.1.
DQ305868 Genomic DNA. Translation: ABC26244.1.
DQ305869 Genomic DNA. Translation: ABC26245.1.
DQ305870 Genomic DNA. Translation: ABC26246.1.
DQ305871 Genomic DNA. Translation: ABC26247.1.
DQ305872 Genomic DNA. Translation: ABC26248.1.
DQ305873 Genomic DNA. Translation: ABC26249.1.
DQ305874 Genomic DNA. Translation: ABC26250.1.
DQ305875 Genomic DNA. Translation: ABC26251.1.
DQ305876 Genomic DNA. Translation: ABC26252.1.
DQ305877 Genomic DNA. Translation: ABC26253.1.
DQ305878 Genomic DNA. Translation: ABC26254.1.
DQ305879 Genomic DNA. Translation: ABC26255.1.
DQ305880 Genomic DNA. Translation: ABC26256.1.
DQ305881 Genomic DNA. Translation: ABC26257.1.
DQ305882 Genomic DNA. Translation: ABC26258.1.
DQ305883 Genomic DNA. Translation: ABC26259.1.
DQ305884 Genomic DNA. Translation: ABC26260.1.
DQ305885 Genomic DNA. Translation: ABC26261.1.
DQ305886 Genomic DNA. Translation: ABC26262.1.
DQ305887 Genomic DNA. Translation: ABC26263.1.
DQ305888 Genomic DNA. Translation: ABC26264.1.
DQ305889 Genomic DNA. Translation: ABC26265.1.
DQ305890 Genomic DNA. Translation: ABC26266.1.
DQ305891 Genomic DNA. Translation: ABC26267.1.
DQ305892 Genomic DNA. Translation: ABC26268.1.
DQ305893 Genomic DNA. Translation: ABC26269.1.
DQ305894 Genomic DNA. Translation: ABC26270.1.
DQ305895 Genomic DNA. Translation: ABC26271.1.
DQ305896 Genomic DNA. Translation: ABC26272.1.
DQ305897 Genomic DNA. Translation: ABC26273.1.
DQ305898 Genomic DNA. Translation: ABC26274.1.
DQ305899 Genomic DNA. Translation: ABC26275.1.
DQ305900 Genomic DNA. Translation: ABC26276.1.
DQ305901 Genomic DNA. Translation: ABC26277.1.
DQ305902 Genomic DNA. Translation: ABC26278.1.
DQ305903 Genomic DNA. Translation: ABC26279.1.
DQ305904 Genomic DNA. Translation: ABC26280.1.
DQ305905 Genomic DNA. Translation: ABC26281.1.
DQ305906 Genomic DNA. Translation: ABC26282.1.
DQ305907 Genomic DNA. Translation: ABC26283.1.
DQ305908 Genomic DNA. Translation: ABC26284.1.
DQ305909 Genomic DNA. Translation: ABC26285.1.
DQ305910 Genomic DNA. Translation: ABC26286.1.
DQ305911 Genomic DNA. Translation: ABC26287.1.
DQ305912 Genomic DNA. Translation: ABC26288.1.
DQ305913 Genomic DNA. Translation: ABC26289.1.
DQ305914 Genomic DNA. Translation: ABC26290.1.
DQ305915 Genomic DNA. Translation: ABC26291.1.
DQ305916 Genomic DNA. Translation: ABC26292.1.
DQ305917 Genomic DNA. Translation: ABC26293.1.
DQ305918 Genomic DNA. Translation: ABC26294.1.
DQ305919 Genomic DNA. Translation: ABC26295.1.
DQ305920 Genomic DNA. Translation: ABC26296.1.
DQ305921 Genomic DNA. Translation: ABC26297.1.
DQ305922 Genomic DNA. Translation: ABC26298.1.
DQ305923 Genomic DNA. Translation: ABC26299.1.
DQ305924 Genomic DNA. Translation: ABC26300.1.
DQ305925 Genomic DNA. Translation: ABC26301.1.
DQ305926 Genomic DNA. Translation: ABC26302.1.
DQ305927 Genomic DNA. Translation: ABC26303.1.
DQ305928 Genomic DNA. Translation: ABC26304.1.
DQ305929 Genomic DNA. Translation: ABC26305.1.
DQ305930 Genomic DNA. Translation: ABC26306.1.
DQ305931 Genomic DNA. Translation: ABC26307.1.
DQ305932 Genomic DNA. Translation: ABC26308.1.
DQ305933 Genomic DNA. Translation: ABC26309.1.
DQ305934 Genomic DNA. Translation: ABC26310.1.
DQ305935 Genomic DNA. Translation: ABC26311.1.
DQ305936 Genomic DNA. Translation: ABC26312.1.
DQ305937 Genomic DNA. Translation: ABC26313.1.
DQ305938 Genomic DNA. Translation: ABC26314.1.
DQ305939 Genomic DNA. Translation: ABC26315.1.
DQ305940 Genomic DNA. Translation: ABC26316.1.
DQ305941 Genomic DNA. Translation: ABC26317.1.
DQ305942 Genomic DNA. Translation: ABC26318.1.
DQ305943 Genomic DNA. Translation: ABC26319.1.
DQ305944 Genomic DNA. Translation: ABC26320.1.
DQ305945 Genomic DNA. Translation: ABC26321.1.
DQ305946 Genomic DNA. Translation: ABC26322.1.
DQ305947 Genomic DNA. Translation: ABC26323.1.
DQ305948 Genomic DNA. Translation: ABC26324.1.
DQ305949 Genomic DNA. Translation: ABC26325.1.
DQ305950 Genomic DNA. Translation: ABC26326.1.
DQ305951 Genomic DNA. Translation: ABC26327.1.
DQ305952 Genomic DNA. Translation: ABC26328.1.
DQ305953 Genomic DNA. Translation: ABC26329.1.
DQ305954 Genomic DNA. Translation: ABC26330.1.
DQ305955 Genomic DNA. Translation: ABC26331.1.
DQ305956 Genomic DNA. Translation: ABC26332.1.
DQ305957 Genomic DNA. Translation: ABC26333.1.
DQ305958 Genomic DNA. Translation: ABC26334.1.
DQ305959 Genomic DNA. Translation: ABC26335.1.
DQ305960 Genomic DNA. Translation: ABC26336.1.
DQ305961 Genomic DNA. Translation: ABC26337.1.
DQ305962 Genomic DNA. Translation: ABC26338.1.
DQ305963 Genomic DNA. Translation: ABC26339.1.
DQ305964 Genomic DNA. Translation: ABC26340.1.
DQ305965 Genomic DNA. Translation: ABC26341.1.
DQ305966 Genomic DNA. Translation: ABC26342.1.
DQ305967 Genomic DNA. Translation: ABC26343.1.
DQ305968 Genomic DNA. Translation: ABC26344.1.
DQ305969 Genomic DNA. Translation: ABC26345.1.
DQ305970 Genomic DNA. Translation: ABC26346.1.
DQ305971 Genomic DNA. Translation: ABC26347.1.
DQ305972 Genomic DNA. Translation: ABC26348.1.
DQ305973 Genomic DNA. Translation: ABC26349.1.
DQ305974 Genomic DNA. Translation: ABC26350.1.
DQ305975 Genomic DNA. Translation: ABC26351.1.
AK290912 mRNA. Translation: BAF83601.1.
AY338489 Genomic DNA. Translation: AAP88036.1.
AY800271 Genomic DNA. Translation: AAV50002.1.
BC047666 mRNA. Translation: AAH47666.1.
M75164 Genomic DNA. Translation: AAA59905.1.

IPI

IPI00644361.

PIR

A34585.

RefSeq

NP_000653.3.

UniGene

Hs.2
Hs.591847

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2DSS	model	-	@	1-290	[»]
2GWU	model	-	A	1-290	[»]
2IJA	X-ray	1.70	A	2-290	[»]
2PQT	X-ray	1.78	A	2-290	[»]

ModBase

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PTM databases

PhosphoSite

P18440.

Proteomic databases

PRIDE

P18440.

Genome annotation databases

Ensembl

ENSG00000171428. Homo sapiens. [Contig view]

GeneID

9.

KEGG

hsa:9.

Organism-specific databases

GeneCards

GC08P018111.

H-InvDB

HIX0007344.

HGNC

HGNC:7645. NAT1.

MIM

108345. gene.

PharmGKB

PA28773.

GenAtlas

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Phylogenomic databases

HOGENOM

P18440.

HOVERGEN

P18440.

OMA

P18440. TLTYRRF.

Enzyme and pathway databases

BRENDA

2.3.1.5. 247.
2.3.1.88. 247.

Reactome

REACT_13433. Biological oxidations.

Gene expression databases

ArrayExpress

P18440.

Bgee

P18440.

CleanEx

HS_NAT1.

GermOnline

ENSG00000171428. Homo sapiens.

Family and domain databases

InterPro

IPR001447. N-AcTrfase.
[Graphical view]

PANTHER

PTHR11786. Acetyltransf2. 1 hit.

Pfam

PF00797. Acetyltransf_2. 1 hit.
[Graphical view]

PRINTS

PR01543. ANATRNSFRASE.

ProDom

PD002783. Acetyltransf2. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

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Other Resources

NextBio

11.

SOURCE

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Entry information

Entry name

ARY1_HUMAN

Accession

Primary (citable) accession number: P18440
Secondary accession number(s): A8K4E7 , O15159, O15300, Q546N1, Q96TE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	February 1, 1991
Last modified:	June 16, 2009
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)