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P18337

- LYAM1_MOUSE

UniProt

P18337 - LYAM1_MOUSE

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Protein

L-selectin

Gene

Sell

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. cell adhesion molecule binding Source: MGI

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. response to ATP Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-1
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor
Lymphocyte antigen 22
Short name:
Ly-22
Lymphocyte surface MEL-14 antigen
CD_antigen: CD62L
Gene namesi
Name:Sell
Synonyms:Lnhr, Ly-22, Ly22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98279. Sell.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 332294ExtracellularSequence AnalysisAdd
BLAST
Transmembranei333 – 35523HelicalSequence AnalysisAdd
BLAST
Topological domaini356 – 37217CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Propeptidei29 – 3810PRO_0000017479
Chaini39 – 372334L-selectinPRO_0000017480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 155By similarity
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 147By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi165 ↔ 180By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi182 ↔ 191By similarity
Disulfide bondi197 ↔ 241By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi227 ↔ 254By similarity
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi259 ↔ 303By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi289 ↔ 316By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18337.
PRIDEiP18337.

PTM databases

PhosphoSiteiP18337.

Expressioni

Tissue specificityi

Predominantly expressed in lymphoid tissue.1 Publication

Gene expression databases

BgeeiP18337.
CleanExiMM_SELL.
ExpressionAtlasiP18337. baseline and differential.
GenevestigatoriP18337.

Interactioni

Subunit structurei

Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP18337.
SMRiP18337. Positions 39-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 155101C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini156 – 19237EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini195 – 25662Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini257 – 31862Sushi 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258998.
HOVERGENiHBG052375.
InParanoidiP18337.
KOiK06495.
OMAiVAIQNKG.
PhylomeDBiP18337.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18337-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFPWRCEGT YWGSRNILKL WVWTLLCCDF LIHHGTHCWT YHYSEKPMNW
60 70 80 90 100
ENARKFCKQN YTDLVAIQNK REIEYLENTL PKSPYYYWIG IRKIGKMWTW
110 120 130 140 150
VGTNKTLTKE AENWGAGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR
160 170 180 190 200
KAALCYTASC QPGSCNGRGE CVETINNHTC ICDAGYYGPQ CQYVVQCEPL
210 220 230 240 250
EAPELGTMDC IHPLGNFSFQ SKCAFNCSEG RELLGTAETQ CGASGNWSSP
260 270 280 290 300
EPICQVVQCE PLEAPELGTM DCIHPLGNFS FQSKCAFNCS EGRELLGTAE
310 320 330 340 350
TQCGASGNWS SPEPICQETN RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
LIWLARRLKK GKKSQERMDD PY
Length:372
Mass (Da):42,288
Last modified:November 1, 1990 - v1
Checksum:i4433EDF6E4CB2B78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321I → T in AAA75651. (PubMed:2004776)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14772 mRNA. Translation: CAA32880.1.
M36005 mRNA. Translation: AAA39722.1.
M36058 mRNA. Translation: AAA39723.1.
M25324 mRNA. Translation: AAA39431.1.
AH003204 Genomic DNA. Translation: AAA75651.1.
BC052681 mRNA. Translation: AAH52681.1.
CCDSiCCDS35753.1.
PIRiA32375.
RefSeqiNP_035476.1. NM_011346.2.
UniGeneiMm.1461.

Genome annotation databases

EnsembliENSMUST00000027871; ENSMUSP00000027871; ENSMUSG00000026581.
GeneIDi20343.
KEGGimmu:20343.
UCSCiuc007dhy.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

L-selectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14772 mRNA. Translation: CAA32880.1 .
M36005 mRNA. Translation: AAA39722.1 .
M36058 mRNA. Translation: AAA39723.1 .
M25324 mRNA. Translation: AAA39431.1 .
AH003204 Genomic DNA. Translation: AAA75651.1 .
BC052681 mRNA. Translation: AAH52681.1 .
CCDSi CCDS35753.1.
PIRi A32375.
RefSeqi NP_035476.1. NM_011346.2.
UniGenei Mm.1461.

3D structure databases

ProteinModelPortali P18337.
SMRi P18337. Positions 39-317.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P18337.
ChEMBLi CHEMBL3162.

PTM databases

PhosphoSitei P18337.

Proteomic databases

PaxDbi P18337.
PRIDEi P18337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027871 ; ENSMUSP00000027871 ; ENSMUSG00000026581 .
GeneIDi 20343.
KEGGi mmu:20343.
UCSCi uc007dhy.2. mouse.

Organism-specific databases

CTDi 6402.
MGIi MGI:98279. Sell.

Phylogenomic databases

eggNOGi NOG258998.
HOVERGENi HBG052375.
InParanoidi P18337.
KOi K06495.
OMAi VAIQNKG.
PhylomeDBi P18337.
TreeFami TF326910.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSi Sell. mouse.
NextBioi 298173.
PROi P18337.
SOURCEi Search...

Gene expression databases

Bgeei P18337.
CleanExi MM_SELL.
ExpressionAtlasi P18337. baseline and differential.
Genevestigatori P18337.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF07974. EGF_2. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view ]
PIRSFi PIRSF002421. L-selectin. 1 hit.
PRINTSi PR00343. SELECTIN.
SMARTi SM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains."
    Siegelman M.H., van de Rijn M., Weissman I.L.
    Science 243:1165-1172(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Lymph node.
  2. "The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding."
    Siegelman M.H., Cheng I.C., Weissman I.L., Wakeland E.K.
    Cell 61:611-622(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Hematopoietic.
  5. "Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons."
    Dowbenko D.J., Diep A., Taylor B.A., Lusis A.J., Lasky L.A.
    Genomics 9:270-277(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-360.

Entry informationi

Entry nameiLYAM1_MOUSE
AccessioniPrimary (citable) accession number: P18337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3