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P18406

- CYR61_MOUSE

UniProt

P18406 - CYR61_MOUSE

Protein

Protein CYR61

Gene

Cyr61

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.By similarity

    GO - Molecular functioni

    1. extracellular matrix binding Source: MGI
    2. heparin binding Source: UniProtKB-KW
    3. integrin binding Source: MGI

    GO - Biological processi

    1. apoptotic process involved in heart morphogenesis Source: MGI
    2. atrial septum morphogenesis Source: MGI
    3. atrioventricular valve morphogenesis Source: MGI
    4. cell adhesion Source: MGI
    5. chemotaxis Source: UniProtKB-KW
    6. chondroblast differentiation Source: MGI
    7. chorio-allantoic fusion Source: MGI
    8. extracellular matrix organization Source: MGI
    9. intussusceptive angiogenesis Source: MGI
    10. labyrinthine layer blood vessel development Source: MGI
    11. negative regulation of apoptotic process Source: MGI
    12. osteoblast differentiation Source: MGI
    13. positive regulation of apoptotic process Source: MGI
    14. positive regulation of BMP signaling pathway Source: Ensembl
    15. positive regulation of cartilage development Source: MGI
    16. positive regulation of cell differentiation Source: MGI
    17. positive regulation of cell migration Source: MGI
    18. positive regulation of cell-substrate adhesion Source: MGI
    19. positive regulation of ceramide biosynthetic process Source: MGI
    20. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    21. positive regulation of osteoblast differentiation Source: Ensembl
    22. positive regulation of osteoblast proliferation Source: Ensembl
    23. positive regulation of phospholipase activity Source: MGI
    24. positive regulation of protein kinase activity Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. reactive oxygen species metabolic process Source: MGI
    27. regulation of cell growth Source: InterPro
    28. regulation of ERK1 and ERK2 cascade Source: Ensembl
    29. single organismal cell-cell adhesion Source: MGI
    30. ventricular septum development Source: MGI
    31. wound healing, spreading of cells Source: Ensembl

    Keywords - Biological processi

    Cell adhesion, Chemotaxis

    Keywords - Ligandi

    Growth factor binding, Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CYR61
    Alternative name(s):
    3CH61
    CCN family member 1
    Cysteine-rich angiogenic inducer 61
    Insulin-like growth factor-binding protein 10
    Short name:
    IBP-10
    Short name:
    IGF-binding protein 10
    Short name:
    IGFBP-10
    Gene namesi
    Name:Cyr61
    Synonyms:Ccn1, Igfbp10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:88613. Cyr61.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 379355Protein CYR61PRO_0000014399Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi284 ↔ 321By similarity
    Disulfide bondi301 ↔ 335By similarity
    Disulfide bondi312 ↔ 351By similarity
    Disulfide bondi315 ↔ 353By similarity
    Disulfide bondi320 ↔ 357By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP18406.
    PRIDEiP18406.

    PTM databases

    PhosphoSiteiP18406.

    Expressioni

    Tissue specificityi

    Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung.

    Developmental stagei

    Expressed from G0/G1 through mid-G1 in normal cells, and at a constant level in rapidly growing cells.

    Inductioni

    By growth factors.

    Gene expression databases

    ArrayExpressiP18406.
    BgeeiP18406.
    CleanExiMM_CYR61.
    GenevestigatoriP18406.

    Interactioni

    Subunit structurei

    Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029846.

    Structurei

    3D structure databases

    ProteinModelPortaliP18406.
    SMRiP18406. Positions 293-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9470IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 27146TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 35875CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni277 – 31337Heparin-bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82014.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiP18406.
    KOiK06829.
    OMAiKCIVQTT.
    OrthoDBiEOG7N8ZXB.
    PhylomeDBiP18406.
    TreeFamiTF326070.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18406-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSTFRTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
    GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
    EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
    VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG LDASEVELTR NNELIAIGKG 200
    SSLKRLPVFG TEPRVLFNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT 250
    NDNPECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG 300
    CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS 350
    CKCNYNCPHP NEASFRLYSL FNDIHKFRD 379
    Length:379
    Mass (Da):41,709
    Last modified:November 1, 1990 - v1
    Checksum:iFA6B5014B56A8EE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32490 mRNA. Translation: AAA37512.1.
    X56790 Genomic DNA. Translation: CAA40109.1.
    BC066019 mRNA. Translation: AAH66019.1.
    CCDSiCCDS17895.1.
    PIRiA35669.
    RefSeqiNP_034646.1. NM_010516.2.
    UniGeneiMm.1231.

    Genome annotation databases

    EnsembliENSMUST00000029846; ENSMUSP00000029846; ENSMUSG00000028195.
    GeneIDi16007.
    KEGGimmu:16007.
    UCSCiuc008rqq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32490 mRNA. Translation: AAA37512.1 .
    X56790 Genomic DNA. Translation: CAA40109.1 .
    BC066019 mRNA. Translation: AAH66019.1 .
    CCDSi CCDS17895.1.
    PIRi A35669.
    RefSeqi NP_034646.1. NM_010516.2.
    UniGenei Mm.1231.

    3D structure databases

    ProteinModelPortali P18406.
    SMRi P18406. Positions 293-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029846.

    PTM databases

    PhosphoSitei P18406.

    Proteomic databases

    PaxDbi P18406.
    PRIDEi P18406.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029846 ; ENSMUSP00000029846 ; ENSMUSG00000028195 .
    GeneIDi 16007.
    KEGGi mmu:16007.
    UCSCi uc008rqq.2. mouse.

    Organism-specific databases

    CTDi 3491.
    MGIi MGI:88613. Cyr61.

    Phylogenomic databases

    eggNOGi NOG82014.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi P18406.
    KOi K06829.
    OMAi KCIVQTT.
    OrthoDBi EOG7N8ZXB.
    PhylomeDBi P18406.
    TreeFami TF326070.

    Miscellaneous databases

    NextBioi 288810.
    PROi P18406.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18406.
    Bgeei P18406.
    CleanExi MM_CYR61.
    Genevestigatori P18406.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of cyr61, a growth factor-inducible immediate-early gene."
      O'Brien T.P., Yang G.P., Sanders L., Lau L.F.
      Mol. Cell. Biol. 10:3569-3577(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Fibroblast.
    2. "Promoter function and structure of the growth factor-inducible immediate early gene cyr61."
      Latinkic B.V., O'Brien T.P., Lau L.F.
      Nucleic Acids Res. 19:3261-3267(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A/J.
      Tissue: Embryonic fibroblast.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."
      Chen N., Chen C.-C., Lau L.F.
      J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: HEPARIN-BINDING DOMAIN.

    Entry informationi

    Entry nameiCYR61_MOUSE
    AccessioniPrimary (citable) accession number: P18406
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3