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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

SRD5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta4-steroid + NADPH.

pH dependencei

Optimally active at alkaline pHs.

GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  • amide binding Source: Ensembl
  • cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  • electron transfer activity Source: UniProtKB
  • NADPH binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDifferentiation, Sexual differentiation
LigandNADP

Enzyme and pathway databases

BioCyciMetaCyc:HS07261-MONOMER
BRENDAi1.3.1.22 2681
1.3.99.5 2681
ReactomeiR-HSA-193048 Androgen biosynthesis
SIGNORiP18405

Chemistry databases

SwissLipidsiSLP:000001636

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:SRD5A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145545.11
HGNCiHGNC:11284 SRD5A1
MIMi184753 gene
neXtProtiNX_P18405

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 29HelicalSequence analysisAdd BLAST18
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi6715
OpenTargetsiENSG00000145545
PharmGKBiPA36112

Chemistry databases

ChEMBLiCHEMBL1787
DrugBankiDB01126 Dutasteride
DB01216 Finasteride
DB00367 Levonorgestrel
DB09389 Norgestrel
DB06412 Oxymetholone
DB00421 Spironolactone

Polymorphism and mutation databases

BioMutaiSRD5A1
DMDMi134151

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136741 – 2593-oxo-5-alpha-steroid 4-dehydrogenase 1Add BLAST259

Proteomic databases

EPDiP18405
MaxQBiP18405
PaxDbiP18405
PeptideAtlasiP18405
PRIDEiP18405

PTM databases

PhosphoSitePlusiP18405

Expressioni

Tissue specificityi

Liver and prostate (at a low level).

Inductioni

Its expression is regulated by androgens such as testosterone.

Gene expression databases

BgeeiENSG00000145545
CleanExiHS_SRD5A1
ExpressionAtlasiP18405 baseline and differential
GenevisibleiP18405 HS

Organism-specific databases

HPAiHPA051402

Interactioni

Protein-protein interaction databases

BioGridi112593, 3 interactors
STRINGi9606.ENSP00000274192

Chemistry databases

BindingDBiP18405

Structurei

3D structure databases

ProteinModelPortaliP18405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1638 Eukaryota
ENOG410XS6P LUCA
GeneTreeiENSGT00510000046634
HOGENOMiHOG000050133
HOVERGENiHBG003402
InParanoidiP18405
KOiK12343
OMAiVEWCGFA
OrthoDBiEOG091G0KU4
PhylomeDBiP18405
TreeFamiTF314668

Family and domain databases

InterProiView protein in InterPro
IPR016636 3-oxo-5-alpha-steroid_4-DH
IPR001104 3-oxo-5_a-steroid_4-DH_C
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
PIRSFiPIRSF015596 5_alpha-SR2, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

P18405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV
60 70 80 90 100
PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL
110 120 130 140 150
IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR
160 170 180 190 200
FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF
210 220 230 240 250
GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF

RKIIIPFLF
Length:259
Mass (Da):29,459
Last modified:November 1, 1990 - v1
Checksum:iAEF9FD5521E43AC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29 – 76Missing in AAF14869 (PubMed:10931946).CuratedAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32313 mRNA Translation: AAA35490.1
M68886
, M68882, M68883, M68884, M68885 Genomic DNA Translation: AAA60995.1
AF052126 mRNA Translation: AAC28620.1
AF113128 mRNA Translation: AAF14869.1
BT006834 mRNA Translation: AAP35480.1
AY341029 Genomic DNA Translation: AAP88935.1
AK313070 mRNA Translation: BAG35898.1
CH471102 Genomic DNA Translation: EAX08104.1
BC007033 mRNA Translation: AAH07033.1
BC008673 mRNA Translation: AAH08673.1
AF073301 Genomic DNA Translation: AAC26862.1
AF073302 Genomic DNA Translation: AAC26863.1
AF073303 Genomic DNA Translation: AAC26864.1
AF073304 Genomic DNA Translation: AAC26865.1
CCDSiCCDS3870.1
PIRiA55274
RefSeqiNP_001038.1, NM_001047.3
NP_001311251.1, NM_001324322.1
NP_001311252.1, NM_001324323.1
UniGeneiHs.552

Genome annotation databases

EnsembliENST00000274192; ENSP00000274192; ENSG00000145545
GeneIDi6715
KEGGihsa:6715
UCSCiuc003jdw.4 human

Similar proteinsi

Entry informationi

Entry nameiS5A1_HUMAN
AccessioniPrimary (citable) accession number: P18405
Secondary accession number(s): B2R7Q1
, Q9UHY4, Q9UP36, Q9UP37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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