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Protein

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene

SRD5A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activityi

A 3-oxo-5-alpha-steroid + NADP+ = a 3-oxo-Delta(4)-steroid + NADPH.

pH dependencei

Optimally active at alkaline pHs.

GO - Molecular functioni

  • 3-oxo-5-alpha-steroid 4-dehydrogenase activity Source: UniProtKB
  • cholestenone 5-alpha-reductase activity Source: UniProtKB-EC
  • electron carrier activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Differentiation, Sexual differentiation

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS07261-MONOMER.
BRENDAi1.3.1.22. 2681.
1.3.99.5. 2681.
ReactomeiREACT_11059. Androgen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC:1.3.1.22)
Alternative name(s):
SR type 1
Steroid 5-alpha-reductase 1
Short name:
S5AR 1
Gene namesi
Name:SRD5A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11284. SRD5A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 2918HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36112.

Chemistry

DrugBankiDB01126. Dutasteride.
DB01216. Finasteride.
DB00367. Levonorgestrel.
DB00421. Spironolactone.

Polymorphism and mutation databases

BioMutaiSRD5A1.
DMDMi134151.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2592593-oxo-5-alpha-steroid 4-dehydrogenase 1PRO_0000213674Add
BLAST

Proteomic databases

MaxQBiP18405.
PRIDEiP18405.

PTM databases

PhosphoSiteiP18405.

Expressioni

Tissue specificityi

Liver and prostate (at a low level).

Inductioni

Its expression is regulated by androgens such as testosterone.

Gene expression databases

BgeeiP18405.
CleanExiHS_SRD5A1.
ExpressionAtlasiP18405. baseline and differential.
GenevisibleiP18405. HS.

Organism-specific databases

HPAiHPA051402.

Interactioni

Protein-protein interaction databases

BioGridi112593. 1 interaction.
STRINGi9606.ENSP00000274192.

Structurei

3D structure databases

ProteinModelPortaliP18405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82739.
GeneTreeiENSGT00510000046634.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiP18405.
KOiK12343.
OMAiRGWFFPL.
OrthoDBiEOG75QR56.
PhylomeDBiP18405.
TreeFamiTF314668.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV
60 70 80 90 100
PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL
110 120 130 140 150
IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR
160 170 180 190 200
FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF
210 220 230 240 250
GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF

RKIIIPFLF
Length:259
Mass (Da):29,459
Last modified:November 1, 1990 - v1
Checksum:iAEF9FD5521E43AC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 7648Missing in AAF14869 (PubMed:10931946).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32313 mRNA. Translation: AAA35490.1.
M68886
, M68882, M68883, M68884, M68885 Genomic DNA. Translation: AAA60995.1.
AF052126 mRNA. Translation: AAC28620.1.
AF113128 mRNA. Translation: AAF14869.1.
BT006834 mRNA. Translation: AAP35480.1.
AY341029 Genomic DNA. Translation: AAP88935.1.
AK313070 mRNA. Translation: BAG35898.1.
CH471102 Genomic DNA. Translation: EAX08104.1.
BC007033 mRNA. Translation: AAH07033.1.
BC008673 mRNA. Translation: AAH08673.1.
AF073301 Genomic DNA. Translation: AAC26862.1.
AF073302 Genomic DNA. Translation: AAC26863.1.
AF073303 Genomic DNA. Translation: AAC26864.1.
AF073304 Genomic DNA. Translation: AAC26865.1.
CCDSiCCDS3870.1.
PIRiA55274.
RefSeqiNP_001038.1. NM_001047.2.
UniGeneiHs.552.

Genome annotation databases

EnsembliENST00000274192; ENSP00000274192; ENSG00000145545.
GeneIDi6715.
KEGGihsa:6715.
UCSCiuc003jdw.3. human.

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

5-alpha reductase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32313 mRNA. Translation: AAA35490.1.
M68886
, M68882, M68883, M68884, M68885 Genomic DNA. Translation: AAA60995.1.
AF052126 mRNA. Translation: AAC28620.1.
AF113128 mRNA. Translation: AAF14869.1.
BT006834 mRNA. Translation: AAP35480.1.
AY341029 Genomic DNA. Translation: AAP88935.1.
AK313070 mRNA. Translation: BAG35898.1.
CH471102 Genomic DNA. Translation: EAX08104.1.
BC007033 mRNA. Translation: AAH07033.1.
BC008673 mRNA. Translation: AAH08673.1.
AF073301 Genomic DNA. Translation: AAC26862.1.
AF073302 Genomic DNA. Translation: AAC26863.1.
AF073303 Genomic DNA. Translation: AAC26864.1.
AF073304 Genomic DNA. Translation: AAC26865.1.
CCDSiCCDS3870.1.
PIRiA55274.
RefSeqiNP_001038.1. NM_001047.2.
UniGeneiHs.552.

3D structure databases

ProteinModelPortaliP18405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112593. 1 interaction.
STRINGi9606.ENSP00000274192.

Chemistry

BindingDBiP18405.
ChEMBLiCHEMBL1787.
DrugBankiDB01126. Dutasteride.
DB01216. Finasteride.
DB00367. Levonorgestrel.
DB00421. Spironolactone.

PTM databases

PhosphoSiteiP18405.

Polymorphism and mutation databases

BioMutaiSRD5A1.
DMDMi134151.

Proteomic databases

MaxQBiP18405.
PRIDEiP18405.

Protocols and materials databases

DNASUi6715.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274192; ENSP00000274192; ENSG00000145545.
GeneIDi6715.
KEGGihsa:6715.
UCSCiuc003jdw.3. human.

Organism-specific databases

CTDi6715.
GeneCardsiGC05P006633.
HGNCiHGNC:11284. SRD5A1.
HPAiHPA051402.
MIMi184753. gene.
neXtProtiNX_P18405.
PharmGKBiPA36112.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG82739.
GeneTreeiENSGT00510000046634.
HOGENOMiHOG000050133.
HOVERGENiHBG003402.
InParanoidiP18405.
KOiK12343.
OMAiRGWFFPL.
OrthoDBiEOG75QR56.
PhylomeDBiP18405.
TreeFamiTF314668.

Enzyme and pathway databases

BioCyciMetaCyc:HS07261-MONOMER.
BRENDAi1.3.1.22. 2681.
1.3.99.5. 2681.
ReactomeiREACT_11059. Androgen biosynthesis.

Miscellaneous databases

GeneWikiiSRD5A1.
GenomeRNAii6715.
NextBioi26192.
PROiP18405.
SOURCEiSearch...

Gene expression databases

BgeeiP18405.
CleanExiHS_SRD5A1.
ExpressionAtlasiP18405. baseline and differential.
GenevisibleiP18405. HS.

Family and domain databases

InterProiIPR016636. 3-oxo-5-alpha-steroid_4-DH.
IPR001104. 3-oxo-5_a-steroid_4-DH_C.
[Graphical view]
PfamiPF02544. Steroid_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015596. 5_alpha-SR2. 1 hit.
PROSITEiPS50244. S5A_REDUCTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases."
    Andersson S., Russell D.W.
    Proc. Natl. Acad. Sci. U.S.A. 87:3640-3644(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue."
    Jenkins E.P., Hsieh C.L., Milatovich A., Normington K., Berman D.M., Francke U., Russell D.W.
    Genomics 11:1102-1112(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Yu W., Sarginson J., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. NIEHS SNPs program
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Urinary bladder.
  10. "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8."
    Eminovic I., Liovic M., Prezelj J., Kocijancic A., Rozman D., Komel R.
    Pflugers Arch. 442:R187-R189(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-98 AND 155-187.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS5A1_HUMAN
AccessioniPrimary (citable) accession number: P18405
Secondary accession number(s): B2R7Q1
, Q9UHY4, Q9UP36, Q9UP37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 22, 2015
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.