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Protein

C-X-C motif chemokine 9

Gene

Cxcl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 9
Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name:
MIG
Short name:
MuMIG
Protein m119
Small-inducible cytokine B9
Gene namesi
Name:Cxcl9
Synonyms:Mig, Scyb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352449. Cxcl9.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 126105C-X-C motif chemokine 9PRO_0000005100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 73By similarity
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18340.
PRIDEiP18340.

PTM databases

iPTMnetiP18340.
PhosphoSiteiP18340.

Expressioni

Inductioni

By interferon gamma.

Gene expression databases

CleanExiMM_CXCL9.
GenevisibleiP18340. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108716.

Structurei

3D structure databases

ProteinModelPortaliP18340.
SMRiP18340. Positions 29-90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP18340.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG7HHWVH.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAVLFLLG IIFLEQCGVR GTLVIRNARC SCISTSRGTI HYKSLKDLKQ
60 70 80 90 100
FAPSPNCNKT EIIATLKNGD QTCLDPDSAN VKKLMKEWEK KISQKKKQKR
110 120
GKKHQKNMKN RKPKTPQSRR RSRKTT
Length:126
Mass (Da):14,444
Last modified:October 3, 2012 - v2
Checksum:iCB682C0E0D5D0322
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401I → V in AAH03343 (PubMed:15489334).Curated
Sequence conflicti93 – 931S → N in AAA39706 (PubMed:2115167).Curated
Sequence conflicti93 – 931S → N in AAH03343 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34815 mRNA. Translation: AAA39706.1.
AK042017 mRNA. Translation: BAC31132.1.
AK156012 mRNA. Translation: BAE33544.1.
AK156029 mRNA. Translation: BAE33552.1.
AK156453 mRNA. Translation: BAE33718.1.
AK157118 mRNA. Translation: BAE33967.1.
CT010194 mRNA. Translation: CAJ18402.1.
AC122365 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05257.1.
BC003343 mRNA. Translation: AAH03343.1.
CCDSiCCDS39152.1.
PIRiA35766.
RefSeqiNP_032625.2. NM_008599.4.
UniGeneiMm.766.

Genome annotation databases

EnsembliENSMUST00000113093; ENSMUSP00000108716; ENSMUSG00000029417.
GeneIDi17329.
KEGGimmu:17329.
UCSCiuc008ycv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34815 mRNA. Translation: AAA39706.1.
AK042017 mRNA. Translation: BAC31132.1.
AK156012 mRNA. Translation: BAE33544.1.
AK156029 mRNA. Translation: BAE33552.1.
AK156453 mRNA. Translation: BAE33718.1.
AK157118 mRNA. Translation: BAE33967.1.
CT010194 mRNA. Translation: CAJ18402.1.
AC122365 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05257.1.
BC003343 mRNA. Translation: AAH03343.1.
CCDSiCCDS39152.1.
PIRiA35766.
RefSeqiNP_032625.2. NM_008599.4.
UniGeneiMm.766.

3D structure databases

ProteinModelPortaliP18340.
SMRiP18340. Positions 29-90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108716.

PTM databases

iPTMnetiP18340.
PhosphoSiteiP18340.

Proteomic databases

PaxDbiP18340.
PRIDEiP18340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113093; ENSMUSP00000108716; ENSMUSG00000029417.
GeneIDi17329.
KEGGimmu:17329.
UCSCiuc008ycv.2. mouse.

Organism-specific databases

CTDi4283.
MGIiMGI:1352449. Cxcl9.

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP18340.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG7HHWVH.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCxcl9. mouse.
PROiP18340.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CXCL9.
GenevisibleiP18340. MM.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines."
    Farber J.M.
    Proc. Natl. Acad. Sci. U.S.A. 87:5238-5242(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Spleen and Thymus.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiCXCL9_MOUSE
AccessioniPrimary (citable) accession number: P18340
Secondary accession number(s): Q8C9J0, Q99J60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: July 6, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.