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Protein

Regulatory protein BlaR1

Gene

blaR1

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

BlaR1 is a potential penicillin-binding protein required for induction of beta-lactamase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei389Acyl-ester intermediateBy similarity1

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM56.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein BlaR1
Gene namesi
Name:blaR1
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3CytoplasmicSequence analysis3
Transmembranei4 – 22HelicalSequence analysisAdd BLAST19
Topological domaini23 – 37ExtracellularSequence analysisAdd BLAST15
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 107CytoplasmicSequence analysisAdd BLAST49
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 213ExtracellularSequence analysisAdd BLAST85
Transmembranei214 – 233HelicalSequence analysisAdd BLAST20
Topological domaini234 – 308CytoplasmicSequence analysisAdd BLAST75
Transmembranei309 – 330HelicalSequence analysisAdd BLAST22
Topological domaini331 – 585ExtracellularSequence analysisAdd BLAST255

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954701 – 585Regulatory protein BlaR1Add BLAST585

Proteomic databases

PRIDEiP18357.

Structurei

Secondary structure

1585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni334 – 337Combined sources4
Beta strandi345 – 350Combined sources6
Helixi353 – 356Combined sources4
Beta strandi360 – 367Combined sources8
Turni368 – 371Combined sources4
Beta strandi372 – 377Combined sources6
Helixi378 – 381Combined sources4
Beta strandi383 – 385Combined sources3
Helixi388 – 391Combined sources4
Helixi392 – 401Combined sources10
Beta strandi402 – 405Combined sources4
Helixi422 – 424Combined sources3
Helixi430 – 435Combined sources6
Helixi439 – 446Combined sources8
Helixi451 – 461Combined sources11
Beta strandi471 – 473Combined sources3
Turni474 – 477Combined sources4
Helixi484 – 496Combined sources13
Helixi503 – 513Combined sources11
Beta strandi514 – 517Combined sources4
Beta strandi519 – 532Combined sources14
Beta strandi535 – 549Combined sources15
Beta strandi551 – 562Combined sources12
Helixi565 – 578Combined sources14
Turni579 – 582Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XA1X-ray1.80A/B/C/D331-585[»]
1XA7X-ray2.40A/B331-585[»]
1XKZX-ray1.75A/B/C/D331-585[»]
3Q81X-ray2.00A/B332-583[»]
3Q82X-ray2.10A/B332-583[»]
3UY6X-ray2.10A/B332-583[»]
ProteinModelPortaliP18357.
SMRiP18357.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18357.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni331 – 585Penicillin-bindingBy similarityAdd BLAST255

Sequence similaritiesi

Belongs to the peptidase M56 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P18357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLIMSIV SFCFIFLLLL FFRYILKRYF NYMLNYKVWY LTLLAGLIPF
60 70 80 90 100
IPIKFSLFKF NNVNNQAPTV ESKSHDLNHN INTTKPIQEF ATDIHKFNWD
110 120 130 140 150
SIDNISTVIW IVLVIILSFK FLKALLYLKY LKKQSLYLNE NEKNKIDTIL
160 170 180 190 200
FNHQYKKNIV IRKAETIQSP ITFWYGKYII LIPSSYFKSV IDKRLKYIIL
210 220 230 240 250
HEYAHAKNRD TLHLIIFNIF SIIMSYNPLV HIVKRKIIHD NEVEADRFVL
260 270 280 290 300
NNINKNEFKT YAESIMDSVL NVPFFNKNIL SHSFNGKKSL LKRRLINIKE
310 320 330 340 350
ANLKKQSKLI LIFICIFTFL LMVIQSQFLM GQSITDYNYK KPLHNDYQIL
360 370 380 390 400
DKSKIFGSNS GSFVMYSMKK DKYYIYNEKE SRKRYSPNST YKIYLAMFGL
410 420 430 440 450
DRHIINDENS RMSWNHKHYP FDAWNKEQDL NTAMQNSVNW YFERISDQIP
460 470 480 490 500
KNYTATQLKQ LNYGNKNLGS YKSYWMEDSL KISNLEQVIV FKNMMEQNNH
510 520 530 540 550
FSKKAKNQLS SSLLIKKNEK YELYGKTGTG IVNGKYNNGW FVGYVITNHD
560 570 580
KYYFATHLSD GKPSGKNAEL ISEKILKEMG VLNGQ
Length:585
Mass (Da):69,246
Last modified:November 1, 1990 - v1
Checksum:i597CAD94E9CF21CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52734 Genomic DNA. Translation: CAA36952.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52734 Genomic DNA. Translation: CAA36952.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XA1X-ray1.80A/B/C/D331-585[»]
1XA7X-ray2.40A/B331-585[»]
1XKZX-ray1.75A/B/C/D331-585[»]
3Q81X-ray2.00A/B332-583[»]
3Q82X-ray2.10A/B332-583[»]
3UY6X-ray2.10A/B332-583[»]
ProteinModelPortaliP18357.
SMRiP18357.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM56.001.

Proteomic databases

PRIDEiP18357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP18357.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLAR_STAAU
AccessioniPrimary (citable) accession number: P18357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.