P18412 (TEC1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ty transcription activator TEC1

Gene names

Name:	TEC1
Synonyms:	ROC1
Ordered Locus Names:	YBR083W
ORF Names:	YBR0750

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	486 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	TEC1 is involved in the activation of TY1 and TY1-mediated gene expression. It is not involved in mating or sporulation processes.
Subcellular location	Nucleus.
Miscellaneous	Present with 530 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 TEA DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chronological cell aging Inferred from mutant phenotype PubMed 21840851. Source: SGD invasive growth in response to glucose limitation Inferred from mutant phenotype PubMed 12455687. Source: SGD positive regulation of transcription from RNA polymerase II promoter in response to stress Inferred from direct assay PubMed 9036858. Source: SGD positive regulation of transposition, RNA-mediated Inferred from mutant phenotype PubMed 10652102. Source: SGD pseudohyphal growth Inferred from mutant phenotype PubMed 8730867PubMed 9036858PubMed 9055077. Source: SGD
Cellular_component	nucleus Inferred from direct assay PubMed 19218425. Source: SGD
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 9036858. Source: SGD RNA polymerase II transcription factor recruiting transcription factor activity Inferred from mutant phenotype PubMed 16782869. Source: SGD sequence-specific DNA binding Inferred from direct assay PubMed 19111667PubMed 19158363. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 486	486	Ty transcription activator TEC1		PRO_0000205941
Regions
	DNA binding	127 – 192	66	TEA
Amino acid modifications
	Modified residue	86	1	Phosphoserine Ref.7
	Modified residue	325	1	Phosphoserine Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P18412 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: F247016D3E75C454	FASTA	486	55,157
	10 20 30 40 50 60 MSLKEDDFGK DNSRNIESYT GRIFDVYIQK DSYSQSALDD MFPEAVVSTA ACVKNEAEDN 70 80 90 100 110 120 INLIDTHPQF ELVNTGLGAK SDDLKSPSAK ATFTDKQRKN EVPNISVSNY FPGQSSETSS 130 140 150 160 170 180 TTESWTIGCD KWSEKVEEAF LEALRLIMKN GTTKIKIRNA NFGRNELISL YIKHKTNEFR 190 200 210 220 230 240 TKKQISSHIQ VWKKTIQNKI KDSLTLSSKE KELLHLIEHG AEQTTENSNL FYDIFEEIID 250 260 270 280 290 300 SLPSVSDSGS LTPKNLYVSN NSSGLSVHSK LLTPITASNE KKIENFIKTN AASQAKTPLI 310 320 330 340 350 360 YAKHIYENID GYKCVPSKRP LEQLSPTELH QGDRPNKASF SNKKAILESA KKIEIEQRKI 370 380 390 400 410 420 INKYQRISRI QEHESNPEFS SNSNSGSEYE SEEEVVPRSA TVTQLQSRPV PYYKNNGMPY 430 440 450 460 470 480 SLSKVRGRPM YPRPAEDAYN ANYIQGLPQY QTSYFSQLLL SSPQHYEHSP HQRNFTPSNQ SHGNFY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TEC1, a gene involved in the activation of Ty1 and Ty1-mediated gene expression in Saccharomyces cerevisiae: cloning and molecular analysis." Laloux I., Dubois E., Dewerchin M., Jacobs E. Mol. Cell. Biol. 10:3541-3550(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete DNA sequence of yeast chromosome II." Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K. EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"The TEA domain: a novel, highly conserved DNA-binding motif." Buerglin T.R. Cell 66:11-12(1991) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN TEA.
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325, MASS SPECTROMETRY.
[7]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32797 Genomic DNA. Translation: AAA35141.1. Z35952 Genomic DNA. Translation: CAA85028.1. BK006936 Genomic DNA. Translation: DAA07202.1.
PIR	A35667.
RefSeq	NP_009639.3. NM_001178431.3.
3D structure databases
ProteinModelPortal	P18412.
SMR	P18412. Positions 132-191.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6311N.
IntAct	P18412. 7 interactions.
MINT	MINT-674450.
STRING	4932.YBR083W.
Proteomic databases
PaxDb	P18412.
PeptideAtlas	P18412.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YBR083W; YBR083W; YBR083W.
GeneID	852377.
KEGG	sce:YBR083W. sce:YBR085W.
Organism-specific databases
CYGD	YBR083w.
SGD	S000000287. TEC1.
Phylogenomic databases
eggNOG	NOG246992.
KO	K05863. K09448.
OrthoDB	EOG4F7RTG.
Gene expression databases
Genevestigator	P18412.
GermOnline	YBR083W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR000818. TEA/ATTS. [Graphical view]
PANTHER	PTHR11834. PTHR11834. 1 hit.
Pfam	PF01285. TEA. 1 hit. [Graphical view]
PRINTS	PR00065. TEADOMAIN.
SMART	SM00426. TEA. 1 hit. [Graphical view]
PROSITE	PS00554. TEA_1. 1 hit. PS51088. TEA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	971171.

Entry information

Entry name

TEC1_YEAST

Accession

Primary (citable) accession number: P18412
Secondary accession number(s): D6VQ82

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	May 1, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program