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P18405

- S5A1_HUMAN

UniProt

P18405 - S5A1_HUMAN

Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

SRD5A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

    Catalytic activityi

    A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

    pH dependencei

    Optimally active at alkaline pHs.

    GO - Molecular functioni

    1. 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
    2. cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
    3. electron carrier activity Source: UniProtKB

    GO - Biological processi

    1. androgen biosynthetic process Source: Reactome
    2. cell differentiation Source: UniProtKB-KW
    3. sex determination Source: ProtInc
    4. sex differentiation Source: UniProtKB-KW
    5. small molecule metabolic process Source: Reactome
    6. steroid metabolic process Source: Reactome

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Differentiation, Sexual differentiation

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciMetaCyc:HS07261-MONOMER.
    ReactomeiREACT_11059. Androgen biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
    Alternative name(s):
    SR type 1
    Steroid 5-alpha-reductase 1
    Short name:
    S5AR 1
    Gene namesi
    Name:SRD5A1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11284. SRD5A1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36112.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2592593-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000213674Add
    BLAST

    Proteomic databases

    MaxQBiP18405.
    PRIDEiP18405.

    PTM databases

    PhosphoSiteiP18405.

    Expressioni

    Tissue specificityi

    Liver and prostate (at a low level).

    Inductioni

    Its expression is regulated by androgens such as testosterone.

    Gene expression databases

    ArrayExpressiP18405.
    BgeeiP18405.
    CleanExiHS_SRD5A1.
    GenevestigatoriP18405.

    Organism-specific databases

    HPAiHPA051402.

    Interactioni

    Protein-protein interaction databases

    BioGridi112593. 2 interactions.
    STRINGi9606.ENSP00000274192.

    Structurei

    3D structure databases

    ProteinModelPortaliP18405.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 2918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the steroid 5-alpha reductase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82739.
    HOGENOMiHOG000050133.
    HOVERGENiHBG003402.
    InParanoidiP18405.
    KOiK12343.
    OMAiVSAANYF.
    OrthoDBiEOG75QR56.
    PhylomeDBiP18405.
    TreeFamiTF314668.

    Family and domain databases

    InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view]
    PfamiPF02544. Steroid_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P18405-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV    50
    PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL 100
    IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR 150
    FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF 200
    GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF 250
    RKIIIPFLF 259
    Length:259
    Mass (Da):29,459
    Last modified:November 1, 1990 - v1
    Checksum:iAEF9FD5521E43AC4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 7648Missing in AAF14869. (PubMed:10931946)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32313 mRNA. Translation: AAA35490.1.
    M68886
    , M68882, M68883, M68884, M68885 Genomic DNA. Translation: AAA60995.1.
    AF052126 mRNA. Translation: AAC28620.1.
    AF113128 mRNA. Translation: AAF14869.1.
    BT006834 mRNA. Translation: AAP35480.1.
    AY341029 Genomic DNA. Translation: AAP88935.1.
    AK313070 mRNA. Translation: BAG35898.1.
    CH471102 Genomic DNA. Translation: EAX08104.1.
    BC007033 mRNA. Translation: AAH07033.1.
    BC008673 mRNA. Translation: AAH08673.1.
    AF073301 Genomic DNA. Translation: AAC26862.1.
    AF073302 Genomic DNA. Translation: AAC26863.1.
    AF073303 Genomic DNA. Translation: AAC26864.1.
    AF073304 Genomic DNA. Translation: AAC26865.1.
    CCDSiCCDS3870.1.
    PIRiA55274.
    RefSeqiNP_001038.1. NM_001047.2.
    UniGeneiHs.552.

    Genome annotation databases

    EnsembliENST00000274192; ENSP00000274192; ENSG00000145545.
    GeneIDi6715.
    KEGGihsa:6715.
    UCSCiuc003jdw.3. human.

    Polymorphism databases

    DMDMi134151.

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs
    Wikipedia

    5-alpha reductase entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32313 mRNA. Translation: AAA35490.1 .
    M68886
    , M68882 , M68883 , M68884 , M68885 Genomic DNA. Translation: AAA60995.1 .
    AF052126 mRNA. Translation: AAC28620.1 .
    AF113128 mRNA. Translation: AAF14869.1 .
    BT006834 mRNA. Translation: AAP35480.1 .
    AY341029 Genomic DNA. Translation: AAP88935.1 .
    AK313070 mRNA. Translation: BAG35898.1 .
    CH471102 Genomic DNA. Translation: EAX08104.1 .
    BC007033 mRNA. Translation: AAH07033.1 .
    BC008673 mRNA. Translation: AAH08673.1 .
    AF073301 Genomic DNA. Translation: AAC26862.1 .
    AF073302 Genomic DNA. Translation: AAC26863.1 .
    AF073303 Genomic DNA. Translation: AAC26864.1 .
    AF073304 Genomic DNA. Translation: AAC26865.1 .
    CCDSi CCDS3870.1.
    PIRi A55274.
    RefSeqi NP_001038.1. NM_001047.2.
    UniGenei Hs.552.

    3D structure databases

    ProteinModelPortali P18405.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112593. 2 interactions.
    STRINGi 9606.ENSP00000274192.

    Chemistry

    BindingDBi P18405.
    ChEMBLi CHEMBL1787.
    DrugBanki DB01126. Dutasteride.
    DB01216. Finasteride.

    PTM databases

    PhosphoSitei P18405.

    Polymorphism databases

    DMDMi 134151.

    Proteomic databases

    MaxQBi P18405.
    PRIDEi P18405.

    Protocols and materials databases

    DNASUi 6715.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274192 ; ENSP00000274192 ; ENSG00000145545 .
    GeneIDi 6715.
    KEGGi hsa:6715.
    UCSCi uc003jdw.3. human.

    Organism-specific databases

    CTDi 6715.
    GeneCardsi GC05P006633.
    HGNCi HGNC:11284. SRD5A1.
    HPAi HPA051402.
    MIMi 184753. gene.
    neXtProti NX_P18405.
    PharmGKBi PA36112.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82739.
    HOGENOMi HOG000050133.
    HOVERGENi HBG003402.
    InParanoidi P18405.
    KOi K12343.
    OMAi VSAANYF.
    OrthoDBi EOG75QR56.
    PhylomeDBi P18405.
    TreeFami TF314668.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS07261-MONOMER.
    Reactomei REACT_11059. Androgen biosynthesis.

    Miscellaneous databases

    GeneWikii SRD5A1.
    GenomeRNAii 6715.
    NextBioi 26192.
    PROi P18405.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18405.
    Bgeei P18405.
    CleanExi HS_SRD5A1.
    Genevestigatori P18405.

    Family and domain databases

    InterProi IPR016636. 3-oxo-5-alpha-steroid_4-DH.
    IPR001104. 3-oxo-5_a-steroid_4-DH_C.
    [Graphical view ]
    Pfami PF02544. Steroid_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015596. 5_alpha-SR2. 1 hit.
    PROSITEi PS50244. S5A_REDUCTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases."
      Andersson S., Russell D.W.
      Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."
      Jenkins E.P., Hsieh C.L., Milatovich A., Normington K., Berman D.M., Francke U., Russell D.W.
      Genomics 11:1102-1112(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Yu W., Sarginson J., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. NIEHS SNPs program
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Urinary bladder.
    10. "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."
      Eminovic I., Liovic M., Prezelj J., Kocijancic A., Rozman D., Komel R.
      Pflugers Arch. 442:R187-R189(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 155-187.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS5A1_HUMAN
    AccessioniPrimary (citable) accession number: P18405
    Secondary accession number(s): B2R7Q1
    , Q9UHY4, Q9UP36, Q9UP37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3