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Protein

Regulatory protein BlaR1

Gene

blaR1

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

BlaR1 is a potential penicillin-binding protein required for induction of beta-lactamase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei389 – 3891Acyl-ester intermediateBy similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM56.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulatory protein BlaR1
Gene namesi
Name:blaR1
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence analysis
Transmembranei4 – 2219HelicalSequence analysisAdd
BLAST
Topological domaini23 – 3715ExtracellularSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Topological domaini59 – 10749CytoplasmicSequence analysisAdd
BLAST
Transmembranei108 – 12821HelicalSequence analysisAdd
BLAST
Topological domaini129 – 21385ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 23320HelicalSequence analysisAdd
BLAST
Topological domaini234 – 30875CytoplasmicSequence analysisAdd
BLAST
Transmembranei309 – 33022HelicalSequence analysisAdd
BLAST
Topological domaini331 – 585255ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Regulatory protein BlaR1PRO_0000195470Add
BLAST

Proteomic databases

PRIDEiP18357.

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni334 – 3374Combined sources
Beta strandi345 – 3506Combined sources
Helixi353 – 3564Combined sources
Beta strandi360 – 3678Combined sources
Turni368 – 3714Combined sources
Beta strandi372 – 3776Combined sources
Helixi378 – 3814Combined sources
Beta strandi383 – 3853Combined sources
Helixi388 – 3914Combined sources
Helixi392 – 40110Combined sources
Beta strandi402 – 4054Combined sources
Helixi422 – 4243Combined sources
Helixi430 – 4356Combined sources
Helixi439 – 4468Combined sources
Helixi451 – 46111Combined sources
Beta strandi471 – 4733Combined sources
Turni474 – 4774Combined sources
Helixi484 – 49613Combined sources
Helixi503 – 51311Combined sources
Beta strandi514 – 5174Combined sources
Beta strandi519 – 53214Combined sources
Beta strandi535 – 54915Combined sources
Beta strandi551 – 56212Combined sources
Helixi565 – 57814Combined sources
Turni579 – 5824Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XA1X-ray1.80A/B/C/D331-585[»]
1XA7X-ray2.40A/B331-585[»]
1XKZX-ray1.75A/B/C/D331-585[»]
3Q81X-ray2.00A/B332-583[»]
3Q82X-ray2.10A/B332-583[»]
3UY6X-ray2.10A/B332-583[»]
ProteinModelPortaliP18357.
SMRiP18357. Positions 338-585.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18357.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni331 – 585255Penicillin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M56 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P18357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLLIMSIV SFCFIFLLLL FFRYILKRYF NYMLNYKVWY LTLLAGLIPF
60 70 80 90 100
IPIKFSLFKF NNVNNQAPTV ESKSHDLNHN INTTKPIQEF ATDIHKFNWD
110 120 130 140 150
SIDNISTVIW IVLVIILSFK FLKALLYLKY LKKQSLYLNE NEKNKIDTIL
160 170 180 190 200
FNHQYKKNIV IRKAETIQSP ITFWYGKYII LIPSSYFKSV IDKRLKYIIL
210 220 230 240 250
HEYAHAKNRD TLHLIIFNIF SIIMSYNPLV HIVKRKIIHD NEVEADRFVL
260 270 280 290 300
NNINKNEFKT YAESIMDSVL NVPFFNKNIL SHSFNGKKSL LKRRLINIKE
310 320 330 340 350
ANLKKQSKLI LIFICIFTFL LMVIQSQFLM GQSITDYNYK KPLHNDYQIL
360 370 380 390 400
DKSKIFGSNS GSFVMYSMKK DKYYIYNEKE SRKRYSPNST YKIYLAMFGL
410 420 430 440 450
DRHIINDENS RMSWNHKHYP FDAWNKEQDL NTAMQNSVNW YFERISDQIP
460 470 480 490 500
KNYTATQLKQ LNYGNKNLGS YKSYWMEDSL KISNLEQVIV FKNMMEQNNH
510 520 530 540 550
FSKKAKNQLS SSLLIKKNEK YELYGKTGTG IVNGKYNNGW FVGYVITNHD
560 570 580
KYYFATHLSD GKPSGKNAEL ISEKILKEMG VLNGQ
Length:585
Mass (Da):69,246
Last modified:November 1, 1990 - v1
Checksum:i597CAD94E9CF21CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52734 Genomic DNA. Translation: CAA36952.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52734 Genomic DNA. Translation: CAA36952.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XA1X-ray1.80A/B/C/D331-585[»]
1XA7X-ray2.40A/B331-585[»]
1XKZX-ray1.75A/B/C/D331-585[»]
3Q81X-ray2.00A/B332-583[»]
3Q82X-ray2.10A/B332-583[»]
3UY6X-ray2.10A/B332-583[»]
ProteinModelPortaliP18357.
SMRiP18357. Positions 338-585.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM56.001.

Proteomic databases

PRIDEiP18357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP18357.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
PfamiPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiBLAR_STAAU
AccessioniPrimary (citable) accession number: P18357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Transposable element

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.