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Protein

Follitropin subunit beta

Gene

Fshb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates development of follicle and spermatogenesis in the reproductive organs.

GO - Molecular functioni

  • follicle-stimulating hormone activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
Gene namesi
Name:Fshb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2630. Fshb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • extracellular exosome Source: Ensembl
  • follicle-stimulating hormone complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 130110Follitropin subunit betaPRO_0000011716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 70By similarity
Glycosylationi26 – 261N-linked (GlcNAc...)Curated
Disulfide bondi36 ↔ 85By similarity
Disulfide bondi39 ↔ 123By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Curated
Disulfide bondi47 ↔ 101By similarity
Disulfide bondi51 ↔ 103By similarity
Disulfide bondi106 ↔ 113By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18427.
PRIDEiP18427.

Expressioni

Gene expression databases

ExpressionAtlasiP18427. baseline and differential.
GenevisibleiP18427. RN.

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

  • follicle-stimulating hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006512.

Structurei

3D structure databases

ProteinModelPortaliP18427.
SMRiP18427. Positions 22-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWHY. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP18427.
KOiK05250.
OMAiAVEKEEC.
OrthoDBiEOG7JQBQF.
PhylomeDBiP18427.
TreeFamiTF332940.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSIQLCIL LWCLRAVCCH SCELTNITIS VEKEECRFCI SINTTWCEGY
60 70 80 90 100
CYTRDLVYKD PARPNTQKVC TFKELVYETI RLPGCARHSD SLYTYPVATE
110 120 130
CHCGKCDSDS TDCTVRGLGP SYCSFGEMKE
Length:130
Mass (Da):14,814
Last modified:February 1, 1991 - v2
Checksum:i690E3FC5FC1BD097
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731K → R in strain: Sprague-Dawley.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36804 mRNA. No translation available.
M27048, M27044 Genomic DNA. Translation: AAB60705.1.
D00577 Genomic DNA. Translation: BAA00455.1.
PIRiA32893.
I83048.
RefSeqiNP_001007598.1. NM_001007597.1.
XP_006234734.1. XM_006234672.2.
UniGeneiRn.92303.

Genome annotation databases

EnsembliENSRNOT00000006512; ENSRNOP00000006512; ENSRNOG00000004898.
GeneIDi25447.
KEGGirno:25447.
UCSCiRGD:2630. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36804 mRNA. No translation available.
M27048, M27044 Genomic DNA. Translation: AAB60705.1.
D00577 Genomic DNA. Translation: BAA00455.1.
PIRiA32893.
I83048.
RefSeqiNP_001007598.1. NM_001007597.1.
XP_006234734.1. XM_006234672.2.
UniGeneiRn.92303.

3D structure databases

ProteinModelPortaliP18427.
SMRiP18427. Positions 22-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006512.

Proteomic databases

PaxDbiP18427.
PRIDEiP18427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006512; ENSRNOP00000006512; ENSRNOG00000004898.
GeneIDi25447.
KEGGirno:25447.
UCSCiRGD:2630. rat.

Organism-specific databases

CTDi2488.
RGDi2630. Fshb.

Phylogenomic databases

eggNOGiENOG410IWHY. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
HOGENOMiHOG000116098.
HOVERGENiHBG006698.
InParanoidiP18427.
KOiK05250.
OMAiAVEKEEC.
OrthoDBiEOG7JQBQF.
PhylomeDBiP18427.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-RNO-209822. Glycoprotein hormones.
R-RNO-375281. Hormone ligand-binding receptors.
R-RNO-418555. G alpha (s) signalling events.

Miscellaneous databases

NextBioi606685.
PROiP18427.

Gene expression databases

ExpressionAtlasiP18427. baseline and differential.
GenevisibleiP18427. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and nucleotide sequence analysis of complementary deoxyribonucleic acid for the beta-subunit of rat follicle stimulating hormone."
    Maurer R.A.
    Mol. Endocrinol. 1:717-723(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Holtzman.
  2. "Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone."
    Gharib S.D., Roy A., Wierman M.E., Chin W.W.
    DNA 8:339-349(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Strain difference in nucleotide sequences of rat glycoprotein hormone subunit cDNAs and gene fragment."
    Kato Y., Ezashi T., Hirai T., Kato T.
    Zool. Sci. 7:877-885(1990)
    Cited for: NUCLEOTIDE SEQUENCE OF 55-130.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFSHB_RAT
AccessioniPrimary (citable) accession number: P18427
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: February 17, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.