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Protein

Lipopolysaccharide-binding protein

Gene

LBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).1 Publication4 Publications

GO - Molecular functioni

  • lipopeptide binding Source: AgBase
  • lipopolysaccharide binding Source: MGI
  • lipoteichoic acid binding Source: MGI
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • cellular defense response Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: MGI
  • cellular response to lipoteichoic acid Source: MGI
  • cytokine-mediated signaling pathway Source: Reactome
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • detection of molecule of bacterial origin Source: BHF-UCL
  • innate immune response Source: BHF-UCL
  • leukocyte chemotaxis involved in inflammatory response Source: Ensembl
  • lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
  • lipopolysaccharide transport Source: BHF-UCL
  • macromolecule localization Source: AgBase
  • macrophage activation involved in immune response Source: UniProtKB
  • negative regulation of growth of symbiont in host Source: Ensembl
  • negative regulation of tumor necrosis factor production Source: BHF-UCL
  • opsonization Source: BHF-UCL
  • positive regulation of chemokine production Source: Ensembl
  • positive regulation of cytolysis Source: AgBase
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of interleukin-8 production Source: BHF-UCL
  • positive regulation of macrophage activation Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: Ensembl
  • positive regulation of respiratory burst involved in inflammatory response Source: BHF-UCL
  • positive regulation of toll-like receptor 4 signaling pathway Source: BHF-UCL
  • positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • positive regulation of tumor necrosis factor production Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • toll-like receptor 4 signaling pathway Source: Reactome
  • toll-like receptor signaling pathway Source: Reactome

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-166020 Transfer of LPS from LBP carrier to CD14
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and 13 signaling
SignaLinkiP18428

Protein family/group databases

TCDBi1.C.40.1.2 the bactericidal permeability increasing protein (bpip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
Gene namesi
Name:LBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000129988.5
HGNCiHGNC:6517 LBP
MIMi151990 gene
neXtProtiNX_P18428

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3929
OpenTargetsiENSG00000129988
PharmGKBiPA30303

Polymorphism and mutation databases

BioMutaiLBP
DMDMi116242615

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001715826 – 481Lipopolysaccharide-binding proteinAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi159 ↔ 198By similarity
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18428
MaxQBiP18428
PaxDbiP18428
PeptideAtlasiP18428
PRIDEiP18428
ProteomicsDBi53558
TopDownProteomicsiP18428

PTM databases

iPTMnetiP18428
PhosphoSitePlusiP18428

Expressioni

Tissue specificityi

Detected in blood serum (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000129988
CleanExiHS_LBP
GenevisibleiP18428 HS

Organism-specific databases

HPAiCAB025905
HPA001508

Interactioni

Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131624EBI-3927059,EBI-2211957

GO - Molecular functioni

  • signaling receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110121, 16 interactors
DIPiDIP-90N
IntActiP18428, 14 interactors
STRINGi9606.ENSP00000217407

Structurei

3D structure databases

ProteinModelPortaliP18428
SMRiP18428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110583
HOGENOMiHOG000231250
HOVERGENiHBG002797
InParanoidiP18428
KOiK05399
OMAiGHYEFHS
OrthoDBiEOG091G08NV
PhylomeDBiP18428
TreeFamiTF315617

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR030180 LBP
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF66 PTHR10504:SF66, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF002417 Lipid_binding_protein, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL
60 70 80 90 100
QSELLRITLP DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG
110 120 130 140 150
LSLSISDSSI RVQGRWKVRK SFFKLQGSFD VSVKGISISV NLLLGSESSG
160 170 180 190 200
RPTVTASSCS SDIADVEVDM SGDLGWLLNL FHNQIESKFQ KVLESRICEM
210 220 230 240 250
IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA QMLEVMFKGE
260 270 280 290 300
IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN
310 320 330 340 350
FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN
360 370 380 390 400
FSPGNLSVDP YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG
410 420 430 440 450
FLKPGKVKVE LKESKVGLFN AELLEALLNY YILNTFYPKF NDKLAEGFPL
460 470 480
PLLKRVQLYD LGLQIHKDFL FLGANVQYMR V
Length:481
Mass (Da):53,384
Last modified:October 17, 2006 - v3
Checksum:i5A0E4B9E5E604C72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → H (PubMed:7517398).Curated1
Sequence conflicti22E → C (PubMed:7517398).Curated1
Sequence conflicti82N → K in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti128S → F in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti154 – 157VTAS → GYCL in AAA59493 (PubMed:2402637).Curated4
Sequence conflicti174L → S in AAA59493 (PubMed:2402637).Curated1
Sequence conflicti257R → S in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti266 – 270VMSLP → A in AAA59493 (PubMed:2402637).Curated5
Sequence conflicti369L → H in AAC39547 (PubMed:9441745).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0282439P → L. Corresponds to variant dbSNP:rs2232580Ensembl.1
Natural variantiVAR_049737111R → Q. Corresponds to variant dbSNP:rs2232583Ensembl.1
Natural variantiVAR_028244125L → I. Corresponds to variant dbSNP:rs2232585Ensembl.1
Natural variantiVAR_049738147E → K. Corresponds to variant dbSNP:rs36015492Ensembl.1
Natural variantiVAR_061293157S → C. Corresponds to variant dbSNP:rs2232586Ensembl.1
Natural variantiVAR_028245166V → M. Corresponds to variant dbSNP:rs5744204Ensembl.1
Natural variantiVAR_028246242M → I. Corresponds to variant dbSNP:rs2232601Ensembl.1
Natural variantiVAR_028247283D → G. Corresponds to variant dbSNP:rs2232607Ensembl.1
Natural variantiVAR_028248294H → R. Corresponds to variant dbSNP:rs2232608Ensembl.1
Natural variantiVAR_028249333P → L Abolishes lipopolysaccharide binding and causes increased proteolytic degradation of the protein. 1 PublicationCorresponds to variant dbSNP:rs2232613EnsemblClinVar.1
Natural variantiVAR_028250339L → F. Corresponds to variant dbSNP:rs5744212Ensembl.1
Natural variantiVAR_049739364I → T. Corresponds to variant dbSNP:rs2232615Ensembl.1
Natural variantiVAR_028251436F → L3 PublicationsCorresponds to variant dbSNP:rs2232618Ensembl.1
Natural variantiVAR_028252445A → T. Corresponds to variant dbSNP:rs2232619Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35533 mRNA Translation: AAA59493.1
X98657
, X98658, X98659, X98660, X98661, X98662, X98663, X98664, X98665, X98666, X98667, X98668 Genomic DNA Translation: CAA67226.1
AF013512
, AF013500, AF013501, AF013502, AF013503, AF013504, AF013505, AF013506, AF013507, AF013508, AF013509, AF013510, AF013511 Genomic DNA Translation: AAC39547.1
AF105067 mRNA Translation: AAD21962.1
AK313625 mRNA Translation: BAG36385.1
AL080249 Genomic DNA Translation: CAC10462.1
CH471077 Genomic DNA Translation: EAW76034.1
L42172 Genomic DNA Translation: AAA66446.1
CCDSiCCDS13304.1
PIRiA35843
A54136
RefSeqiNP_004130.2, NM_004139.4
UniGeneiHs.154078

Genome annotation databases

EnsembliENST00000217407; ENSP00000217407; ENSG00000129988
GeneIDi3929
KEGGihsa:3929
UCSCiuc002xic.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLBP_HUMAN
AccessioniPrimary (citable) accession number: P18428
Secondary accession number(s): B2R938
, O43438, Q92672, Q9H403, Q9UD66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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