P18407 (ALLC_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Allantoicase
EC=3.5.3.4

Gene names

Name:	alc-1
Synonyms:	alc
ORF Names:	B8B8.070, NCU01816

Organism

Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)

Taxonomic identifier

367110 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Utilization of purines as secondary nitrogen sources, when primary sources are limiting.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
Induction	Induced by uric acid. Repressed by nitrogen.
Sequence similarities	Belongs to the allantoicase family.

Ontologies

Keywords
Biological process	Purine metabolism
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Allantoicase		PRO_0000205912
Experimental info
	Sequence conflict	42	1	L → S in AAA33556. Ref.1
	Sequence conflict	140	1	R → L in AAA33556. Ref.1
	Sequence conflict	159	1	G → C in AAA33556. Ref.1
	Sequence conflict	288	1	A → R in AAA33556. Ref.1
	Sequence conflict	296	1	E → R in AAA33556. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P18407 [UniParc]. Last modified May 9, 2003. Version 2. Checksum: 302761471D1A253F	FASTA	354	39,073
	10 20 30 40 50 60 MTDIDYKLEA VPATRIAADD IDKTFRSSTI DLISGALGGK VLGFSDEWFA EAANLLTPTA 70 80 90 100 110 120 PIRQPGKMVY TGAWYDGWET RRHNPAEFDW VVIRLGVASG TVEGVEIDTA FFNGNHAPAI 130 140 150 160 170 180 SVEGCFSQND DEVLSWKGER GGWETILGVQ ECGPSQRFGW KLENPTKKQY THVRLNMYPD 190 200 210 220 230 240 GGIARFRLFG HAVPVFPDNT DAIFDLAAAQ NGGVAISCSD QHFGTKDNLI LPGRGKDMGD 250 260 270 280 290 300 GWETARSRTK GHVDWTIIRL GAPGYIQNFM VDTAHFRGNY PQQVKLQAIE WKSEGEPGAD 310 320 330 340 350 SEGWTEVVEP IKCGPDQEHP VESLVKDKPF THVKLIIVPD GGVKRLRVFA KRAV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and DNA recognition elements of alc, the structural gene which encodes allantoicase, a purine catabolic enzyme of Neurospora crassa." Lee H., Fu Y.H., Marzluf G.A. Biochemistry 29:8779-8787(1990) [PubMed: 2148685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]	"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence." Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U. Nucleic Acids Res. 31:1944-1954(2003) [PubMed: 12655011] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]	"The genome sequence of the filamentous fungus Neurospora crassa." Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W. Nature 422:859-868(2003) [PubMed: 12712197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02927 Genomic DNA. Translation: AAA33556.1. BX284761 Genomic DNA. Translation: CAD70499.1. AABX02000005 Genomic DNA. Translation: EAA27258.1.
PIR	A35829.
RefSeq	XP_956494.1. XM_951401.1.
3D structure databases
ProteinModelPortal	P18407.
ModBase	Search...
Protein-protein interaction databases
STRING	P18407.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	EFNCRT00000001652; EFNCRP00000001652; EFNCRG00000001650.
GeneID	3872616.
KEGG	ncr:NCU01816.
NMPDR	fig|5141.1.peg.6188.
Phylogenomic databases
eggNOG	fuNOG06867.
GeneTree	EFGT00050000007906.
OrthoDB	EOG4V9Z0N.
Enzyme and pathway databases
BioCyc	NCRA-XX3-01:NCRA-XX3-01-005526-MONOMER.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_dom. IPR008979. Galactose-bd-like. [Graphical view]
KO	K01477.
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
PIRSF	PIRSF016516. Allantoicase. 1 hit.
SUPFAM	SSF49785. Gal_bind_like. 2 hits.
TIGRFAMs	TIGR02961. Allantoicase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALLC_NEUCR

Accession

Primary (citable) accession number: P18407
Secondary accession number(s): Q7RXF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	May 9, 2003
Last modified:	December 14, 2011
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program