Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Drebrin

Gene

DBN1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin
Alternative name(s):
Developmentally-regulated brain protein
Gene namesi
Name:DBN1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcell cortex By similarity
  • Cell junction By similarity
  • Cell projection By similarity
  • Cell projectiongrowth cone By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 652651DrebrinPRO_0000080007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP18302.

Expressioni

Tissue specificityi

Brain neurons.

Interactioni

Subunit structurei

Binds F-actin.By similarity

Structurei

3D structure databases

ProteinModelPortaliP18302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 134130ADF-HPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 504Poly-Gly
Compositional biasi332 – 3398Poly-Ser
Compositional biasi542 – 55211Poly-GluAdd
BLAST
Compositional biasi643 – 6464Poly-Glu

Sequence similaritiesi

Contains 1 ADF-H domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000823.
InParanoidiP18302.
PhylomeDBiP18302.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028438. Drebrin.
[Graphical view]
PANTHERiPTHR10829:SF1. PTHR10829:SF1. 2 hits.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P18302-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGVGFAAHR LELLASYQDV IGEDSPTDWA LYTYEDGSDD LKLAASGGGG
60 70 80 90 100
LLELSGHFEI QKVMYGFCSV KEPQAVLPKY VLVNWVGEDV PDARKCACAS
110 120 130 140 150
HVAKIAEFFQ GVDVIVNASS VEDIDPGAIG QRLSNGLARV SSPVLHRLRL
160 170 180 190 200
REDENAEPVG TTYQKTDATV EMKRLNREQF WEQAKKEEEL RKEEERKKAL
210 220 230 240 250
DARLRFEQER MEQERLEQEE RERRYREREE QIEEHRRKQQ SMEAEEARQR
260 270 280 290 300
LKEQSIFGEQ QEEDDRQQLR KSESEVEEAA AIIAQRPDNP REFFKQQERV
310 320 330 340 350
ASGSGDAISP GSHRTGRLHC PFIKTADSGP PSSSSSSSSP PRTPFPYITC
360 370 380 390 400
HRTPNLSSFF PCSQSDYRKV SAAGCSPCES SPASTPLGEQ RTRAPAEETP
410 420 430 440 450
ATPKDSPSPS TQVAEPAATE QHWPFPGPED KAAEPPGDEP DPDPRPAWTA
460 470 480 490 500
GADVLGDLVT LEPSEPSPAP AASEPQPVET PGVAEPLIEL WQSDGAAPAA
510 520 530 540 550
TSTWPLPDTP AGPPVPPEEG TLLGLDELPE PPATFCDAEQ HEEVEEEEEE
560 570 580 590 600
EEATAGEPHP TGLGYQEGYQ EGPEVPPITN GEMGPKDGTA GRGEQASEGY
610 620 630 640 650
FSQSQEEEAP PPEEPSAKAP QPVFYNKPPE IDITCWDTDP LPEEEESFGG

GL
Length:652
Mass (Da):71,535
Last modified:January 23, 2007 - v4
Checksum:i8EF72CA549833E65
GO
Isoform E1 (identifier: P18302-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-362: Missing.

Show »
Length:606
Mass (Da):66,557
Checksum:i559C92CCBB63FEC4
GO
Isoform E2 (identifier: P18302-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     307-405: Missing.

Show »
Length:553
Mass (Da):61,146
Checksum:i853EC333D56BF9B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti552 – 5521E → EE in AAA48750 (PubMed:3208110).Curated
Sequence conflicti552 – 5521E → EE in AAB28011 (PubMed:3208110).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei307 – 40599Missing in isoform E2. 1 PublicationVSP_004197Add
BLAST
Alternative sequencei317 – 36246Missing in isoform E1. 1 PublicationVSP_004196Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36961 mRNA. Translation: AAA48750.1.
S65296
, S65279, S65280, S65281, S65288, S65289, S65290, S65291, S65292, S65294 Genomic DNA. Translation: AAB28012.1.
S65267 mRNA. Translation: AAB28011.2.
S65230 mRNA. Translation: AAB28010.1.
PIRiA43776.
I51213.
RefSeqiNP_990830.1. NM_205499.1.
UniGeneiGga.9093.

Genome annotation databases

GeneIDi396496.
KEGGigga:396496.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36961 mRNA. Translation: AAA48750.1.
S65296
, S65279, S65280, S65281, S65288, S65289, S65290, S65291, S65292, S65294 Genomic DNA. Translation: AAB28012.1.
S65267 mRNA. Translation: AAB28011.2.
S65230 mRNA. Translation: AAB28010.1.
PIRiA43776.
I51213.
RefSeqiNP_990830.1. NM_205499.1.
UniGeneiGga.9093.

3D structure databases

ProteinModelPortaliP18302.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP18302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396496.
KEGGigga:396496.

Organism-specific databases

CTDi1627.

Phylogenomic databases

HOVERGENiHBG000823.
InParanoidiP18302.
PhylomeDBiP18302.

Miscellaneous databases

PROiP18302.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR028438. Drebrin.
[Graphical view]
PANTHERiPTHR10829:SF1. PTHR10829:SF1. 2 hits.
PfamiPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
SMARTiSM00102. ADF. 1 hit.
[Graphical view]
PROSITEiPS51263. ADF_H. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDREB_CHICK
AccessioniPrimary (citable) accession number: P18302
Secondary accession number(s): Q91358, Q91359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 101 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Drebrins are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). The time course of their appearance are different from each other. Their structures are closely related.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.