Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutathione peroxidase 2

Gene

GPX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei401

GO - Molecular functioni

  • electron carrier activity Source: UniProtKB
  • glutathione peroxidase activity Source: Reactome

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMetaCyc:HS11006-MONOMER.
ZFISH:HS11006-MONOMER.
BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-2142688. Synthesis of 5-eicosatetraenoic acids.
R-HSA-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-HSA-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
SABIO-RKP18283.

Protein family/group databases

PeroxiBasei3601. HsGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Short name:
GPx-2
Short name:
GSHPx-2
Alternative name(s):
Gastrointestinal glutathione peroxidase
Glutathione peroxidase-gastrointestinal
Short name:
GPx-GI
Short name:
GSHPx-GI
Glutathione peroxidase-related protein 2
Short name:
GPRP-2
Gene namesi
Name:GPX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:4554. GPX2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: ProtInc
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2877.
OpenTargetsiENSG00000176153.
PharmGKBiPA28950.

Chemistry databases

DrugBankiDB00143. Glutathione.

Polymorphism and mutation databases

BioMutaiGPX2.
DMDMi172046064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666191 – 190Glutathione peroxidase 2Add BLAST190

Proteomic databases

EPDiP18283.
MaxQBiP18283.
PaxDbiP18283.
PeptideAtlasiP18283.
PRIDEiP18283.

PTM databases

iPTMnetiP18283.
PhosphoSitePlusiP18283.

Expressioni

Tissue specificityi

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Gene expression databases

BgeeiENSG00000176153.
CleanExiHS_GPX2.
ExpressionAtlasiP18283. baseline and differential.
GenevisibleiP18283. HS.

Organism-specific databases

HPAiHPA003545.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi109135. 3 interactors.
IntActiP18283. 3 interactors.
STRINGi9606.ENSP00000374265.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 10Combined sources3
Beta strandi12 – 15Combined sources4
Beta strandi20 – 22Combined sources3
Helixi23 – 26Combined sources4
Beta strandi29 – 36Combined sources8
Helixi43 – 56Combined sources14
Turni58 – 60Combined sources3
Beta strandi61 – 68Combined sources8
Helixi79 – 81Combined sources3
Helixi82 – 88Combined sources7
Beta strandi98 – 102Combined sources5
Beta strandi105 – 109Combined sources5
Helixi114 – 122Combined sources9
Helixi137 – 139Combined sources3
Beta strandi156 – 159Combined sources4
Beta strandi165 – 169Combined sources5
Helixi175 – 178Combined sources4
Helixi179 – 186Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE3X-ray2.10A4-188[»]
ProteinModelPortaliP18283.
SMRiP18283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18283.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiP18283.
KOiK00432.
OMAiQSKYPHR.
OrthoDBiEOG091G10LN.
PhylomeDBiP18283.
TreeFamiTF105318.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL
60 70 80 90 100
NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT
110 120 130 140 150
LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV
160 170 180 190
AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Length:190
Mass (Da):21,954
Last modified:February 26, 2008 - v3
Checksum:iFC8C4E69C4DE83A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → R in CAB43534 (PubMed:2388849).Curated1
Sequence conflicti77C → S in CAB43534 (PubMed:2388849).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00361537A → L Requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_020916126P → L.1 PublicationCorresponds to variant rs17881652dbSNPEnsembl.1
Natural variantiVAR_020917146R → C.1 PublicationCorresponds to variant rs17880492dbSNPEnsembl.1
Natural variantiVAR_003616176I → M.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei40Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53463 mRNA. Translation: CAB43534.1.
X68314 mRNA. Translation: CAA48394.1.
AF199441 Genomic DNA. Translation: AAF74026.1.
AY785560 Genomic DNA. Translation: AAV31780.1.
AL139022 Genomic DNA. No translation available.
BC005277 mRNA. Translation: AAH05277.1.
BC016756 mRNA. Translation: AAH16756.1.
BC022820 mRNA. Translation: AAH22820.2.
BC067221 mRNA. Translation: AAH67221.1.
CCDSiCCDS41964.1.
PIRiA45207.
RefSeqiNP_002074.2. NM_002083.3.
UniGeneiHs.2704.

Genome annotation databases

EnsembliENST00000389614; ENSP00000374265; ENSG00000176153.
GeneIDi2877.
KEGGihsa:2877.
UCSCiuc021ruq.3. human.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53463 mRNA. Translation: CAB43534.1.
X68314 mRNA. Translation: CAA48394.1.
AF199441 Genomic DNA. Translation: AAF74026.1.
AY785560 Genomic DNA. Translation: AAV31780.1.
AL139022 Genomic DNA. No translation available.
BC005277 mRNA. Translation: AAH05277.1.
BC016756 mRNA. Translation: AAH16756.1.
BC022820 mRNA. Translation: AAH22820.2.
BC067221 mRNA. Translation: AAH67221.1.
CCDSiCCDS41964.1.
PIRiA45207.
RefSeqiNP_002074.2. NM_002083.3.
UniGeneiHs.2704.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HE3X-ray2.10A4-188[»]
ProteinModelPortaliP18283.
SMRiP18283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109135. 3 interactors.
IntActiP18283. 3 interactors.
STRINGi9606.ENSP00000374265.

Chemistry databases

DrugBankiDB00143. Glutathione.

Protein family/group databases

PeroxiBasei3601. HsGPx02.

PTM databases

iPTMnetiP18283.
PhosphoSitePlusiP18283.

Polymorphism and mutation databases

BioMutaiGPX2.
DMDMi172046064.

Proteomic databases

EPDiP18283.
MaxQBiP18283.
PaxDbiP18283.
PeptideAtlasiP18283.
PRIDEiP18283.

Protocols and materials databases

DNASUi2877.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389614; ENSP00000374265; ENSG00000176153.
GeneIDi2877.
KEGGihsa:2877.
UCSCiuc021ruq.3. human.

Organism-specific databases

CTDi2877.
DisGeNETi2877.
GeneCardsiGPX2.
H-InvDBHIX0037716.
HGNCiHGNC:4554. GPX2.
HPAiHPA003545.
MIMi138319. gene.
neXtProtiNX_P18283.
OpenTargetsiENSG00000176153.
PharmGKBiPA28950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiP18283.
KOiK00432.
OMAiQSKYPHR.
OrthoDBiEOG091G10LN.
PhylomeDBiP18283.
TreeFamiTF105318.

Enzyme and pathway databases

BioCyciMetaCyc:HS11006-MONOMER.
ZFISH:HS11006-MONOMER.
BRENDAi1.11.1.9. 2681.
ReactomeiR-HSA-2142688. Synthesis of 5-eicosatetraenoic acids.
R-HSA-2142712. Synthesis of 12-eicosatetraenoic acid derivatives.
R-HSA-2142770. Synthesis of 15-eicosatetraenoic acid derivatives.
R-HSA-3299685. Detoxification of Reactive Oxygen Species.
R-HSA-5628897. TP53 Regulates Metabolic Genes.
SABIO-RKP18283.

Miscellaneous databases

EvolutionaryTraceiP18283.
GeneWikiiGPX2_(gene).
GenomeRNAii2877.
PROiP18283.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176153.
CleanExiHS_GPX2.
ExpressionAtlasiP18283. baseline and differential.
GenevisibleiP18283. HS.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPX2_HUMAN
AccessioniPrimary (citable) accession number: P18283
Secondary accession number(s): Q6PJ52, Q8WWI7, Q9NRP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.