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P18434 (ATP4B_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
gp60-90
Gene names
Name:ATP4B
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Composed of two subunits: alpha (catalytic) and beta.

Subcellular location

Membrane; Single-pass type II membrane protein.

Tissue specificity

Stomach.

Involvement in disease

Note=Parietal cell autoantigen associated with autoimmune gastritis.

Sequence similarities

Belongs to the X(+)/potassium ATPases subunit beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Potassium-transporting ATPase subunit beta
PRO_0000219093

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain58 – 290233Extracellular Potential

Amino acid modifications

Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Glycosylation2211N-linked (GlcNAc...)
Disulfide bond131 ↔ 152 By similarity
Disulfide bond162 ↔ 178 By similarity
Disulfide bond201 ↔ 262 By similarity

Experimental info

Sequence conflict1851R → H AA sequence Ref.2
Sequence conflict2211N → D AA sequence Ref.2

Sequences

Sequence LengthMass (Da)Tools
P18434 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 90DAA9D5B8200590

FASTA29033,076
        10         20         30         40         50         60 
MAALQEKKSC SQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV MSGIFALCIY 

        70         80         90        100        110        120 
VLMRTIDPYT PDYQDQLKSP GVTLRPDVYG EKGLDISYNV SDSTTWAGLA HTLHRFLAGY 

       130        140        150        160        170        180 
SPAAQEGSIN CTSEKYFFQE SFLAPNHTKF SCKFTADMLQ NCSGRPDPTF GFAEGKPCFI 

       190        200        210        220        230        240 
IKMNRIVKFL PGNSTAPRVD CAFLDQPRDG PPLQVEYFPA NGTYSLHYFP YYGKKAQPHY 

       250        260        270        280        290 
SNPLVAAKLL NVPRNRDVVI VCKILAEHVS FDNPHDPYEG KVEFKLKIQK

« Hide

References

[1]"The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump)."
Toh B.-H., Gleeson P.A., Simpson R.J., Moritz R.L., Callaghan J.M., Goldkorn I., Jones C.M., Martinelli T.M., Mu F.-T., Humphris D.C., Pettitt J.M., Mori Y., Masuda T., Sobieszczuk P., Weinstock J., Mantamadiotis T., Baldwin G.S.
Proc. Natl. Acad. Sci. U.S.A. 87:6418-6422(1990) [PubMed: 1974721] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Location of the carbohydrates present in the HK-ATPase vesicles isolated from hog gastric mucosa."
Hall K., Perez G., Anderson D., Gutierrez C., Munson K., Hersey S.J., Kaplan J.H., Sachs G.
Biochemistry 29:701-706(1990) [PubMed: 2159787] [Abstract]
Cited for: PROTEIN SEQUENCE OF 175-190 AND 216-245.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M35497 mRNA. Translation: AAA31040.1.
PIRA36021.
RefSeqNP_001001258.1. NM_001001258.1.
UniGeneSsc.227.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2XZBelectron microscopy7.00B1-290[»]
ProteinModelPortalP18434.
ModBaseSearch...

Protein-protein interaction databases

STRINGP18434.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397131.
KEGGssc:100620548.
ssc:397131.

Organism-specific databases

CTD496.

Phylogenomic databases

GeneTreeENSGT00550000074530.
HOVERGENHBG050603.
OrthoDBEOG4TXBS9.

Family and domain databases

InterProIPR000402. ATPase_P-typ_cation-exchng_bsu.
[Graphical view]
KOK01543.
PANTHERPTHR11523. ATPase_H_Na/K_b. 1 hit.
PfamPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATP4B_PIG
AccessionPrimary (citable) accession number: P18434
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 14, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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