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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Mitogen, Pyrogen

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-SSC-446652. Interleukin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Gene namesi
Name:IL1A
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

  • Secreted

  • Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 112112PRO_0000015275Add
BLAST
Chaini113 – 270158Interleukin-1 alphaPRO_0000015276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei87 – 871PhosphoserineBy similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP18430.

Expressioni

Gene expression databases

GenevisibleiP18430. SS.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008638.

Structurei

3D structure databases

ProteinModelPortaliP18430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP18430.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG76473H.
TreeFamiTF300203.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDLFED LKNCYSENEE YSSDIDHLSL NQKSFYDASY EPLPGDGMDK
60 70 80 90 100
FMPLSTSKTS KTSRLNFKDS VVMAAANGKI LKKRRLSLNQ FITDDDLEAI
110 120 130 140 150
ANDTEEEIIK PRSATYSFQS NMKYNFMRVI NHQCILNDAR NQSIIRDPSG
160 170 180 190 200
QYLMAAVLNN LDEAVKFDMA AYTSNDDSQL PVTLRISETR LFVSAQNEDE
210 220 230 240 250
PVLLKELPET PKTIKDETSL LFFWEKHGNM DYFKSAAHPK LFIATRQEKL
260 270
VHMAPGLPSV TDFQILENQS
Length:270
Mass (Da):30,789
Last modified:November 1, 1990 - v1
Checksum:i5677BF2B0EF63839
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891N → I in AAA73198 (Ref. 2) Curated
Sequence conflicti242 – 2421F → L in AAA73198 (Ref. 2) Curated
Sequence conflicti255 – 2551P → R in AAA73198 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52731 mRNA. Translation: CAA36945.1.
M86730 mRNA. Translation: AAA73198.1.
PIRiI46620.
S10532.
RefSeqiNP_999194.1. NM_214029.1.
XP_005655255.1. XM_005655198.2.
XP_013843310.1. XM_013987856.1.
UniGeneiSsc.113.

Genome annotation databases

EnsembliENSSSCT00000008863; ENSSSCP00000008638; ENSSSCG00000008090.
GeneIDi397094.
KEGGissc:397094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52731 mRNA. Translation: CAA36945.1.
M86730 mRNA. Translation: AAA73198.1.
PIRiI46620.
S10532.
RefSeqiNP_999194.1. NM_214029.1.
XP_005655255.1. XM_005655198.2.
XP_013843310.1. XM_013987856.1.
UniGeneiSsc.113.

3D structure databases

ProteinModelPortaliP18430.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008638.

Proteomic databases

PaxDbiP18430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008863; ENSSSCP00000008638; ENSSSCG00000008090.
GeneIDi397094.
KEGGissc:397094.

Organism-specific databases

CTDi3552.

Phylogenomic databases

eggNOGiENOG410JAAI. Eukaryota.
ENOG411151X. LUCA.
GeneTreeiENSGT00390000013353.
HOGENOMiHOG000113034.
HOVERGENiHBG002432.
InParanoidiP18430.
KOiK04383.
OMAiNQKSFYD.
OrthoDBiEOG76473H.
TreeFamiTF300203.

Enzyme and pathway databases

ReactomeiR-SSC-446652. Interleukin-1 signaling.

Gene expression databases

GenevisibleiP18430. SS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR003295. IL-1_alpha.
IPR003294. IL-1_alpha/beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
[Graphical view]
PfamiPF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
[Graphical view]
PRINTSiPR00264. INTERLEUKIN1.
PR01358. INTRLEUKIN1A.
PR01357. INTRLEUKN1AB.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00253. INTERLEUKIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning and sequencing of a cDNA encoding porcine interleukin-1 alpha."
    Huether M.J., Scamurra R.W., Murtaugh M.P., Molitor T.W.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiIL1A_PIG
AccessioniPrimary (citable) accession number: P18430
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.