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P18410 (SPO7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sporulation-specific protein SPO7
Gene names
Name:SPO7
Ordered Locus Names:YAL009W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for sporulation. Essential for the formation of a spherical nucleus and meiotic division. Probable regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates PAH1/SMP2. Ref.6 Ref.8

Subunit structure

Component of the NEM1-SPO7 complex. Ref.6

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein Ref.6.

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NEM1P387574EBI-17857,EBI-24435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Sporulation-specific protein SPO7
PRO_0000072145

Regions

Topological domain1 – 7272Cytoplasmic Potential
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 10613Extracellular Potential
Transmembrane107 – 12721Helical; Potential
Topological domain128 – 259132Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P18410 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 480A73B62EA85E18

FASTA25930,114
        10         20         30         40         50         60 
MEPESIGDVG NHAQDDSASI VSGPRRRSTS KTSSAKNIRN SSNISPASMI FRNLLILEDD 

        70         80         90        100        110        120 
LRRQAHEQKI LKWQFTLFLA SMAGVGAFTF YELYFTSDYV KGLHRVILQF TLSFISITVV 

       130        140        150        160        170        180 
LFHISGQYRR TIVIPRRFFT STNKGIRQFN VKLVKVQSTW DEKYTDSVRF VSRTIAYCNI 

       190        200        210        220        230        240 
YCLKKFLWLK DDNAIVKFWK SVTIQSQPRI GAVDVKLVLN PRAFSAEIRE GWEIYRDEFW 

       250 
AREGARRRKQ AHELRPKSE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene."
Whyte W., Koepp L.H., Lamb J., Crowley J.C., Kaback D.B.
Gene 95:65-72(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[3]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"A novel complex of membrane proteins required for formation of a spherical nucleus."
Siniossoglou S., Santos-Rosa H., Rappsilber J., Mann M., Hurt E.
EMBO J. 17:6449-6464(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE NEM1-SPO7 COMPLEX, SUBCELLULAR LOCATION.
[7]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]"The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth."
Santos-Rosa H., Leung J., Grimsey N., Peak-Chew S., Siniossoglou S.
EMBO J. 24:1931-1941(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE NEM1-SPO7 COMPLEX.
[9]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36073 Genomic DNA. Translation: AAA35073.1.
L22015 Genomic DNA. Translation: AAC04949.1.
AY558585 Genomic DNA. Translation: AAS56911.1.
BK006935 Genomic DNA. Translation: DAA06979.1.
PIRJN0099.
RefSeqNP_009393.1. NM_001178154.1.

3D structure databases

ProteinModelPortalP18410.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31757. 78 interactions.
DIPDIP-2441N.
IntActP18410. 18 interactions.
MINTMINT-617898.
STRING4932.YAL009W.

Proteomic databases

MaxQBP18410.
PaxDbP18410.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL009W; YAL009W; YAL009W.
GeneID851224.
KEGGsce:YAL009W.

Organism-specific databases

CYGDYAL009w.
SGDS000000007. SPO7.

Phylogenomic databases

eggNOGNOG71981.
HOGENOMHOG000111152.
OMARDEFWAR.
OrthoDBEOG71CFX7.

Enzyme and pathway databases

BioCycYEAST:G3O-28822-MONOMER.

Gene expression databases

GenevestigatorP18410.

Family and domain databases

InterProIPR005605. Spore/nuc_morph_Spo7.
[Graphical view]
PfamPF03907. Spo7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968127.

Entry information

Entry nameSPO7_YEAST
AccessionPrimary (citable) accession number: P18410
Secondary accession number(s): D6VPK9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD