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Protein

Sporulation-specific protein SPO7

Gene

SPO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates the phosphatidic acid phosphohydrolase PAH1 (PubMed:15889145). Essential for the formation of a spherical nucleus and meiotic division (PubMed:9822591). The NEM1-SPOo7 protein phosphatase is required for efficient mitophagy under prolonged respiration, as well as for reticulophagy and pexophagy (PubMed:29305265).3 Publications

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • lipid metabolic process Source: UniProtKB-KW
  • negative regulation of phospholipid biosynthetic process Source: SGD
  • nuclear envelope organization Source: SGD
  • positive regulation of phosphatidate phosphatase activity Source: SGD
  • protein dephosphorylation Source: SGD
  • sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

Keywordsi

Biological processLipid metabolism, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28822-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific protein SPO7
Gene namesi
Name:SPO7
Ordered Locus Names:YAL009W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL009W
SGDiS000000007 SPO7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 72CytoplasmicSequence analysisAdd BLAST72
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 106ExtracellularSequence analysisAdd BLAST13
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Topological domaini128 – 259CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Leads to inefficient mitochondrial sequestration and degradation, as well as to defective reticulophagy and pexophagy (PubMed:29305265).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000721451 – 259Sporulation-specific protein SPO7Add BLAST259

Proteomic databases

MaxQBiP18410
PaxDbiP18410
PRIDEiP18410

Interactioni

Subunit structurei

Component of the NEM1-SPO7 complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NEM1P387573EBI-17857,EBI-24435

Protein-protein interaction databases

BioGridi31757, 206 interactors
DIPiDIP-2441N
IntActiP18410, 18 interactors
MINTiP18410
STRINGi4932.YAL009W

Structurei

3D structure databases

ProteinModelPortaliP18410
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000111152
InParanoidiP18410
OMAiIYRDEFW
OrthoDBiEOG092C45RC

Family and domain databases

InterProiView protein in InterPro
IPR005605 Spore/nuc_morph_Spo7
PfamiView protein in Pfam
PF03907 Spo7, 1 hit

Sequencei

Sequence statusi: Complete.

P18410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPESIGDVG NHAQDDSASI VSGPRRRSTS KTSSAKNIRN SSNISPASMI
60 70 80 90 100
FRNLLILEDD LRRQAHEQKI LKWQFTLFLA SMAGVGAFTF YELYFTSDYV
110 120 130 140 150
KGLHRVILQF TLSFISITVV LFHISGQYRR TIVIPRRFFT STNKGIRQFN
160 170 180 190 200
VKLVKVQSTW DEKYTDSVRF VSRTIAYCNI YCLKKFLWLK DDNAIVKFWK
210 220 230 240 250
SVTIQSQPRI GAVDVKLVLN PRAFSAEIRE GWEIYRDEFW AREGARRRKQ

AHELRPKSE
Length:259
Mass (Da):30,114
Last modified:November 1, 1990 - v1
Checksum:i480A73B62EA85E18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36073 Genomic DNA Translation: AAA35073.1
L22015 Genomic DNA Translation: AAC04949.1
AY558585 Genomic DNA Translation: AAS56911.1
BK006935 Genomic DNA Translation: DAA06979.1
PIRiJN0099
RefSeqiNP_009393.1, NM_001178154.1

Genome annotation databases

EnsemblFungiiYAL009W; YAL009W; YAL009W
GeneIDi851224
KEGGisce:YAL009W

Similar proteinsi

Entry informationi

Entry nameiSPO7_YEAST
AccessioniPrimary (citable) accession number: P18410
Secondary accession number(s): D6VPK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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