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Protein

C-X-C motif chemokine 9

Gene

Cxcl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 9
Alternative name(s):
Gamma-interferon-induced monokine
Monokine induced by interferon-gamma
Short name:
MIG
Short name:
MuMIG
Protein m119
Small-inducible cytokine B9
Gene namesi
Name:Cxcl9
Synonyms:Mig, Scyb9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352449. Cxcl9.

Subcellular locationi

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000000510022 – 126C-X-C motif chemokine 9Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 57By similarity
Disulfide bondi32 ↔ 73By similarity
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18340.
PRIDEiP18340.

PTM databases

iPTMnetiP18340.
PhosphoSitePlusiP18340.

Expressioni

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSMUSG00000029417.
CleanExiMM_CXCL9.
GenevisibleiP18340. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108716.

Structurei

3D structure databases

ProteinModelPortaliP18340.
SMRiP18340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP18340.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG091G0YSL.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSAVLFLLG IIFLEQCGVR GTLVIRNARC SCISTSRGTI HYKSLKDLKQ
60 70 80 90 100
FAPSPNCNKT EIIATLKNGD QTCLDPDSAN VKKLMKEWEK KISQKKKQKR
110 120
GKKHQKNMKN RKPKTPQSRR RSRKTT
Length:126
Mass (Da):14,444
Last modified:October 3, 2012 - v2
Checksum:iCB682C0E0D5D0322
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40I → V in AAH03343 (PubMed:15489334).Curated1
Sequence conflicti93S → N in AAA39706 (PubMed:2115167).Curated1
Sequence conflicti93S → N in AAH03343 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34815 mRNA. Translation: AAA39706.1.
AK042017 mRNA. Translation: BAC31132.1.
AK156012 mRNA. Translation: BAE33544.1.
AK156029 mRNA. Translation: BAE33552.1.
AK156453 mRNA. Translation: BAE33718.1.
AK157118 mRNA. Translation: BAE33967.1.
CT010194 mRNA. Translation: CAJ18402.1.
AC122365 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05257.1.
BC003343 mRNA. Translation: AAH03343.1.
CCDSiCCDS39152.1.
PIRiA35766.
RefSeqiNP_032625.2. NM_008599.4.
UniGeneiMm.766.

Genome annotation databases

EnsembliENSMUST00000113093; ENSMUSP00000108716; ENSMUSG00000029417.
GeneIDi17329.
KEGGimmu:17329.
UCSCiuc008ycv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34815 mRNA. Translation: AAA39706.1.
AK042017 mRNA. Translation: BAC31132.1.
AK156012 mRNA. Translation: BAE33544.1.
AK156029 mRNA. Translation: BAE33552.1.
AK156453 mRNA. Translation: BAE33718.1.
AK157118 mRNA. Translation: BAE33967.1.
CT010194 mRNA. Translation: CAJ18402.1.
AC122365 Genomic DNA. No translation available.
CH466617 Genomic DNA. Translation: EDL05257.1.
BC003343 mRNA. Translation: AAH03343.1.
CCDSiCCDS39152.1.
PIRiA35766.
RefSeqiNP_032625.2. NM_008599.4.
UniGeneiMm.766.

3D structure databases

ProteinModelPortaliP18340.
SMRiP18340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108716.

PTM databases

iPTMnetiP18340.
PhosphoSitePlusiP18340.

Proteomic databases

PaxDbiP18340.
PRIDEiP18340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113093; ENSMUSP00000108716; ENSMUSG00000029417.
GeneIDi17329.
KEGGimmu:17329.
UCSCiuc008ycv.2. mouse.

Organism-specific databases

CTDi4283.
MGIiMGI:1352449. Cxcl9.

Phylogenomic databases

eggNOGiENOG410J1Z5. Eukaryota.
ENOG410Z394. LUCA.
GeneTreeiENSGT00530000063958.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP18340.
KOiK05416.
OMAiNGRCSCI.
OrthoDBiEOG091G0YSL.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

ChiTaRSiCxcl9. mouse.
PROiP18340.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029417.
CleanExiMM_CXCL9.
GenevisibleiP18340. MM.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
IPR027225. CXCL9.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PTHR10179:SF44. PTHR10179:SF44. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL9_MOUSE
AccessioniPrimary (citable) accession number: P18340
Secondary accession number(s): Q8C9J0, Q99J60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.