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Protein

Lipopolysaccharide-binding protein

Gene

LBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).1 Publication4 Publications

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB
  • lipoteichoic acid binding Source: MGI
  • receptor binding Source: BHF-UCL

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • cellular defense response Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: UniProtKB
  • cellular response to lipoteichoic acid Source: MGI
  • defense response to Gram-negative bacterium Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • detection of molecule of bacterial origin Source: BHF-UCL
  • innate immune response Source: BHF-UCL
  • leukocyte chemotaxis involved in inflammatory response Source: Ensembl
  • lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
  • lipopolysaccharide transport Source: BHF-UCL
  • macrophage activation involved in immune response Source: UniProtKB
  • negative regulation of growth of symbiont in host Source: Ensembl
  • negative regulation of tumor necrosis factor production Source: BHF-UCL
  • opsonization Source: BHF-UCL
  • positive regulation of chemokine production Source: Ensembl
  • positive regulation of interleukin-6 production Source: BHF-UCL
  • positive regulation of interleukin-8 production Source: BHF-UCL
  • positive regulation of macrophage activation Source: BHF-UCL
  • positive regulation of neutrophil chemotaxis Source: Ensembl
  • positive regulation of respiratory burst involved in inflammatory response Source: BHF-UCL
  • positive regulation of toll-like receptor 4 signaling pathway Source: BHF-UCL
  • positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
  • positive regulation of tumor necrosis factor production Source: UniProtKB
  • response to lipopolysaccharide Source: BHF-UCL
  • toll-like receptor 4 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity, Lipid transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129988-MONOMER.
ReactomeiR-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-166020. Transfer of LPS from LBP carrier to CD14.
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SignaLinkiP18428.

Protein family/group databases

TCDBi1.C.40.1.2. the bactericidal permeability increasing protein (bpip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-binding protein
Short name:
LBP
Gene namesi
Name:LBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6517. LBP.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3929.
OpenTargetsiENSG00000129988.
PharmGKBiPA30303.

Polymorphism and mutation databases

BioMutaiLBP.
DMDMi116242615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001715826 – 481Lipopolysaccharide-binding proteinAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi159 ↔ 198By similarity
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi355N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi394N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP18428.
PaxDbiP18428.
PeptideAtlasiP18428.
PRIDEiP18428.
TopDownProteomicsiP18428.

PTM databases

iPTMnetiP18428.
PhosphoSitePlusiP18428.

Expressioni

Tissue specificityi

Detected in blood serum (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000129988.
CleanExiHS_LBP.
GenevisibleiP18428. HS.

Organism-specific databases

HPAiCAB025905.
HPA001508.

Interactioni

Subunit structurei

When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14.1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131624EBI-3927059,EBI-2211957

GO - Molecular functioni

  • receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi110121. 16 interactors.
DIPiDIP-90N.
IntActiP18428. 13 interactors.
STRINGi9606.ENSP00000217407.

Structurei

3D structure databases

ProteinModelPortaliP18428.
SMRiP18428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000231250.
HOVERGENiHBG002797.
InParanoidiP18428.
KOiK05399.
OMAiRVQGRWK.
OrthoDBiEOG091G08NV.
PhylomeDBiP18428.
TreeFamiTF315617.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR030180. LBP.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF66. PTHR10504:SF66. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALARALPS ILLALLLTST PEALGANPGL VARITDKGLQ YAAQEGLLAL
60 70 80 90 100
QSELLRITLP DFTGDLRIPH VGRGRYEFHS LNIHSCELLH SALRPVPGQG
110 120 130 140 150
LSLSISDSSI RVQGRWKVRK SFFKLQGSFD VSVKGISISV NLLLGSESSG
160 170 180 190 200
RPTVTASSCS SDIADVEVDM SGDLGWLLNL FHNQIESKFQ KVLESRICEM
210 220 230 240 250
IQKSVSSDLQ PYLQTLPVTT EIDSFADIDY SLVEAPRATA QMLEVMFKGE
260 270 280 290 300
IFHRNHRSPV TLLAAVMSLP EEHNKMVYFA ISDYVFNTAS LVYHEEGYLN
310 320 330 340 350
FSITDDMIPP DSNIRLTTKS FRPFVPRLAR LYPNMNLELQ GSVPSAPLLN
360 370 380 390 400
FSPGNLSVDP YMEIDAFVLL PSSSKEPVFR LSVATNVSAT LTFNTSKITG
410 420 430 440 450
FLKPGKVKVE LKESKVGLFN AELLEALLNY YILNTFYPKF NDKLAEGFPL
460 470 480
PLLKRVQLYD LGLQIHKDFL FLGANVQYMR V
Length:481
Mass (Da):53,384
Last modified:October 17, 2006 - v3
Checksum:i5A0E4B9E5E604C72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → H (PubMed:7517398).Curated1
Sequence conflicti22E → C (PubMed:7517398).Curated1
Sequence conflicti82N → K in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti128S → F in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti154 – 157VTAS → GYCL in AAA59493 (PubMed:2402637).Curated4
Sequence conflicti174L → S in AAA59493 (PubMed:2402637).Curated1
Sequence conflicti257R → S in AAC39547 (PubMed:9441745).Curated1
Sequence conflicti266 – 270VMSLP → A in AAA59493 (PubMed:2402637).Curated5
Sequence conflicti369L → H in AAC39547 (PubMed:9441745).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0282439P → L.Corresponds to variant rs2232580dbSNPEnsembl.1
Natural variantiVAR_049737111R → Q.Corresponds to variant rs2232583dbSNPEnsembl.1
Natural variantiVAR_028244125L → I.Corresponds to variant rs2232585dbSNPEnsembl.1
Natural variantiVAR_049738147E → K.Corresponds to variant rs36015492dbSNPEnsembl.1
Natural variantiVAR_061293157S → C.Corresponds to variant rs2232586dbSNPEnsembl.1
Natural variantiVAR_028245166V → M.Corresponds to variant rs5744204dbSNPEnsembl.1
Natural variantiVAR_028246242M → I.Corresponds to variant rs2232601dbSNPEnsembl.1
Natural variantiVAR_028247283D → G.Corresponds to variant rs2232607dbSNPEnsembl.1
Natural variantiVAR_028248294H → R.Corresponds to variant rs2232608dbSNPEnsembl.1
Natural variantiVAR_028249333P → L Abolishes lipopolysaccharide binding and causes increased proteolytic degradation of the protein. 1 PublicationCorresponds to variant rs2232613dbSNPEnsembl.1
Natural variantiVAR_028250339L → F.Corresponds to variant rs5744212dbSNPEnsembl.1
Natural variantiVAR_049739364I → T.Corresponds to variant rs2232615dbSNPEnsembl.1
Natural variantiVAR_028251436F → L.3 PublicationsCorresponds to variant rs2232618dbSNPEnsembl.1
Natural variantiVAR_028252445A → T.Corresponds to variant rs2232619dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35533 mRNA. Translation: AAA59493.1.
X98657
, X98658, X98659, X98660, X98661, X98662, X98663, X98664, X98665, X98666, X98667, X98668 Genomic DNA. Translation: CAA67226.1.
AF013512
, AF013500, AF013501, AF013502, AF013503, AF013504, AF013505, AF013506, AF013507, AF013508, AF013509, AF013510, AF013511 Genomic DNA. Translation: AAC39547.1.
AF105067 mRNA. Translation: AAD21962.1.
AK313625 mRNA. Translation: BAG36385.1.
AL080249 Genomic DNA. Translation: CAC10462.1.
CH471077 Genomic DNA. Translation: EAW76034.1.
L42172 Genomic DNA. Translation: AAA66446.1.
CCDSiCCDS13304.1.
PIRiA35843.
A54136.
RefSeqiNP_004130.2. NM_004139.4.
UniGeneiHs.154078.

Genome annotation databases

EnsembliENST00000217407; ENSP00000217407; ENSG00000129988.
GeneIDi3929.
KEGGihsa:3929.
UCSCiuc002xic.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35533 mRNA. Translation: AAA59493.1.
X98657
, X98658, X98659, X98660, X98661, X98662, X98663, X98664, X98665, X98666, X98667, X98668 Genomic DNA. Translation: CAA67226.1.
AF013512
, AF013500, AF013501, AF013502, AF013503, AF013504, AF013505, AF013506, AF013507, AF013508, AF013509, AF013510, AF013511 Genomic DNA. Translation: AAC39547.1.
AF105067 mRNA. Translation: AAD21962.1.
AK313625 mRNA. Translation: BAG36385.1.
AL080249 Genomic DNA. Translation: CAC10462.1.
CH471077 Genomic DNA. Translation: EAW76034.1.
L42172 Genomic DNA. Translation: AAA66446.1.
CCDSiCCDS13304.1.
PIRiA35843.
A54136.
RefSeqiNP_004130.2. NM_004139.4.
UniGeneiHs.154078.

3D structure databases

ProteinModelPortaliP18428.
SMRiP18428.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110121. 16 interactors.
DIPiDIP-90N.
IntActiP18428. 13 interactors.
STRINGi9606.ENSP00000217407.

Protein family/group databases

TCDBi1.C.40.1.2. the bactericidal permeability increasing protein (bpip) family.

PTM databases

iPTMnetiP18428.
PhosphoSitePlusiP18428.

Polymorphism and mutation databases

BioMutaiLBP.
DMDMi116242615.

Proteomic databases

MaxQBiP18428.
PaxDbiP18428.
PeptideAtlasiP18428.
PRIDEiP18428.
TopDownProteomicsiP18428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217407; ENSP00000217407; ENSG00000129988.
GeneIDi3929.
KEGGihsa:3929.
UCSCiuc002xic.3. human.

Organism-specific databases

CTDi3929.
DisGeNETi3929.
GeneCardsiLBP.
HGNCiHGNC:6517. LBP.
HPAiCAB025905.
HPA001508.
MIMi151990. gene.
neXtProtiNX_P18428.
OpenTargetsiENSG00000129988.
PharmGKBiPA30303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4160. Eukaryota.
ENOG410Z88E. LUCA.
GeneTreeiENSGT00730000110583.
HOGENOMiHOG000231250.
HOVERGENiHBG002797.
InParanoidiP18428.
KOiK05399.
OMAiRVQGRWK.
OrthoDBiEOG091G08NV.
PhylomeDBiP18428.
TreeFamiTF315617.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129988-MONOMER.
ReactomeiR-HSA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-HSA-166020. Transfer of LPS from LBP carrier to CD14.
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SignaLinkiP18428.

Miscellaneous databases

GeneWikiiLipopolysaccharide-binding_protein.
GenomeRNAii3929.
PROiP18428.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129988.
CleanExiHS_LBP.
GenevisibleiP18428. HS.

Family and domain databases

InterProiIPR017943. Bactericidal_perm-incr_a/b_dom.
IPR030675. BPI/LBP.
IPR032942. BPI/LBP/Plunc.
IPR030180. LBP.
IPR001124. Lipid-bd_serum_glycop_C.
IPR017954. Lipid-bd_serum_glycop_CS.
IPR017942. Lipid-bd_serum_glycop_N.
[Graphical view]
PANTHERiPTHR10504. PTHR10504. 1 hit.
PTHR10504:SF66. PTHR10504:SF66. 1 hit.
PfamiPF01273. LBP_BPI_CETP. 1 hit.
PF02886. LBP_BPI_CETP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002417. Lipid_binding_protein. 1 hit.
SMARTiSM00328. BPI1. 1 hit.
SM00329. BPI2. 1 hit.
[Graphical view]
SUPFAMiSSF55394. SSF55394. 2 hits.
PROSITEiPS00400. LBP_BPI_CETP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLBP_HUMAN
AccessioniPrimary (citable) accession number: P18428
Secondary accession number(s): B2R938
, O43438, Q92672, Q9H403, Q9UD66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.