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Protein

L-selectin

Gene

Sell

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes (PubMed:1693096). Promotes initial tethering and rolling of leukocytes in endothelia (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi118CalciumBy similarity1
Metal bindingi120CalciumBy similarity1
Metal bindingi126CalciumBy similarity1
Metal bindingi143CalciumBy similarity1
Metal bindingi144CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
L-selectin
Alternative name(s):
CD62 antigen-like family member L
Leukocyte adhesion molecule 1
Short name:
LAM-1
Leukocyte-endothelial cell adhesion molecule 1
Short name:
LECAM1
Lymph node homing receptor1 Publication
Lymphocyte antigen 221 Publication
Short name:
Ly-221 Publication
Lymphocyte surface MEL-14 antigen
CD_antigen: CD62L
Gene namesi
Name:Sell
Synonyms:Lnhr, Ly-22, Ly22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98279 Sell

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 332ExtracellularSequence analysisAdd BLAST294
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Topological domaini356 – 372CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3162

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Add BLAST28
PropeptideiPRO_000001747929 – 3810
ChainiPRO_000001748039 – 372L-selectinAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 155By similarity
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi128 ↔ 160By similarity
Disulfide bondi128 ↔ 147By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi165 ↔ 180By similarity
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 191By similarity
Disulfide bondi197 ↔ 241By similarity
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi227 ↔ 254By similarity
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 303By similarity
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi289 ↔ 316By similarity
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP18337
PaxDbiP18337
PeptideAtlasiP18337
PRIDEiP18337

PTM databases

iPTMnetiP18337
PhosphoSitePlusiP18337

Expressioni

Tissue specificityi

Predominantly expressed in lymphoid tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000026581
CleanExiMM_SELL
ExpressionAtlasiP18337 baseline and differential
GenevisibleiP18337 MM

Interactioni

Subunit structurei

Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: MGI
  • protease binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027871

Chemistry databases

BindingDBiP18337

Structurei

3D structure databases

ProteinModelPortaliP18337
SMRiP18337
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 155C-type lectinPROSITE-ProRule annotationAdd BLAST101
Domaini156 – 192EGF-likePROSITE-ProRule annotationAdd BLAST37
Domaini195 – 256Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini257 – 318Sushi 2PROSITE-ProRule annotationAdd BLAST62

Sequence similaritiesi

Belongs to the selectin/LECAM family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3T Eukaryota
ENOG410YB82 LUCA
GeneTreeiENSGT00910000143999
HOVERGENiHBG052375
InParanoidiP18337
KOiK06495
PhylomeDBiP18337
TreeFamiTF326910

Family and domain databases

CDDicd00033 CCP, 2 hits
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR016348 L-selectin
IPR002396 Selectin_superfamily
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
PF00084 Sushi, 2 hits
PIRSFiPIRSF002421 L-selectin, 1 hit
PRINTSiPR00343 SELECTIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
PS50923 SUSHI, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFPWRCEGT YWGSRNILKL WVWTLLCCDF LIHHGTHCWT YHYSEKPMNW
60 70 80 90 100
ENARKFCKQN YTDLVAIQNK REIEYLENTL PKSPYYYWIG IRKIGKMWTW
110 120 130 140 150
VGTNKTLTKE AENWGAGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR
160 170 180 190 200
KAALCYTASC QPGSCNGRGE CVETINNHTC ICDAGYYGPQ CQYVVQCEPL
210 220 230 240 250
EAPELGTMDC IHPLGNFSFQ SKCAFNCSEG RELLGTAETQ CGASGNWSSP
260 270 280 290 300
EPICQVVQCE PLEAPELGTM DCIHPLGNFS FQSKCAFNCS EGRELLGTAE
310 320 330 340 350
TQCGASGNWS SPEPICQETN RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF
360 370
LIWLARRLKK GKKSQERMDD PY
Length:372
Mass (Da):42,288
Last modified:November 1, 1990 - v1
Checksum:i4433EDF6E4CB2B78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32I → T in AAA75651 (PubMed:2004776).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14772 mRNA Translation: CAA32880.1
M36005 mRNA Translation: AAA39722.1
M36058 mRNA Translation: AAA39723.1
M25324 mRNA Translation: AAA39431.1
AH003204 Genomic DNA Translation: AAA75651.1
BC052681 mRNA Translation: AAH52681.1
CCDSiCCDS35753.1
PIRiA32375
RefSeqiNP_035476.1, NM_011346.2
UniGeneiMm.1461

Genome annotation databases

EnsembliENSMUST00000027871; ENSMUSP00000027871; ENSMUSG00000026581
GeneIDi20343
KEGGimmu:20343
UCSCiuc007dhy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLYAM1_MOUSE
AccessioniPrimary (citable) accession number: P18337
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 20, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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