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P18337

- LYAM1_MOUSE

UniProt

P18337 - LYAM1_MOUSE

Protein

L-selectin

Gene

Sell

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia By similarity.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. cell adhesion molecule binding Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. response to ATP Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Enzyme and pathway databases

    ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-selectin
    Alternative name(s):
    CD62 antigen-like family member L
    Leukocyte adhesion molecule 1
    Short name:
    LAM-1
    Leukocyte-endothelial cell adhesion molecule 1
    Short name:
    LECAM1
    Lymph node homing receptor
    Lymphocyte antigen 22
    Short name:
    Ly-22
    Lymphocyte surface MEL-14 antigen
    CD_antigen: CD62L
    Gene namesi
    Name:Sell
    Synonyms:Lnhr, Ly-22, Ly22
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:98279. Sell.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Add
    BLAST
    Propeptidei29 – 3810PRO_0000017479
    Chaini39 – 372334L-selectinPRO_0000017480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 155By similarity
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 147By similarity
    Disulfide bondi160 ↔ 171By similarity
    Disulfide bondi165 ↔ 180By similarity
    Glycosylationi177 – 1771N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi182 ↔ 191By similarity
    Disulfide bondi197 ↔ 241By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi227 ↔ 254By similarity
    Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi259 ↔ 303By similarity
    Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi289 ↔ 316By similarity
    Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP18337.
    PRIDEiP18337.

    PTM databases

    PhosphoSiteiP18337.

    Expressioni

    Tissue specificityi

    Predominantly expressed in lymphoid tissue.1 Publication

    Gene expression databases

    ArrayExpressiP18337.
    BgeeiP18337.
    CleanExiMM_SELL.
    GenevestigatoriP18337.

    Interactioni

    Subunit structurei

    Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on 'Tyr-51' of PSGL1 is important for L-selectin binding By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP18337.
    SMRiP18337. Positions 39-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini39 – 332294ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini356 – 37217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei333 – 35523HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 155101C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini156 – 19237EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 25662Sushi 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 31862Sushi 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the selectin/LECAM family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 2 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG258998.
    HOVERGENiHBG052375.
    InParanoidiP18337.
    KOiK06495.
    OMAiVAIQNKG.
    PhylomeDBiP18337.
    TreeFamiTF326910.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR016348. L-selectin.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF07974. EGF_2. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002421. L-selectin. 1 hit.
    PRINTSiPR00343. SELECTIN.
    SMARTiSM00032. CCP. 2 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFPWRCEGT YWGSRNILKL WVWTLLCCDF LIHHGTHCWT YHYSEKPMNW    50
    ENARKFCKQN YTDLVAIQNK REIEYLENTL PKSPYYYWIG IRKIGKMWTW 100
    VGTNKTLTKE AENWGAGEPN NKKSKEDCVE IYIKRERDSG KWNDDACHKR 150
    KAALCYTASC QPGSCNGRGE CVETINNHTC ICDAGYYGPQ CQYVVQCEPL 200
    EAPELGTMDC IHPLGNFSFQ SKCAFNCSEG RELLGTAETQ CGASGNWSSP 250
    EPICQVVQCE PLEAPELGTM DCIHPLGNFS FQSKCAFNCS EGRELLGTAE 300
    TQCGASGNWS SPEPICQETN RSFSKIKEGD YNPLFIPVAV MVTAFSGLAF 350
    LIWLARRLKK GKKSQERMDD PY 372
    Length:372
    Mass (Da):42,288
    Last modified:November 1, 1990 - v1
    Checksum:i4433EDF6E4CB2B78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321I → T in AAA75651. (PubMed:2004776)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14772 mRNA. Translation: CAA32880.1.
    M36005 mRNA. Translation: AAA39722.1.
    M36058 mRNA. Translation: AAA39723.1.
    M25324 mRNA. Translation: AAA39431.1.
    AH003204 Genomic DNA. Translation: AAA75651.1.
    BC052681 mRNA. Translation: AAH52681.1.
    CCDSiCCDS35753.1.
    PIRiA32375.
    RefSeqiNP_035476.1. NM_011346.2.
    UniGeneiMm.1461.

    Genome annotation databases

    EnsembliENSMUST00000027871; ENSMUSP00000027871; ENSMUSG00000026581.
    GeneIDi20343.
    KEGGimmu:20343.
    UCSCiuc007dhy.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    L-selectin

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14772 mRNA. Translation: CAA32880.1 .
    M36005 mRNA. Translation: AAA39722.1 .
    M36058 mRNA. Translation: AAA39723.1 .
    M25324 mRNA. Translation: AAA39431.1 .
    AH003204 Genomic DNA. Translation: AAA75651.1 .
    BC052681 mRNA. Translation: AAH52681.1 .
    CCDSi CCDS35753.1.
    PIRi A32375.
    RefSeqi NP_035476.1. NM_011346.2.
    UniGenei Mm.1461.

    3D structure databases

    ProteinModelPortali P18337.
    SMRi P18337. Positions 39-321.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P18337.
    ChEMBLi CHEMBL3162.

    PTM databases

    PhosphoSitei P18337.

    Proteomic databases

    PaxDbi P18337.
    PRIDEi P18337.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027871 ; ENSMUSP00000027871 ; ENSMUSG00000026581 .
    GeneIDi 20343.
    KEGGi mmu:20343.
    UCSCi uc007dhy.2. mouse.

    Organism-specific databases

    CTDi 6402.
    MGIi MGI:98279. Sell.

    Phylogenomic databases

    eggNOGi NOG258998.
    HOVERGENi HBG052375.
    InParanoidi P18337.
    KOi K06495.
    OMAi VAIQNKG.
    PhylomeDBi P18337.
    TreeFami TF326910.

    Enzyme and pathway databases

    Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    ChiTaRSi SELL. mouse.
    NextBioi 298173.
    PROi P18337.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P18337.
    Bgeei P18337.
    CleanExi MM_SELL.
    Genevestigatori P18337.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR013111. EGF_extracell.
    IPR016348. L-selectin.
    IPR002396. Selectin_superfamily.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF07974. EGF_2. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002421. L-selectin. 1 hit.
    PRINTSi PR00343. SELECTIN.
    SMARTi SM00032. CCP. 2 hits.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    SSF57535. SSF57535. 2 hits.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50923. SUSHI. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains."
      Siegelman M.H., van de Rijn M., Weissman I.L.
      Science 243:1165-1172(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Lymph node.
    2. "The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding."
      Siegelman M.H., Cheng I.C., Weissman I.L., Wakeland E.K.
      Cell 61:611-622(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Hematopoietic.
    5. "Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons."
      Dowbenko D.J., Diep A., Taylor B.A., Lusis A.J., Lasky L.A.
      Genomics 9:270-277(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-360.

    Entry informationi

    Entry nameiLYAM1_MOUSE
    AccessioniPrimary (citable) accession number: P18337
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3