P18433 (PTPRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase alpha
Short name=Protein-tyrosine phosphatase alpha
Short name=R-PTP-alpha
EC=3.1.3.48

Gene names

Name:	PTPRA
Synonyms:	PTPA, PTPRL2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	802 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara protein phosphorylation Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P18433-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P18433-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     139-147: Missing.

Isoform 3 (identifier: P18433-3)

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: S → SGNSDSKDRR
     179-187: Missing.

Isoform 4 (identifier: P18433-4)

The sequence of this isoform differs from the canonical sequence as follows:
     179-187: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 802	783	Receptor-type tyrosine-protein phosphatase alpha		PRO_0000025433
Regions
	Topological domain	20 – 142	123	Extracellular Potential
	Transmembrane	143 – 165	23	Helical; Potential
	Topological domain	166 – 802	637	Cytoplasmic Potential
	Domain	241 – 501	261	Tyrosine-protein phosphatase 1
	Domain	533 – 791	259	Tyrosine-protein phosphatase 2
	Region	442 – 448	7	Substrate binding By similarity
Sites
	Active site	442	1	Phosphocysteine intermediate By similarity
	Active site	732	1	Phosphocysteine intermediate By similarity
	Binding site	410	1	Substrate By similarity
	Binding site	486	1	Substrate By similarity
Amino acid modifications
	Modified residue	189	1	Phosphoserine By similarity
	Modified residue	213	1	Phosphoserine By similarity
	Modified residue	798	1	Phosphotyrosine Ref.13 Ref.14
	Glycosylation	21	1	N-linked (GlcNAc...) Potential
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
	Glycosylation	68	1	N-linked (GlcNAc...) Potential
	Glycosylation	80	1	N-linked (GlcNAc...) Potential
	Glycosylation	86	1	N-linked (GlcNAc...) Potential
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	124	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	138	1	S → SGNSDSKDRR in isoform 3.		VSP_007776
	Alternative sequence	139 – 147	9	Missing in isoform 2.		VSP_005145
	Alternative sequence	179 – 187	9	Missing in isoform 3 and isoform 4.		VSP_007777
	Natural variant	109	1	P → L. Corresponds to variant rs1178027 [ dbSNP | Ensembl ].		VAR_057134
Experimental info
	Sequence conflict	114	1	T → M in CAA38662. Ref.4
	Sequence conflict	122	1	E → P in CAA37447. Ref.5
	Sequence conflict	289	1	G → E in CAA38662. Ref.4
	Sequence conflict	367	1	V → A in CAA38662. Ref.4
	Sequence conflict	493	1	F → S in CAA38662. Ref.4
	Sequence conflict	786	1	K → E in CAA38662. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 1, 1991. Version 2. Checksum: 8E964C3B56B5BE32	FASTA	802	90,600
	10 20 30 40 50 60 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS 70 80 90 100 110 120 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 130 140 150 160 170 180 WEGNSSTAAT TPETFPPSDE TPIIAVMVAL SSLLVIVFII IVLYMLRFKK YKQAGSHSNS 190 200 210 220 230 240 KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL 250 260 270 280 290 300 FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF 310 320 330 340 350 360 INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW 370 380 390 400 410 420 TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM 430 440 450 460 470 480 LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ 490 500 510 520 530 540 RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL 550 560 570 580 590 600 TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK 610 620 630 640 650 660 DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV 670 680 690 700 710 720 ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ 730 740 750 760 770 780 QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ 790 800 YEFCYKVVQE YIDAFSDYAN FK
	Isoform 2 (Short) [UniParc]. Checksum: F49533B2022536E0	FASTA	793	89,630
	10 20 30 40 50 60 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS 70 80 90 100 110 120 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 130 140 150 160 170 180 WEGNSSTAAT TPETFPPSVA LSSLLVIVFI IIVLYMLRFK KYKQAGSHSN SKQAGSHSNS 190 200 210 220 230 240 FRLSNGRTED VEPQSVPLLA RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP 250 260 270 280 290 300 ACPIQATCEA ASKEENKEKN RYVNILPYDH SRVHLTPVEG VPDSDYINAS FINGYQEKNK 310 320 330 340 350 360 FIAAQGPKEE TVNDFWRMIW EQNTATIVMV TNLKERKECK CAQYWPDQGC WTYGNIRVSV 370 380 390 400 410 420 EDVTVLVDYT VRKFCIQQVG DMTNRKPQRL ITQFHFTSWP DFGVPFTPIG MLKFLKKVKA 430 440 450 460 470 480 CNPQYAGAIV VHCSAGVGRT GTFVVIDAML DMMHTERKVD VYGFVSRIRA QRCQMVQTDM 490 500 510 520 530 540 QYVFIYQALL EHYLYGDTEL EVTSLETHLQ KIYNKIPGTS NNGLEEEFKK LTSIKIQNDK 550 560 570 580 590 600 MRTGNLPANM KKNRVLQIIP YEFNRVIIPV KRGEENTDYV NASFIDGYRQ KDSYIASQGP 610 620 630 640 650 660 LLHTIEDFWR MIWEWKSCSI VMLTELEERG QEKCAQYWPS DGLVSYGDIT VELKKEEECE 670 680 690 700 710 720 SYTVRDLLVT NTRENKSRQI RQFHFHGWPE VGIPSDGKGM ISIIAAVQKQ QQQSGNHPIT 730 740 750 760 770 780 VHCSAGAGRT GTFCALSTVL ERVKAEGILD VFQTVKSLRL QRPHMVQTLE QYEFCYKVVQ 790 EYIDAFSDYA NFK
	Isoform 3 [UniParc]. Checksum: D1E6A5E86FE4D3F0	FASTA	802	90,719
	10 20 30 40 50 60 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS 70 80 90 100 110 120 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 130 140 150 160 170 180 WEGNSSTAAT TPETFPPSGN SDSKDRRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY 190 200 210 220 230 240 KQAGSHSNSF RLSNGRTEDV EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL 250 260 270 280 290 300 FREEFNALPA CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF 310 320 330 340 350 360 INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC AQYWPDQGCW 370 380 390 400 410 420 TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI TQFHFTSWPD FGVPFTPIGM 430 440 450 460 470 480 LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ 490 500 510 520 530 540 RCQMVQTDMQ YVFIYQALLE HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL 550 560 570 580 590 600 TSIKIQNDKM RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK 610 620 630 640 650 660 DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD GLVSYGDITV 670 680 690 700 710 720 ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV GIPSDGKGMI SIIAAVQKQQ 730 740 750 760 770 780 QQSGNHPITV HCSAGAGRTG TFCALSTVLE RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ 790 800 YEFCYKVVQE YIDAFSDYAN FK
	Isoform 4 [UniParc]. Checksum: 487CCC1C06F6E860	FASTA	793	89,703
	10 20 30 40 50 60 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS 70 80 90 100 110 120 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 130 140 150 160 170 180 WEGNSSTAAT TPETFPPSDE TPIIAVMVAL SSLLVIVFII IVLYMLRFKK YKQAGSHSNS 190 200 210 220 230 240 FRLSNGRTED VEPQSVPLLA RSPSTNRKYP PLPVDKLEEE INRRMADDNK LFREEFNALP 250 260 270 280 290 300 ACPIQATCEA ASKEENKEKN RYVNILPYDH SRVHLTPVEG VPDSDYINAS FINGYQEKNK 310 320 330 340 350 360 FIAAQGPKEE TVNDFWRMIW EQNTATIVMV TNLKERKECK CAQYWPDQGC WTYGNIRVSV 370 380 390 400 410 420 EDVTVLVDYT VRKFCIQQVG DMTNRKPQRL ITQFHFTSWP DFGVPFTPIG MLKFLKKVKA 430 440 450 460 470 480 CNPQYAGAIV VHCSAGVGRT GTFVVIDAML DMMHTERKVD VYGFVSRIRA QRCQMVQTDM 490 500 510 520 530 540 QYVFIYQALL EHYLYGDTEL EVTSLETHLQ KIYNKIPGTS NNGLEEEFKK LTSIKIQNDK 550 560 570 580 590 600 MRTGNLPANM KKNRVLQIIP YEFNRVIIPV KRGEENTDYV NASFIDGYRQ KDSYIASQGP 610 620 630 640 650 660 LLHTIEDFWR MIWEWKSCSI VMLTELEERG QEKCAQYWPS DGLVSYGDIT VELKKEEECE 670 680 690 700 710 720 SYTVRDLLVT NTRENKSRQI RQFHFHGWPE VGIPSDGKGM ISIIAAVQKQ QQQSGNHPIT 730 740 750 760 770 780 VHCSAGAGRT GTFCALSTVL ERVKAEGILD VFQTVKSLRL QRPHMVQTLE QYEFCYKVVQ 790 EYIDAFSDYA NFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a widely expressed receptor tyrosine phosphatase." Sap J., D'Eustachio P., Givol D., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:6112-6116(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain." Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]	"Structural diversity and evolution of human receptor-like protein tyrosine phosphatases." Krueger N.X., Streuli M., Saito H. EMBO J. 9:3241-3252(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[4]	"Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)." Ohagi S., Nishi M., Steiner D.F. Nucleic Acids Res. 18:7159-7159(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Kidney.
[5]	"Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase." Jirik F.R., Janzen N.M., Melhado I.G., Harder K.W. FEBS Lett. 273:239-242(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Thalamus.
[7]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph node.
[8]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Skin.
[11]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34668 mRNA. Translation: AAA36528.1. X54130 mRNA. Translation: CAA38065.1. X54890 mRNA. Translation: CAA38662.1. X53364 mRNA. Translation: CAA37447.1. AK290233 mRNA. Translation: BAF82922.1. BX571753 mRNA. Translation: CAE11878.1. AL121905 Genomic DNA. Translation: CAC10336.1. AL121905 Genomic DNA. Translation: CAC10337.1. CH471133 Genomic DNA. Translation: EAX10562.1. CH471133 Genomic DNA. Translation: EAX10563.1. BC027308 mRNA. Translation: AAH27308.1.
IPI	IPI00221067. IPI00304030. IPI00843944. IPI01011765.
PIR	A36065.
RefSeq	NP_002827.1. NM_002836.3. NP_543030.1. NM_080840.2. NP_543031.1. NM_080841.2.
UniGene	Hs.269577.
3D structure databases
ProteinModelPortal	P18433.
ModBase	Search...
Protein-protein interaction databases
IntAct	P18433. 3 interactions.
MINT	MINT-138874.
STRING	9606.ENSP00000369756.
PTM databases
PhosphoSite	P18433.
Polymorphism databases
DMDM	126467.
Proteomic databases
PaxDb	P18433.
PRIDE	P18433.
Protocols and materials databases
DNASU	5786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216877; ENSP00000216877; ENSG00000132670. ENST00000318266; ENSP00000314568; ENSG00000132670. ENST00000356147; ENSP00000348468; ENSG00000132670. ENST00000380393; ENSP00000369756; ENSG00000132670. ENST00000399903; ENSP00000382787; ENSG00000132670.
GeneID	5786.
KEGG	hsa:5786.
UCSC	uc002whj.3. human. uc002whk.3. human. uc002whm.3. human.
Organism-specific databases
CTD	5786.
GeneCards	GC20P002844.
HGNC	HGNC:9664. PTPRA.
HPA	HPA029412.
MIM	176884. gene.
neXtProt	NX_P18433.
PharmGKB	PA34009.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5599.
HOGENOM	HOG000231464.
HOVERGEN	HBG053758.
InParanoid	P18433.
KO	K01104.
Enzyme and pathway databases
Pathway_Interaction_DB	insulin_pathway. Insulin Pathway.
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P18433.
Bgee	P18433.
CleanEx	HS_PTPRA.
Genevestigator	P18433.
GermOnline	ENSG00000132670. Homo sapiens.
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. IPR016336. Tyr_Pase_rcpt_a/e-type. IPR027262. Tyr_Pase_rcpt_alpha. [Graphical view]
Pfam	PF00102. Y_phosphatase. 2 hits. [Graphical view]
PIRSF	PIRSF500808. PTPR_alpha. 1 hit. PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTS	PR00700. PRTYPHPHTASE.
SMART	SM00194. PTPc. 2 hits. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P18433.
ChEMBL	CHEMBL3918.
ChiTaRS	PTPRA. human.
GenomeRNAi	5786.
NextBio	22506.
SOURCE	Search...

Entry information

Entry name

PTPRA_HUMAN

Accession

Primary (citable) accession number: P18433
Secondary accession number(s): A8K2G8 , D3DVX5, Q14513, Q7Z2I2, Q96TD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1991
Last modified:	May 1, 2013
This is version 148 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.