UniProtKB - P18431 (SGG_DROME)
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Protein
Protein kinase shaggy
Gene
sgg
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering calcineurin activation via sra phosphorylation. Phosphorylates microtubule-associated protein futsch in axons.8 Publications
Catalytic activityi
ATP + a protein = ADP + a phosphoprotein.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 83 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 179 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 60 – 68 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: FlyBase
GO - Biological processi
- chaeta development Source: FlyBase
- chaeta morphogenesis Source: FlyBase
- chitin-based larval cuticle pattern formation Source: FlyBase
- circadian rhythm Source: FlyBase
- entrainment of circadian clock Source: FlyBase
- epithelial cell morphogenesis Source: FlyBase
- establishment of epithelial cell planar polarity Source: FlyBase
- female meiotic nuclear division Source: FlyBase
- habituation Source: FlyBase
- heart development Source: FlyBase
- imaginal disc-derived wing margin morphogenesis Source: FlyBase
- locomotor rhythm Source: FlyBase
- negative regulation of canonical Wnt signaling pathway Source: FlyBase
- negative regulation of JUN kinase activity Source: FlyBase
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: FlyBase
- negative regulation of smoothened signaling pathway Source: FlyBase
- negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
- olfactory learning Source: FlyBase
- oogenesis Source: FlyBase
- ovarian follicle cell development Source: FlyBase
- positive regulation of mitotic metaphase/anaphase transition Source: FlyBase
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
- positive regulation of protein catabolic process Source: FlyBase
- protein phosphorylation Source: FlyBase
- pseudocleavage involved in syncytial blastoderm formation Source: UniProtKB
- regulation of calcineurin-NFAT signaling cascade Source: UniProtKB
- regulation of circadian rhythm Source: FlyBase
- regulation of hemocyte differentiation Source: FlyBase
- regulation of microtubule cytoskeleton organization Source: UniProtKB
- regulation of protein import into nucleus Source: FlyBase
- regulation of proteolysis Source: FlyBase
- response to anesthetic Source: FlyBase
- rhythmic behavior Source: FlyBase
- segment polarity determination Source: FlyBase
- somatic stem cell population maintenance Source: FlyBase
- spindle organization Source: FlyBase
- synaptic growth at neuromuscular junction Source: FlyBase
- wing and notum subfield formation Source: FlyBase
Keywordsi
Molecular function | Developmental protein, Kinase, Segmentation polarity protein, Serine/threonine-protein kinase, Transferase |
Biological process | Meiosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.26. 1994. |
Reactomei | R-DME-195253. Degradation of beta-catenin by the destruction complex. R-DME-196299. Beta-catenin phosphorylation cascade. R-DME-209155. Phosphorylation of AXN and APC. R-DME-209159. Assembly of the CI containing complexes. R-DME-209190. Phosphorylation of CI. R-DME-209214. Phosphorylation of SMO. R-DME-209360. Ubiquitination and proteolysis of phosphorylated CI. R-DME-209387. Phosphorylation of ARR. R-DME-209396. Phosphorylation of ARM. R-DME-209413. Assembly of the 'destruction complex'. R-DME-209440. Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM. R-DME-209461. Ubiquitination and degradation of phosphorylated ARM. R-DME-3371453. Regulation of HSF1-mediated heat shock response. R-DME-432553. Phosphorylation of PER and TIM. R-DME-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane. R-DME-5610785. GLI3 is processed to GLI3R by the proteasome. |
SignaLinki | P18431. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:sgg Synonyms:gsk3, zw3 ORF Names:CG2621 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0003371. sgg. |
Subcellular locationi
Keywords - Cellular componenti
Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, SynapsePathology & Biotechi
Disruption phenotypei
Mutants display an overdeveloped neuromuscular junction (NMJ), with the number of boutons greatly increased.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 81 | A → T: Increases the amount of synaptic boutons and microtubule loops when expressed presynaptically. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086641 | 1 – 514 | Protein kinase shaggyAdd BLAST | 514 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 213 | Phosphoserine1 Publication | 1 | |
Modified residuei | 214 | Phosphotyrosine2 Publications | 1 | |
Modified residuei | 217 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P18431. |
PRIDEi | P18431. |
PTM databases
iPTMneti | P18431. |
Expressioni
Tissue specificityi
Expressed in ovaries and activated eggs (at protein level). Expression is over all the embryo at all stages, no local accumulation is observed.3 Publications
Developmental stagei
Isoform SGG46 is expressed at low levels in 12-24 hours embryos. Isoform Zygotic and isoform SGG39 are expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages (at protein level). Isoform Zygotic is expressed maternally and zygotically but reduced throughout later embryonic development. Expression persists throughout larval stages.2 Publications
Gene expression databases
Bgeei | FBgn0003371. |
ExpressionAtlasi | P18431. differential. |
Genevisiblei | P18431. DM. |
Interactioni
Subunit structurei
Interacts with cos.2 Publications
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
cry | O77059 | 2 | EBI-242141,EBI-94117 |
Protein-protein interaction databases
BioGridi | 57779. 178 interactors. |
DIPi | DIP-39170N. |
IntActi | P18431. 703 interactors. |
STRINGi | 7227.FBpp0304140. |
Structurei
3D structure databases
ProteinModelPortali | P18431. |
SMRi | P18431. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 338 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 386 – 509 | Ala/Gly-richAdd BLAST | 124 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0658. Eukaryota. COG0515. LUCA. |
GeneTreei | ENSGT00520000055635. |
InParanoidi | P18431. |
KOi | K03083. |
OMAi | HRIIPEQ. |
OrthoDBi | EOG091G099S. |
Family and domain databases
InterProi | View protein in InterPro IPR033573. GSK3B. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. |
PANTHERi | PTHR24057:SF8. PTHR24057:SF8. 1 hit. |
Pfami | View protein in Pfam PF00069. Pkinase. 1 hit. |
SMARTi | View protein in SMART SM00220. S_TKc. 1 hit. |
SUPFAMi | SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform Zygotic (identifier: P18431-2) [UniParc]FASTAAdd to basket
Also known as: B, C
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSGRPRTSSF AEGNKQSPSL VLGGVKTCSR DGSKITTVVA TPGQGTDRVQ
60 70 80 90 100
EVSYTDTKVI GNGSFGVVFQ AKLCDTGELV AIKKVLQDRR FKNRELQIMR
110 120 130 140 150
KLEHCNIVKL LYFFYSSGEK RDEVFLNLVL EYIPETVYKV ARQYAKTKQT
160 170 180 190 200
IPINFIRLYM YQLFRSLAYI HSLGICHRDI KPQNLLLDPE TAVLKLCDFG
210 220 230 240 250
SAKQLLHGEP NVSYICSRYY RAPELIFGAI NYTTKIDVWS AGCVLAELLL
260 270 280 290 300
GQPIFPGDSG VDQLVEVIKV LGTPTREQIR EMNPNYTEFK FPQIKSHPWQ
310 320 330 340 350
KVFRIRTPTE AINLVSLLLE YTPSARITPL KACAHPFFDE LRMEGNHTLP
360 370 380 390 400
NGRDMPPLFN FTEHELSIQP SLVPQLLPKH LQNASGPGGN RPSAGGAASI
410 420 430 440 450
AASGSTSVSS TGSGASVEGS AQPQSQGTAA AAGSGSGGAT AGTGGASAGG
460 470 480 490 500
PGSGNNSSSG GASGAPSAVA AGGANAAVAG GAGGGGGAGA ATAAATATGA
510
IGATNAGGAN VTDS
Note: Major isoform.
Isoform SGG46 (identifier: P18431-1) [UniParc]FASTAAdd to basket
Also known as: Maternal, D
The sequence of this isoform differs from the canonical sequence as follows:
1-29: MSGRPRTSSFAEGNKQSPSLVLGGVKTCS → MATTTTTQRA...VVQKFKNILG
Isoform SGG39 (identifier: P18431-3) [UniParc]FASTAAdd to basket
Also known as: A, J
The sequence of this isoform differs from the canonical sequence as follows:
513-514: DS → GSQSNSALNSSGSGGSGNGEAAGSGSGSGSGSGGGNGGDNDAGDSGAIASGGGAAETEAAASG
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 244 | V → I in CAA37419 (PubMed:8467811).Curated | 1 | ||
Sequence conflicti | 397 | A → R in CAA37952 (PubMed:2113617).Curated | 1 | ||
Sequence conflicti | 406 | T → A in CAA37419 (PubMed:8467811).Curated | 1 | ||
Sequence conflicti | 406 | T → A in AAM50318 (PubMed:2113617).Curated | 1 | ||
Sequence conflicti | 446 | A → R in CAA37952 (PubMed:2113617).Curated | 1 | ||
Sequence conflicti | 462 | A → R in CAA37952 (PubMed:2113617).Curated | 1 | ||
Sequence conflicti | 473 | Missing in CAA37952 (PubMed:2113617).Curated | 1 | ||
Sequence conflicti | 513 – 514 | DS → GE in CAA19676 (PubMed:10731137).Curated | 2 | ||
Sequence conflicti | 513 – 514 | DS → GE in CAB65860 (PubMed:10731137).Curated | 2 | ||
Isoform SGG46 (identifier: P18431-1) | |||||
Sequence conflicti | 9 | R → A in AAF45801 (PubMed:10731132).Curated | 1 | ||
Sequence conflicti | 9 | R → A in CAA19676 (PubMed:10731137).Curated | 1 | ||
Sequence conflicti | 9 | R → A in CAB65860 (PubMed:10731137).Curated | 1 | ||
Sequence conflicti | 256 – 259 | EEEE → E in CAA37952 (PubMed:2113617).Curated | 4 | ||
Sequence conflicti | 258 – 259 | EE → E in CAA19676 (PubMed:10731137).Curated | 2 | ||
Sequence conflicti | 258 – 259 | EE → E in CAB65860 (PubMed:10731137).Curated | 2 | ||
Sequence conflicti | 539 – 540 | AD → RI in CAA37952 (PubMed:2113617).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044104 | 1 – 29 | MSGRP…VKTCS → MLINRGSLLEG in isoform G. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_044105 | 1 – 29 | MSGRP…VKTCS → MATTTTTQRAGAAPALNLLP ASNNNINNTLINNNNNNNNT SNSNNNNNNVISQPIKIPLT ERFSSQTSTGSADSGVIVSS ASQQQLQLPPPRSSSGSLSL PQAPPGGKWRQKQQRQQLLL SQDSGIENGVTTRPSKAKDN QGAGKASHNATSSKESGAQS NSSSESLGSNCSEAQEQQRV RASSALELSSVDTPVIVGGV VSGGNSILRSRIKYKSTNST GTQGFDVEDRIDEVDICDDD DVDCDDRGSEIEEEEEEEED DGVNVDDDVEEADNQSDNQS GIIINLKSQTEQEEEVDEVD AKPKNRLLPPDQAELTVAAA MARRRDAKSLATDGHIYFPL LKISEDPHIDSKLINRKDGL QDTMYYLDEFGSPKLREKFA RKQKQLLAKQQKQLMKRERR SEEQRKKRNTTVASNLAASG AVVDDTKDDYKQQPHCDTSS RSKNNSVPNPPSSHLHQNHN HLVVDVQEDVDDVNVVATSD VDSGVVKMRRHSHDNHYDRI PRSNAATITTRPQIDQQSSH HQNTEDVEQGAEPQIDGEAD LDADADADSDGSGENVKTAK LARTQSCVSWTKVVQKFKNI LG in isoform SGG46. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_044106 | 513 – 514 | DS → GSQSNSALNSSGSGGSGNGE AAGSGSGSGSGSGGGNGGDN DAGDSGAIASGGGAAETEAA ASG in isoform SGG39. 1 Publication | 2 |
Sequence databases
Genome annotation databases
EnsemblMetazoai | FBtr0070466; FBpp0070449; FBgn0003371. [P18431-2] FBtr0070467; FBpp0070450; FBgn0003371. [P18431-3] FBtr0070468; FBpp0070451; FBgn0003371. [P18431-2] FBtr0070469; FBpp0070452; FBgn0003371. [P18431-2] FBtr0070470; FBpp0070453; FBgn0003371. [P18431-2] FBtr0070472; FBpp0089162; FBgn0003371. [P18431-2] FBtr0070473; FBpp0089158; FBgn0003371. [P18431-2] FBtr0070474; FBpp0089159; FBgn0003371. [P18431-3] FBtr0070475; FBpp0089160; FBgn0003371. [P18431-4] |
GeneIDi | 31248. |
KEGGi | dme:Dmel_CG2621. |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | SGG_DROME | |
Accessioni | P18431Primary (citable) accession number: P18431 Secondary accession number(s): O76881 Q9W4X3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1990 |
Last sequence update: | September 5, 2012 | |
Last modified: | March 28, 2018 | |
This is version 206 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |