SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P18406

- CYR61_MOUSE

UniProt

P18406 - CYR61_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein CYR61
Gene
Cyr61, Ccn1, Igfbp10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.

GO - Molecular functioni

  1. extracellular matrix binding Source: MGI
  2. heparin binding Source: UniProtKB-KW
  3. integrin binding Source: MGI

GO - Biological processi

  1. apoptotic process involved in heart morphogenesis Source: MGI
  2. atrial septum morphogenesis Source: MGI
  3. atrioventricular valve morphogenesis Source: MGI
  4. cell adhesion Source: MGI
  5. chemotaxis Source: UniProtKB-KW
  6. chondroblast differentiation Source: MGI
  7. chorio-allantoic fusion Source: MGI
  8. extracellular matrix organization Source: MGI
  9. intussusceptive angiogenesis Source: MGI
  10. labyrinthine layer blood vessel development Source: MGI
  11. negative regulation of apoptotic process Source: MGI
  12. osteoblast differentiation Source: MGI
  13. positive regulation of BMP signaling pathway Source: Ensembl
  14. positive regulation of apoptotic process Source: MGI
  15. positive regulation of cartilage development Source: MGI
  16. positive regulation of cell differentiation Source: MGI
  17. positive regulation of cell migration Source: MGI
  18. positive regulation of cell-substrate adhesion Source: MGI
  19. positive regulation of ceramide biosynthetic process Source: MGI
  20. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  21. positive regulation of osteoblast differentiation Source: Ensembl
  22. positive regulation of osteoblast proliferation Source: Ensembl
  23. positive regulation of phospholipase activity Source: MGI
  24. positive regulation of protein kinase activity Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. reactive oxygen species metabolic process Source: MGI
  27. regulation of ERK1 and ERK2 cascade Source: Ensembl
  28. regulation of cell growth Source: InterPro
  29. single organismal cell-cell adhesion Source: MGI
  30. ventricular septum development Source: MGI
  31. wound healing, spreading of cells Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Chemotaxis

Keywords - Ligandi

Growth factor binding, Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
3CH61
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name:
IBP-10
Short name:
IGF-binding protein 10
Short name:
IGFBP-10
Gene namesi
Name:Cyr61
Synonyms:Ccn1, Igfbp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88613. Cyr61.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 379355Protein CYR61
PRO_0000014399Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi284 ↔ 321 By similarity
Disulfide bondi301 ↔ 335 By similarity
Disulfide bondi312 ↔ 351 By similarity
Disulfide bondi315 ↔ 353 By similarity
Disulfide bondi320 ↔ 357 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP18406.
PRIDEiP18406.

PTM databases

PhosphoSiteiP18406.

Expressioni

Tissue specificityi

Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung.

Developmental stagei

Expressed from G0/G1 through mid-G1 in normal cells, and at a constant level in rapidly growing cells.

Inductioni

By growth factors.

Gene expression databases

ArrayExpressiP18406.
BgeeiP18406.
CleanExiMM_CYR61.
GenevestigatoriP18406.

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029846.

Structurei

3D structure databases

ProteinModelPortaliP18406.
SMRiP18406. Positions 293-358.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9470IGFBP N-terminal
Add
BLAST
Domaini98 – 16467VWFC
Add
BLAST
Domaini226 – 27146TSP type-1
Add
BLAST
Domaini284 – 35875CTCK
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 31337Heparin-binding
Add
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG82014.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP18406.
KOiK06829.
OMAiKCIVQTT.
OrthoDBiEOG7N8ZXB.
PhylomeDBiP18406.
TreeFamiTF326070.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18406-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSTFRTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG LDASEVELTR NNELIAIGKG 200
SSLKRLPVFG TEPRVLFNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT 250
NDNPECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG 300
CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS 350
CKCNYNCPHP NEASFRLYSL FNDIHKFRD 379
Length:379
Mass (Da):41,709
Last modified:November 1, 1990 - v1
Checksum:iFA6B5014B56A8EE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32490 mRNA. Translation: AAA37512.1.
X56790 Genomic DNA. Translation: CAA40109.1.
BC066019 mRNA. Translation: AAH66019.1.
CCDSiCCDS17895.1.
PIRiA35669.
RefSeqiNP_034646.1. NM_010516.2.
UniGeneiMm.1231.

Genome annotation databases

EnsembliENSMUST00000029846; ENSMUSP00000029846; ENSMUSG00000028195.
GeneIDi16007.
KEGGimmu:16007.
UCSCiuc008rqq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32490 mRNA. Translation: AAA37512.1 .
X56790 Genomic DNA. Translation: CAA40109.1 .
BC066019 mRNA. Translation: AAH66019.1 .
CCDSi CCDS17895.1.
PIRi A35669.
RefSeqi NP_034646.1. NM_010516.2.
UniGenei Mm.1231.

3D structure databases

ProteinModelPortali P18406.
SMRi P18406. Positions 293-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029846.

PTM databases

PhosphoSitei P18406.

Proteomic databases

PaxDbi P18406.
PRIDEi P18406.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029846 ; ENSMUSP00000029846 ; ENSMUSG00000028195 .
GeneIDi 16007.
KEGGi mmu:16007.
UCSCi uc008rqq.2. mouse.

Organism-specific databases

CTDi 3491.
MGIi MGI:88613. Cyr61.

Phylogenomic databases

eggNOGi NOG82014.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P18406.
KOi K06829.
OMAi KCIVQTT.
OrthoDBi EOG7N8ZXB.
PhylomeDBi P18406.
TreeFami TF326070.

Miscellaneous databases

NextBioi 288810.
PROi P18406.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18406.
Bgeei P18406.
CleanExi MM_CYR61.
Genevestigatori P18406.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of cyr61, a growth factor-inducible immediate-early gene."
    O'Brien T.P., Yang G.P., Sanders L., Lau L.F.
    Mol. Cell. Biol. 10:3569-3577(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Fibroblast.
  2. "Promoter function and structure of the growth factor-inducible immediate early gene cyr61."
    Latinkic B.V., O'Brien T.P., Lau L.F.
    Nucleic Acids Res. 19:3261-3267(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A/J.
    Tissue: Embryonic fibroblast.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."
    Chen N., Chen C.-C., Lau L.F.
    J. Biol. Chem. 275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: HEPARIN-BINDING DOMAIN.

Entry informationi

Entry nameiCYR61_MOUSE
AccessioniPrimary (citable) accession number: P18406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi