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P18337

- LYAM1_MOUSE

UniProt

P18337 - LYAM1_MOUSE

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Protein

L-selectin

Gene
Sell, Lnhr, Ly-22, Ly22
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia By similarity.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. cell adhesion molecule binding Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. response to ATP Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-1
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor
Lymphocyte antigen 22
Short name:
Ly-22
Lymphocyte surface MEL-14 antigen
CD_antigen: CD62L
Gene namesi
Name:Sell
Synonyms:Lnhr, Ly-22, Ly22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98279. Sell.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 332294Extracellular Reviewed predictionAdd
BLAST
Transmembranei333 – 35523Helical; Reviewed predictionAdd
BLAST
Topological domaini356 – 37217Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. external side of plasma membrane Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Add
BLAST
Propeptidei29 – 3810PRO_0000017479
Chaini39 – 372334L-selectinPRO_0000017480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 155 By similarity
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi104 – 1041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi128 ↔ 147 By similarity
Disulfide bondi160 ↔ 171 By similarity
Disulfide bondi165 ↔ 180 By similarity
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi182 ↔ 191 By similarity
Disulfide bondi197 ↔ 241 By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi226 – 2261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi227 ↔ 254 By similarity
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi259 ↔ 303 By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi289 ↔ 316 By similarity
Glycosylationi308 – 3081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18337.
PRIDEiP18337.

PTM databases

PhosphoSiteiP18337.

Expressioni

Tissue specificityi

Predominantly expressed in lymphoid tissue.1 Publication

Gene expression databases

ArrayExpressiP18337.
BgeeiP18337.
CleanExiMM_SELL.
GenevestigatoriP18337.

Interactioni

Subunit structurei

Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding By similarity.

Structurei

3D structure databases

ProteinModelPortaliP18337.
SMRiP18337. Positions 39-321.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 155101C-type lectinAdd
BLAST
Domaini156 – 19237EGF-likeAdd
BLAST
Domaini195 – 25662Sushi 1Add
BLAST
Domaini257 – 31862Sushi 2Add
BLAST

Sequence similaritiesi

Belongs to the selectin/LECAM family.
Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG258998.
HOVERGENiHBG052375.
InParanoidiP18337.
KOiK06495.
OMAiVAIQNKG.
PhylomeDBiP18337.
TreeFamiTF326910.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF07974. EGF_2. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view]
PIRSFiPIRSF002421. L-selectin. 1 hit.
PRINTSiPR00343. SELECTIN.
SMARTiSM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18337-1 [UniParc]FASTAAdd to Basket

« Hide

MVFPWRCEGT YWGSRNILKL WVWTLLCCDF LIHHGTHCWT YHYSEKPMNW    50
ENARKFCKQN YTDLVAIQNK REIEYLENTL PKSPYYYWIG IRKIGKMWTW 100
VGTNKTLTKE AENWGAGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR 150
KAALCYTASC QPGSCNGRGE CVETINNHTC ICDAGYYGPQ CQYVVQCEPL 200
EAPELGTMDC IHPLGNFSFQ SKCAFNCSEG RELLGTAETQ CGASGNWSSP 250
EPICQVVQCE PLEAPELGTM DCIHPLGNFS FQSKCAFNCS EGRELLGTAE 300
TQCGASGNWS SPEPICQETN RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF 350
LIWLARRLKK GKKSQERMDD PY 372
Length:372
Mass (Da):42,288
Last modified:November 1, 1990 - v1
Checksum:i4433EDF6E4CB2B78
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321I → T in AAA75651. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14772 mRNA. Translation: CAA32880.1.
M36005 mRNA. Translation: AAA39722.1.
M36058 mRNA. Translation: AAA39723.1.
M25324 mRNA. Translation: AAA39431.1.
AH003204 Genomic DNA. Translation: AAA75651.1.
BC052681 mRNA. Translation: AAH52681.1.
CCDSiCCDS35753.1.
PIRiA32375.
RefSeqiNP_035476.1. NM_011346.2.
UniGeneiMm.1461.

Genome annotation databases

EnsembliENSMUST00000027871; ENSMUSP00000027871; ENSMUSG00000026581.
GeneIDi20343.
KEGGimmu:20343.
UCSCiuc007dhy.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

L-selectin

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14772 mRNA. Translation: CAA32880.1 .
M36005 mRNA. Translation: AAA39722.1 .
M36058 mRNA. Translation: AAA39723.1 .
M25324 mRNA. Translation: AAA39431.1 .
AH003204 Genomic DNA. Translation: AAA75651.1 .
BC052681 mRNA. Translation: AAH52681.1 .
CCDSi CCDS35753.1.
PIRi A32375.
RefSeqi NP_035476.1. NM_011346.2.
UniGenei Mm.1461.

3D structure databases

ProteinModelPortali P18337.
SMRi P18337. Positions 39-321.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P18337.
ChEMBLi CHEMBL3162.

PTM databases

PhosphoSitei P18337.

Proteomic databases

PaxDbi P18337.
PRIDEi P18337.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027871 ; ENSMUSP00000027871 ; ENSMUSG00000026581 .
GeneIDi 20343.
KEGGi mmu:20343.
UCSCi uc007dhy.2. mouse.

Organism-specific databases

CTDi 6402.
MGIi MGI:98279. Sell.

Phylogenomic databases

eggNOGi NOG258998.
HOVERGENi HBG052375.
InParanoidi P18337.
KOi K06495.
OMAi VAIQNKG.
PhylomeDBi P18337.
TreeFami TF326910.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

ChiTaRSi SELL. mouse.
NextBioi 298173.
PROi P18337.
SOURCEi Search...

Gene expression databases

ArrayExpressi P18337.
Bgeei P18337.
CleanExi MM_SELL.
Genevestigatori P18337.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR013111. EGF_extracell.
IPR016348. L-selectin.
IPR002396. Selectin_superfamily.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF07974. EGF_2. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 2 hits.
[Graphical view ]
PIRSFi PIRSF002421. L-selectin. 1 hit.
PRINTSi PR00343. SELECTIN.
SMARTi SM00032. CCP. 2 hits.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
SSF57535. SSF57535. 2 hits.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50923. SUSHI. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains."
    Siegelman M.H., van de Rijn M., Weissman I.L.
    Science 243:1165-1172(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Lymph node.
  2. "The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding."
    Siegelman M.H., Cheng I.C., Weissman I.L., Wakeland E.K.
    Cell 61:611-622(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Hematopoietic.
  5. "Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons."
    Dowbenko D.J., Diep A., Taylor B.A., Lusis A.J., Lasky L.A.
    Genomics 9:270-277(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-360.

Entry informationi

Entry nameiLYAM1_MOUSE
AccessioniPrimary (citable) accession number: P18337
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi