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Protein

Cold shock domain-containing protein E1

Gene

Csde1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein E1
Alternative name(s):
Protein UNR
Gene namesi
Name:Csde1
Synonyms:Unr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi619726. Csde1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003501 – 798Cold shock domain-containing protein E1Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81N6-acetyllysineBy similarity1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei123PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei514PhosphoserineBy similarity1
Modified residuei584PhosphoserineBy similarity1
Modified residuei761PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP18395.
PRIDEiP18395.

PTM databases

iPTMnetiP18395.
PhosphoSitePlusiP18395.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030302.
GenevisibleiP18395. RN.

Interactioni

Subunit structurei

Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Interacts with STRAP. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, HNRPD and SYNCRIP. The interaction with PABPC1 is direct and RNA-independent (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051275.

Structurei

3D structure databases

ProteinModelPortaliP18395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 87CSD 1Add BLAST62
Domaini136 – 179CSD 2; truncatedAdd BLAST44
Domaini186 – 245CSD 3Add BLAST60
Domaini297 – 337CSD 4; truncatedAdd BLAST41
Domaini349 – 410CSD 5Add BLAST62
Domaini447 – 507CSD 6Add BLAST61
Domaini519 – 579CSD 7Add BLAST61
Domaini610 – 670CSD 8Add BLAST61
Domaini674 – 735CSD 9Add BLAST62

Sequence similaritiesi

Contains 9 CSD (cold-shock) domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IF27. Eukaryota.
ENOG410ZH8Y. LUCA.
GeneTreeiENSGT00390000016950.
HOGENOMiHOG000013035.
HOVERGENiHBG013042.
InParanoidiP18395.
OMAiLFFHMSE.
OrthoDBiEOG091G053Z.
PhylomeDBiP18395.

Family and domain databases

CDDicd04458. CSP_CDS. 2 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF00313. CSD. 5 hits.
PF12901. SUZ-C. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 5 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFDPNLLHN NGHNGYPNGT SAALRETGVI EKLLTSYGFI QCSERQARLF
60 70 80 90 100
FHCSQYNGNL QDLKVGDDVE FEVSSDRRTG KPIAIKLVKI KPEIHPEERM
110 120 130 140 150
NGQVVCAVPH NLESKSPAAP GQSPTGSVCY ERNGEVFYLT YTSEDVEGNV
160 170 180 190 200
QLETGDKINF VIDNNKHTGA VSARNIMLLK KKQARYQGVV CAMKEAFGFI
210 220 230 240 250
ERGDVVKEIF FHYSEFKGDL ETLQPGDDVE FTIKDRNGKE VATDVRLLPQ
260 270 280 290 300
GTVIFEDISI EHFEGTVTKV IPKVPSKNQN DPLPGRIKVD FVIPKELPFG
310 320 330 340 350
DKDTKSKVTL LEGDHVRFNI STDRRDKLER ATNIEVLSNT FQFTNEAREM
360 370 380 390 400
GVIAAMRDGF GFIKCVDRDA RMFFHFSEIL DGNQLHIADE VEFTVVPDML
410 420 430 440 450
SAQRNHAIRI KKLPKGTVSF HSHSDHRFLG TVEKEATFSN PKTTSPNKGK
460 470 480 490 500
DKEAEDGIIA YDDCGVKLTI AFQAKDVEGS TSPQIGDKVE FSISDKQRPG
510 520 530 540 550
QQIATCVRLL GRNSNSKRLL GYVATLKDNF GFIETANHDK EIFFHYSEFS
560 570 580 590 600
GDVDSLELGD MVEYSLSKGK GNKVSAEKVN KTHSVNGITE EANPTIYSGK
610 620 630 640 650
VIRPLRGVDP TQIEYQGMIE IVEEGDMKGE VYPFGIVGMA NKGDCLQKGE
660 670 680 690 700
SVKFQLCVLG QNAQTMAYNI TPLRRATVEC VKDQFGFINY EVGDSKKLFF
710 720 730 740 750
HVKEVQDGIE LQAGDEVEFS VILNQRTGKC SACNVWRVCE GPKAVAAPRP
760 770 780 790
DRLVNRLKNI TLDDASAPRL MVLRQPRGPD NSMGFGAERK IRQAGVID
Length:798
Mass (Da):88,895
Last modified:November 1, 1990 - v1
Checksum:iF484B3FA8B0995A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52311 mRNA. Translation: CAA36549.1.
PIRiS11210.
RefSeqiNP_446458.1. NM_054006.1.
XP_003751901.1. XM_003751853.4.
UniGeneiRn.121327.
Rn.3562.

Genome annotation databases

EnsembliENSRNOT00000091210; ENSRNOP00000069264; ENSRNOG00000061058.
GeneIDi100364335.
117180.
KEGGirno:100364335.
rno:117180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52311 mRNA. Translation: CAA36549.1.
PIRiS11210.
RefSeqiNP_446458.1. NM_054006.1.
XP_003751901.1. XM_003751853.4.
UniGeneiRn.121327.
Rn.3562.

3D structure databases

ProteinModelPortaliP18395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051275.

PTM databases

iPTMnetiP18395.
PhosphoSitePlusiP18395.

Proteomic databases

PaxDbiP18395.
PRIDEiP18395.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091210; ENSRNOP00000069264; ENSRNOG00000061058.
GeneIDi100364335.
117180.
KEGGirno:100364335.
rno:117180.

Organism-specific databases

CTDi7812.
RGDi619726. Csde1.

Phylogenomic databases

eggNOGiENOG410IF27. Eukaryota.
ENOG410ZH8Y. LUCA.
GeneTreeiENSGT00390000016950.
HOGENOMiHOG000013035.
HOVERGENiHBG013042.
InParanoidiP18395.
OMAiLFFHMSE.
OrthoDBiEOG091G053Z.
PhylomeDBiP18395.

Miscellaneous databases

PROiP18395.

Gene expression databases

BgeeiENSRNOG00000030302.
GenevisibleiP18395. RN.

Family and domain databases

CDDicd04458. CSP_CDS. 2 hits.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
IPR024642. SUZ-C.
[Graphical view]
PfamiPF00313. CSD. 5 hits.
PF12901. SUZ-C. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 5 hits.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 5 hits.
PROSITEiPS00352. COLD_SHOCK. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSDE1_RAT
AccessioniPrimary (citable) accession number: P18395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.