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Protein

Arylamine N-acetyltransferase 1

Gene

NAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Acyl-thioester intermediate1
Binding sitei103Coenzyme ABy similarity1
Binding sitei104Coenzyme A; via amide nitrogenBy similarity1
Active sitei1071
Active sitei1221
Binding sitei208Coenzyme ABy similarity1
Binding sitei214Coenzyme ABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS10301-MONOMER.
BRENDAi2.3.1.5. 2681.
2.3.1.88. 2681.
ReactomeiR-HSA-156582. Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name:
MNAT
N-acetyltransferase type 1
Short name:
NAT-1
Gene namesi
Name:NAT1
Synonyms:AAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7645. NAT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi64R → A, M, Q or K: Reduced enzymatic activity. 1 Publication1

Organism-specific databases

DisGeNETi9.
MalaCardsiNAT1.
OpenTargetsiENSG00000171428.
PharmGKBiPA17.

Chemistry databases

ChEMBLiCHEMBL5101.
DrugBankiDB01015. Sulfamethoxazole.

Polymorphism and mutation databases

BioMutaiNAT1.
DMDMi114234.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001079041 – 290Arylamine N-acetyltransferase 1Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP18440.
MaxQBiP18440.
PaxDbiP18440.
PeptideAtlasiP18440.
PRIDEiP18440.

PTM databases

iPTMnetiP18440.
PhosphoSitePlusiP18440.
SwissPalmiP18440.

Expressioni

Gene expression databases

BgeeiENSG00000171428.
CleanExiHS_NAT1.
ExpressionAtlasiP18440. baseline and differential.
GenevisibleiP18440. HS.

Organism-specific databases

HPAiCAB017782.
HPA043704.

Interactioni

Protein-protein interaction databases

BioGridi106527. 2 interactors.
IntActiP18440. 1 interactor.
STRINGi9606.ENSP00000443194.

Chemistry databases

BindingDBiP18440.

Structurei

Secondary structure

1290
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 9Combined sources8
Helixi21 – 34Combined sources14
Helixi42 – 44Combined sources3
Helixi52 – 60Combined sources9
Helixi68 – 82Combined sources15
Beta strandi85 – 95Combined sources11
Turni96 – 99Combined sources4
Beta strandi107 – 114Combined sources8
Beta strandi117 – 121Combined sources5
Beta strandi123 – 125Combined sources3
Helixi127 – 129Combined sources3
Beta strandi142 – 144Combined sources3
Beta strandi149 – 155Combined sources7
Beta strandi158 – 164Combined sources7
Beta strandi167 – 169Combined sources3
Helixi173 – 175Combined sources3
Beta strandi185 – 192Combined sources8
Helixi199 – 202Combined sources4
Helixi203 – 211Combined sources9
Helixi216 – 219Combined sources4
Beta strandi222 – 226Combined sources5
Beta strandi228 – 235Combined sources8
Beta strandi238 – 243Combined sources6
Beta strandi247 – 257Combined sources11
Helixi260 – 271Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DSSmodel-@1-290[»]
2GWUmodel-A1-290[»]
2IJAX-ray1.70A2-290[»]
2PQTX-ray1.78A2-290[»]
ProteinModelPortaliP18440.
SMRiP18440.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18440.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 107Substrate binding2

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
GeneTreeiENSGT00390000012054.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiP18440.
KOiK00622.
PhylomeDBiP18440.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

P18440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL
60 70 80 90 100
GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK
110 120 130 140 150
YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF
160 170 180 190 200
RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE
210 220 230 240 250
DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT
260 270 280 290
DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI
Length:290
Mass (Da):33,899
Last modified:February 1, 1991 - v2
Checksum:iC015F7F3D4830107
GO

Polymorphismi

N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder (PubMed:7585580).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00460664R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 PublicationCorresponds to variant rs56379106dbSNPEnsembl.1
Natural variantiVAR_009510117R → T in allele NAT1*5. 1 PublicationCorresponds to variant rs55641436dbSNPEnsembl.1
Natural variantiVAR_004607149V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 PublicationsCorresponds to variant rs4987076dbSNPEnsembl.1
Natural variantiVAR_009511166 – 167RE → TQ in allele NAT1*5. Corresponds to variant rs72554608dbSNPEnsembl.2
Natural variantiVAR_009069187R → Q in allele NAT1*14; a slow acetylator. 2 PublicationsCorresponds to variant rs4986782dbSNPEnsembl.1
Natural variantiVAR_009070205M → V in allele NAT1*21. Corresponds to variant rs72554609dbSNPEnsembl.1
Natural variantiVAR_020384207T → I.Corresponds to variant rs4987195dbSNPEnsembl.1
Natural variantiVAR_009071214S → A in allele NAT1*11. 5 PublicationsCorresponds to variant rs4986783dbSNPEnsembl.1
Natural variantiVAR_009072251D → V in allele NAT1*22. Corresponds to variant rs56172717dbSNPEnsembl.1
Natural variantiVAR_009073261E → K in allele NAT1*24. Corresponds to variant rs72554610dbSNPEnsembl.1
Natural variantiVAR_009074263I → V in allele NAT1*25. Corresponds to variant rs72554611dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17059 Genomic DNA. Translation: CAA34905.1.
D90041 mRNA. Translation: BAA14095.1.
AF032677 Genomic DNA. Translation: AAB86878.1.
AF032678 Genomic DNA. Translation: AAB86879.1.
U80835 Genomic DNA. Translation: AAB62398.1.
AF008204 Genomic DNA. Translation: AAB84384.1.
AF071552 Genomic DNA. Translation: AAC24712.1.
AF067408 Genomic DNA. Translation: AAC24707.1.
AF082903 Genomic DNA. Translation: AAD13343.1.
AF082904 Genomic DNA. Translation: AAC32388.1.
AJ278017 Genomic DNA. Translation: CAC01128.1.
AJ307007 Genomic DNA. Translation: CAC38345.1.
DQ305816 Genomic DNA. Translation: ABC26192.1.
DQ305817 Genomic DNA. Translation: ABC26193.1.
DQ305818 Genomic DNA. Translation: ABC26194.1.
DQ305819 Genomic DNA. Translation: ABC26195.1.
DQ305820 Genomic DNA. Translation: ABC26196.1.
DQ305821 Genomic DNA. Translation: ABC26197.1.
DQ305822 Genomic DNA. Translation: ABC26198.1.
DQ305823 Genomic DNA. Translation: ABC26199.1.
DQ305824 Genomic DNA. Translation: ABC26200.1.
DQ305825 Genomic DNA. Translation: ABC26201.1.
DQ305826 Genomic DNA. Translation: ABC26202.1.
DQ305827 Genomic DNA. Translation: ABC26203.1.
DQ305828 Genomic DNA. Translation: ABC26204.1.
DQ305829 Genomic DNA. Translation: ABC26205.1.
DQ305830 Genomic DNA. Translation: ABC26206.1.
DQ305831 Genomic DNA. Translation: ABC26207.1.
DQ305832 Genomic DNA. Translation: ABC26208.1.
DQ305833 Genomic DNA. Translation: ABC26209.1.
DQ305834 Genomic DNA. Translation: ABC26210.1.
DQ305835 Genomic DNA. Translation: ABC26211.1.
DQ305836 Genomic DNA. Translation: ABC26212.1.
DQ305837 Genomic DNA. Translation: ABC26213.1.
DQ305838 Genomic DNA. Translation: ABC26214.1.
DQ305839 Genomic DNA. Translation: ABC26215.1.
DQ305840 Genomic DNA. Translation: ABC26216.1.
DQ305841 Genomic DNA. Translation: ABC26217.1.
DQ305842 Genomic DNA. Translation: ABC26218.1.
DQ305843 Genomic DNA. Translation: ABC26219.1.
DQ305844 Genomic DNA. Translation: ABC26220.1.
DQ305845 Genomic DNA. Translation: ABC26221.1.
DQ305846 Genomic DNA. Translation: ABC26222.1.
DQ305847 Genomic DNA. Translation: ABC26223.1.
DQ305848 Genomic DNA. Translation: ABC26224.1.
DQ305849 Genomic DNA. Translation: ABC26225.1.
DQ305850 Genomic DNA. Translation: ABC26226.1.
DQ305851 Genomic DNA. Translation: ABC26227.1.
DQ305852 Genomic DNA. Translation: ABC26228.1.
DQ305853 Genomic DNA. Translation: ABC26229.1.
DQ305854 Genomic DNA. Translation: ABC26230.1.
DQ305855 Genomic DNA. Translation: ABC26231.1.
DQ305856 Genomic DNA. Translation: ABC26232.1.
DQ305857 Genomic DNA. Translation: ABC26233.1.
DQ305858 Genomic DNA. Translation: ABC26234.1.
DQ305859 Genomic DNA. Translation: ABC26235.1.
DQ305860 Genomic DNA. Translation: ABC26236.1.
DQ305861 Genomic DNA. Translation: ABC26237.1.
DQ305862 Genomic DNA. Translation: ABC26238.1.
DQ305863 Genomic DNA. Translation: ABC26239.1.
DQ305864 Genomic DNA. Translation: ABC26240.1.
DQ305865 Genomic DNA. Translation: ABC26241.1.
DQ305866 Genomic DNA. Translation: ABC26242.1.
DQ305867 Genomic DNA. Translation: ABC26243.1.
DQ305868 Genomic DNA. Translation: ABC26244.1.
DQ305869 Genomic DNA. Translation: ABC26245.1.
DQ305870 Genomic DNA. Translation: ABC26246.1.
DQ305871 Genomic DNA. Translation: ABC26247.1.
DQ305872 Genomic DNA. Translation: ABC26248.1.
DQ305873 Genomic DNA. Translation: ABC26249.1.
DQ305874 Genomic DNA. Translation: ABC26250.1.
DQ305875 Genomic DNA. Translation: ABC26251.1.
DQ305876 Genomic DNA. Translation: ABC26252.1.
DQ305877 Genomic DNA. Translation: ABC26253.1.
DQ305878 Genomic DNA. Translation: ABC26254.1.
DQ305879 Genomic DNA. Translation: ABC26255.1.
DQ305880 Genomic DNA. Translation: ABC26256.1.
DQ305881 Genomic DNA. Translation: ABC26257.1.
DQ305882 Genomic DNA. Translation: ABC26258.1.
DQ305883 Genomic DNA. Translation: ABC26259.1.
DQ305884 Genomic DNA. Translation: ABC26260.1.
DQ305885 Genomic DNA. Translation: ABC26261.1.
DQ305886 Genomic DNA. Translation: ABC26262.1.
DQ305887 Genomic DNA. Translation: ABC26263.1.
DQ305888 Genomic DNA. Translation: ABC26264.1.
DQ305889 Genomic DNA. Translation: ABC26265.1.
DQ305890 Genomic DNA. Translation: ABC26266.1.
DQ305891 Genomic DNA. Translation: ABC26267.1.
DQ305892 Genomic DNA. Translation: ABC26268.1.
DQ305893 Genomic DNA. Translation: ABC26269.1.
DQ305894 Genomic DNA. Translation: ABC26270.1.
DQ305895 Genomic DNA. Translation: ABC26271.1.
DQ305896 Genomic DNA. Translation: ABC26272.1.
DQ305897 Genomic DNA. Translation: ABC26273.1.
DQ305898 Genomic DNA. Translation: ABC26274.1.
DQ305899 Genomic DNA. Translation: ABC26275.1.
DQ305900 Genomic DNA. Translation: ABC26276.1.
DQ305901 Genomic DNA. Translation: ABC26277.1.
DQ305902 Genomic DNA. Translation: ABC26278.1.
DQ305903 Genomic DNA. Translation: ABC26279.1.
DQ305904 Genomic DNA. Translation: ABC26280.1.
DQ305905 Genomic DNA. Translation: ABC26281.1.
DQ305906 Genomic DNA. Translation: ABC26282.1.
DQ305907 Genomic DNA. Translation: ABC26283.1.
DQ305908 Genomic DNA. Translation: ABC26284.1.
DQ305909 Genomic DNA. Translation: ABC26285.1.
DQ305910 Genomic DNA. Translation: ABC26286.1.
DQ305911 Genomic DNA. Translation: ABC26287.1.
DQ305912 Genomic DNA. Translation: ABC26288.1.
DQ305913 Genomic DNA. Translation: ABC26289.1.
DQ305914 Genomic DNA. Translation: ABC26290.1.
DQ305915 Genomic DNA. Translation: ABC26291.1.
DQ305916 Genomic DNA. Translation: ABC26292.1.
DQ305917 Genomic DNA. Translation: ABC26293.1.
DQ305918 Genomic DNA. Translation: ABC26294.1.
DQ305919 Genomic DNA. Translation: ABC26295.1.
DQ305920 Genomic DNA. Translation: ABC26296.1.
DQ305921 Genomic DNA. Translation: ABC26297.1.
DQ305922 Genomic DNA. Translation: ABC26298.1.
DQ305923 Genomic DNA. Translation: ABC26299.1.
DQ305924 Genomic DNA. Translation: ABC26300.1.
DQ305925 Genomic DNA. Translation: ABC26301.1.
DQ305926 Genomic DNA. Translation: ABC26302.1.
DQ305927 Genomic DNA. Translation: ABC26303.1.
DQ305928 Genomic DNA. Translation: ABC26304.1.
DQ305929 Genomic DNA. Translation: ABC26305.1.
DQ305930 Genomic DNA. Translation: ABC26306.1.
DQ305931 Genomic DNA. Translation: ABC26307.1.
DQ305932 Genomic DNA. Translation: ABC26308.1.
DQ305933 Genomic DNA. Translation: ABC26309.1.
DQ305934 Genomic DNA. Translation: ABC26310.1.
DQ305935 Genomic DNA. Translation: ABC26311.1.
DQ305936 Genomic DNA. Translation: ABC26312.1.
DQ305937 Genomic DNA. Translation: ABC26313.1.
DQ305938 Genomic DNA. Translation: ABC26314.1.
DQ305939 Genomic DNA. Translation: ABC26315.1.
DQ305940 Genomic DNA. Translation: ABC26316.1.
DQ305941 Genomic DNA. Translation: ABC26317.1.
DQ305942 Genomic DNA. Translation: ABC26318.1.
DQ305943 Genomic DNA. Translation: ABC26319.1.
DQ305944 Genomic DNA. Translation: ABC26320.1.
DQ305945 Genomic DNA. Translation: ABC26321.1.
DQ305946 Genomic DNA. Translation: ABC26322.1.
DQ305947 Genomic DNA. Translation: ABC26323.1.
DQ305948 Genomic DNA. Translation: ABC26324.1.
DQ305949 Genomic DNA. Translation: ABC26325.1.
DQ305950 Genomic DNA. Translation: ABC26326.1.
DQ305951 Genomic DNA. Translation: ABC26327.1.
DQ305952 Genomic DNA. Translation: ABC26328.1.
DQ305953 Genomic DNA. Translation: ABC26329.1.
DQ305954 Genomic DNA. Translation: ABC26330.1.
DQ305955 Genomic DNA. Translation: ABC26331.1.
DQ305956 Genomic DNA. Translation: ABC26332.1.
DQ305957 Genomic DNA. Translation: ABC26333.1.
DQ305958 Genomic DNA. Translation: ABC26334.1.
DQ305959 Genomic DNA. Translation: ABC26335.1.
DQ305960 Genomic DNA. Translation: ABC26336.1.
DQ305961 Genomic DNA. Translation: ABC26337.1.
DQ305962 Genomic DNA. Translation: ABC26338.1.
DQ305963 Genomic DNA. Translation: ABC26339.1.
DQ305964 Genomic DNA. Translation: ABC26340.1.
DQ305965 Genomic DNA. Translation: ABC26341.1.
DQ305966 Genomic DNA. Translation: ABC26342.1.
DQ305967 Genomic DNA. Translation: ABC26343.1.
DQ305968 Genomic DNA. Translation: ABC26344.1.
DQ305969 Genomic DNA. Translation: ABC26345.1.
DQ305970 Genomic DNA. Translation: ABC26346.1.
DQ305971 Genomic DNA. Translation: ABC26347.1.
DQ305972 Genomic DNA. Translation: ABC26348.1.
DQ305973 Genomic DNA. Translation: ABC26349.1.
DQ305974 Genomic DNA. Translation: ABC26350.1.
DQ305975 Genomic DNA. Translation: ABC26351.1.
AK290912 mRNA. Translation: BAF83601.1.
AY338489 Genomic DNA. Translation: AAP88036.1.
AY800271 Genomic DNA. Translation: AAV50002.1.
BC047666 mRNA. Translation: AAH47666.1.
M75164 Genomic DNA. Translation: AAA59905.1.
CCDSiCCDS6007.1.
PIRiA34585.
RefSeqiNP_000653.3. NM_000662.7.
NP_001153642.1. NM_001160170.3.
NP_001153643.1. NM_001160171.3.
NP_001153644.1. NM_001160172.3.
NP_001153645.1. NM_001160173.3.
NP_001153646.1. NM_001160174.2.
NP_001153651.1. NM_001160179.2.
XP_006716473.1. XM_006716410.3.
XP_011542991.1. XM_011544689.2.
UniGeneiHs.2.
Hs.591847.

Genome annotation databases

EnsembliENST00000307719; ENSP00000307218; ENSG00000171428.
ENST00000517492; ENSP00000429407; ENSG00000171428.
ENST00000518029; ENSP00000428270; ENSG00000171428.
ENST00000520546; ENSP00000429341; ENSG00000171428.
ENST00000541942; ENSP00000440900; ENSG00000171428.
GeneIDi9.
KEGGihsa:9.
UCSCiuc003wyq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17059 Genomic DNA. Translation: CAA34905.1.
D90041 mRNA. Translation: BAA14095.1.
AF032677 Genomic DNA. Translation: AAB86878.1.
AF032678 Genomic DNA. Translation: AAB86879.1.
U80835 Genomic DNA. Translation: AAB62398.1.
AF008204 Genomic DNA. Translation: AAB84384.1.
AF071552 Genomic DNA. Translation: AAC24712.1.
AF067408 Genomic DNA. Translation: AAC24707.1.
AF082903 Genomic DNA. Translation: AAD13343.1.
AF082904 Genomic DNA. Translation: AAC32388.1.
AJ278017 Genomic DNA. Translation: CAC01128.1.
AJ307007 Genomic DNA. Translation: CAC38345.1.
DQ305816 Genomic DNA. Translation: ABC26192.1.
DQ305817 Genomic DNA. Translation: ABC26193.1.
DQ305818 Genomic DNA. Translation: ABC26194.1.
DQ305819 Genomic DNA. Translation: ABC26195.1.
DQ305820 Genomic DNA. Translation: ABC26196.1.
DQ305821 Genomic DNA. Translation: ABC26197.1.
DQ305822 Genomic DNA. Translation: ABC26198.1.
DQ305823 Genomic DNA. Translation: ABC26199.1.
DQ305824 Genomic DNA. Translation: ABC26200.1.
DQ305825 Genomic DNA. Translation: ABC26201.1.
DQ305826 Genomic DNA. Translation: ABC26202.1.
DQ305827 Genomic DNA. Translation: ABC26203.1.
DQ305828 Genomic DNA. Translation: ABC26204.1.
DQ305829 Genomic DNA. Translation: ABC26205.1.
DQ305830 Genomic DNA. Translation: ABC26206.1.
DQ305831 Genomic DNA. Translation: ABC26207.1.
DQ305832 Genomic DNA. Translation: ABC26208.1.
DQ305833 Genomic DNA. Translation: ABC26209.1.
DQ305834 Genomic DNA. Translation: ABC26210.1.
DQ305835 Genomic DNA. Translation: ABC26211.1.
DQ305836 Genomic DNA. Translation: ABC26212.1.
DQ305837 Genomic DNA. Translation: ABC26213.1.
DQ305838 Genomic DNA. Translation: ABC26214.1.
DQ305839 Genomic DNA. Translation: ABC26215.1.
DQ305840 Genomic DNA. Translation: ABC26216.1.
DQ305841 Genomic DNA. Translation: ABC26217.1.
DQ305842 Genomic DNA. Translation: ABC26218.1.
DQ305843 Genomic DNA. Translation: ABC26219.1.
DQ305844 Genomic DNA. Translation: ABC26220.1.
DQ305845 Genomic DNA. Translation: ABC26221.1.
DQ305846 Genomic DNA. Translation: ABC26222.1.
DQ305847 Genomic DNA. Translation: ABC26223.1.
DQ305848 Genomic DNA. Translation: ABC26224.1.
DQ305849 Genomic DNA. Translation: ABC26225.1.
DQ305850 Genomic DNA. Translation: ABC26226.1.
DQ305851 Genomic DNA. Translation: ABC26227.1.
DQ305852 Genomic DNA. Translation: ABC26228.1.
DQ305853 Genomic DNA. Translation: ABC26229.1.
DQ305854 Genomic DNA. Translation: ABC26230.1.
DQ305855 Genomic DNA. Translation: ABC26231.1.
DQ305856 Genomic DNA. Translation: ABC26232.1.
DQ305857 Genomic DNA. Translation: ABC26233.1.
DQ305858 Genomic DNA. Translation: ABC26234.1.
DQ305859 Genomic DNA. Translation: ABC26235.1.
DQ305860 Genomic DNA. Translation: ABC26236.1.
DQ305861 Genomic DNA. Translation: ABC26237.1.
DQ305862 Genomic DNA. Translation: ABC26238.1.
DQ305863 Genomic DNA. Translation: ABC26239.1.
DQ305864 Genomic DNA. Translation: ABC26240.1.
DQ305865 Genomic DNA. Translation: ABC26241.1.
DQ305866 Genomic DNA. Translation: ABC26242.1.
DQ305867 Genomic DNA. Translation: ABC26243.1.
DQ305868 Genomic DNA. Translation: ABC26244.1.
DQ305869 Genomic DNA. Translation: ABC26245.1.
DQ305870 Genomic DNA. Translation: ABC26246.1.
DQ305871 Genomic DNA. Translation: ABC26247.1.
DQ305872 Genomic DNA. Translation: ABC26248.1.
DQ305873 Genomic DNA. Translation: ABC26249.1.
DQ305874 Genomic DNA. Translation: ABC26250.1.
DQ305875 Genomic DNA. Translation: ABC26251.1.
DQ305876 Genomic DNA. Translation: ABC26252.1.
DQ305877 Genomic DNA. Translation: ABC26253.1.
DQ305878 Genomic DNA. Translation: ABC26254.1.
DQ305879 Genomic DNA. Translation: ABC26255.1.
DQ305880 Genomic DNA. Translation: ABC26256.1.
DQ305881 Genomic DNA. Translation: ABC26257.1.
DQ305882 Genomic DNA. Translation: ABC26258.1.
DQ305883 Genomic DNA. Translation: ABC26259.1.
DQ305884 Genomic DNA. Translation: ABC26260.1.
DQ305885 Genomic DNA. Translation: ABC26261.1.
DQ305886 Genomic DNA. Translation: ABC26262.1.
DQ305887 Genomic DNA. Translation: ABC26263.1.
DQ305888 Genomic DNA. Translation: ABC26264.1.
DQ305889 Genomic DNA. Translation: ABC26265.1.
DQ305890 Genomic DNA. Translation: ABC26266.1.
DQ305891 Genomic DNA. Translation: ABC26267.1.
DQ305892 Genomic DNA. Translation: ABC26268.1.
DQ305893 Genomic DNA. Translation: ABC26269.1.
DQ305894 Genomic DNA. Translation: ABC26270.1.
DQ305895 Genomic DNA. Translation: ABC26271.1.
DQ305896 Genomic DNA. Translation: ABC26272.1.
DQ305897 Genomic DNA. Translation: ABC26273.1.
DQ305898 Genomic DNA. Translation: ABC26274.1.
DQ305899 Genomic DNA. Translation: ABC26275.1.
DQ305900 Genomic DNA. Translation: ABC26276.1.
DQ305901 Genomic DNA. Translation: ABC26277.1.
DQ305902 Genomic DNA. Translation: ABC26278.1.
DQ305903 Genomic DNA. Translation: ABC26279.1.
DQ305904 Genomic DNA. Translation: ABC26280.1.
DQ305905 Genomic DNA. Translation: ABC26281.1.
DQ305906 Genomic DNA. Translation: ABC26282.1.
DQ305907 Genomic DNA. Translation: ABC26283.1.
DQ305908 Genomic DNA. Translation: ABC26284.1.
DQ305909 Genomic DNA. Translation: ABC26285.1.
DQ305910 Genomic DNA. Translation: ABC26286.1.
DQ305911 Genomic DNA. Translation: ABC26287.1.
DQ305912 Genomic DNA. Translation: ABC26288.1.
DQ305913 Genomic DNA. Translation: ABC26289.1.
DQ305914 Genomic DNA. Translation: ABC26290.1.
DQ305915 Genomic DNA. Translation: ABC26291.1.
DQ305916 Genomic DNA. Translation: ABC26292.1.
DQ305917 Genomic DNA. Translation: ABC26293.1.
DQ305918 Genomic DNA. Translation: ABC26294.1.
DQ305919 Genomic DNA. Translation: ABC26295.1.
DQ305920 Genomic DNA. Translation: ABC26296.1.
DQ305921 Genomic DNA. Translation: ABC26297.1.
DQ305922 Genomic DNA. Translation: ABC26298.1.
DQ305923 Genomic DNA. Translation: ABC26299.1.
DQ305924 Genomic DNA. Translation: ABC26300.1.
DQ305925 Genomic DNA. Translation: ABC26301.1.
DQ305926 Genomic DNA. Translation: ABC26302.1.
DQ305927 Genomic DNA. Translation: ABC26303.1.
DQ305928 Genomic DNA. Translation: ABC26304.1.
DQ305929 Genomic DNA. Translation: ABC26305.1.
DQ305930 Genomic DNA. Translation: ABC26306.1.
DQ305931 Genomic DNA. Translation: ABC26307.1.
DQ305932 Genomic DNA. Translation: ABC26308.1.
DQ305933 Genomic DNA. Translation: ABC26309.1.
DQ305934 Genomic DNA. Translation: ABC26310.1.
DQ305935 Genomic DNA. Translation: ABC26311.1.
DQ305936 Genomic DNA. Translation: ABC26312.1.
DQ305937 Genomic DNA. Translation: ABC26313.1.
DQ305938 Genomic DNA. Translation: ABC26314.1.
DQ305939 Genomic DNA. Translation: ABC26315.1.
DQ305940 Genomic DNA. Translation: ABC26316.1.
DQ305941 Genomic DNA. Translation: ABC26317.1.
DQ305942 Genomic DNA. Translation: ABC26318.1.
DQ305943 Genomic DNA. Translation: ABC26319.1.
DQ305944 Genomic DNA. Translation: ABC26320.1.
DQ305945 Genomic DNA. Translation: ABC26321.1.
DQ305946 Genomic DNA. Translation: ABC26322.1.
DQ305947 Genomic DNA. Translation: ABC26323.1.
DQ305948 Genomic DNA. Translation: ABC26324.1.
DQ305949 Genomic DNA. Translation: ABC26325.1.
DQ305950 Genomic DNA. Translation: ABC26326.1.
DQ305951 Genomic DNA. Translation: ABC26327.1.
DQ305952 Genomic DNA. Translation: ABC26328.1.
DQ305953 Genomic DNA. Translation: ABC26329.1.
DQ305954 Genomic DNA. Translation: ABC26330.1.
DQ305955 Genomic DNA. Translation: ABC26331.1.
DQ305956 Genomic DNA. Translation: ABC26332.1.
DQ305957 Genomic DNA. Translation: ABC26333.1.
DQ305958 Genomic DNA. Translation: ABC26334.1.
DQ305959 Genomic DNA. Translation: ABC26335.1.
DQ305960 Genomic DNA. Translation: ABC26336.1.
DQ305961 Genomic DNA. Translation: ABC26337.1.
DQ305962 Genomic DNA. Translation: ABC26338.1.
DQ305963 Genomic DNA. Translation: ABC26339.1.
DQ305964 Genomic DNA. Translation: ABC26340.1.
DQ305965 Genomic DNA. Translation: ABC26341.1.
DQ305966 Genomic DNA. Translation: ABC26342.1.
DQ305967 Genomic DNA. Translation: ABC26343.1.
DQ305968 Genomic DNA. Translation: ABC26344.1.
DQ305969 Genomic DNA. Translation: ABC26345.1.
DQ305970 Genomic DNA. Translation: ABC26346.1.
DQ305971 Genomic DNA. Translation: ABC26347.1.
DQ305972 Genomic DNA. Translation: ABC26348.1.
DQ305973 Genomic DNA. Translation: ABC26349.1.
DQ305974 Genomic DNA. Translation: ABC26350.1.
DQ305975 Genomic DNA. Translation: ABC26351.1.
AK290912 mRNA. Translation: BAF83601.1.
AY338489 Genomic DNA. Translation: AAP88036.1.
AY800271 Genomic DNA. Translation: AAV50002.1.
BC047666 mRNA. Translation: AAH47666.1.
M75164 Genomic DNA. Translation: AAA59905.1.
CCDSiCCDS6007.1.
PIRiA34585.
RefSeqiNP_000653.3. NM_000662.7.
NP_001153642.1. NM_001160170.3.
NP_001153643.1. NM_001160171.3.
NP_001153644.1. NM_001160172.3.
NP_001153645.1. NM_001160173.3.
NP_001153646.1. NM_001160174.2.
NP_001153651.1. NM_001160179.2.
XP_006716473.1. XM_006716410.3.
XP_011542991.1. XM_011544689.2.
UniGeneiHs.2.
Hs.591847.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DSSmodel-@1-290[»]
2GWUmodel-A1-290[»]
2IJAX-ray1.70A2-290[»]
2PQTX-ray1.78A2-290[»]
ProteinModelPortaliP18440.
SMRiP18440.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106527. 2 interactors.
IntActiP18440. 1 interactor.
STRINGi9606.ENSP00000443194.

Chemistry databases

BindingDBiP18440.
ChEMBLiCHEMBL5101.
DrugBankiDB01015. Sulfamethoxazole.

PTM databases

iPTMnetiP18440.
PhosphoSitePlusiP18440.
SwissPalmiP18440.

Polymorphism and mutation databases

BioMutaiNAT1.
DMDMi114234.

Proteomic databases

EPDiP18440.
MaxQBiP18440.
PaxDbiP18440.
PeptideAtlasiP18440.
PRIDEiP18440.

Protocols and materials databases

DNASUi9.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307719; ENSP00000307218; ENSG00000171428.
ENST00000517492; ENSP00000429407; ENSG00000171428.
ENST00000518029; ENSP00000428270; ENSG00000171428.
ENST00000520546; ENSP00000429341; ENSG00000171428.
ENST00000541942; ENSP00000440900; ENSG00000171428.
GeneIDi9.
KEGGihsa:9.
UCSCiuc003wyq.4. human.

Organism-specific databases

CTDi9.
DisGeNETi9.
GeneCardsiNAT1.
HGNCiHGNC:7645. NAT1.
HPAiCAB017782.
HPA043704.
MalaCardsiNAT1.
MIMi108345. gene.
neXtProtiNX_P18440.
OpenTargetsiENSG00000171428.
PharmGKBiPA17.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFD6. Eukaryota.
COG2162. LUCA.
GeneTreeiENSGT00390000012054.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiP18440.
KOiK00622.
PhylomeDBiP18440.

Enzyme and pathway databases

BioCyciZFISH:HS10301-MONOMER.
BRENDAi2.3.1.5. 2681.
2.3.1.88. 2681.
ReactomeiR-HSA-156582. Acetylation.

Miscellaneous databases

ChiTaRSiNAT1. human.
EvolutionaryTraceiP18440.
GeneWikiiN-acetyltransferase_1.
GenomeRNAii9.
PROiP18440.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171428.
CleanExiHS_NAT1.
ExpressionAtlasiP18440. baseline and differential.
GenevisibleiP18440. HS.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.
ProtoNetiSearch...

Entry informationi

Entry nameiARY1_HUMAN
AccessioniPrimary (citable) accession number: P18440
Secondary accession number(s): A8K4E7
, O15159, O15300, Q546N1, Q96TE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

Caution

The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.