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P18405

- S5A1_HUMAN

UniProt

P18405 - S5A1_HUMAN

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Protein
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Gene
SRD5A1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

pH dependencei

Optimally active at alkaline pHs.

GO - Molecular functioni

  1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  3. electron carrier activity Source: UniProtKB

GO - Biological processi

  1. androgen biosynthetic process Source: Reactome
  2. cell differentiation Source: UniProtKB-KW
  3. sex determination Source: ProtInc
  4. sex differentiation Source: UniProtKB-KW
  5. small molecule metabolic process Source: Reactome
  6. steroid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS07261-MONOMER.
ReactomeiREACT_11059. Androgen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:SRD5A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11284. SRD5A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 2918Helical; Reviewed prediction
Add
BLAST
Transmembranei86 – 10621Helical; Reviewed prediction
Add
BLAST
Transmembranei111 – 13121Helical; Reviewed prediction
Add
BLAST
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST
Transmembranei209 – 22921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2592593-oxo-5-alpha-steroid 4-dehydrogenase 1
PRO_0000213674Add
BLAST

Proteomic databases

MaxQBiP18405.
PRIDEiP18405.

PTM databases

PhosphoSiteiP18405.

Expressioni

Tissue specificityi

Liver and prostate (at a low level).

Inductioni

Its expression is regulated by androgens such as testosterone.

Gene expression databases

ArrayExpressiP18405.
BgeeiP18405.
CleanExiHS_SRD5A1.
GenevestigatoriP18405.

Organism-specific databases

HPAiHPA051402.

Interactioni

Protein-protein interaction databases

BioGridi112593. 2 interactions.
STRINGi9606.ENSP00000274192.

Structurei

3D structure databases

ProteinModelPortaliP18405.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82739.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiP18405.
KOiK12343.
OMAiVSAANYF.
OrthoDBiEOG75QR56.
PhylomeDBiP18405.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18405-1 [UniParc]FASTAAdd to Basket

« Hide

MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV    50
PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL 100
IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR 150
FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF 200
GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF 250
RKIIIPFLF 259
Length:259
Mass (Da):29,459
Last modified:November 1, 1990 - v1
Checksum:iAEF9FD5521E43AC4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 7648Missing in AAF14869. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32313 mRNA. Translation: AAA35490.1.
M68886
, M68882, M68883, M68884, M68885 Genomic DNA. Translation: AAA60995.1.
AF052126 mRNA. Translation: AAC28620.1.
AF113128 mRNA. Translation: AAF14869.1.
BT006834 mRNA. Translation: AAP35480.1.
AY341029 Genomic DNA. Translation: AAP88935.1.
AK313070 mRNA. Translation: BAG35898.1.
CH471102 Genomic DNA. Translation: EAX08104.1.
BC007033 mRNA. Translation: AAH07033.1.
BC008673 mRNA. Translation: AAH08673.1.
AF073301 Genomic DNA. Translation: AAC26862.1.
AF073302 Genomic DNA. Translation: AAC26863.1.
AF073303 Genomic DNA. Translation: AAC26864.1.
AF073304 Genomic DNA. Translation: AAC26865.1.
CCDSiCCDS3870.1.
PIRiA55274.
RefSeqiNP_001038.1. NM_001047.2.
UniGeneiHs.552.

Genome annotation databases

EnsembliENST00000274192; ENSP00000274192; ENSG00000145545.
GeneIDi6715.
KEGGihsa:6715.
UCSCiuc003jdw.3. human.

Polymorphism databases

DMDMi134151.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

5-alpha reductase entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32313 mRNA. Translation: AAA35490.1 .
M68886
, M68882 , M68883 , M68884 , M68885 Genomic DNA. Translation: AAA60995.1 .
AF052126 mRNA. Translation: AAC28620.1 .
AF113128 mRNA. Translation: AAF14869.1 .
BT006834 mRNA. Translation: AAP35480.1 .
AY341029 Genomic DNA. Translation: AAP88935.1 .
AK313070 mRNA. Translation: BAG35898.1 .
CH471102 Genomic DNA. Translation: EAX08104.1 .
BC007033 mRNA. Translation: AAH07033.1 .
BC008673 mRNA. Translation: AAH08673.1 .
AF073301 Genomic DNA. Translation: AAC26862.1 .
AF073302 Genomic DNA. Translation: AAC26863.1 .
AF073303 Genomic DNA. Translation: AAC26864.1 .
AF073304 Genomic DNA. Translation: AAC26865.1 .
CCDSi CCDS3870.1.
PIRi A55274.
RefSeqi NP_001038.1. NM_001047.2.
UniGenei Hs.552.

3D structure databases

ProteinModelPortali P18405.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112593. 2 interactions.
STRINGi 9606.ENSP00000274192.

Chemistry

BindingDBi P18405.
ChEMBLi CHEMBL1787.
DrugBanki DB01126. Dutasteride.
DB01216. Finasteride.

PTM databases

PhosphoSitei P18405.

Polymorphism databases

DMDMi 134151.

Proteomic databases

MaxQBi P18405.
PRIDEi P18405.

Protocols and materials databases

DNASUi 6715.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274192 ; ENSP00000274192 ; ENSG00000145545 .
GeneIDi 6715.
KEGGi hsa:6715.
UCSCi uc003jdw.3. human.

Organism-specific databases

CTDi 6715.
GeneCardsi GC05P006633.
HGNCi HGNC:11284. SRD5A1.
HPAi HPA051402.
MIMi 184753. gene.
neXtProti NX_P18405.
PharmGKBi PA36112.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82739.
HOGENOMi HOG000050133.
HOVERGENi HBG003402.
InParanoidi P18405.
KOi K12343.
OMAi VSAANYF.
OrthoDBi EOG75QR56.
PhylomeDBi P18405.
TreeFami TF314668.

Enzyme and pathway databases

BioCyci MetaCyc:HS07261-MONOMER.
Reactomei REACT_11059. Androgen biosynthesis.

Miscellaneous databases

GeneWikii SRD5A1.
GenomeRNAii 6715.
NextBioi 26192.
PROi P18405.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18405.
Bgeei P18405.
CleanExi HS_SRD5A1.
Genevestigatori P18405.

Family and domain databases

InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view ]
Pfami PF02544. Steroid_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases."
    Andersson S., Russell D.W.
    Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."
    Jenkins E.P., Hsieh C.L., Milatovich A., Normington K., Berman D.M., Francke U., Russell D.W.
    Genomics 11:1102-1112(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Yu W., Sarginson J., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. NIEHS SNPs program
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Urinary bladder.
  10. "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."
    Eminovic I., Liovic M., Prezelj J., Kocijancic A., Rozman D., Komel R.
    Pflugers Arch. 442:R187-R189(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 155-187.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS5A1_HUMAN
AccessioniPrimary (citable) accession number: P18405
Secondary accession number(s): B2R7Q1
, Q9UHY4, Q9UP36, Q9UP37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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