Reviewed, UniProtKB/Swiss-Prot P18395 (CSDE1_RAT)

Names and origin

Protein names

Recommended name:
    Cold shock domain-containing protein E1
Alternative name(s):
    Protein UNR

Gene names

Name:	Csde1
Synonyms:	Unr

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	798 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain By similarity.
Subunit structure	Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Contains 9 CSD (cold-shock) domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 798	798	Cold shock domain-containing protein E1		PRO_0000100350
Regions
	Domain	26 – 87	62	CSD 1
	Domain	136 – 179	44	CSD 2; truncated
	Domain	186 – 245	60	CSD 3
	Domain	297 – 337	41	CSD 4; truncated
	Domain	349 – 410	62	CSD 5
	Domain	447 – 507	61	CSD 6
	Domain	519 – 579	61	CSD 7
	Domain	610 – 670	61	CSD 8
	Domain	674 – 735	62	CSD 9
Amino acid modifications
	Modified residue	81	1	N6-acetyllysine By similarity
	Modified residue	116	1	Phosphoserine By similarity
	Modified residue	123	1	Phosphoserine By similarity
	Modified residue	444	1	Phosphothreonine By similarity
	Modified residue	445	1	Phosphoserine By similarity
	Modified residue	481	1	Phosphothreonine By similarity
	Modified residue	514	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P18395-1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: F484B3FA8B0995A4	FASTA	798	88,895
	10 20 30 40 50 60 MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF FHCSQYNGNL 70 80 90 100 110 120 QDLKVGDDVE FEVSSDRRTG KPIAIKLVKI KPEIHPEERM NGQVVCAVPH NLESKSPAAP 130 140 150 160 170 180 GQSPTGSVCY ERNGEVFYLT YTSEDVEGNV QLETGDKINF VIDNNKHTGA VSARNIMLLK 190 200 210 220 230 240 KKQARYQGVV CAMKEAFGFI ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE 250 260 270 280 290 300 VATDVRLLPQ GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG 310 320 330 340 350 360 DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM GVIAAMRDGF 370 380 390 400 410 420 GFIKCVDRDA RMFFHFSEIL DGNQLHIADE VEFTVVPDML SAQRNHAIRI KKLPKGTVSF 430 440 450 460 470 480 HSHSDHRFLG TVEKEATFSN PKTTSPNKGK DKEAEDGIIA YDDCGVKLTI AFQAKDVEGS 490 500 510 520 530 540 TSPQIGDKVE FSISDKQRPG QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK 550 560 570 580 590 600 EIFFHYSEFS GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KTHSVNGITE EANPTIYSGK 610 620 630 640 650 660 VIRPLRGVDP TQIEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE SVKFQLCVLG 670 680 690 700 710 720 QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF HVKEVQDGIE LQAGDEVEFS 730 740 750 760 770 780 VILNQRTGKC SACNVWRVCE GPKAVAAPRP DRLVNRLKNI TLDDASAPRL MVLRQPRGPD 790 NSMGFGAERK IRQAGVID

References

[1]	"Characterization of unr; a gene closely linked to N-ras." Jeffers M., Paciucci R., Pellicer A. Nucleic Acids Res. 18:4891-4899(1990) [PubMed: 2204029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52311 mRNA. Translation: CAA36549.1.
IPI	IPI00190971.
PIR	S11210.
RefSeq	NP_446458.1.
UniGene	Rn.3562
3D structure databases
SMR	P18395. Positions 16-90, 172-259, 345-424, 508-582, 673-744.
ModBase	Search...
PTM databases
PhosphoSite	P18395.
Genome annotation databases
Ensembl	ENSRNOT00000041529; ENSRNOP00000051275; ENSRNOG00000030302; Rattus norvegicus. [Genome view]
GeneID	117180.
KEGG	rno:117180.
UCSC	NM_054006. rat.
Organism-specific databases
CTD	117180.
RGD	619726. Csde1.
Phylogenomic databases
eggNOG	roNOG14308.
HOVERGEN	P18395.
Gene expression databases
Genevestigator	P18395.
Family and domain databases
InterPro	IPR019844. Cold-shock_CS. IPR011129. Cold_shock_prot. IPR002059. CSP_DNA_bd. IPR016027. NA-bd_OB-fold-like. [Graphical view]
Pfam	PF00313. CSD. 5 hits. [Graphical view]
SMART	SM00357. CSP. 5 hits. [Graphical view]
PROSITE	PS00352. COLD_SHOCK. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	620034.

Entry information

Entry name

CSDE1_RAT

Accession

Primary (citable) accession number: P18395

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	January 19, 2010
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)