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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-SSC-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
gp60-90
Gene namesi
Name:ATP4B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 290ExtracellularSequence analysisAdd BLAST233

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Parietal cell autoantigen associated with autoimmune gastritis.1 Publication

Chemistry databases

ChEMBLiCHEMBL2538

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190931 – 290Potassium-transporting ATPase subunit betaAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 1521 Publication
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 262By similarity
Glycosylationi221N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18434
PeptideAtlasiP18434
PRIDEiP18434

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

BgeeiENSSSCG00000009561
GenevisibleiP18434 SS

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010209

Chemistry databases

BindingDBiP18434

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZBelectron microscopy7.00B1-290[»]
2YN9electron microscopy8.00B1-290[»]
3IXZelectron microscopy6.50B1-290[»]
4UX1electron microscopy8.00B1-290[»]
4UX2electron microscopy7.00B1-290[»]
5Y0Belectron microscopy6.70B1-290[»]
ProteinModelPortaliP18434
SMRiP18434
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18434

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 290immunoglobulin-likeBy similarityAdd BLAST97

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927 Eukaryota
ENOG411150A LUCA
GeneTreeiENSGT00550000074530
HOGENOMiHOG000039248
HOVERGENiHBG050603
InParanoidiP18434
KOiK01543
OMAiHYFPYYG
OrthoDBiEOG091G0DJ4
TreeFamiTF314618

Family and domain databases

Gene3Di2.60.40.1660, 1 hit
InterProiView protein in InterPro
IPR000402 Na/K_ATPase_sub_beta
IPR038702 Na/K_ATPase_sub_beta_sf
PANTHERiPTHR11523 PTHR11523, 1 hit
PfamiView protein in Pfam
PF00287 Na_K-ATPase, 1 hit
TIGRFAMsiTIGR01107 Na_K_ATPase_bet, 1 hit
PROSITEiView protein in PROSITE
PS00390 ATPASE_NA_K_BETA_1, 1 hit
PS00391 ATPASE_NA_K_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P18434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MSGIFALCIY VLMRTIDPYT PDYQDQLKSP GVTLRPDVYG EKGLDISYNV
110 120 130 140 150
SDSTTWAGLA HTLHRFLAGY SPAAQEGSIN CTSEKYFFQE SFLAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGRPDPTF GFAEGKPCFI IKMNRIVKFL PGNSTAPRVD
210 220 230 240 250
CAFLDQPRDG PPLQVEYFPA NGTYSLHYFP YYGKKAQPHY SNPLVAAKLL
260 270 280 290
NVPRNRDVVI VCKILAEHVS FDNPHDPYEG KVEFKLKIQK
Length:290
Mass (Da):33,076
Last modified:November 1, 1990 - v1
Checksum:i90DAA9D5B8200590
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185R → H AA sequence (PubMed:2159787).Curated1
Sequence conflicti221N → D AA sequence (PubMed:2159787).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35497 mRNA Translation: AAA31040.1
PIRiA36021
RefSeqiNP_001001258.1, NM_001001258.1
XP_005653896.1, XM_005653839.2
UniGeneiSsc.227

Genome annotation databases

EnsembliENSSSCT00000010481; ENSSSCP00000010209; ENSSSCG00000009561
GeneIDi397131
KEGGissc:397131

Similar proteinsi

Entry informationi

Entry nameiATP4B_PIG
AccessioniPrimary (citable) accession number: P18434
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health