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P18283 (GPX2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 141. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione peroxidase 2

Short name=GPx-2
Short name=GSHPx-2
EC=1.11.1.9
Alternative name(s):
Gastrointestinal glutathione peroxidase
Glutathione peroxidase-gastrointestinal
Short name=GPx-GI
Short name=GSHPx-GI
Glutathione peroxidase-related protein 2
Short name=GPRP-2
Gene names
Name:GPX2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Catalytic activity

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm. Note: Mainly cytoplasmic.

Tissue specificity

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Sequence similarities

Belongs to the glutathione peroxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Glutathione peroxidase 2
PRO_0000066619

Sites

Active site401

Amino acid modifications

Non-standard residue401Selenocysteine

Natural variations

Natural variant371A → L Requires 2 nucleotide substitutions. Ref.3
VAR_003615
Natural variant1261P → L. Ref.4
Corresponds to variant rs17881652 [ dbSNP | Ensembl ].
VAR_020916
Natural variant1461R → C. Ref.4
Corresponds to variant rs17880492 [ dbSNP | Ensembl ].
VAR_020917
Natural variant1761I → M.
VAR_003616

Experimental info

Sequence conflict371A → R in CAB43534. Ref.1
Sequence conflict771C → S in CAB43534. Ref.1

Secondary structure

................................. 190
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P18283 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: FC8C4E69C4DE83A0

FASTA19021,954
        10         20         30         40         50         60 
MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL NELQCRFPRR 

        70         80         90        100        110        120 
LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT LVQKCEVNGQ NEHPVFAYLK 

       130        140        150        160        170        180 
DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV AWNFEKFLIG PEGEPFRRYS RTFPTINIEP 

       190 
DIKRLLKVAI 

« Hide

References

« Hide 'large scale' references
[1]"A human cDNA sequence of a novel glutathione peroxidase-related protein."
Akasaka M., Mizoguchi J., Takahashi K.
Nucleic Acids Res. 18:4619-4619(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI."
Chu F.-F., Doroshow J.H., Esworthy R.S.
J. Biol. Chem. 268:2571-2576(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: Liver.
[3]"Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents."
Kelner M.J., Bagnell R.D., Montoya M.A., Lanham K.A.
Gene 248:109-116(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-37.
[4]NIEHS SNPs program
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-126 AND CYS-146.
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Prostate and Urinary bladder.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Crystal structure of the selenocysteine to cysteine mutant of human glutathione peroxidase 2 (GPX2)."
Structural genomics consortium (SGC)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 4-188.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53463 mRNA. Translation: CAB43534.1.
X68314 mRNA. Translation: CAA48394.1.
AF199441 Genomic DNA. Translation: AAF74026.1.
AY785560 Genomic DNA. Translation: AAV31780.1.
AL139022 Genomic DNA. No translation available.
BC005277 mRNA. Translation: AAH05277.1.
BC016756 mRNA. Translation: AAH16756.1.
BC022820 mRNA. Translation: AAH22820.2.
BC067221 mRNA. Translation: AAH67221.1.
CCDSCCDS41964.1.
PIRA45207.
RefSeqNP_002074.2. NM_002083.3.
UniGeneHs.2704.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE3X-ray2.10A4-188[»]
ProteinModelPortalP18283.
SMRP18283. Positions 4-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109135. 3 interactions.
IntActP18283. 3 interactions.
STRING9606.ENSP00000374265.

Chemistry

DrugBankDB00143. Glutathione.

Protein family/group databases

PeroxiBase3601. HsGPx02.

PTM databases

PhosphoSiteP18283.

Polymorphism databases

DMDM172046064.

Proteomic databases

MaxQBP18283.
PaxDbP18283.
PRIDEP18283.

Protocols and materials databases

DNASU2877.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389614; ENSP00000374265; ENSG00000176153.
GeneID2877.
KEGGhsa:2877.
UCSCuc021ruq.2. human.

Organism-specific databases

CTD2877.
GeneCardsGC14M065405.
H-InvDBHIX0037716.
HGNCHGNC:4554. GPX2.
HPAHPA003545.
MIM138319. gene.
neXtProtNX_P18283.
PharmGKBPA28950.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0386.
HOGENOMHOG000277055.
HOVERGENHBG004333.
InParanoidP18283.
KOK00432.
OMAKMVENEY.
PhylomeDBP18283.
TreeFamTF105318.

Enzyme and pathway databases

BioCycMetaCyc:HS11006-MONOMER.
ReactomeREACT_111217. Metabolism.
REACT_120956. Cellular responses to stress.
SABIO-RKP18283.

Gene expression databases

ArrayExpressP18283.
BgeeP18283.
CleanExHS_GPX2.
GenevestigatorP18283.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11592. PTHR11592. 1 hit.
PfamPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFPIRSF000303. Glutathion_perox. 1 hit.
PRINTSPR01011. GLUTPROXDASE.
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP18283.
GeneWikiGPX2_(gene).
GenomeRNAi2877.
NextBio11359.
PROP18283.
SOURCESearch...

Entry information

Entry nameGPX2_HUMAN
AccessionPrimary (citable) accession number: P18283
Secondary accession number(s): Q6PJ52, Q8WWI7, Q9NRP9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM