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Protein

Glutathione peroxidase 2

Gene

GPX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei401

GO - Molecular functioni

  • electron transfer activity Source: UniProtKB
  • glutathione peroxidase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMetaCyc:HS11006-MONOMER
BRENDAi1.11.1.9 2681
ReactomeiR-HSA-2142688 Synthesis of 5-eicosatetraenoic acids
R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-5628897 TP53 Regulates Metabolic Genes
SABIO-RKiP18283

Protein family/group databases

PeroxiBasei3601 HsGPx02

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Short name:
GPx-2
Short name:
GSHPx-2
Alternative name(s):
Gastrointestinal glutathione peroxidase
Glutathione peroxidase-gastrointestinal
Short name:
GPx-GI
Short name:
GSHPx-GI
Glutathione peroxidase-related protein 2
Short name:
GPRP-2
Gene namesi
Name:GPX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176153.11
HGNCiHGNC:4554 GPX2
MIMi138319 gene
neXtProtiNX_P18283

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2877
OpenTargetsiENSG00000176153
PharmGKBiPA28950

Chemistry databases

DrugBankiDB00143 Glutathione

Polymorphism and mutation databases

BioMutaiGPX2
DMDMi172046064

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666191 – 190Glutathione peroxidase 2Add BLAST190

Proteomic databases

MaxQBiP18283
PaxDbiP18283
PeptideAtlasiP18283
PRIDEiP18283

PTM databases

iPTMnetiP18283
PhosphoSitePlusiP18283

Expressioni

Tissue specificityi

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Gene expression databases

BgeeiENSG00000176153
CleanExiHS_GPX2
ExpressionAtlasiP18283 baseline and differential
GenevisibleiP18283 HS

Organism-specific databases

HPAiHPA003545

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi109135, 3 interactors
IntActiP18283, 3 interactors
STRINGi9606.ENSP00000374265

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi20 – 22Combined sources3
Helixi23 – 26Combined sources4
Beta strandi29 – 36Combined sources8
Helixi43 – 56Combined sources14
Turni58 – 60Combined sources3
Beta strandi61 – 68Combined sources8
Helixi79 – 81Combined sources3
Helixi82 – 88Combined sources7
Beta strandi98 – 102Combined sources5
Beta strandi105 – 109Combined sources5
Helixi114 – 122Combined sources9
Helixi137 – 139Combined sources3
Beta strandi156 – 159Combined sources4
Beta strandi165 – 169Combined sources5
Helixi175 – 178Combined sources4
Helixi179 – 186Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE3X-ray2.10A4-188[»]
ProteinModelPortaliP18283
SMRiP18283
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18283

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
GeneTreeiENSGT00760000119230
HOGENOMiHOG000277055
HOVERGENiHBG004333
InParanoidiP18283
KOiK00432
OMAiPFKRYSK
OrthoDBiEOG091G10LN
PhylomeDBiP18283
TreeFamiTF105318

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

P18283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL
60 70 80 90 100
NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT
110 120 130 140 150
LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV
160 170 180 190
AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Length:190
Mass (Da):21,954
Last modified:February 26, 2008 - v3
Checksum:iFC8C4E69C4DE83A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → R in CAB43534 (PubMed:2388849).Curated1
Sequence conflicti77C → S in CAB43534 (PubMed:2388849).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00361537A → L Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_020916126P → L1 PublicationCorresponds to variant dbSNP:rs17881652Ensembl.1
Natural variantiVAR_020917146R → C1 PublicationCorresponds to variant dbSNP:rs17880492Ensembl.1
Natural variantiVAR_003616176I → M. 1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei40Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53463 mRNA Translation: CAB43534.1
X68314 mRNA Translation: CAA48394.1
AF199441 Genomic DNA Translation: AAF74026.1
AY785560 Genomic DNA Translation: AAV31780.1
AL139022 Genomic DNA No translation available.
BC005277 mRNA Translation: AAH05277.1
BC016756 mRNA Translation: AAH16756.1
BC022820 mRNA Translation: AAH22820.2
BC067221 mRNA Translation: AAH67221.1
CCDSiCCDS41964.1
PIRiA45207
RefSeqiNP_002074.2, NM_002083.3
UniGeneiHs.2704

Genome annotation databases

EnsembliENST00000389614; ENSP00000374265; ENSG00000176153
GeneIDi2877
KEGGihsa:2877
UCSCiuc021ruq.3 human

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiGPX2_HUMAN
AccessioniPrimary (citable) accession number: P18283
Secondary accession number(s): Q6PJ52, Q8WWI7, Q9NRP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health