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Reviewed, UniProtKB/Swiss-Prot P18431 (SGG_DROME)

Last modified February 9, 2010. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Protein kinase shaggy
    EC=2.7.11.1
Alternative name(s):
    Protein zeste-white 3
Gene names
Name: sgg
Synonyms: zw3
ORF Names: CG2621
OrganismDrosophila melanogaster (Fruit fly) [Complete proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

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Protein attributes

Sequence length1067 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Required for several developmental events such as synctial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for Arm phosphorylation. Wg signaling operates by inactivating the Sgg repression of en autoactivation. Ref.1 Ref.2 Ref.3 Ref.9

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

Expression is over all the embryo at all stages, no local accumulation is observed. Ref.1 Ref.2

Developmental stage

Isoform SGG46 is expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages. Isoform zygotic is expressed maternally and zygotically but reduced throughout later embryonic development. Expression persists throughout larval stages. Isoform SGG39 is expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages. Ref.1 Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence CAA50216.1 differs from that shown. Reason: Miscellaneous discrepancy. Intron retention.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandATP-binding
Nucleotide-binding
   Molecular functionDevelopmental protein
Kinase
Segmentation polarity protein
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNotch signaling pathway

Traceable author statement. Source: FlyBase

Wnt receptor signaling pathway

Traceable author statement. Source: FlyBase

bristle morphogenesis

Non-traceable author statement. Source: FlyBase

entrainment of circadian clock

Inferred from mutant phenotype. Source: FlyBase

habituation

Inferred from mutant phenotype. Source: FlyBase

heart development

Traceable author statement. Source: FlyBase

locomotor rhythm

Non-traceable author statement. Source: FlyBase

negative regulation of Wnt receptor signaling pathway

Traceable author statement. Source: FlyBase

negative regulation of smoothened signaling pathway

Inferred from direct assay. Source: FlyBase

olfactory learning

Inferred from mutant phenotype. Source: FlyBase

ovarian follicle cell development

Inferred from mutant phenotype. Source: FlyBase

protein amino acid phosphorylation

Inferred from direct assay. Source: FlyBase

protein localization

Traceable author statement. Source: FlyBase

regulation of hemocyte differentiation

Inferred from mutant phenotype. Source: FlyBase

regulation of protein import into nucleus

Traceable author statement. Source: FlyBase

regulation of proteolysis

Inferred from direct assay. Source: FlyBase

segment polarity determination

Inferred from mutant phenotype. Source: FlyBase

synaptic growth at neuromuscular junction

Inferred from mutant phenotype. Source: FlyBase

wing and notum subfield formation

Inferred from mutant phenotype. Source: FlyBase

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycogen synthase kinase 3 activity

Non-traceable author statement. Source: FlyBase

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q9VI271EBI-242171,EBI-186590
cryO770592EBI-242141,EBI-94117

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform SGG46 (identifier: P18431-1)

Also known as: Maternal; D;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Zygotic (identifier: P18431-2)

Also known as: B; C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-553: Missing.
     554-582: ENVKTAKLARTQSCVSWTKVVQKFKNILG → MSGRPRTSSFAEGNKQSPSLVLGGVKTCS
Isoform SGG39 (identifier: P18431-3)

Also known as: A; J;

The sequence of this isoform differs from the canonical sequence as follows:
     1-553: Missing.
     554-582: ENVKTAKLARTQSCVSWTKVVQKFKNILG → MSGRPRTSSFAEGNKQSPSLVLGGVKTCS
     1066-1067: DS → GSQSNSALNSSGSGGSGNGEAAGSGSGSGSGSGGGNGGDNDAGDSGAIASGGGAAETEAAASG
Isoform G (identifier: P18431-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-571: Missing.
     572-581: KVVQKFKNIL → MLINRGSLLE
Note: No experimental confirmation available.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10671067Protein kinase shaggy
PRO_0000086641

Regions

Domain607 – 891285Protein kinase
Nucleotide binding613 – 6219ATP By similarity
Compositional bias938 – 1067130Ala/Gly/Ser-rich

Sites

Active site7321Proton acceptor By similarity
Binding site6361ATP By similarity

Amino acid modifications

Modified residue7661Phosphoserine Ref.11
Modified residue7671Phosphotyrosine Ref.11 Ref.8
Modified residue7701Phosphoserine Ref.11

Natural variations

Alternative sequence1 – 571571Missing in isoform G.
VSP_009439
Alternative sequence1 – 553553Missing in isoform Zygotic and isoform SGG39.
VSP_004849
Alternative sequence554 – 58229ENVKT…KNILG → MSGRPRTSSFAEGNKQSPSL VLGGVKTCS in isoform Zygotic and isoform SGG39.
VSP_004850
Alternative sequence572 – 58110KVVQKFKNIL → MLINRGSLLE in isoform G.
VSP_009440
Alternative sequence1066 – 10672DS → GSQSNSALNSSGSGGSGNGE AAGSGSGSGSGSGGGNGGDN DAGDSGAIASGGGAAETEAA ASG in isoform SGG39.
VSP_004851

Experimental info

Sequence conflict91R → A in AAF45801. Ref.4
Sequence conflict91R → A in CAA19676. Ref.6
Sequence conflict91R → A in CAB65860. Ref.6
Sequence conflict1931T → I Ref.3
Sequence conflict257 – 2593Missing Ref.3
Sequence conflict2591Missing in CAA19676. Ref.6
Sequence conflict2591Missing in CAB65860. Ref.6
Sequence conflict539 – 5402AD → RI in CAA37952. Ref.3
Sequence conflict7501C → R in CAA50214. Ref.1
Sequence conflict7971V → I in CAA37419. Ref.2
Sequence conflict9481G → D in CAA50214. Ref.1
Sequence conflict9501A → R in CAA37952. Ref.3
Sequence conflict9591T → A in CAA37419. Ref.2
Sequence conflict9591T → A in AAM50318. Ref.7
Sequence conflict9991A → R in CAA37952. Ref.3
Sequence conflict10151A → R in CAA37952. Ref.3
Sequence conflict1026 – 106742GANAA…NVTDS → EPMPPSLAVLVVVAEPVRRP QLQQQLAL Ref.3
Sequence conflict1066 – 10672DS → GE in CAA19676. Ref.6
Sequence conflict1066 – 10672DS → GE in CAB65860. Ref.6

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Sequences

Sequence LengthMass (Da)Tools
Isoform SGG46 (Maternal) (D) [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: B4E98AFBF4807979

FASTA1,067114,440
        10         20         30         40         50         60 
MATTTTTQRA GAAPALNLLP ASNNNINNTL INNNNNNNNT SNSNNNNNNV ISQPIKIPLT 

        70         80         90        100        110        120 
ERFSSQTSTG SADSGVIVSS ASQQQLQLPP PRSSSGSLSL PQAPPGGKWR QKQQRQQLLL 

       130        140        150        160        170        180 
SQDSGIENGV TTRPSKAKDN QGAGKASHNA TSSKESGAQS NSSSESLGSN CSEAQEQQRV 

       190        200        210        220        230        240 
RASSALELSS VDTPVIVGGV VSGGNSILRS RIKYKSTNST GTQGFDVEDR IDEVDICDDD 

       250        260        270        280        290        300 
DVDCDDRGSE IEEEEEEEED DGVNVDDDVE EADNQSDNQS GIIINLKSQT EQEEEVDEVD 

       310        320        330        340        350        360 
AKPKNRLLPP DQAELTVAAA MARRRDAKSL ATDGHIYFPL LKISEDPHID SKLINRKDGL 

       370        380        390        400        410        420 
QDTMYYLDEF GSPKLREKFA RKQKQLLAKQ QKQLMKRERR SEEQRKKRNT TVASNLAASG 

       430        440        450        460        470        480 
AVVDDTKDDY KQQPHCDTSS RSKNNSVPNP PSSHLHQNHN HLVVDVQEDV DDVNVVATSD 

       490        500        510        520        530        540 
VDSGVVKMRR HSHDNHYDRI PRSNAATITT RPQIDQQSSH HQNTEDVEQG AEPQIDGEAD 

       550        560        570        580        590        600 
LDADADADSD GSGENVKTAK LARTQSCVSW TKVVQKFKNI LGRDGSKITT VVATPGQGTD 

       610        620        630        640        650        660 
RVQEVSYTDT KVIGNGSFGV VFQAKLCDTG ELVAIKKVLQ DRRFKNRELQ IMRKLEHCNI 

       670        680        690        700        710        720 
VKLLYFFYSS GEKRDEVFLN LVLEYIPETV YKVARQYAKT KQTIPINFIR LYMYQLFRSL 

       730        740        750        760        770        780 
AYIHSLGICH RDIKPQNLLL DPETAVLKLC DFGSAKQLLH GEPNVSYICS RYYRAPELIF 

       790        800        810        820        830        840 
GAINYTTKID VWSAGCVLAE LLLGQPIFPG DSGVDQLVEV IKVLGTPTRE QIREMNPNYT 

       850        860        870        880        890        900 
EFKFPQIKSH PWQKVFRIRT PTEAINLVSL LLEYTPSARI TPLKACAHPF FDELRMEGNH 

       910        920        930        940        950        960 
TLPNGRDMPP LFNFTEHELS IQPSLVPQLL PKHLQNASGP GGNRPSAGGA ASIAASGSTS 

       970        980        990       1000       1010       1020 
VSSTGSGASV EGSAQPQSQG TAAAAGSGSG GATAGTGGAS AGGPGSGNNS SSGGASGAPS 

      1030       1040       1050       1060 
AVAAGGANAA VAGGAGGGGG AGAATAAATA TGAIGATNAG GANVTDS

« Hide

Isoform Zygotic (B) (C).

Checksum: 193EE2A1294BE494
Show »

FASTA51453,872
Isoform SGG39 (A) (J).

Checksum: 477B3E036464E4D5
Show »

FASTA57558,772
Isoform G.

Checksum: 8059B6236E7B268D
Show »

FASTA49652,092

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References

« Hide 'large scale' references
[1]"Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila."
Ruel L., Pantesco V., Lutz Y., Simpson P., Bourouis M.
EMBO J. 12:1657-1669(1993) [PubMed: 8467811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SGG39; SGG46 AND ZYGOTIC), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Embryo.
[2]"An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily."
Bourouis M., Moore P., Ruel L., Grau Y., Heitzler P., Simpson P.
EMBO J. 9:2877-2884(1990) [PubMed: 2118107] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ZYGOTIC), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: DP CN BW.
Tissue: Embryo.
[3]"Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3."
Siegfried E., Perkins L.A., Capaci T.M., Perrimon N.
Nature 345:825-829(1990) [PubMed: 2113617] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 193-1067 (ISOFORMS SGG46 AND ZYGOTIC), FUNCTION.
Tissue: Embryo and Ovary.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[6]"From sequence to chromosome: the tip of the X chromosome of D. melanogaster."
Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. expand/collapse author list , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M.
Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Oregon-R.
[7]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS G AND ZYGOTIC).
Strain: Berkeley.
Tissue: Embryo.
[8]"Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation."
Hughes K., Nikolakaki E., Plyte S.E., Totty N.F., Woodgett J.R.
EMBO J. 12:803-808(1993) [PubMed: 8382613] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-767.
[9]"Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase."
Peifer M., Pai L.-M., Casey M.
Dev. Biol. 166:543-556(1994) [PubMed: 7529201] [Abstract]
Cited for: FUNCTION IN PHOSPHORYLATION OF ARM.
[10]"wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate."
Siegfried E., Chou T.B., Perrimon N.
Cell 71:1167-1179(1992) [PubMed: 1335365] [Abstract]
Cited for: INTERACTION WITH WG AND EN.
Tissue: Embryo.
[11]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-766; TYR-767 AND SER-770, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X70862 mRNA. Translation: CAA50212.1.
X70863 mRNA. Translation: CAA50213.1.
X70864 mRNA. Translation: CAA50214.1.
X70865 mRNA. Translation: CAA50215.1.
X70866 mRNA. Translation: CAA50216.1. Sequence problems.
X53332 mRNA. Translation: CAA37419.1.
X54005 mRNA. Translation: CAA37951.1.
X54006 mRNA. Translation: CAA37952.1.
AE014298 Genomic DNA. Translation: AAF45801.2.
AE014298 Genomic DNA. Translation: AAN09082.1.
AE014298 Genomic DNA. Translation: AAN09083.1.
AE014298 Genomic DNA. Translation: AAS65255.1.
AL024485, AL034544 Genomic DNA. Translation: CAA19676.1.
AL121804, AL024485 Genomic DNA. Translation: CAB65860.1.
AL121804, AL024485 Genomic DNA. Translation: CAB72296.1.
AY122193 mRNA. Translation: AAM52705.1.
AY119664 mRNA. Translation: AAM50318.1.
PIRS35325.
S35327.
S35423. S35328.
RefSeqNP_476714.1.
NP_476715.1.
NP_476716.2.
NP_599105.1.
NP_726822.1.
NP_726823.1.
NP_996335.1.
NP_996336.1.
NP_996337.1.
NP_996338.1.

3D structure databases

SMRP18431. Positions 583-933.
ModBaseSearch...

Protein-protein interaction databases

IntActP18431. 8 interactions.
STRINGP18431.

Genome annotation databases

EnsemblFBtr0070466; FBpp0070449; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070467; FBpp0070450; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070468; FBpp0070451; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070469; FBpp0070452; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070470; FBpp0070453; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070471; FBpp0070454; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070472; FBpp0089162; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070473; FBpp0089158; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070474; FBpp0089159; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070475; FBpp0089160; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0070476; FBpp0089161; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0111035; FBpp0110334; FBgn0003371; Drosophila melanogaster. [Genome view]
FBtr0112828; FBpp0111741; FBgn0003371; Drosophila melanogaster. [Genome view]
GeneID31248.

Organism-specific databases

CTD31248.
FlyBaseFBgn0003371. sgg.

Phylogenomic databases

eggNOGinNOG08744.
InParanoidP18431.
OMARHRDERI.
PhylomeDBP18431.

Enzyme and pathway databases

BRENDA2.7.11.1. 48.
2.7.11.26. 48.

Gene expression databases

BgeeP18431.
GermOnlineCG2621. Drosophila melanogaster.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio772634.

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Entry information

Entry nameSGG_DROME
AccessionPrimary (citable) accession number: P18431
Secondary accession number(s): O76881 expand/collapse secondary AC list , P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 21, 2001
Last modified: February 9, 2010
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectDrosophila annotation project

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Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents