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P18440

- ARY1_HUMAN

UniProt

P18440 - ARY1_HUMAN

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Protein

Arylamine N-acetyltransferase 1

Gene
NAT1, AAC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Catalytic activityi

Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei68 – 681Acyl-thioester intermediate
Binding sitei103 – 1031Coenzyme A By similarity
Binding sitei104 – 1041Coenzyme A; via amide nitrogen By similarity
Active sitei107 – 1071
Active sitei122 – 1221
Binding sitei208 – 2081Coenzyme A By similarity
Binding sitei214 – 2141Coenzyme A By similarity

GO - Molecular functioni

  1. arylamine N-acetyltransferase activity Source: ProtInc

GO - Biological processi

  1. small molecule metabolic process Source: Reactome
  2. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.5. 2681.
ReactomeiREACT_6732. Acetylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Arylamine N-acetyltransferase 1 (EC:2.3.1.5)
Alternative name(s):
Arylamide acetylase 1
Monomorphic arylamine N-acetyltransferase
Short name:
MNAT
N-acetyltransferase type 1
Short name:
NAT-1
Gene namesi
Name:NAT1
Synonyms:AAC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:7645. NAT1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi64 – 641R → A, M, Q or K: Reduced enzymatic activity. 1 Publication

Organism-specific databases

PharmGKBiPA17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Arylamine N-acetyltransferase 1PRO_0000107904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP18440.
PaxDbiP18440.
PRIDEiP18440.

PTM databases

PhosphoSiteiP18440.

Expressioni

Gene expression databases

ArrayExpressiP18440.
BgeeiP18440.
CleanExiHS_NAT1.
GenevestigatoriP18440.

Organism-specific databases

HPAiCAB017782.
HPA043704.

Interactioni

Protein-protein interaction databases

BioGridi106527. 2 interactions.
IntActiP18440. 1 interaction.
STRINGi9606.ENSP00000307218.

Structurei

Secondary structure

1
290
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 98
Helixi21 – 3414
Helixi42 – 443
Helixi52 – 609
Helixi68 – 8215
Beta strandi85 – 9511
Turni96 – 994
Beta strandi107 – 1148
Beta strandi117 – 1215
Beta strandi123 – 1253
Helixi127 – 1293
Beta strandi142 – 1443
Beta strandi149 – 1557
Beta strandi158 – 1647
Beta strandi167 – 1693
Helixi173 – 1753
Beta strandi185 – 1928
Helixi199 – 2024
Helixi203 – 2119
Helixi216 – 2194
Beta strandi222 – 2265
Beta strandi228 – 2358
Beta strandi238 – 2436
Beta strandi247 – 25711
Helixi260 – 27112

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DSSmodel-@1-290[»]
2GWUmodel-A1-290[»]
2IJAX-ray1.70A2-290[»]
2PQTX-ray1.78A2-290[»]
ProteinModelPortaliP18440.
SMRiP18440. Positions 2-290.

Miscellaneous databases

EvolutionaryTraceiP18440.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072Substrate binding

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2162.
HOGENOMiHOG000205435.
HOVERGENiHBG000165.
InParanoidiP18440.
KOiK00622.
OrthoDBiEOG7BP83H.
PhylomeDBiP18440.

Family and domain databases

InterProiIPR001447. Arylamine_N-AcTrfase.
[Graphical view]
PANTHERiPTHR11786. PTHR11786. 1 hit.
PfamiPF00797. Acetyltransf_2. 1 hit.
[Graphical view]
PRINTSiPR01543. ANATRNSFRASE.

Sequencei

Sequence statusi: Complete.

P18440-1 [UniParc]FASTAAdd to Basket

« Hide

MDIEAYLERI GYKKSRNKLD LETLTDILQH QIRAVPFENL NIHCGDAMDL    50
GLEAIFDQVV RRNRGGWCLQ VNHLLYWALT TIGFETTMLG GYVYSTPAKK 100
YSTGMIHLLL QVTIDGRNYI VDAGFGRSYQ MWQPLELISG KDQPQVPCVF 150
RLTEENGFWY LDQIRREQYI PNEEFLHSDL LEDSKYRKIY SFTLKPRTIE 200
DFESMNTYLQ TSPSSVFTSK SFCSLQTPDG VHCLVGFTLT HRRFNYKDNT 250
DLIEFKTLSE EEIEKVLKNI FNISLQRKLV PKHGDRFFTI 290
Length:290
Mass (Da):33,899
Last modified:February 1, 1991 - v2
Checksum:iC015F7F3D4830107
GO

Polymorphismi

N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641R → W in allele NAT1*17; a slow acetylator; has defective enzyme activity. 1 Publication
Corresponds to variant rs56379106 [ dbSNP | Ensembl ].
VAR_004606
Natural varianti117 – 1171R → T in allele NAT1*5. 1 Publication
Corresponds to variant rs55641436 [ dbSNP | Ensembl ].
VAR_009510
Natural varianti149 – 1491V → I in allele NAT1*11; catalyzes the N-acetylation of aromatic amines and the O- and N,O-acetylation of their N-hydroxylated metabolites at rates up to 2-fold higher. 5 Publications
Corresponds to variant rs4987076 [ dbSNP | Ensembl ].
VAR_004607
Natural varianti166 – 1672RE → TQ in allele NAT1*5.
VAR_009511
Natural varianti187 – 1871R → Q in allele NAT1*14; a slow acetylator. 2 Publications
Corresponds to variant rs4986782 [ dbSNP | Ensembl ].
VAR_009069
Natural varianti205 – 2051M → V in allele NAT1*21.
VAR_009070
Natural varianti207 – 2071T → I.
Corresponds to variant rs4987195 [ dbSNP | Ensembl ].
VAR_020384
Natural varianti214 – 2141S → A in allele NAT1*11. 5 Publications
Corresponds to variant rs4986783 [ dbSNP | Ensembl ].
VAR_009071
Natural varianti251 – 2511D → V in allele NAT1*22.
Corresponds to variant rs56172717 [ dbSNP | Ensembl ].
VAR_009072
Natural varianti261 – 2611E → K in allele NAT1*24.
VAR_009073
Natural varianti263 – 2631I → V in allele NAT1*25.
VAR_009074

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17059 Genomic DNA. Translation: CAA34905.1.
D90041 mRNA. Translation: BAA14095.1.
AF032677 Genomic DNA. Translation: AAB86878.1.
AF032678 Genomic DNA. Translation: AAB86879.1.
U80835 Genomic DNA. Translation: AAB62398.1.
AF008204 Genomic DNA. Translation: AAB84384.1.
AF071552 Genomic DNA. Translation: AAC24712.1.
AF067408 Genomic DNA. Translation: AAC24707.1.
AF082903 Genomic DNA. Translation: AAD13343.1.
AF082904 Genomic DNA. Translation: AAC32388.1.
AJ278017 Genomic DNA. Translation: CAC01128.1.
AJ307007 Genomic DNA. Translation: CAC38345.1.
DQ305816 Genomic DNA. Translation: ABC26192.1.
DQ305817 Genomic DNA. Translation: ABC26193.1.
DQ305818 Genomic DNA. Translation: ABC26194.1.
DQ305819 Genomic DNA. Translation: ABC26195.1.
DQ305820 Genomic DNA. Translation: ABC26196.1.
DQ305821 Genomic DNA. Translation: ABC26197.1.
DQ305822 Genomic DNA. Translation: ABC26198.1.
DQ305823 Genomic DNA. Translation: ABC26199.1.
DQ305824 Genomic DNA. Translation: ABC26200.1.
DQ305825 Genomic DNA. Translation: ABC26201.1.
DQ305826 Genomic DNA. Translation: ABC26202.1.
DQ305827 Genomic DNA. Translation: ABC26203.1.
DQ305828 Genomic DNA. Translation: ABC26204.1.
DQ305829 Genomic DNA. Translation: ABC26205.1.
DQ305830 Genomic DNA. Translation: ABC26206.1.
DQ305831 Genomic DNA. Translation: ABC26207.1.
DQ305832 Genomic DNA. Translation: ABC26208.1.
DQ305833 Genomic DNA. Translation: ABC26209.1.
DQ305834 Genomic DNA. Translation: ABC26210.1.
DQ305835 Genomic DNA. Translation: ABC26211.1.
DQ305836 Genomic DNA. Translation: ABC26212.1.
DQ305837 Genomic DNA. Translation: ABC26213.1.
DQ305838 Genomic DNA. Translation: ABC26214.1.
DQ305839 Genomic DNA. Translation: ABC26215.1.
DQ305840 Genomic DNA. Translation: ABC26216.1.
DQ305841 Genomic DNA. Translation: ABC26217.1.
DQ305842 Genomic DNA. Translation: ABC26218.1.
DQ305843 Genomic DNA. Translation: ABC26219.1.
DQ305844 Genomic DNA. Translation: ABC26220.1.
DQ305845 Genomic DNA. Translation: ABC26221.1.
DQ305846 Genomic DNA. Translation: ABC26222.1.
DQ305847 Genomic DNA. Translation: ABC26223.1.
DQ305848 Genomic DNA. Translation: ABC26224.1.
DQ305849 Genomic DNA. Translation: ABC26225.1.
DQ305850 Genomic DNA. Translation: ABC26226.1.
DQ305851 Genomic DNA. Translation: ABC26227.1.
DQ305852 Genomic DNA. Translation: ABC26228.1.
DQ305853 Genomic DNA. Translation: ABC26229.1.
DQ305854 Genomic DNA. Translation: ABC26230.1.
DQ305855 Genomic DNA. Translation: ABC26231.1.
DQ305856 Genomic DNA. Translation: ABC26232.1.
DQ305857 Genomic DNA. Translation: ABC26233.1.
DQ305858 Genomic DNA. Translation: ABC26234.1.
DQ305859 Genomic DNA. Translation: ABC26235.1.
DQ305860 Genomic DNA. Translation: ABC26236.1.
DQ305861 Genomic DNA. Translation: ABC26237.1.
DQ305862 Genomic DNA. Translation: ABC26238.1.
DQ305863 Genomic DNA. Translation: ABC26239.1.
DQ305864 Genomic DNA. Translation: ABC26240.1.
DQ305865 Genomic DNA. Translation: ABC26241.1.
DQ305866 Genomic DNA. Translation: ABC26242.1.
DQ305867 Genomic DNA. Translation: ABC26243.1.
DQ305868 Genomic DNA. Translation: ABC26244.1.
DQ305869 Genomic DNA. Translation: ABC26245.1.
DQ305870 Genomic DNA. Translation: ABC26246.1.
DQ305871 Genomic DNA. Translation: ABC26247.1.
DQ305872 Genomic DNA. Translation: ABC26248.1.
DQ305873 Genomic DNA. Translation: ABC26249.1.
DQ305874 Genomic DNA. Translation: ABC26250.1.
DQ305875 Genomic DNA. Translation: ABC26251.1.
DQ305876 Genomic DNA. Translation: ABC26252.1.
DQ305877 Genomic DNA. Translation: ABC26253.1.
DQ305878 Genomic DNA. Translation: ABC26254.1.
DQ305879 Genomic DNA. Translation: ABC26255.1.
DQ305880 Genomic DNA. Translation: ABC26256.1.
DQ305881 Genomic DNA. Translation: ABC26257.1.
DQ305882 Genomic DNA. Translation: ABC26258.1.
DQ305883 Genomic DNA. Translation: ABC26259.1.
DQ305884 Genomic DNA. Translation: ABC26260.1.
DQ305885 Genomic DNA. Translation: ABC26261.1.
DQ305886 Genomic DNA. Translation: ABC26262.1.
DQ305887 Genomic DNA. Translation: ABC26263.1.
DQ305888 Genomic DNA. Translation: ABC26264.1.
DQ305889 Genomic DNA. Translation: ABC26265.1.
DQ305890 Genomic DNA. Translation: ABC26266.1.
DQ305891 Genomic DNA. Translation: ABC26267.1.
DQ305892 Genomic DNA. Translation: ABC26268.1.
DQ305893 Genomic DNA. Translation: ABC26269.1.
DQ305894 Genomic DNA. Translation: ABC26270.1.
DQ305895 Genomic DNA. Translation: ABC26271.1.
DQ305896 Genomic DNA. Translation: ABC26272.1.
DQ305897 Genomic DNA. Translation: ABC26273.1.
DQ305898 Genomic DNA. Translation: ABC26274.1.
DQ305899 Genomic DNA. Translation: ABC26275.1.
DQ305900 Genomic DNA. Translation: ABC26276.1.
DQ305901 Genomic DNA. Translation: ABC26277.1.
DQ305902 Genomic DNA. Translation: ABC26278.1.
DQ305903 Genomic DNA. Translation: ABC26279.1.
DQ305904 Genomic DNA. Translation: ABC26280.1.
DQ305905 Genomic DNA. Translation: ABC26281.1.
DQ305906 Genomic DNA. Translation: ABC26282.1.
DQ305907 Genomic DNA. Translation: ABC26283.1.
DQ305908 Genomic DNA. Translation: ABC26284.1.
DQ305909 Genomic DNA. Translation: ABC26285.1.
DQ305910 Genomic DNA. Translation: ABC26286.1.
DQ305911 Genomic DNA. Translation: ABC26287.1.
DQ305912 Genomic DNA. Translation: ABC26288.1.
DQ305913 Genomic DNA. Translation: ABC26289.1.
DQ305914 Genomic DNA. Translation: ABC26290.1.
DQ305915 Genomic DNA. Translation: ABC26291.1.
DQ305916 Genomic DNA. Translation: ABC26292.1.
DQ305917 Genomic DNA. Translation: ABC26293.1.
DQ305918 Genomic DNA. Translation: ABC26294.1.
DQ305919 Genomic DNA. Translation: ABC26295.1.
DQ305920 Genomic DNA. Translation: ABC26296.1.
DQ305921 Genomic DNA. Translation: ABC26297.1.
DQ305922 Genomic DNA. Translation: ABC26298.1.
DQ305923 Genomic DNA. Translation: ABC26299.1.
DQ305924 Genomic DNA. Translation: ABC26300.1.
DQ305925 Genomic DNA. Translation: ABC26301.1.
DQ305926 Genomic DNA. Translation: ABC26302.1.
DQ305927 Genomic DNA. Translation: ABC26303.1.
DQ305928 Genomic DNA. Translation: ABC26304.1.
DQ305929 Genomic DNA. Translation: ABC26305.1.
DQ305930 Genomic DNA. Translation: ABC26306.1.
DQ305931 Genomic DNA. Translation: ABC26307.1.
DQ305932 Genomic DNA. Translation: ABC26308.1.
DQ305933 Genomic DNA. Translation: ABC26309.1.
DQ305934 Genomic DNA. Translation: ABC26310.1.
DQ305935 Genomic DNA. Translation: ABC26311.1.
DQ305936 Genomic DNA. Translation: ABC26312.1.
DQ305937 Genomic DNA. Translation: ABC26313.1.
DQ305938 Genomic DNA. Translation: ABC26314.1.
DQ305939 Genomic DNA. Translation: ABC26315.1.
DQ305940 Genomic DNA. Translation: ABC26316.1.
DQ305941 Genomic DNA. Translation: ABC26317.1.
DQ305942 Genomic DNA. Translation: ABC26318.1.
DQ305943 Genomic DNA. Translation: ABC26319.1.
DQ305944 Genomic DNA. Translation: ABC26320.1.
DQ305945 Genomic DNA. Translation: ABC26321.1.
DQ305946 Genomic DNA. Translation: ABC26322.1.
DQ305947 Genomic DNA. Translation: ABC26323.1.
DQ305948 Genomic DNA. Translation: ABC26324.1.
DQ305949 Genomic DNA. Translation: ABC26325.1.
DQ305950 Genomic DNA. Translation: ABC26326.1.
DQ305951 Genomic DNA. Translation: ABC26327.1.
DQ305952 Genomic DNA. Translation: ABC26328.1.
DQ305953 Genomic DNA. Translation: ABC26329.1.
DQ305954 Genomic DNA. Translation: ABC26330.1.
DQ305955 Genomic DNA. Translation: ABC26331.1.
DQ305956 Genomic DNA. Translation: ABC26332.1.
DQ305957 Genomic DNA. Translation: ABC26333.1.
DQ305958 Genomic DNA. Translation: ABC26334.1.
DQ305959 Genomic DNA. Translation: ABC26335.1.
DQ305960 Genomic DNA. Translation: ABC26336.1.
DQ305961 Genomic DNA. Translation: ABC26337.1.
DQ305962 Genomic DNA. Translation: ABC26338.1.
DQ305963 Genomic DNA. Translation: ABC26339.1.
DQ305964 Genomic DNA. Translation: ABC26340.1.
DQ305965 Genomic DNA. Translation: ABC26341.1.
DQ305966 Genomic DNA. Translation: ABC26342.1.
DQ305967 Genomic DNA. Translation: ABC26343.1.
DQ305968 Genomic DNA. Translation: ABC26344.1.
DQ305969 Genomic DNA. Translation: ABC26345.1.
DQ305970 Genomic DNA. Translation: ABC26346.1.
DQ305971 Genomic DNA. Translation: ABC26347.1.
DQ305972 Genomic DNA. Translation: ABC26348.1.
DQ305973 Genomic DNA. Translation: ABC26349.1.
DQ305974 Genomic DNA. Translation: ABC26350.1.
DQ305975 Genomic DNA. Translation: ABC26351.1.
AK290912 mRNA. Translation: BAF83601.1.
AY338489 Genomic DNA. Translation: AAP88036.1.
AY800271 Genomic DNA. Translation: AAV50002.1.
BC047666 mRNA. Translation: AAH47666.1.
M75164 Genomic DNA. Translation: AAA59905.1.
CCDSiCCDS6007.1.
PIRiA34585.
RefSeqiNP_000653.3. NM_000662.7.
NP_001153642.1. NM_001160170.3.
NP_001153643.1. NM_001160171.3.
NP_001153644.1. NM_001160172.3.
NP_001153645.1. NM_001160173.3.
NP_001153646.1. NM_001160174.2.
NP_001153651.1. NM_001160179.2.
XP_006716473.1. XM_006716410.1.
UniGeneiHs.2.
Hs.591847.

Genome annotation databases

EnsembliENST00000307719; ENSP00000307218; ENSG00000171428.
ENST00000517492; ENSP00000429407; ENSG00000171428.
ENST00000518029; ENSP00000428270; ENSG00000171428.
ENST00000520546; ENSP00000429341; ENSG00000171428.
ENST00000535084; ENSP00000444609; ENSG00000171428.
ENST00000539092; ENSP00000440434; ENSG00000171428.
ENST00000541942; ENSP00000440900; ENSG00000171428.
GeneIDi9.
KEGGihsa:9.
UCSCiuc003wyq.3. human.

Polymorphism databases

DMDMi114234.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NAT

NAT alleles

NIEHS-SNPs
SHMPD

The Singapore human mutation and polymorphism database

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17059 Genomic DNA. Translation: CAA34905.1 .
D90041 mRNA. Translation: BAA14095.1 .
AF032677 Genomic DNA. Translation: AAB86878.1 .
AF032678 Genomic DNA. Translation: AAB86879.1 .
U80835 Genomic DNA. Translation: AAB62398.1 .
AF008204 Genomic DNA. Translation: AAB84384.1 .
AF071552 Genomic DNA. Translation: AAC24712.1 .
AF067408 Genomic DNA. Translation: AAC24707.1 .
AF082903 Genomic DNA. Translation: AAD13343.1 .
AF082904 Genomic DNA. Translation: AAC32388.1 .
AJ278017 Genomic DNA. Translation: CAC01128.1 .
AJ307007 Genomic DNA. Translation: CAC38345.1 .
DQ305816 Genomic DNA. Translation: ABC26192.1 .
DQ305817 Genomic DNA. Translation: ABC26193.1 .
DQ305818 Genomic DNA. Translation: ABC26194.1 .
DQ305819 Genomic DNA. Translation: ABC26195.1 .
DQ305820 Genomic DNA. Translation: ABC26196.1 .
DQ305821 Genomic DNA. Translation: ABC26197.1 .
DQ305822 Genomic DNA. Translation: ABC26198.1 .
DQ305823 Genomic DNA. Translation: ABC26199.1 .
DQ305824 Genomic DNA. Translation: ABC26200.1 .
DQ305825 Genomic DNA. Translation: ABC26201.1 .
DQ305826 Genomic DNA. Translation: ABC26202.1 .
DQ305827 Genomic DNA. Translation: ABC26203.1 .
DQ305828 Genomic DNA. Translation: ABC26204.1 .
DQ305829 Genomic DNA. Translation: ABC26205.1 .
DQ305830 Genomic DNA. Translation: ABC26206.1 .
DQ305831 Genomic DNA. Translation: ABC26207.1 .
DQ305832 Genomic DNA. Translation: ABC26208.1 .
DQ305833 Genomic DNA. Translation: ABC26209.1 .
DQ305834 Genomic DNA. Translation: ABC26210.1 .
DQ305835 Genomic DNA. Translation: ABC26211.1 .
DQ305836 Genomic DNA. Translation: ABC26212.1 .
DQ305837 Genomic DNA. Translation: ABC26213.1 .
DQ305838 Genomic DNA. Translation: ABC26214.1 .
DQ305839 Genomic DNA. Translation: ABC26215.1 .
DQ305840 Genomic DNA. Translation: ABC26216.1 .
DQ305841 Genomic DNA. Translation: ABC26217.1 .
DQ305842 Genomic DNA. Translation: ABC26218.1 .
DQ305843 Genomic DNA. Translation: ABC26219.1 .
DQ305844 Genomic DNA. Translation: ABC26220.1 .
DQ305845 Genomic DNA. Translation: ABC26221.1 .
DQ305846 Genomic DNA. Translation: ABC26222.1 .
DQ305847 Genomic DNA. Translation: ABC26223.1 .
DQ305848 Genomic DNA. Translation: ABC26224.1 .
DQ305849 Genomic DNA. Translation: ABC26225.1 .
DQ305850 Genomic DNA. Translation: ABC26226.1 .
DQ305851 Genomic DNA. Translation: ABC26227.1 .
DQ305852 Genomic DNA. Translation: ABC26228.1 .
DQ305853 Genomic DNA. Translation: ABC26229.1 .
DQ305854 Genomic DNA. Translation: ABC26230.1 .
DQ305855 Genomic DNA. Translation: ABC26231.1 .
DQ305856 Genomic DNA. Translation: ABC26232.1 .
DQ305857 Genomic DNA. Translation: ABC26233.1 .
DQ305858 Genomic DNA. Translation: ABC26234.1 .
DQ305859 Genomic DNA. Translation: ABC26235.1 .
DQ305860 Genomic DNA. Translation: ABC26236.1 .
DQ305861 Genomic DNA. Translation: ABC26237.1 .
DQ305862 Genomic DNA. Translation: ABC26238.1 .
DQ305863 Genomic DNA. Translation: ABC26239.1 .
DQ305864 Genomic DNA. Translation: ABC26240.1 .
DQ305865 Genomic DNA. Translation: ABC26241.1 .
DQ305866 Genomic DNA. Translation: ABC26242.1 .
DQ305867 Genomic DNA. Translation: ABC26243.1 .
DQ305868 Genomic DNA. Translation: ABC26244.1 .
DQ305869 Genomic DNA. Translation: ABC26245.1 .
DQ305870 Genomic DNA. Translation: ABC26246.1 .
DQ305871 Genomic DNA. Translation: ABC26247.1 .
DQ305872 Genomic DNA. Translation: ABC26248.1 .
DQ305873 Genomic DNA. Translation: ABC26249.1 .
DQ305874 Genomic DNA. Translation: ABC26250.1 .
DQ305875 Genomic DNA. Translation: ABC26251.1 .
DQ305876 Genomic DNA. Translation: ABC26252.1 .
DQ305877 Genomic DNA. Translation: ABC26253.1 .
DQ305878 Genomic DNA. Translation: ABC26254.1 .
DQ305879 Genomic DNA. Translation: ABC26255.1 .
DQ305880 Genomic DNA. Translation: ABC26256.1 .
DQ305881 Genomic DNA. Translation: ABC26257.1 .
DQ305882 Genomic DNA. Translation: ABC26258.1 .
DQ305883 Genomic DNA. Translation: ABC26259.1 .
DQ305884 Genomic DNA. Translation: ABC26260.1 .
DQ305885 Genomic DNA. Translation: ABC26261.1 .
DQ305886 Genomic DNA. Translation: ABC26262.1 .
DQ305887 Genomic DNA. Translation: ABC26263.1 .
DQ305888 Genomic DNA. Translation: ABC26264.1 .
DQ305889 Genomic DNA. Translation: ABC26265.1 .
DQ305890 Genomic DNA. Translation: ABC26266.1 .
DQ305891 Genomic DNA. Translation: ABC26267.1 .
DQ305892 Genomic DNA. Translation: ABC26268.1 .
DQ305893 Genomic DNA. Translation: ABC26269.1 .
DQ305894 Genomic DNA. Translation: ABC26270.1 .
DQ305895 Genomic DNA. Translation: ABC26271.1 .
DQ305896 Genomic DNA. Translation: ABC26272.1 .
DQ305897 Genomic DNA. Translation: ABC26273.1 .
DQ305898 Genomic DNA. Translation: ABC26274.1 .
DQ305899 Genomic DNA. Translation: ABC26275.1 .
DQ305900 Genomic DNA. Translation: ABC26276.1 .
DQ305901 Genomic DNA. Translation: ABC26277.1 .
DQ305902 Genomic DNA. Translation: ABC26278.1 .
DQ305903 Genomic DNA. Translation: ABC26279.1 .
DQ305904 Genomic DNA. Translation: ABC26280.1 .
DQ305905 Genomic DNA. Translation: ABC26281.1 .
DQ305906 Genomic DNA. Translation: ABC26282.1 .
DQ305907 Genomic DNA. Translation: ABC26283.1 .
DQ305908 Genomic DNA. Translation: ABC26284.1 .
DQ305909 Genomic DNA. Translation: ABC26285.1 .
DQ305910 Genomic DNA. Translation: ABC26286.1 .
DQ305911 Genomic DNA. Translation: ABC26287.1 .
DQ305912 Genomic DNA. Translation: ABC26288.1 .
DQ305913 Genomic DNA. Translation: ABC26289.1 .
DQ305914 Genomic DNA. Translation: ABC26290.1 .
DQ305915 Genomic DNA. Translation: ABC26291.1 .
DQ305916 Genomic DNA. Translation: ABC26292.1 .
DQ305917 Genomic DNA. Translation: ABC26293.1 .
DQ305918 Genomic DNA. Translation: ABC26294.1 .
DQ305919 Genomic DNA. Translation: ABC26295.1 .
DQ305920 Genomic DNA. Translation: ABC26296.1 .
DQ305921 Genomic DNA. Translation: ABC26297.1 .
DQ305922 Genomic DNA. Translation: ABC26298.1 .
DQ305923 Genomic DNA. Translation: ABC26299.1 .
DQ305924 Genomic DNA. Translation: ABC26300.1 .
DQ305925 Genomic DNA. Translation: ABC26301.1 .
DQ305926 Genomic DNA. Translation: ABC26302.1 .
DQ305927 Genomic DNA. Translation: ABC26303.1 .
DQ305928 Genomic DNA. Translation: ABC26304.1 .
DQ305929 Genomic DNA. Translation: ABC26305.1 .
DQ305930 Genomic DNA. Translation: ABC26306.1 .
DQ305931 Genomic DNA. Translation: ABC26307.1 .
DQ305932 Genomic DNA. Translation: ABC26308.1 .
DQ305933 Genomic DNA. Translation: ABC26309.1 .
DQ305934 Genomic DNA. Translation: ABC26310.1 .
DQ305935 Genomic DNA. Translation: ABC26311.1 .
DQ305936 Genomic DNA. Translation: ABC26312.1 .
DQ305937 Genomic DNA. Translation: ABC26313.1 .
DQ305938 Genomic DNA. Translation: ABC26314.1 .
DQ305939 Genomic DNA. Translation: ABC26315.1 .
DQ305940 Genomic DNA. Translation: ABC26316.1 .
DQ305941 Genomic DNA. Translation: ABC26317.1 .
DQ305942 Genomic DNA. Translation: ABC26318.1 .
DQ305943 Genomic DNA. Translation: ABC26319.1 .
DQ305944 Genomic DNA. Translation: ABC26320.1 .
DQ305945 Genomic DNA. Translation: ABC26321.1 .
DQ305946 Genomic DNA. Translation: ABC26322.1 .
DQ305947 Genomic DNA. Translation: ABC26323.1 .
DQ305948 Genomic DNA. Translation: ABC26324.1 .
DQ305949 Genomic DNA. Translation: ABC26325.1 .
DQ305950 Genomic DNA. Translation: ABC26326.1 .
DQ305951 Genomic DNA. Translation: ABC26327.1 .
DQ305952 Genomic DNA. Translation: ABC26328.1 .
DQ305953 Genomic DNA. Translation: ABC26329.1 .
DQ305954 Genomic DNA. Translation: ABC26330.1 .
DQ305955 Genomic DNA. Translation: ABC26331.1 .
DQ305956 Genomic DNA. Translation: ABC26332.1 .
DQ305957 Genomic DNA. Translation: ABC26333.1 .
DQ305958 Genomic DNA. Translation: ABC26334.1 .
DQ305959 Genomic DNA. Translation: ABC26335.1 .
DQ305960 Genomic DNA. Translation: ABC26336.1 .
DQ305961 Genomic DNA. Translation: ABC26337.1 .
DQ305962 Genomic DNA. Translation: ABC26338.1 .
DQ305963 Genomic DNA. Translation: ABC26339.1 .
DQ305964 Genomic DNA. Translation: ABC26340.1 .
DQ305965 Genomic DNA. Translation: ABC26341.1 .
DQ305966 Genomic DNA. Translation: ABC26342.1 .
DQ305967 Genomic DNA. Translation: ABC26343.1 .
DQ305968 Genomic DNA. Translation: ABC26344.1 .
DQ305969 Genomic DNA. Translation: ABC26345.1 .
DQ305970 Genomic DNA. Translation: ABC26346.1 .
DQ305971 Genomic DNA. Translation: ABC26347.1 .
DQ305972 Genomic DNA. Translation: ABC26348.1 .
DQ305973 Genomic DNA. Translation: ABC26349.1 .
DQ305974 Genomic DNA. Translation: ABC26350.1 .
DQ305975 Genomic DNA. Translation: ABC26351.1 .
AK290912 mRNA. Translation: BAF83601.1 .
AY338489 Genomic DNA. Translation: AAP88036.1 .
AY800271 Genomic DNA. Translation: AAV50002.1 .
BC047666 mRNA. Translation: AAH47666.1 .
M75164 Genomic DNA. Translation: AAA59905.1 .
CCDSi CCDS6007.1.
PIRi A34585.
RefSeqi NP_000653.3. NM_000662.7.
NP_001153642.1. NM_001160170.3.
NP_001153643.1. NM_001160171.3.
NP_001153644.1. NM_001160172.3.
NP_001153645.1. NM_001160173.3.
NP_001153646.1. NM_001160174.2.
NP_001153651.1. NM_001160179.2.
XP_006716473.1. XM_006716410.1.
UniGenei Hs.2.
Hs.591847.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DSS model - @ 1-290 [» ]
2GWU model - A 1-290 [» ]
2IJA X-ray 1.70 A 2-290 [» ]
2PQT X-ray 1.78 A 2-290 [» ]
ProteinModelPortali P18440.
SMRi P18440. Positions 2-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106527. 2 interactions.
IntActi P18440. 1 interaction.
STRINGi 9606.ENSP00000307218.

Chemistry

BindingDBi P18440.
ChEMBLi CHEMBL5101.

PTM databases

PhosphoSitei P18440.

Polymorphism databases

DMDMi 114234.

Proteomic databases

MaxQBi P18440.
PaxDbi P18440.
PRIDEi P18440.

Protocols and materials databases

DNASUi 9.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307719 ; ENSP00000307218 ; ENSG00000171428 .
ENST00000517492 ; ENSP00000429407 ; ENSG00000171428 .
ENST00000518029 ; ENSP00000428270 ; ENSG00000171428 .
ENST00000520546 ; ENSP00000429341 ; ENSG00000171428 .
ENST00000535084 ; ENSP00000444609 ; ENSG00000171428 .
ENST00000539092 ; ENSP00000440434 ; ENSG00000171428 .
ENST00000541942 ; ENSP00000440900 ; ENSG00000171428 .
GeneIDi 9.
KEGGi hsa:9.
UCSCi uc003wyq.3. human.

Organism-specific databases

CTDi 9.
GeneCardsi GC08P018031.
HGNCi HGNC:7645. NAT1.
HPAi CAB017782.
HPA043704.
MIMi 108345. gene.
neXtProti NX_P18440.
PharmGKBi PA17.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2162.
HOGENOMi HOG000205435.
HOVERGENi HBG000165.
InParanoidi P18440.
KOi K00622.
OrthoDBi EOG7BP83H.
PhylomeDBi P18440.

Enzyme and pathway databases

BRENDAi 2.3.1.5. 2681.
Reactomei REACT_6732. Acetylation.

Miscellaneous databases

EvolutionaryTracei P18440.
GeneWikii N-acetyltransferase_1.
GenomeRNAii 9.
NextBioi 11.
PROi P18440.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18440.
Bgeei P18440.
CleanExi HS_NAT1.
Genevestigatori P18440.

Family and domain databases

InterProi IPR001447. Arylamine_N-AcTrfase.
[Graphical view ]
PANTHERi PTHR11786. PTHR11786. 1 hit.
Pfami PF00797. Acetyltransf_2. 1 hit.
[Graphical view ]
PRINTSi PR01543. ANATRNSFRASE.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression."
    Blum M., Grant D.M., McBride W., Heim M., Meyer U.A.
    DNA Cell Biol. 9:193-203(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
    Tissue: Leukocyte.
  2. "Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver."
    Ohsako S., Deguchi T.
    J. Biol. Chem. 265:4630-4634(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS NAT1*5 THR-117 AND 166-THR-GLN-167.
    Tissue: Liver.
  3. "Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus."
    Vatsis K.P., Weber W.W.
    Arch. Biochem. Biophys. 301:71-76(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
  4. "Identification of a novel allele at the human NAT1 acetyltransferase locus."
    Doll M.A., Jiang W., Deitz A.C., Rustan T.D., Hein D.W.
    Biochem. Biophys. Res. Commun. 233:584-591(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
    Tissue: Blood.
  5. "Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations."
    Butcher N.J., Ilett K.F., Minchin R.F.
    Pharmacogenetics 8:67-72(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*17 TRP-64 AND NAT1*14 GLN-187.
  6. "Homo sapiens N-acetyltransferase-1 (NAT1) gene complete cds."
    Deitz A.C., Fretland A.J., Leff M.A., Doll M.A., Hein D.W.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay."
    Lo-Guidice J.-M., Allorge D., Chevalier D., Debuysere H., Fazio F., Lafitte J.-J., Broly F.
    Pharmacogenetics 10:293-300(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, allele NAT1*11B."
    Johnson N., Sim E.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
  9. "Homo sapiens arylamine N-acetyltransferase type 1 (NAT1) gene, NAT1*4 allele."
    Johnson N., Sim E.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE NAT1*4).
  10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NAT1*11 ILE-149 AND ALA-214.
  11. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  12. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-149 AND ALA-214.
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  14. "Structure and restriction fragment length polymorphism of genes for human liver arylamine N-acetyltransferases."
    Ebisawa T., Deguchi T.
    Biochem. Biophys. Res. Commun. 177:1252-1257(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22.
    Tissue: Liver.
  15. "Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis."
    Delomenie C., Goodfellow G.H., Krishnamoorthy R., Grant D.M., Dupret J.-M.
    Biochem. J. 323:207-215(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-64.
  16. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases."
    Wu H., Dombrovsky L., Tempel W., Martin F., Loppnau P., Goodfellow G.H., Grant D.M., Plotnikov A.N.
    J. Biol. Chem. 282:30189-30197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF WILD-TYPE IN COMPLEX WITH 2-BROMOACETANILIDE AND OF MUTANT SER-125, IDENTIFICATION BY MASS SPECTROMETRY.
  18. "Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe."
    Hughes N.C., Janezic S.A., McQueen K.L., Jewett M.A., Castranio T., Bell D.A., Grant D.M.
    Pharmacogenetics 8:55-66(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NAT1*14 GLN-187.
  19. "Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas."
    Lin H.J., Probst-Hensch N.M., Hughes N.C., Sakamoto G.T., Louie A.D., Kau I.H., Lin B.K., Lee D.B., Lin J., Frankl H.D., Lee E.R., Hardy S., Grant D.M., Haile R.W.
    Pharmacogenetics 8:269-281(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS NAT1*17; NAT1*21; NAT1*22; NAT1*24 AND NAT1*25.

Entry informationi

Entry nameiARY1_HUMAN
AccessioniPrimary (citable) accession number: P18440
Secondary accession number(s): A8K4E7
, O15159, O15300, Q546N1, Q96TE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme.

Caution

The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by the nomenclature committee.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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