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Protein

Receptor-type tyrosine-protein phosphatase alpha

Gene

PTPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei410SubstrateBy similarity1
Active sitei442Phosphocysteine intermediateBy similarity1
Binding sitei486SubstrateBy similarity1
Active sitei732Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: ProtInc
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS05671-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-5673001. RAF/MAP kinase cascade.
SignaLinkiP18433.
SIGNORiP18433.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase alpha (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase alpha
Short name:
R-PTP-alpha
Gene namesi
Name:PTPRA
Synonyms:PTPA, PTPRL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:9664. PTPRA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 142ExtracellularSequence analysisAdd BLAST123
Transmembranei143 – 165HelicalSequence analysisAdd BLAST23
Topological domaini166 – 802CytoplasmicSequence analysisAdd BLAST637

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
  • receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5786.
OpenTargetsiENSG00000132670.
PharmGKBiPA34009.

Chemistry databases

ChEMBLiCHEMBL3918.

Polymorphism and mutation databases

BioMutaiPTPRA.
DMDMi126467.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002543320 – 802Receptor-type tyrosine-protein phosphatase alphaAdd BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi86N-linked (GlcNAc...)Sequence analysis1
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Modified residuei211PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei798PhosphotyrosineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP18433.
PaxDbiP18433.
PeptideAtlasiP18433.
PRIDEiP18433.

PTM databases

DEPODiP18433.
iPTMnetiP18433.
PhosphoSitePlusiP18433.

Expressioni

Gene expression databases

BgeeiENSG00000132670.
CleanExiHS_PTPRA.
ExpressionAtlasiP18433. baseline and differential.
GenevisibleiP18433. HS.

Organism-specific databases

HPAiCAB034366.
HPA029412.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CNTN1P147813EBI-2609645,EBI-2123196From a different organism.
FynP396882EBI-2609645,EBI-524514From a different organism.
GRB2P629938EBI-2609645,EBI-401755
SRCP005234EBI-2609645,EBI-848039From a different organism.
SRCP129314EBI-2609645,EBI-621482

Protein-protein interaction databases

BioGridi111750. 21 interactors.
IntActiP18433. 13 interactors.
MINTiMINT-138874.
STRINGi9606.ENSP00000369756.

Chemistry databases

BindingDBiP18433.

Structurei

3D structure databases

ProteinModelPortaliP18433.
SMRiP18433.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 501Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST261
Domaini533 – 791Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST259

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni442 – 448Substrate bindingBy similarity7

Sequence similaritiesi

Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18433.
KOiK18032.
OMAiFNRVIIP.
OrthoDBiEOG091G02ID.
PhylomeDBiP18433.
TreeFamiTF351829.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P18433-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS
60 70 80 90 100
NPTSSLTSLS VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT
110 120 130 140 150
ISPNGTWLPD NQFTDARTEP WEGNSSTAAT TPETFPPSDE TPIIAVMVAL
160 170 180 190 200
SSLLVIVFII IVLYMLRFKK YKQAGSHSNS KQAGSHSNSF RLSNGRTEDV
210 220 230 240 250
EPQSVPLLAR SPSTNRKYPP LPVDKLEEEI NRRMADDNKL FREEFNALPA
260 270 280 290 300
CPIQATCEAA SKEENKEKNR YVNILPYDHS RVHLTPVEGV PDSDYINASF
310 320 330 340 350
INGYQEKNKF IAAQGPKEET VNDFWRMIWE QNTATIVMVT NLKERKECKC
360 370 380 390 400
AQYWPDQGCW TYGNIRVSVE DVTVLVDYTV RKFCIQQVGD MTNRKPQRLI
410 420 430 440 450
TQFHFTSWPD FGVPFTPIGM LKFLKKVKAC NPQYAGAIVV HCSAGVGRTG
460 470 480 490 500
TFVVIDAMLD MMHTERKVDV YGFVSRIRAQ RCQMVQTDMQ YVFIYQALLE
510 520 530 540 550
HYLYGDTELE VTSLETHLQK IYNKIPGTSN NGLEEEFKKL TSIKIQNDKM
560 570 580 590 600
RTGNLPANMK KNRVLQIIPY EFNRVIIPVK RGEENTDYVN ASFIDGYRQK
610 620 630 640 650
DSYIASQGPL LHTIEDFWRM IWEWKSCSIV MLTELEERGQ EKCAQYWPSD
660 670 680 690 700
GLVSYGDITV ELKKEEECES YTVRDLLVTN TRENKSRQIR QFHFHGWPEV
710 720 730 740 750
GIPSDGKGMI SIIAAVQKQQ QQSGNHPITV HCSAGAGRTG TFCALSTVLE
760 770 780 790 800
RVKAEGILDV FQTVKSLRLQ RPHMVQTLEQ YEFCYKVVQE YIDAFSDYAN

FK
Length:802
Mass (Da):90,600
Last modified:November 1, 1991 - v2
Checksum:i8E964C3B56B5BE32
GO
Isoform 2 (identifier: P18433-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     139-147: Missing.

Show »
Length:793
Mass (Da):89,630
Checksum:iF49533B2022536E0
GO
Isoform 3 (identifier: P18433-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-138: S → SGNSDSKDRR
     179-187: Missing.

Show »
Length:802
Mass (Da):90,719
Checksum:iD1E6A5E86FE4D3F0
GO
Isoform 4 (identifier: P18433-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-187: Missing.

Show »
Length:793
Mass (Da):89,703
Checksum:i487CCC1C06F6E860
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114T → M in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti122E → P in CAA37447 (PubMed:2172030).Curated1
Sequence conflicti289G → E in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti367V → A in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti493F → S in CAA38662 (PubMed:2175890).Curated1
Sequence conflicti786K → E in CAA38662 (PubMed:2175890).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057134109P → L.Corresponds to variant rs1178027dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007776138S → SGNSDSKDRR in isoform 3. 1 Publication1
Alternative sequenceiVSP_005145139 – 147Missing in isoform 2. Curated9
Alternative sequenceiVSP_007777179 – 187Missing in isoform 3 and isoform 4. 7 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA. Translation: AAA36528.1.
X54130 mRNA. Translation: CAA38065.1.
X54890 mRNA. Translation: CAA38662.1.
X53364 mRNA. Translation: CAA37447.1.
AK290233 mRNA. Translation: BAF82922.1.
BX571753 mRNA. Translation: CAE11878.1.
AL121905 Genomic DNA. Translation: CAC10336.1.
AL121905 Genomic DNA. Translation: CAC10337.1.
CH471133 Genomic DNA. Translation: EAX10562.1.
CH471133 Genomic DNA. Translation: EAX10563.1.
BC027308 mRNA. Translation: AAH27308.1.
CCDSiCCDS13038.1. [P18433-3]
CCDS13039.1. [P18433-4]
PIRiA36065.
RefSeqiNP_002827.1. NM_002836.3. [P18433-3]
NP_543030.1. NM_080840.2. [P18433-4]
NP_543031.1. NM_080841.2. [P18433-4]
UniGeneiHs.269577.

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670. [P18433-4]
ENST00000318266; ENSP00000314568; ENSG00000132670. [P18433-4]
ENST00000356147; ENSP00000348468; ENSG00000132670. [P18433-4]
ENST00000380393; ENSP00000369756; ENSG00000132670. [P18433-3]
ENST00000399903; ENSP00000382787; ENSG00000132670. [P18433-3]
GeneIDi5786.
KEGGihsa:5786.
UCSCiuc002whj.4. human. [P18433-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34668 mRNA. Translation: AAA36528.1.
X54130 mRNA. Translation: CAA38065.1.
X54890 mRNA. Translation: CAA38662.1.
X53364 mRNA. Translation: CAA37447.1.
AK290233 mRNA. Translation: BAF82922.1.
BX571753 mRNA. Translation: CAE11878.1.
AL121905 Genomic DNA. Translation: CAC10336.1.
AL121905 Genomic DNA. Translation: CAC10337.1.
CH471133 Genomic DNA. Translation: EAX10562.1.
CH471133 Genomic DNA. Translation: EAX10563.1.
BC027308 mRNA. Translation: AAH27308.1.
CCDSiCCDS13038.1. [P18433-3]
CCDS13039.1. [P18433-4]
PIRiA36065.
RefSeqiNP_002827.1. NM_002836.3. [P18433-3]
NP_543030.1. NM_080840.2. [P18433-4]
NP_543031.1. NM_080841.2. [P18433-4]
UniGeneiHs.269577.

3D structure databases

ProteinModelPortaliP18433.
SMRiP18433.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111750. 21 interactors.
IntActiP18433. 13 interactors.
MINTiMINT-138874.
STRINGi9606.ENSP00000369756.

Chemistry databases

BindingDBiP18433.
ChEMBLiCHEMBL3918.

PTM databases

DEPODiP18433.
iPTMnetiP18433.
PhosphoSitePlusiP18433.

Polymorphism and mutation databases

BioMutaiPTPRA.
DMDMi126467.

Proteomic databases

MaxQBiP18433.
PaxDbiP18433.
PeptideAtlasiP18433.
PRIDEiP18433.

Protocols and materials databases

DNASUi5786.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216877; ENSP00000216877; ENSG00000132670. [P18433-4]
ENST00000318266; ENSP00000314568; ENSG00000132670. [P18433-4]
ENST00000356147; ENSP00000348468; ENSG00000132670. [P18433-4]
ENST00000380393; ENSP00000369756; ENSG00000132670. [P18433-3]
ENST00000399903; ENSP00000382787; ENSG00000132670. [P18433-3]
GeneIDi5786.
KEGGihsa:5786.
UCSCiuc002whj.4. human. [P18433-1]

Organism-specific databases

CTDi5786.
DisGeNETi5786.
GeneCardsiPTPRA.
HGNCiHGNC:9664. PTPRA.
HPAiCAB034366.
HPA029412.
MIMi176884. gene.
neXtProtiNX_P18433.
OpenTargetsiENSG00000132670.
PharmGKBiPA34009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000231464.
HOVERGENiHBG053758.
InParanoidiP18433.
KOiK18032.
OMAiFNRVIIP.
OrthoDBiEOG091G02ID.
PhylomeDBiP18433.
TreeFamiTF351829.

Enzyme and pathway databases

BioCyciZFISH:HS05671-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-375165. NCAM signaling for neurite out-growth.
R-HSA-5673001. RAF/MAP kinase cascade.
SignaLinkiP18433.
SIGNORiP18433.

Miscellaneous databases

ChiTaRSiPTPRA. human.
GeneWikiiPTPRA.
GenomeRNAii5786.
PROiP18433.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132670.
CleanExiHS_PTPRA.
ExpressionAtlasiP18433. baseline and differential.
GenevisibleiP18433. HS.

Family and domain databases

Gene3Di3.90.190.10. 2 hits.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR016336. Tyr_Pase_rcpt_a/e-type.
IPR027262. Tyr_Pase_rcpt_alpha.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 2 hits.
[Graphical view]
PIRSFiPIRSF500808. PTPR_alpha. 1 hit.
PIRSF002006. PTPR_alpha_epsilon. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRA_HUMAN
AccessioniPrimary (citable) accession number: P18433
Secondary accession number(s): A8K2G8
, D3DVX5, Q14513, Q7Z2I2, Q96TD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.