Reviewed,
UniProtKB/Swiss-Prot P18433 (PTPRA_HUMAN)
Last modified
June 16, 2009.
Version 108.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Receptor-type tyrosine-protein phosphatase alpha Short name=Protein-tyrosine phosphatase alpha Short name=R-PTP-alpha EC=3.1.3.48 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 802 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily. Contains 2 tyrosine-protein phosphatase domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Repeat Signal Transmembrane |
| Molecular function | Hydrolase Protein phosphatase |
| PTM | Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylationInferred from electronic annotation. Source: InterPro |
| Cellular component | integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc |
| Molecular function | transmembrane receptor protein tyrosine phosphatase activity Ref.2 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: P18433-1) Also known as: Long; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P18433-2) Also known as: Short; The sequence of this isoform differs from the canonical sequence as follows: 139-147: Missing. | ||||||
| Isoform 3 (identifier: P18433-3) The sequence of this isoform differs from the canonical sequence as follows: 138-138: S → SGNSDSKDRR 179-187: Missing. | ||||||
| Isoform 4 (identifier: P18433-4) The sequence of this isoform differs from the canonical sequence as follows: 179-187: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||
| Chain | 20 – 802 | 783 | Receptor-type tyrosine-protein phosphatase alpha | PRO_0000025433 | |||||
Regions | |||||||||
| Topological domain | 20 – 142 | 123 | Extracellular Potential | ||||||
| Transmembrane | 143 – 165 | 23 | Potential | ||||||
| Topological domain | 166 – 802 | 637 | Cytoplasmic Potential | ||||||
| Domain | 241 – 501 | 261 | Tyrosine-protein phosphatase 1 | ||||||
| Domain | 533 – 791 | 259 | Tyrosine-protein phosphatase 2 | ||||||
Sites | |||||||||
| Active site | 442 | 1 | Phosphocysteine intermediate By similarity | ||||||
| Active site | 732 | 1 | Phosphocysteine intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 180 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 189 | 1 | Phosphoserine Ref.11 | ||||||
| Modified residue | 213 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 798 | 1 | Phosphotyrosine Ref.9 Ref.10 Ref.12 | ||||||
| Glycosylation | 21 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 36 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 68 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 80 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 86 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 104 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 124 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 138 | 1 | S → SGNSDSKDRR in isoform 3. | VSP_007776 | |||||
| Alternative sequence | 139 – 147 | 9 | Missing in isoform 2. | VSP_005145 | |||||
| Alternative sequence | 179 – 187 | 9 | Missing in isoform 3 and isoform 4. | VSP_007777 | |||||
| Natural variant | 109 | 1 | P → L: dbSNP rs1178027. | VAR_057134 | |||||
Experimental info | |||||||||
| Sequence conflict | 114 | 1 | T → M in CAA38662. Ref.4 | ||||||
| Sequence conflict | 122 | 1 | E → P in CAA37447. Ref.5 | ||||||
| Sequence conflict | 289 | 1 | G → E in CAA38662. Ref.4 | ||||||
| Sequence conflict | 367 | 1 | V → A in CAA38662. Ref.4 | ||||||
| Sequence conflict | 493 | 1 | F → S in CAA38662. Ref.4 | ||||||
| Sequence conflict | 786 | 1 | K → E in CAA38662. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and expression of a widely expressed receptor tyrosine phosphatase." Sap J., D'Eustachio P., Givol D., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:6112-6116(1990) [PubMed: 2166945] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain." Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J. Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1990) [PubMed: 2169617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). |
| [3] | "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases." Krueger N.X., Streuli M., Saito H. EMBO J. 9:3241-3252(1990) [PubMed: 2170109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). |
| [4] | "Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)." Ohagi S., Nishi M., Steiner D.F. Nucleic Acids Res. 18:7159-7159(1990) [PubMed: 2175890] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Tissue: Kidney. |
| [5] | "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase." Jirik F.R., Janzen N.M., Melhado I.G., Harder K.W. FEBS Lett. 273:239-242(1990) [PubMed: 2172030] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). |
| [6] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Lymph node. |
| [7] | "The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. Rogers J.Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [8] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Skin. |
| [9] | "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J., Lauffenburger D.A., White F.M. Mol. Cell. Proteomics 4:1240-1250(2005) [PubMed: 15951569] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, MASS SPECTROMETRY. Tissue: Epithelium. |
| [10] | "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, MASS SPECTROMETRY. |
| [11] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, MASS SPECTROMETRY. Tissue: Epithelium. |
| [12] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M34668 mRNA. Translation: AAA36528.1. X54130 mRNA. Translation: CAA38065.1. X54890 mRNA. Translation: CAA38662.1. X53364 mRNA. Translation: CAA37447.1. BX571753 mRNA. Translation: CAE11878.1. AL121905 Genomic DNA. Translation: CAC10336.1. AL121905 Genomic DNA. Translation: CAC10337.1. BC027308 mRNA. Translation: AAH27308.1. | |
| IPI | IPI00221067. IPI00304030. IPI00743698. IPI00843944. |
| PIR | A36065. |
| RefSeq | NP_002827.1. NP_543030.1. NP_543031.1. |
| UniGene | Hs.269577 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1C88 based on UniProtKB P18031. |
| SMR | P18433. Positions 217-504. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P18433. |
Proteomic databases | |
| PRIDE | P18433. |
Genome annotation databases | |
| Ensembl | ENSG00000132670. Homo sapiens. [Contig view] |
| GeneID | 5786. |
| KEGG | hsa:5786. |
Organism-specific databases | |
| GeneCards | GC20P002796. |
| H-InvDB | HIX0021327. |
| HGNC | HGNC:9664. PTPRA. |
| MIM | 176884. gene. |
| PharmGKB | PA34009. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P18433. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.48. 247. |
| Pathway_Interaction_DB | insulin_pathway. Insulin Pathway. |
Gene expression databases | |
| ArrayExpress | P18433. |
| Bgee | P18433. |
| CleanEx | HS_PTPRA. |
| GermOnline | ENSG00000132670. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. IPR016336. Tyr_Pase_rcpt_a/e-type. [Graphical view] |
| Pfam | PF00102. Y_phosphatase. 2 hits. [Graphical view] |
| PIRSF | PIRSF002006. PTPR_alpha_epsilon. 1 hit. |
| PRINTS | PR00700. PRTYPHPHTASE. |
| SMART | SM00194. PTPc. 2 hits. [Graphical view] |
| PROSITE | PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 22506. |
| SOURCE | Search... |
Entry information
| Entry name | PTPRA_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P18433 Secondary accession number(s): Q14513, Q7Z2I2, Q96TD9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 20 Human chromosome 20: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


