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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-SSC-448706 Interleukin-1 processing
R-SSC-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152751 – 112Add BLAST112
ChainiPRO_0000015276113 – 270Interleukin-1 alphaAdd BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18430
PRIDEiP18430

Expressioni

Gene expression databases

BgeeiENSSSCG00000008090
GenevisibleiP18430 SS

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008638

Structurei

3D structure databases

ProteinModelPortaliP18430
SMRiP18430
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP18430
KOiK04383
OMAiNQKSFYD
OrthoDBiEOG091G0MAP
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENEE YSSDIDHLSL NQKSFYDASY EPLPGDGMDK
60 70 80 90 100
FMPLSTSKTS KTSRLNFKDS VVMAAANGKI LKKRRLSLNQ FITDDDLEAI
110 120 130 140 150
ANDTEEEIIK PRSATYSFQS NMKYNFMRVI NHQCILNDAR NQSIIRDPSG
160 170 180 190 200
QYLMAAVLNN LDEAVKFDMA AYTSNDDSQL PVTLRISETR LFVSAQNEDE
210 220 230 240 250
PVLLKELPET PKTIKDETSL LFFWEKHGNM DYFKSAAHPK LFIATRQEKL
260 270
VHMAPGLPSV TDFQILENQS
Length:270
Mass (Da):30,789
Last modified:November 1, 1990 - v1
Checksum:i5677BF2B0EF63839
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89N → I in AAA73198 (Ref. 2) Curated1
Sequence conflicti242F → L in AAA73198 (Ref. 2) Curated1
Sequence conflicti255P → R in AAA73198 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52731 mRNA Translation: CAA36945.1
M86730 mRNA Translation: AAA73198.1
PIRiI46620
S10532
RefSeqiNP_999194.1, NM_214029.1
XP_005655255.1, XM_005655198.2
XP_013843310.1, XM_013987856.1
UniGeneiSsc.113

Genome annotation databases

EnsembliENSSSCT00000008863; ENSSSCP00000008638; ENSSSCG00000008090
GeneIDi397094
KEGGissc:397094

Similar proteinsi

Entry informationi

Entry nameiIL1A_PIG
AccessioniPrimary (citable) accession number: P18430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health