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Protein

Sapecin

Gene
N/A
Organism
Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sapecins, which are potent bactericidal proteins, are produced in response to injury. Sapecin is cytotoxic to Gram-positive bacteria, and to a lesser extent against Gram-negative bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.47.1.3. the insect/fungal defensin (insect/fungal defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sapecin
OrganismiSarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)
Taxonomic identifieri7386 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaSarcophagidaeSarcophagaBoettcherisca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 54311 PublicationPRO_0000006756Add
BLAST
Peptidei55 – 9440SapecinPRO_0000006757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 84PROSITE-ProRule annotation1 Publication
Disulfide bondi70 ↔ 90PROSITE-ProRule annotation1 Publication
Disulfide bondi74 ↔ 92PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Hemocytes and fat body.

Inductioni

By injury to the larval cell wall.

Structurei

Secondary structure

1
94
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi57 – 604Combined sources
Helixi68 – 7811Combined sources
Beta strandi80 – 856Combined sources
Turni86 – 883Combined sources
Beta strandi89 – 935Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L4VNMR-A55-94[»]
ProteinModelPortaliP18313.
SMRiP18313. Positions 55-94.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18313.

Family & Domainsi

Sequence similaritiesi

Belongs to the invertebrate defensin family. Type 1 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR017982. Defensin_insect.
IPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
PRINTSiPR00271. DEFENSIN.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFIVLAVT LCLAAFFMGQ SVASPAAAAE ESKFVDGLHA LKTIEPELHG
60 70 80 90
RYKRATCDLL SGTGINHSAC AAHCLLRGNR GGYCNGKAVC VCRN
Length:94
Mass (Da):9,915
Last modified:November 1, 1990 - v1
Checksum:i36170AB3073EC947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04053 mRNA. Translation: AAA29984.1.
PIRiA31792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04053 mRNA. Translation: AAA29984.1.
PIRiA31792.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1L4VNMR-A55-94[»]
ProteinModelPortaliP18313.
SMRiP18313. Positions 55-94.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.47.1.3. the insect/fungal defensin (insect/fungal defensin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP18313.

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR017982. Defensin_insect.
IPR001542. Defensin_invertebrate/fungal.
IPR003614. Scorpion_toxin-like.
[Graphical view]
PfamiPF01097. Defensin_2. 1 hit.
[Graphical view]
PRINTSiPR00271. DEFENSIN.
SUPFAMiSSF57095. SSF57095. 1 hit.
PROSITEiPS51378. INVERT_DEFENSINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAPE_SARPE
AccessioniPrimary (citable) accession number: P18313
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.