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Reviewed, UniProtKB/Swiss-Prot P18405 (S5A1_HUMAN)

Last modified January 19, 2010. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    EC=1.3.99.5
Alternative name(s):
    Steroid 5-alpha-reductase 1
      Short name=S5AR
    SR type 1
Gene names
Name: SRD5A1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activity

A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.

Subcellular location

Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Tissue specificity

Liver and prostate (at a low level).

Induction

Its expression is regulated by androgens such as testosterone.

Sequence similarities

Belongs to the steroid 5-alpha reductase family.

Biophysicochemical properties

pH dependence:

Optimally active at alkaline pHs.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2592593-oxo-5-alpha-steroid 4-dehydrogenase 1
PRO_0000213674

Regions

Transmembrane12 – 2918 Potential
Transmembrane86 – 10621 Potential
Transmembrane111 – 13121 Potential
Transmembrane151 – 17121 Potential
Transmembrane209 – 22921 Potential

Experimental info

Sequence conflict29 – 7648Missing in AAF14869. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
P18405-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: AEF9FD5521E43AC4

FASTA25929,459
        10         20         30         40         50         60 
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE 

        70         80         90        100        110        120 
LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA 

       130        140        150        160        170        180 
IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD 

       190        200        210        220        230        240 
TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY 

       250 
LRKFEEYPKF RKIIIPFLF

« Hide

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References

« Hide 'large scale' references
[1]"Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases."
Andersson S., Russell D.W.
Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed: 2339109] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."
Jenkins E.P., Hsieh C.L., Milatovich A., Normington K., Berman D.M., Francke U., Russell D.W.
Genomics 11:1102-1112(1991) [PubMed: 1686016] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Yu W., Sarginson J., Gibbs R.A.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adrenal gland.
[5]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]NIEHS SNPs program
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Urinary bladder.
[10]"New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."
Eminovic I., Liovic M., Prezelj J., Kocijancic A., Rozman D., Komel R.
Pflugers Arch. 442:R187-R189(2001) [PubMed: 11678334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 155-187.
+Additional computationally mapped references.

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Web resources

NIEHS-SNPs
Wikipedia

5-alpha reductase entry

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M32313 mRNA. Translation: AAA35490.1.
M68886 expand/collapse EMBL AC list , M68882, M68883, M68884, M68885 Genomic DNA. Translation: AAA60995.1.
AF052126 mRNA. Translation: AAC28620.1.
AF113128 mRNA. Translation: AAF14869.1.
BT006834 mRNA. Translation: AAP35480.1.
AY341029 Genomic DNA. Translation: AAP88935.1.
AK313070 mRNA. Translation: BAG35898.1.
CH471102 Genomic DNA. Translation: EAX08104.1.
BC007033 mRNA. Translation: AAH07033.1.
BC008673 mRNA. Translation: AAH08673.1.
AF073301 Genomic DNA. Translation: AAC26862.1.
AF073302 Genomic DNA. Translation: AAC26863.1.
AF073303 Genomic DNA. Translation: AAC26864.1.
AF073304 Genomic DNA. Translation: AAC26865.1.
IPIIPI00032233.
PIRA55274.
RefSeqNP_001038.1.
UniGeneHs.552

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP18405.

Proteomic databases

PRIDEP18405.

Genome annotation databases

EnsemblENST00000274192; ENSP00000274192; ENSG00000145545; Homo sapiens. [Genome view]
GeneID6715.
KEGGhsa:6715.
UCSCuc003jdw.1. human.

Organism-specific databases

CTD6715.
GeneCardsGC05P006686.
H-InvDBHIX0004734.
HGNCHGNC:11284. SRD5A1.
MIM184753. gene.
PharmGKBPA36112.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG05245.
HOGENOMHBG714186.
HOVERGENP18405.
InParanoidP18405.
OMASAANYFG.
OrthoDBEOG9QFZZH.
PhylomeDBP18405.

Enzyme and pathway databases

BRENDA1.3.99.5. 247.

Gene expression databases

ArrayExpressP18405.
BgeeP18405.
CleanExHS_SRD5A1.
GenevestigatorP18405.
GermOnlineENSG00000145545. Homo sapiens.

Family and domain databases

InterProIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB01126. Dutasteride.
DB01216. Finasteride.
NextBio26192.
SOURCESearch...

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Entry information

Entry nameS5A1_HUMAN
AccessionPrimary (citable) accession number: P18405
Secondary accession number(s): B2R7Q1 expand/collapse secondary AC list , Q9UHY4, Q9UP36, Q9UP37
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: January 19, 2010
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents