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Protein

Apolipoprotein E

Gene

APOE

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

  • beta-amyloid binding Source: ARUK-UCL
  • heparin binding Source: UniProtKB-KW
  • lipid binding Source: InterPro
  • peptide binding Source: ARUK-UCL
  • protein homodimerization activity Source: ARUK-UCL

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • chylomicron Source: UniProtKB-KW
  • high-density lipoprotein particle Source: ARUK-UCL
  • intermediate-density lipoprotein particle Source: ARUK-UCL
  • low-density lipoprotein particle Source: ARUK-UCL
  • very-low-density lipoprotein particle Source: ARUK-UCL

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000199519 – 311Apolipoprotein EAdd BLAST293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136Methionine sulfoxideBy similarity1
Modified residuei140PhosphoserineBy similarity1
Glycosylationi205O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PRIDEiP18287.

Expressioni

Tissue specificityi

Secreted in plasma.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: ARUK-UCL

Structurei

3D structure databases

ProteinModelPortaliP18287.
SMRiP18287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati74 – 951Add BLAST22
Repeati96 – 1162Add BLAST21
Repeati117 – 1383Add BLAST22
Repeati139 – 1604Add BLAST22
Repeati161 – 1825Add BLAST22
Repeati183 – 2046Add BLAST22
Repeati205 – 2267Add BLAST22
Repeati227 – 2488Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni74 – 2488 X 22 AA approximate tandem repeatsAdd BLAST175
Regioni151 – 161LDL receptor bindingBy similarityAdd BLAST11
Regioni155 – 158Heparin-bindingBy similarity4
Regioni222 – 229Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG010582.
InParanoidiP18287.
KOiK04524.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVWWAVLAA AILAGCRAQT EQEVEVPEQA RWKAGQPWEL ALGRFWDYLR
60 70 80 90 100
WVQSLSDQVQ EELLSSQVTQ ELTMLMEETM KEVKAYKSEL EEQLSPMAQE
110 120 130 140 150
HRARLSKELQ VAGALEADME DVCNRLAQYR GEAQAMLGQS TEELARAFSS
160 170 180 190 200
HLRKLRKRLL RDAEDLQKRM AVYGAGAREG AERGVSAVRE RLGSRLERGR
210 220 230 240 250
LRVATVGTLA GRPLRERAQA WGERLRGHLE EVGSRARDRL NEVREQVEEV
260 270 280 290 300
RVKVEEQAPQ MRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKLQAAMPS
310
KAPAAAPIEN Q
Length:311
Mass (Da):35,497
Last modified:November 1, 1990 - v1
Checksum:i3E1566BC1AAE2655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36603 mRNA. Translation: AAA31164.1.
PIRiA45951.
RefSeqiNP_001076112.1. NM_001082643.1.
UniGeneiOcu.6224.

Genome annotation databases

GeneIDi100009337.
KEGGiocu:100009337.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAPOE_RABIT
AccessioniPrimary (citable) accession number: P18287
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: July 5, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families