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P18357 (BLAR_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Regulatory protein BlaR1
Gene names
Name:blaR1
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length585 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

BlaR1 is a potential penicillin-binding protein required for induction of beta-lactamase.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the peptidase M56 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical term3D-structure
Transposable element
Gene Ontology (GO)
   Biological processpeptidoglycan-based cell wall biogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpenicillin binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 585585Regulatory protein BlaR1
PRO_0000195470

Regions

Topological domain1 – 33Cytoplasmic Potential
Transmembrane4 – 2219Helical; Potential
Topological domain23 – 3715Extracellular Potential
Transmembrane38 – 5821Helical; Potential
Topological domain59 – 10749Cytoplasmic Potential
Transmembrane108 – 12821Helical; Potential
Topological domain129 – 21385Extracellular Potential
Transmembrane214 – 23320Helical; Potential
Topological domain234 – 30875Cytoplasmic Potential
Transmembrane309 – 33022Helical; Potential
Topological domain331 – 585255Extracellular Potential
Region331 – 585255Penicillin-binding By similarity

Sites

Active site3891Acyl-ester intermediate By similarity

Secondary structure

1 ....................................... 585
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18357 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 597CAD94E9CF21CE

FASTA58569,246
        10         20         30         40         50         60 
MAKLLIMSIV SFCFIFLLLL FFRYILKRYF NYMLNYKVWY LTLLAGLIPF IPIKFSLFKF 

        70         80         90        100        110        120 
NNVNNQAPTV ESKSHDLNHN INTTKPIQEF ATDIHKFNWD SIDNISTVIW IVLVIILSFK 

       130        140        150        160        170        180 
FLKALLYLKY LKKQSLYLNE NEKNKIDTIL FNHQYKKNIV IRKAETIQSP ITFWYGKYII 

       190        200        210        220        230        240 
LIPSSYFKSV IDKRLKYIIL HEYAHAKNRD TLHLIIFNIF SIIMSYNPLV HIVKRKIIHD 

       250        260        270        280        290        300 
NEVEADRFVL NNINKNEFKT YAESIMDSVL NVPFFNKNIL SHSFNGKKSL LKRRLINIKE 

       310        320        330        340        350        360 
ANLKKQSKLI LIFICIFTFL LMVIQSQFLM GQSITDYNYK KPLHNDYQIL DKSKIFGSNS 

       370        380        390        400        410        420 
GSFVMYSMKK DKYYIYNEKE SRKRYSPNST YKIYLAMFGL DRHIINDENS RMSWNHKHYP 

       430        440        450        460        470        480 
FDAWNKEQDL NTAMQNSVNW YFERISDQIP KNYTATQLKQ LNYGNKNLGS YKSYWMEDSL 

       490        500        510        520        530        540 
KISNLEQVIV FKNMMEQNNH FSKKAKNQLS SSLLIKKNEK YELYGKTGTG IVNGKYNNGW 

       550        560        570        580 
FVGYVITNHD KYYFATHLSD GKPSGKNAEL ISEKILKEMG VLNGQ

« Hide

References

[1]"Tn552, a novel transposable element from Staphylococcus aureus."
Rowland S.J., Dyke K.G.H.
Mol. Microbiol. 4:961-975(1990) [PubMed: 2170815] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NCTC 9789.
Transposon: Tn552.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X52734 Genomic DNA. Translation: CAA36952.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1XA1X-ray1.80A/B/C/D331-585[»]
1XA7X-ray2.40A/B331-585[»]
1XKZX-ray1.75A/B/C/D331-585[»]
3Q81X-ray2.00A/B332-583[»]
3Q82X-ray2.10A/B332-583[»]
ProteinModelPortalP18357.
SMRP18357. Positions 338-585.
ModBaseSearch...

Protein family/group databases

MEROPSM56.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR012338. Beta-lactam/transpept-like.
IPR001460. PCN-bd_Tpept.
IPR008756. Peptidase_M56.
[Graphical view]
Gene3DG3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.
PfamPF05569. Peptidase_M56. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBLAR_STAAU
AccessionPrimary (citable) accession number: P18357
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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