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P18417

- STSY_CATRO

UniProt

P18417 - STSY_CATRO

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Protein

Strictosidine synthase

Gene

STR1

Organism
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

Catalytic activityi

3-alpha-(S)-strictosidine + H2O = tryptamine + secologanin.

Pathwayi

GO - Molecular functioni

  1. strictosidine synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. alkaloid metabolic process Source: UniProtKB-KW
  2. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Alkaloid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11582.
UniPathwayiUPA00311; UER00447.

Names & Taxonomyi

Protein namesi
Recommended name:
Strictosidine synthase (EC:4.3.3.2)
Gene namesi
Name:STR1
Synonyms:SSS
OrganismiCatharanthus roseus (Madagascar periwinkle) (Vinca rosea)
Taxonomic identifieri4058 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesApocynaceaeRauvolfioideaeVinceaeCatharanthinaeCatharanthus

Subcellular locationi

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 31311 PublicationAdd
BLAST
Chaini32 – 352321Strictosidine synthasePRO_0000033332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP18417.
SMRiP18417. Positions 33-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the strictosidine synthase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view]
PANTHERiPTHR10426:SF22. PTHR10426:SF22. 1 hit.
PfamiPF03088. Str_synth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18417-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANFSESKSM MAVFFMFFLL LLSSSSSSSS SSPILKKIFI ESPSYAPNAF
60 70 80 90 100
TFDSTDKGFY TSVQDGRVIK YEGPNSGFTD FAYASPFWNK AFCENSTDPE
110 120 130 140 150
KRPLCGRTYD ISYDYKNSQM YIVDGHYHLC VVGKEGGYAT QLATSVQGVP
160 170 180 190 200
FKWLYAVTVD QRTGIVYFTD VSSIHDDSPE GVEEIMNTSD RTGRLMKYDP
210 220 230 240 250
STKETTLLLK ELHVPGGAEI SADGSFVVVA EFLSNRIVKY WLEGPKKGSA
260 270 280 290 300
EFLVTIPNPG NIKRNSDGHF WVSSSEELDG GQHGRVVSRG IKFDGFGNIL
310 320 330 340 350
QVIPLPPPYE GEHFEQIQEH DGLLYIGSLF HSSVGILVYD DHDNKGNSYV

SS
Length:352
Mass (Da):39,094
Last modified:April 1, 1993 - v2
Checksum:i1D6DD289A00272B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2851R → S in CAA37671. (PubMed:2395663)Curated
Sequence conflicti330 – 3301F → S in CAA37671. (PubMed:2395663)Curated
Sequence conflicti352 – 3521S → QLVIN in CAA37671. (PubMed:2395663)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61932 mRNA. Translation: CAA43936.1.
Y10182 Genomic DNA. Translation: CAA71255.1.
X53602 mRNA. Translation: CAA37671.1.
PIRiS22464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61932 mRNA. Translation: CAA43936.1 .
Y10182 Genomic DNA. Translation: CAA71255.1 .
X53602 mRNA. Translation: CAA37671.1 .
PIRi S22464.

3D structure databases

ProteinModelPortali P18417.
SMRi P18417. Positions 33-339.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL4369.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00311 ; UER00447 .
BioCyci MetaCyc:MONOMER-11582.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR018119. Strictosidine_synth_cons-reg.
IPR004141. Strictosidine_synthase.
[Graphical view ]
PANTHERi PTHR10426:SF22. PTHR10426:SF22. 1 hit.
Pfami PF03088. Str_synth. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors."
    Pasquali G., Goddijn O.J.M., de Waal A., Verpoorte R., Schilperoort R.A., Hoge J.H.C., Memelink J.
    Plant Mol. Biol. 18:1121-1131(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-52.
    Strain: cv. G. Don.
  2. Pasquali G., Erven A., Menke F., Memelink J.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: cv. Morning mist.
  3. "Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus."
    McKnight T.D., Roessner C.A., Devagupta R., Scott A.I., Nessler C.L.
    Nucleic Acids Res. 18:4939-4939(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-352.

Entry informationi

Entry nameiSTSY_CATRO
AccessioniPrimary (citable) accession number: P18417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3