P18411 (FUN14_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FUN14

Gene names

Name:	FUN14
Ordered Locus Names:	YAL008W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Miscellaneous	Present with 1920 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the FUN14 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from direct assay PubMed 16407407. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ALO1	P54783	1	EBI-20609,EBI-2519
UIP4	Q08926	1	EBI-20609,EBI-2044051

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Protein FUN14		PRO_0000202412
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	112 – 132	21	Helical; Potential
	Transmembrane	172 – 192	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P18411 [UniParc]. Last modified February 1, 1995. Version 3. Checksum: F2AB77E54D53C791	FASTA	198	22,063
	10 20 30 40 50 60 MTLAFNMQRL VFRNLNVGKR MFKNVPLWRF NVANKLGKPL TRSVGLGGAG IVAGGFYLMN 70 80 90 100 110 120 RQPSKLIFND SLGAAVKQQG PLEPTVGNST AITEERRNKI SSHKQMFLGS LFGVVLGVTV 130 140 150 160 170 180 AKISILFMYV GITSMLLCEW LRYKGWIRIN LKNIKSVIVL KDVDLKKLLI DGLLGTEYMG 190 FKVFFTLSFV LASLNANK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region." Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H. Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae." Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K. Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[5]	"Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene." Whyte W., Koepp L.H., Lamb J., Crowley J.C., Kaback D.B. Gene 95:65-72(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-74.
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L05146 Genomic DNA. No translation available. L22015 Genomic DNA. Translation: AAC04950.1. AY557707 Genomic DNA. Translation: AAS56033.1. M36073 Genomic DNA. Translation: AAA35074.2. BK006935 Genomic DNA. Translation: DAA06980.1.
PIR	S43447.
RefSeq	NP_009394.1. NM_001178153.1.
3D structure databases
ProteinModelPortal	P18411.
ModBase	Search...
Protein-protein interaction databases
IntAct	P18411. 3 interactions.
MINT	MINT-2735020.
STRING	4932.YAL008W.
Proteomic databases
PaxDb	P18411.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YAL008W; YAL008W; YAL008W.
GeneID	851225.
KEGG	sce:YAL008W.
Organism-specific databases
CYGD	YAL008w.
SGD	S000000006. FUN14.
Phylogenomic databases
eggNOG	NOG80282.
OMA	GWIRINL.
OrthoDB	EOG4HQHV3.
Gene expression databases
Genevestigator	P18411.
GermOnline	YAL008W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR007014. FUN14. [Graphical view]
Pfam	PF04930. FUN14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	968130.

Entry information

Entry name

FUN14_YEAST

Accession

Primary (citable) accession number: P18411
Secondary accession number(s): D6VPL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program