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P18410

- SPO7_YEAST

UniProt

P18410 - SPO7_YEAST

Protein

Sporulation-specific protein SPO7

Gene

SPO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Required for sporulation. Essential for the formation of a spherical nucleus and meiotic division. Probable regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates PAH1/SMP2.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. dephosphorylation Source: GOC
    2. lipid metabolic process Source: UniProtKB-KW
    3. negative regulation of phospholipid biosynthetic process Source: SGD
    4. nuclear envelope organization Source: SGD
    5. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid metabolism, Sporulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28822-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sporulation-specific protein SPO7
    Gene namesi
    Name:SPO7
    Ordered Locus Names:YAL009W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL009w.
    SGDiS000000007. SPO7.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Nucleus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: SGD
    3. Nem1-Spo7 phosphatase complex Source: SGD
    4. nuclear membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Sporulation-specific protein SPO7PRO_0000072145Add
    BLAST

    Proteomic databases

    MaxQBiP18410.
    PaxDbiP18410.

    Expressioni

    Gene expression databases

    GenevestigatoriP18410.

    Interactioni

    Subunit structurei

    Component of the NEM1-SPO7 complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NEM1P387574EBI-17857,EBI-24435

    Protein-protein interaction databases

    BioGridi31757. 78 interactions.
    DIPiDIP-2441N.
    IntActiP18410. 18 interactions.
    MINTiMINT-617898.
    STRINGi4932.YAL009W.

    Structurei

    3D structure databases

    ProteinModelPortaliP18410.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 10613ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 259132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71981.
    HOGENOMiHOG000111152.
    OMAiRDEFWAR.
    OrthoDBiEOG71CFX7.

    Family and domain databases

    InterProiIPR005605. Spore/nuc_morph_Spo7.
    [Graphical view]
    PfamiPF03907. Spo7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18410-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPESIGDVG NHAQDDSASI VSGPRRRSTS KTSSAKNIRN SSNISPASMI    50
    FRNLLILEDD LRRQAHEQKI LKWQFTLFLA SMAGVGAFTF YELYFTSDYV 100
    KGLHRVILQF TLSFISITVV LFHISGQYRR TIVIPRRFFT STNKGIRQFN 150
    VKLVKVQSTW DEKYTDSVRF VSRTIAYCNI YCLKKFLWLK DDNAIVKFWK 200
    SVTIQSQPRI GAVDVKLVLN PRAFSAEIRE GWEIYRDEFW AREGARRRKQ 250
    AHELRPKSE 259
    Length:259
    Mass (Da):30,114
    Last modified:November 1, 1990 - v1
    Checksum:i480A73B62EA85E18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36073 Genomic DNA. Translation: AAA35073.1.
    L22015 Genomic DNA. Translation: AAC04949.1.
    AY558585 Genomic DNA. Translation: AAS56911.1.
    BK006935 Genomic DNA. Translation: DAA06979.1.
    PIRiJN0099.
    RefSeqiNP_009393.1. NM_001178154.1.

    Genome annotation databases

    EnsemblFungiiYAL009W; YAL009W; YAL009W.
    GeneIDi851224.
    KEGGisce:YAL009W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36073 Genomic DNA. Translation: AAA35073.1 .
    L22015 Genomic DNA. Translation: AAC04949.1 .
    AY558585 Genomic DNA. Translation: AAS56911.1 .
    BK006935 Genomic DNA. Translation: DAA06979.1 .
    PIRi JN0099.
    RefSeqi NP_009393.1. NM_001178154.1.

    3D structure databases

    ProteinModelPortali P18410.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31757. 78 interactions.
    DIPi DIP-2441N.
    IntActi P18410. 18 interactions.
    MINTi MINT-617898.
    STRINGi 4932.YAL009W.

    Proteomic databases

    MaxQBi P18410.
    PaxDbi P18410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL009W ; YAL009W ; YAL009W .
    GeneIDi 851224.
    KEGGi sce:YAL009W.

    Organism-specific databases

    CYGDi YAL009w.
    SGDi S000000007. SPO7.

    Phylogenomic databases

    eggNOGi NOG71981.
    HOGENOMi HOG000111152.
    OMAi RDEFWAR.
    OrthoDBi EOG71CFX7.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28822-MONOMER.

    Miscellaneous databases

    NextBioi 968127.

    Gene expression databases

    Genevestigatori P18410.

    Family and domain databases

    InterProi IPR005605. Spore/nuc_morph_Spo7.
    [Graphical view ]
    Pfami PF03907. Spo7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene."
      Whyte W., Koepp L.H., Lamb J., Crowley J.C., Kaback D.B.
      Gene 95:65-72(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
      Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
      Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "A novel complex of membrane proteins required for formation of a spherical nucleus."
      Siniossoglou S., Santos-Rosa H., Rappsilber J., Mann M., Hurt E.
      EMBO J. 17:6449-6464(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE NEM1-SPO7 COMPLEX, SUBCELLULAR LOCATION.
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth."
      Santos-Rosa H., Leung J., Grimsey N., Peak-Chew S., Siniossoglou S.
      EMBO J. 24:1931-1941(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE NEM1-SPO7 COMPLEX.
    9. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiSPO7_YEAST
    AccessioniPrimary (citable) accession number: P18410
    Secondary accession number(s): D6VPK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 861 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3