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Protein

Potassium-transporting ATPase subunit beta

Gene

ATP4B

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-SSC-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase subunit beta
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit beta
Proton pump beta chain
gp60-90
Gene namesi
Name:ATP4B
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 11

Subcellular locationi

  • Cell membrane 1 Publication; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini58 – 290ExtracellularSequence analysisAdd BLAST233

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Parietal cell autoantigen associated with autoimmune gastritis.

Chemistry databases

ChEMBLiCHEMBL2538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190931 – 290Potassium-transporting ATPase subunit betaAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi131 ↔ 1521 Publication
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi162 ↔ 178By similarity
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 262By similarity
Glycosylationi221N-linked (GlcNAc...)1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18434.
PeptideAtlasiP18434.
PRIDEiP18434.

Expressioni

Tissue specificityi

Stomach.

Gene expression databases

BgeeiENSSSCG00000009561.
GenevisibleiP18434. SS.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010209.

Chemistry databases

BindingDBiP18434.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZBelectron microscopy7.00B1-290[»]
2YN9electron microscopy8.00B1-290[»]
3IXZelectron microscopy6.50B1-290[»]
4UX1electron microscopy8.00B1-290[»]
4UX2electron microscopy7.00B1-290[»]
ProteinModelPortaliP18434.
SMRiP18434.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18434.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni194 – 290immunoglobulin-likeBy similarityAdd BLAST97

Domaini

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18434.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQEKKSC SQRMEEFQRY CWNPDTGQML GRTLSRWVWI SLYYVAFYVV
60 70 80 90 100
MSGIFALCIY VLMRTIDPYT PDYQDQLKSP GVTLRPDVYG EKGLDISYNV
110 120 130 140 150
SDSTTWAGLA HTLHRFLAGY SPAAQEGSIN CTSEKYFFQE SFLAPNHTKF
160 170 180 190 200
SCKFTADMLQ NCSGRPDPTF GFAEGKPCFI IKMNRIVKFL PGNSTAPRVD
210 220 230 240 250
CAFLDQPRDG PPLQVEYFPA NGTYSLHYFP YYGKKAQPHY SNPLVAAKLL
260 270 280 290
NVPRNRDVVI VCKILAEHVS FDNPHDPYEG KVEFKLKIQK
Length:290
Mass (Da):33,076
Last modified:November 1, 1990 - v1
Checksum:i90DAA9D5B8200590
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185R → H AA sequence (PubMed:2159787).Curated1
Sequence conflicti221N → D AA sequence (PubMed:2159787).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35497 mRNA. Translation: AAA31040.1.
PIRiA36021.
RefSeqiNP_001001258.1. NM_001001258.1.
XP_005653896.1. XM_005653839.2.
UniGeneiSsc.227.

Genome annotation databases

EnsembliENSSSCT00000010481; ENSSSCP00000010209; ENSSSCG00000009561.
GeneIDi397131.
KEGGissc:397131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35497 mRNA. Translation: AAA31040.1.
PIRiA36021.
RefSeqiNP_001001258.1. NM_001001258.1.
XP_005653896.1. XM_005653839.2.
UniGeneiSsc.227.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XZBelectron microscopy7.00B1-290[»]
2YN9electron microscopy8.00B1-290[»]
3IXZelectron microscopy6.50B1-290[»]
4UX1electron microscopy8.00B1-290[»]
4UX2electron microscopy7.00B1-290[»]
ProteinModelPortaliP18434.
SMRiP18434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010209.

Chemistry databases

BindingDBiP18434.
ChEMBLiCHEMBL2538.

Proteomic databases

PaxDbiP18434.
PeptideAtlasiP18434.
PRIDEiP18434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000010481; ENSSSCP00000010209; ENSSSCG00000009561.
GeneIDi397131.
KEGGissc:397131.

Organism-specific databases

CTDi496.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiP18434.
KOiK01543.
OMAiCKFTADM.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-SSC-936837. Ion transport by P-type ATPases.

Miscellaneous databases

EvolutionaryTraceiP18434.
PROiP18434.

Gene expression databases

BgeeiENSSSCG00000009561.
GenevisibleiP18434. SS.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4B_PIG
AccessioniPrimary (citable) accession number: P18434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.