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Protein

Follitropin subunit beta

Gene

Fshb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stimulates development of follicle and spermatogenesis in the reproductive organs.

GO - Molecular functioni

  • follicle-stimulating hormone activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-209822 Glycoprotein hormones
R-RNO-375281 Hormone ligand-binding receptors
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
Gene namesi
Name:Fshb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2630 Fshb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001171621 – 130Follitropin subunit betaAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 70By similarity
Glycosylationi26N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi36 ↔ 85By similarity
Disulfide bondi39 ↔ 123By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi47 ↔ 101By similarity
Disulfide bondi51 ↔ 103By similarity
Disulfide bondi106 ↔ 113By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18427
PRIDEiP18427

Expressioni

Gene expression databases

BgeeiENSRNOG00000004898
ExpressionAtlasiP18427 baseline and differential
GenevisibleiP18427 RN

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

  • follicle-stimulating hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006512

Structurei

3D structure databases

ProteinModelPortaliP18427
SMRiP18427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWHY Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP18427
KOiK05250
OMAiAVEKEEC
OrthoDBiEOG091G0XFH
PhylomeDBiP18427
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSIQLCIL LWCLRAVCCH SCELTNITIS VEKEECRFCI SINTTWCEGY
60 70 80 90 100
CYTRDLVYKD PARPNTQKVC TFKELVYETI RLPGCARHSD SLYTYPVATE
110 120 130
CHCGKCDSDS TDCTVRGLGP SYCSFGEMKE
Length:130
Mass (Da):14,814
Last modified:February 1, 1991 - v2
Checksum:i690E3FC5FC1BD097
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti73K → R in strain: Sprague-Dawley. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36804 mRNA No translation available.
M27048, M27044 Genomic DNA Translation: AAB60705.1
D00577 Genomic DNA Translation: BAA00455.1
PIRiA32893
I83048
RefSeqiNP_001007598.1, NM_001007597.2
UniGeneiRn.92303

Genome annotation databases

EnsembliENSRNOT00000006512; ENSRNOP00000006512; ENSRNOG00000004898
GeneIDi25447
KEGGirno:25447
UCSCiRGD:2630 rat

Similar proteinsi

Entry informationi

Entry nameiFSHB_RAT
AccessioniPrimary (citable) accession number: P18427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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