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Protein

Enterobactin biosynthesis protein YbdZ

Gene

ybdZ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. Plays a role in the catalytic function of EntF. It is required for adenylation of amino acids in non-ribosomal peptide biosynthesis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Enterobactin biosynthesis

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2659.
ECOL316407:JW0577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Enterobactin biosynthesis protein YbdZ1 Publication
Gene namesi
Name:ybdZ1 Publication
Ordered Locus Names:b4511, JW0577
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14353. ybdZ.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene are not able to produce enough enterobactin for efficient growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Enterobactin biosynthesis protein YbdZPRO_0000168673Add
BLAST

Proteomic databases

PaxDbiP18393.
PRIDEiP18393.

Interactioni

Protein-protein interaction databases

IntActiP18393. 1 interaction.
STRINGi511145.b4511.

Structurei

3D structure databases

ProteinModelPortaliP18393.
SMRiP18393. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MbtH-like family.Curated

Phylogenomic databases

eggNOGiENOG41085A6. Bacteria.
COG3251. LUCA.
HOGENOMiHOG000249284.
InParanoidiP18393.
OMAiHWQDMRP.
OrthoDBiEOG686NNB.
PhylomeDBiP18393.

Family and domain databases

InterProiIPR005153. MbtH.
[Graphical view]
PfamiPF03621. MbtH. 1 hit.
[Graphical view]
SMARTiSM00923. MbtH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSNPFDDP QGAFYILRNA QGQFSLWPQQ CVLPAGWDIV CQPQSQASCQ
60 70
QWLEAHWRTL TPTNFTQLQE AQ
Length:72
Mass (Da):8,271
Last modified:November 1, 1990 - v1
Checksum:i164E0B87E00F1BB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04216 Genomic DNA. Translation: AAA23758.1.
M60177 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18641.1.
AP009048 Genomic DNA. Translation: BAE76340.1.
PIRiB31958. Q3ECFS.
RefSeqiWP_000885798.1. NZ_LN832404.1.
YP_588441.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiABD18641; ABD18641; b4511.
BAE76340; BAE76340; BAE76340.
GeneIDi1450243.
KEGGiecj:JW0577.
eco:b4511.
PATRICi32116344. VBIEscCol129921_0612.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04216 Genomic DNA. Translation: AAA23758.1.
M60177 Genomic DNA. No translation available.
U00096 Genomic DNA. Translation: ABD18641.1.
AP009048 Genomic DNA. Translation: BAE76340.1.
PIRiB31958. Q3ECFS.
RefSeqiWP_000885798.1. NZ_LN832404.1.
YP_588441.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP18393.
SMRiP18393. Positions 4-65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP18393. 1 interaction.
STRINGi511145.b4511.

Proteomic databases

PaxDbiP18393.
PRIDEiP18393.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD18641; ABD18641; b4511.
BAE76340; BAE76340; BAE76340.
GeneIDi1450243.
KEGGiecj:JW0577.
eco:b4511.
PATRICi32116344. VBIEscCol129921_0612.

Organism-specific databases

EchoBASEiEB4099.
EcoGeneiEG14353. ybdZ.

Phylogenomic databases

eggNOGiENOG41085A6. Bacteria.
COG3251. LUCA.
HOGENOMiHOG000249284.
InParanoidiP18393.
OMAiHWQDMRP.
OrthoDBiEOG686NNB.
PhylomeDBiP18393.

Enzyme and pathway databases

BioCyciEcoCyc:MONOMER0-2659.
ECOL316407:JW0577-MONOMER.

Miscellaneous databases

PROiP18393.

Family and domain databases

InterProiIPR005153. MbtH.
[Graphical view]
PfamiPF03621. MbtH. 1 hit.
[Graphical view]
SMARTiSM00923. MbtH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional mapping and nucleotide sequence of the Escherichia coli fepA-fes enterobactin region. Identification of a unique iron-regulated bidirectional promoter."
    Pettis G.S., Brickman T.J., McIntosh M.A.
    J. Biol. Chem. 263:18857-18863(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Biosynthesis of the Escherichia coli siderophore enterobactin: sequence of the entF gene, expression and purification of EntF, and analysis of covalent phosphopantetheine."
    Rusnak F., Sakaitani M., Drueckhammer D., Reichert J., Walsh C.T.
    Biochemistry 30:2916-2927(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "MbtH-like proteins as integral components of bacterial nonribosomal peptide synthetases."
    Felnagle E.A., Barkei J.J., Park H., Podevels A.M., McMahon M.D., Drott D.W., Thomas M.G.
    Biochemistry 49:8815-8817(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiYBDZ_ECOLI
AccessioniPrimary (citable) accession number: P18393
Secondary accession number(s): Q2EEQ6, Q2MBL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 11, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.