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Protein

T-cell surface glycoprotein CD3 delta chain

Gene

CD3D

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The CD3 complex mediates signal transduction.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD3 delta chain
Alternative name(s):
T-cell receptor T3 delta chain
CD_antigen: CD3d
Gene namesi
Name:CD3D
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 100ExtracellularSequence analysisAdd BLAST79
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 167CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001649222 – 167T-cell surface glycoprotein CD3 delta chainAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 73By similarity
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Modified residuei145PhosphotyrosinePROSITE-ProRule annotationBy similarity1
Modified residuei156PhosphotyrosinePROSITE-ProRule annotationBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP18438.

Interactioni

Subunit structurei

The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 29Combined sources8
Beta strandi32 – 36Combined sources5
Beta strandi38 – 40Combined sources3
Beta strandi42 – 46Combined sources5
Beta strandi51 – 58Combined sources8
Beta strandi68 – 72Combined sources5
Beta strandi75 – 77Combined sources3
Beta strandi81 – 86Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMWNMR-A22-88[»]
ProteinModelPortaliP18438.
SMRiP18438.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18438.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 162ITAMPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005278.
KOiK06450.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHSRCLSCL ILAALLSQVN PRALEVLEAE DKVILKCNSS ITLLQGTAGQ
60 70 80 90 100
EVSDNKTLNL GKRIEDPRGM YQCGENAKSF TLQVYYRMCQ NCVELDSATL
110 120 130 140 150
AGLIITDIIA TVLLALGVYC FAGHETGRFS RAADTQVLMG NDQLYQPLRE
160
RNDAQYSRLG DKWARNK
Length:167
Mass (Da):18,562
Last modified:November 1, 1990 - v1
Checksum:i35D55493AE369714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52993 mRNA. Translation: CAA37182.1.
PIRiB43547. RWSHD3.
RefSeqiNP_001009382.1. NM_001009382.1.
UniGeneiOar.427.

Genome annotation databases

GeneIDi443397.
KEGGioas:443397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52993 mRNA. Translation: CAA37182.1.
PIRiB43547. RWSHD3.
RefSeqiNP_001009382.1. NM_001009382.1.
UniGeneiOar.427.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XMWNMR-A22-88[»]
ProteinModelPortaliP18438.
SMRiP18438.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP18438.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443397.
KEGGioas:443397.

Organism-specific databases

CTDi915.

Phylogenomic databases

HOVERGENiHBG005278.
KOiK06450.

Miscellaneous databases

EvolutionaryTraceiP18438.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015484. CD3_esu/gsu/dsu.
IPR015485. CD3D.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR032052. Ig_4.
IPR003110. Phos_immunorcpt_sig_ITAM.
[Graphical view]
PANTHERiPTHR10570. PTHR10570. 1 hit.
PTHR10570:SF5. PTHR10570:SF5. 1 hit.
PfamiPF16680. Ig_4. 1 hit.
PF02189. ITAM. 1 hit.
[Graphical view]
SMARTiSM00077. ITAM. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS51055. ITAM_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD3D_SHEEP
AccessioniPrimary (citable) accession number: P18438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.