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P18283

- GPX2_HUMAN

UniProt

P18283 - GPX2_HUMAN

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Protein

Glutathione peroxidase 2

Gene

GPX2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB
  2. glutathione peroxidase activity Source: Reactome

GO - Biological processi

  1. interaction with symbiont Source: Ensembl
  2. negative regulation of inflammatory response to antigenic stimulus Source: Ensembl
  3. response to oxidative stress Source: InterPro
  4. response to symbiotic bacterium Source: Ensembl
  5. temperature homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Enzyme and pathway databases

BioCyciMetaCyc:HS11006-MONOMER.
ReactomeiREACT_150201. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_150209. Synthesis of 5-eicosatetraenoic acids.
REACT_150422. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_172715. Detoxification of Reactive Oxygen Species.
SABIO-RKP18283.

Protein family/group databases

PeroxiBasei3601. HsGPx02.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidase 2 (EC:1.11.1.9)
Short name:
GPx-2
Short name:
GSHPx-2
Alternative name(s):
Gastrointestinal glutathione peroxidase
Glutathione peroxidase-gastrointestinal
Short name:
GPx-GI
Short name:
GSHPx-GI
Glutathione peroxidase-related protein 2
Short name:
GPRP-2
Gene namesi
Name:GPX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:4554. GPX2.

Subcellular locationi

Cytoplasm
Note: Mainly cytoplasmic.

GO - Cellular componenti

  1. cytoplasm Source: ProtInc
  2. cytosol Source: Reactome
  3. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Glutathione peroxidase 2PRO_0000066619Add
BLAST

Proteomic databases

MaxQBiP18283.
PaxDbiP18283.
PRIDEiP18283.

PTM databases

PhosphoSiteiP18283.

Expressioni

Tissue specificityi

Mostly in liver and gastrointestinal tract, not found in heart or kidney.

Gene expression databases

BgeeiP18283.
CleanExiHS_GPX2.
ExpressionAtlasiP18283. baseline and differential.
GenevestigatoriP18283.

Organism-specific databases

HPAiHPA003545.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

BioGridi109135. 3 interactions.
IntActiP18283. 3 interactions.
STRINGi9606.ENSP00000374265.

Structurei

Secondary structure

1
190
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi8 – 103
Beta strandi12 – 154
Beta strandi20 – 223
Helixi23 – 264
Beta strandi29 – 368
Helixi43 – 5614
Turni58 – 603
Beta strandi61 – 688
Helixi79 – 813
Helixi82 – 887
Beta strandi98 – 1025
Beta strandi105 – 1095
Helixi114 – 1229
Helixi137 – 1393
Beta strandi156 – 1594
Beta strandi165 – 1695
Helixi175 – 1784
Helixi179 – 1868

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HE3X-ray2.10A4-188[»]
ProteinModelPortaliP18283.
SMRiP18283. Positions 4-187.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP18283.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiCOG0386.
GeneTreeiENSGT00760000119230.
HOGENOMiHOG000277055.
HOVERGENiHBG004333.
InParanoidiP18283.
KOiK00432.
OMAiKMVENEY.
PhylomeDBiP18283.
TreeFamiTF105318.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P18283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFIAKSFYD LSAISLDGEK VDFNTFRGRA VLIENVASLU GTTTRDFTQL
60 70 80 90 100
NELQCRFPRR LVVLGFPCNQ FGHQENCQNE EILNSLKYVR PGGGYQPTFT
110 120 130 140 150
LVQKCEVNGQ NEHPVFAYLK DKLPYPYDDP FSLMTDPKLI IWSPVRRSDV
160 170 180 190
AWNFEKFLIG PEGEPFRRYS RTFPTINIEP DIKRLLKVAI
Length:190
Mass (Da):21,954
Last modified:February 26, 2008 - v3
Checksum:iFC8C4E69C4DE83A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → R in CAB43534. (PubMed:2388849)Curated
Sequence conflicti77 – 771C → S in CAB43534. (PubMed:2388849)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371A → L Requires 2 nucleotide substitutions. 1 Publication
VAR_003615
Natural varianti126 – 1261P → L.1 Publication
Corresponds to variant rs17881652 [ dbSNP | Ensembl ].
VAR_020916
Natural varianti146 – 1461R → C.1 Publication
Corresponds to variant rs17880492 [ dbSNP | Ensembl ].
VAR_020917
Natural varianti176 – 1761I → M.
VAR_003616

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei40 – 401Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53463 mRNA. Translation: CAB43534.1.
X68314 mRNA. Translation: CAA48394.1.
AF199441 Genomic DNA. Translation: AAF74026.1.
AY785560 Genomic DNA. Translation: AAV31780.1.
AL139022 Genomic DNA. No translation available.
BC005277 mRNA. Translation: AAH05277.1.
BC016756 mRNA. Translation: AAH16756.1.
BC022820 mRNA. Translation: AAH22820.2.
BC067221 mRNA. Translation: AAH67221.1.
CCDSiCCDS41964.1.
PIRiA45207.
RefSeqiNP_002074.2. NM_002083.3.
UniGeneiHs.2704.

Genome annotation databases

EnsembliENST00000389614; ENSP00000374265; ENSG00000176153.
GeneIDi2877.
KEGGihsa:2877.
UCSCiuc021ruq.2. human.

Polymorphism databases

DMDMi172046064.

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53463 mRNA. Translation: CAB43534.1 .
X68314 mRNA. Translation: CAA48394.1 .
AF199441 Genomic DNA. Translation: AAF74026.1 .
AY785560 Genomic DNA. Translation: AAV31780.1 .
AL139022 Genomic DNA. No translation available.
BC005277 mRNA. Translation: AAH05277.1 .
BC016756 mRNA. Translation: AAH16756.1 .
BC022820 mRNA. Translation: AAH22820.2 .
BC067221 mRNA. Translation: AAH67221.1 .
CCDSi CCDS41964.1.
PIRi A45207.
RefSeqi NP_002074.2. NM_002083.3.
UniGenei Hs.2704.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HE3 X-ray 2.10 A 4-188 [» ]
ProteinModelPortali P18283.
SMRi P18283. Positions 4-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109135. 3 interactions.
IntActi P18283. 3 interactions.
STRINGi 9606.ENSP00000374265.

Chemistry

DrugBanki DB00143. Glutathione.

Protein family/group databases

PeroxiBasei 3601. HsGPx02.

PTM databases

PhosphoSitei P18283.

Polymorphism databases

DMDMi 172046064.

Proteomic databases

MaxQBi P18283.
PaxDbi P18283.
PRIDEi P18283.

Protocols and materials databases

DNASUi 2877.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389614 ; ENSP00000374265 ; ENSG00000176153 .
GeneIDi 2877.
KEGGi hsa:2877.
UCSCi uc021ruq.2. human.

Organism-specific databases

CTDi 2877.
GeneCardsi GC14M065405.
H-InvDB HIX0037716.
HGNCi HGNC:4554. GPX2.
HPAi HPA003545.
MIMi 138319. gene.
neXtProti NX_P18283.
PharmGKBi PA28950.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0386.
GeneTreei ENSGT00760000119230.
HOGENOMi HOG000277055.
HOVERGENi HBG004333.
InParanoidi P18283.
KOi K00432.
OMAi KMVENEY.
PhylomeDBi P18283.
TreeFami TF105318.

Enzyme and pathway databases

BioCyci MetaCyc:HS11006-MONOMER.
Reactomei REACT_150201. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_150209. Synthesis of 5-eicosatetraenoic acids.
REACT_150422. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_172715. Detoxification of Reactive Oxygen Species.
SABIO-RK P18283.

Miscellaneous databases

EvolutionaryTracei P18283.
GeneWikii GPX2_(gene).
GenomeRNAii 2877.
NextBioi 11359.
PROi P18283.
SOURCEi Search...

Gene expression databases

Bgeei P18283.
CleanExi HS_GPX2.
ExpressionAtlasi P18283. baseline and differential.
Genevestigatori P18283.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human cDNA sequence of a novel glutathione peroxidase-related protein."
    Akasaka M., Mizoguchi J., Takahashi K.
    Nucleic Acids Res. 18:4619-4619(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI."
    Chu F.-F., Doroshow J.H., Esworthy R.S.
    J. Biol. Chem. 268:2571-2576(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: Liver.
  3. "Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents."
    Kelner M.J., Bagnell R.D., Montoya M.A., Lanham K.A.
    Gene 248:109-116(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-37.
  4. NIEHS SNPs program
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LEU-126 AND CYS-146.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Prostate and Urinary bladder.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of the selenocysteine to cysteine mutant of human glutathione peroxidase 2 (GPX2)."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 4-188.

Entry informationi

Entry nameiGPX2_HUMAN
AccessioniPrimary (citable) accession number: P18283
Secondary accession number(s): Q6PJ52, Q8WWI7, Q9NRP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3