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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

PTPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei410 – 4101SubstrateBy similarity
Active sitei442 – 4421Phosphocysteine intermediateBy similarity
Binding sitei486 – 4861SubstrateBy similarity
Active sitei732 – 7321Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: ProtInc
  2. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. insulin receptor signaling pathway Source: Ensembl
  3. peptidyl-tyrosine dephosphorylation Source: GOC
  4. protein phosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.
ReactomeiREACT_18334. NCAM signaling for neurite out-growth.
SignaLinkiP18433.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:PTPRA
Synonyms:PTPA, PTPRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9664. PTPRA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 142123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei143 – 16523HelicalSequence AnalysisAdd
BLAST
Topological domaini166 – 802637CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
  4. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 802783Receptor-type tyrosine-protein phosphatase alphaPRO_0000025433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Modified residuei211 – 2111PhosphoserineBy similarity
Modified residuei213 – 2131PhosphoserineBy similarity
Modified residuei798 – 7981Phosphotyrosine3 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP18433.
PaxDbiP18433.
PRIDEiP18433.

PTM databases

DEPODiP18433.
PhosphoSiteiP18433.

Expressioni

Gene expression databases

BgeeiP18433.
CleanExiHS_PTPRA.
ExpressionAtlasiP18433. baseline and differential.
GenevestigatoriP18433.

Organism-specific databases

HPAiCAB034366.
HPA029412.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CNTN1P147813EBI-2609645,EBI-2123196From a different organism.
FynP396882EBI-2609645,EBI-524514From a different organism.
GRB2P629938EBI-2609645,EBI-401755
SRCP005234EBI-2609645,EBI-848039From a different organism.
SRCP129314EBI-2609645,EBI-621482

Protein-protein interaction databases

BioGridi111750. 10 interactions.
IntActiP18433. 10 interactions.
MINTiMINT-138874.
STRINGi9606.ENSP00000369756.

Structurei

3D structure databases

ProteinModelPortaliP18433.
SMRiP18433. Positions 217-794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini241 – 501261Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 791259Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni442 – 4487Substrate bindingBy similarity

Sequence similaritiesi

Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18433.
KOiK18032.
OrthoDBiEOG7B31M8.
PhylomeDBiP18433.
TreeFamiTF351829.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18433-1) [UniParc]FASTAAdd to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS
60 70 80 90 100
NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT
110 120 130 140 150
ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSDE TPIIAVMVAL
160 170 180 190 200
SSLLVIVFII IVLYMLRFKK YKQAGSHSNS KQAGSHSNSF RLSNGRTEDV
210 220 230 240 250
EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA
260 270 280 290 300
CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
310 320 330 340 350
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC
360 370 380 390 400
AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI
410 420 430 440 450
TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG
460 470 480 490 500
TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE
510 520 530 540 550
HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM
560 570 580 590 600
RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
610 620 630 640 650
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD
660 670 680 690 700
GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV
710 720 730 740 750
GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE
760 770 780 790 800
RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN

FK
Length:802
Mass (Da):90,600
Last modified:November 1, 1991 - v2
Checksum:i8E964C3B56B5BE32
GO
Isoform 2 (identifier: P18433-2) [UniParc]FASTAAdd to basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     139-147: Missing.

Show »
Length:793
Mass (Da):89,630
Checksum:iF49533B2022536E0
GO
Isoform 3 (identifier: P18433-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: S → SGNSDSKDRR
     179-187: Missing.

Show »
Length:802
Mass (Da):90,719
Checksum:iD1E6A5E86FE4D3F0
GO
Isoform 4 (identifier: P18433-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-187: Missing.

Show »
Length:793
Mass (Da):89,703
Checksum:i487CCC1C06F6E860
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141T → M in CAA38662 (PubMed:2175890).Curated
Sequence conflicti122 – 1221E → P in CAA37447 (PubMed:2172030).Curated
Sequence conflicti289 – 2891G → E in CAA38662 (PubMed:2175890).Curated
Sequence conflicti367 – 3671V → A in CAA38662 (PubMed:2175890).Curated
Sequence conflicti493 – 4931F → S in CAA38662 (PubMed:2175890).Curated
Sequence conflicti786 – 7861K → E in CAA38662 (PubMed:2175890).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti109 – 1091P → L.
Corresponds to variant rs1178027 [ dbSNP | Ensembl ].
VAR_057134

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei138 – 1381S → SGNSDSKDRR in isoform 3. 1 PublicationVSP_007776
Alternative sequencei139 – 1479Missing in isoform 2. CuratedVSP_005145
Alternative sequencei179 – 1879Missing in isoform 3 and isoform 4. 7 PublicationsVSP_007777

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA. Translation: AAA36528.1.
X54130 mRNA. Translation: CAA38065.1.
X54890 mRNA. Translation: CAA38662.1.
X53364 mRNA. Translation: CAA37447.1.
AK290233 mRNA. Translation: BAF82922.1.
BX571753 mRNA. Translation: CAE11878.1.
AL121905 Genomic DNA. Translation: CAC10336.1.
AL121905 Genomic DNA. Translation: CAC10337.1.
CH471133 Genomic DNA. Translation: EAX10562.1.
CH471133 Genomic DNA. Translation: EAX10563.1.
BC027308 mRNA. Translation: AAH27308.1.
CCDSiCCDS13038.1. [P18433-3]
CCDS13039.1. [P18433-4]
PIRiA36065.
RefSeqiNP_002827.1. NM_002836.3. [P18433-3]
NP_543030.1. NM_080840.2. [P18433-4]
NP_543031.1. NM_080841.2. [P18433-4]
UniGeneiHs.269577.

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670. [P18433-4]
ENST00000318266; ENSP00000314568; ENSG00000132670. [P18433-4]
ENST00000356147; ENSP00000348468; ENSG00000132670. [P18433-4]
ENST00000380393; ENSP00000369756; ENSG00000132670. [P18433-3]
ENST00000399903; ENSP00000382787; ENSG00000132670. [P18433-3]
GeneIDi5786.
KEGGihsa:5786.
UCSCiuc002whj.3. human. [P18433-3]
uc002whk.3. human. [P18433-4]
uc002whm.3. human. [P18433-1]

Polymorphism databases

DMDMi126467.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA. Translation: AAA36528.1.
X54130 mRNA. Translation: CAA38065.1.
X54890 mRNA. Translation: CAA38662.1.
X53364 mRNA. Translation: CAA37447.1.
AK290233 mRNA. Translation: BAF82922.1.
BX571753 mRNA. Translation: CAE11878.1.
AL121905 Genomic DNA. Translation: CAC10336.1.
AL121905 Genomic DNA. Translation: CAC10337.1.
CH471133 Genomic DNA. Translation: EAX10562.1.
CH471133 Genomic DNA. Translation: EAX10563.1.
BC027308 mRNA. Translation: AAH27308.1.
CCDSiCCDS13038.1. [P18433-3]
CCDS13039.1. [P18433-4]
PIRiA36065.
RefSeqiNP_002827.1. NM_002836.3. [P18433-3]
NP_543030.1. NM_080840.2. [P18433-4]
NP_543031.1. NM_080841.2. [P18433-4]
UniGeneiHs.269577.

3D structure databases

ProteinModelPortaliP18433.
SMRiP18433. Positions 217-794.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111750. 10 interactions.
IntActiP18433. 10 interactions.
MINTiMINT-138874.
STRINGi9606.ENSP00000369756.

Chemistry

BindingDBiP18433.
ChEMBLiCHEMBL3918.

PTM databases

DEPODiP18433.
PhosphoSiteiP18433.

Polymorphism databases

DMDMi126467.

Proteomic databases

MaxQBiP18433.
PaxDbiP18433.
PRIDEiP18433.

Protocols and materials databases

DNASUi5786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670. [P18433-4]
ENST00000318266; ENSP00000314568; ENSG00000132670. [P18433-4]
ENST00000356147; ENSP00000348468; ENSG00000132670. [P18433-4]
ENST00000380393; ENSP00000369756; ENSG00000132670. [P18433-3]
ENST00000399903; ENSP00000382787; ENSG00000132670. [P18433-3]
GeneIDi5786.
KEGGihsa:5786.
UCSCiuc002whj.3. human. [P18433-3]
uc002whk.3. human. [P18433-4]
uc002whm.3. human. [P18433-1]

Organism-specific databases

CTDi5786.
GeneCardsiGC20P002844.
HGNCiHGNC:9664. PTPRA.
HPAiCAB034366.
HPA029412.
MIMi176884. gene.
neXtProtiNX_P18433.
PharmGKBiPA34009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18433.
KOiK18032.
OrthoDBiEOG7B31M8.
PhylomeDBiP18433.
TreeFamiTF351829.

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.
ReactomeiREACT_18334. NCAM signaling for neurite out-growth.
SignaLinkiP18433.

Miscellaneous databases

ChiTaRSiPTPRA. human.
GeneWikiiPTPRA.
GenomeRNAii5786.
NextBioi22506.
PROiP18433.
SOURCEiSearch...

Gene expression databases

BgeeiP18433.
CleanExiHS_PTPRA.
ExpressionAtlasiP18433. baseline and differential.
GenevestigatoriP18433.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of a widely expressed receptor tyrosine phosphatase."
    Sap J., D'Eustachio P., Givol D., Schlessinger J.
    Proc. Natl. Acad. Sci. U.S.A. 87:6112-6116(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain."
    Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J.
    Proc. Natl. Acad. Sci. U.S.A. 87:7000-7004(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases."
    Krueger N.X., Streuli M., Saito H.
    EMBO J. 9:3241-3252(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  4. "Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)."
    Ohagi S., Nishi M., Steiner D.F.
    Nucleic Acids Res. 18:7159-7159(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Kidney.
  5. "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase."
    Jirik F.R., Janzen N.M., Melhado I.G., Harder K.W.
    FEBS Lett. 273:239-242(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Thalamus.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Lymph node.
  8. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Skin.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-798, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPTPRA_HUMAN
AccessioniPrimary (citable) accession number: P18433
Secondary accession number(s): A8K2G8
, D3DVX5, Q14513, Q7Z2I2, Q96TD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1991
Last modified: April 1, 2015
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.