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P18410

- SPO7_YEAST

UniProt

P18410 - SPO7_YEAST

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Protein
Sporulation-specific protein SPO7
Gene
SPO7, YAL009W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for sporulation. Essential for the formation of a spherical nucleus and meiotic division. Probable regulatory component of the NEM1-SPO7 complex which acts as a phosphatase and dephosphorylates PAH1/SMP2.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. lipid metabolic process Source: UniProtKB-KW
  3. negative regulation of phospholipid biosynthetic process Source: SGD
  4. nuclear envelope organization Source: SGD
  5. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid metabolism, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-28822-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific protein SPO7
Gene namesi
Name:SPO7
Ordered Locus Names:YAL009W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL009w.
SGDiS000000007. SPO7.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Topological domaini94 – 10613Extracellular Reviewed prediction
Add
BLAST
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Topological domaini128 – 259132Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Nem1-Spo7 phosphatase complex Source: SGD
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: SGD
  4. nuclear membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Sporulation-specific protein SPO7
PRO_0000072145Add
BLAST

Proteomic databases

MaxQBiP18410.
PaxDbiP18410.

Expressioni

Gene expression databases

GenevestigatoriP18410.

Interactioni

Subunit structurei

Component of the NEM1-SPO7 complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NEM1P387574EBI-17857,EBI-24435

Protein-protein interaction databases

BioGridi31757. 78 interactions.
DIPiDIP-2441N.
IntActiP18410. 18 interactions.
MINTiMINT-617898.
STRINGi4932.YAL009W.

Structurei

3D structure databases

ProteinModelPortaliP18410.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71981.
HOGENOMiHOG000111152.
OMAiRDEFWAR.
OrthoDBiEOG71CFX7.

Family and domain databases

InterProiIPR005605. Spore/nuc_morph_Spo7.
[Graphical view]
PfamiPF03907. Spo7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18410-1 [UniParc]FASTAAdd to Basket

« Hide

MEPESIGDVG NHAQDDSASI VSGPRRRSTS KTSSAKNIRN SSNISPASMI    50
FRNLLILEDD LRRQAHEQKI LKWQFTLFLA SMAGVGAFTF YELYFTSDYV 100
KGLHRVILQF TLSFISITVV LFHISGQYRR TIVIPRRFFT STNKGIRQFN 150
VKLVKVQSTW DEKYTDSVRF VSRTIAYCNI YCLKKFLWLK DDNAIVKFWK 200
SVTIQSQPRI GAVDVKLVLN PRAFSAEIRE GWEIYRDEFW AREGARRRKQ 250
AHELRPKSE 259
Length:259
Mass (Da):30,114
Last modified:November 1, 1990 - v1
Checksum:i480A73B62EA85E18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36073 Genomic DNA. Translation: AAA35073.1.
L22015 Genomic DNA. Translation: AAC04949.1.
AY558585 Genomic DNA. Translation: AAS56911.1.
BK006935 Genomic DNA. Translation: DAA06979.1.
PIRiJN0099.
RefSeqiNP_009393.1. NM_001178154.1.

Genome annotation databases

EnsemblFungiiYAL009W; YAL009W; YAL009W.
GeneIDi851224.
KEGGisce:YAL009W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36073 Genomic DNA. Translation: AAA35073.1 .
L22015 Genomic DNA. Translation: AAC04949.1 .
AY558585 Genomic DNA. Translation: AAS56911.1 .
BK006935 Genomic DNA. Translation: DAA06979.1 .
PIRi JN0099.
RefSeqi NP_009393.1. NM_001178154.1.

3D structure databases

ProteinModelPortali P18410.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31757. 78 interactions.
DIPi DIP-2441N.
IntActi P18410. 18 interactions.
MINTi MINT-617898.
STRINGi 4932.YAL009W.

Proteomic databases

MaxQBi P18410.
PaxDbi P18410.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL009W ; YAL009W ; YAL009W .
GeneIDi 851224.
KEGGi sce:YAL009W.

Organism-specific databases

CYGDi YAL009w.
SGDi S000000007. SPO7.

Phylogenomic databases

eggNOGi NOG71981.
HOGENOMi HOG000111152.
OMAi RDEFWAR.
OrthoDBi EOG71CFX7.

Enzyme and pathway databases

BioCyci YEAST:G3O-28822-MONOMER.

Miscellaneous databases

NextBioi 968127.

Gene expression databases

Genevestigatori P18410.

Family and domain databases

InterProi IPR005605. Spore/nuc_morph_Spo7.
[Graphical view ]
Pfami PF03907. Spo7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene."
    Whyte W., Koepp L.H., Lamb J., Crowley J.C., Kaback D.B.
    Gene 95:65-72(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region."
    Clark M.W., Keng T., Storms R.K., Zhong W.-W., Fortin N., Zeng B., Delaney S., Ouellette B.F.F., Barton A.B., Kaback D.B., Bussey H.
    Yeast 10:535-541(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A novel complex of membrane proteins required for formation of a spherical nucleus."
    Siniossoglou S., Santos-Rosa H., Rappsilber J., Mann M., Hurt E.
    EMBO J. 17:6449-6464(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE NEM1-SPO7 COMPLEX, SUBCELLULAR LOCATION.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth."
    Santos-Rosa H., Leung J., Grimsey N., Peak-Chew S., Siniossoglou S.
    EMBO J. 24:1931-1941(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE NEM1-SPO7 COMPLEX.
  9. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiSPO7_YEAST
AccessioniPrimary (citable) accession number: P18410
Secondary accession number(s): D6VPK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 861 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3

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