ID   NTF3_RAT                Reviewed;         258 AA.
AC   P18280; Q6NS33;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-NOV-2009, entry version 79.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=Neurotrophic factor;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   Flags: Precursor;
GN   Name=Ntf3; Synonyms=Ntf-3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90319130; PubMed=2164684; DOI=10.1073/pnas.87.14.5454;
RA   Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.;
RT   "Molecular cloning and neurotrophic activities of a protein with
RT   structural similarities to nerve growth factor: developmental and
RT   topographical expression in the brain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=90208301; PubMed=2321006; DOI=10.1126/science.2321006;
RA   Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E.,
RA   Lindsay R.M., Yancopoulos G.D.;
RT   "Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.";
RL   Science 247:1446-1451(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=91365361; PubMed=1889806; DOI=10.1016/0888-7543(91)90436-I;
RA   Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y.,
RA   Belluscio L., de la Monte S.M., Squinto S., Furth M.E.,
RA   Yancopoulos G.D.;
RT   "Human and rat brain-derived neurotrophic factor and neurotrophin-3:
RT   gene structures, distributions, and chromosomal localizations.";
RL   Genomics 10:558-568(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 195-237.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   MEDLINE=91222573; PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Seems to promotes the survival of visceral and
CC       proprioceptive sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain and peripheral tissues.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; M34643; AAA41313.1; -; mRNA.
DR   EMBL; M33968; AAA41727.1; -; Genomic_DNA.
DR   EMBL; M61179; AAA63497.1; -; Genomic_DNA.
DR   EMBL; BC070504; AAH70504.1; -; mRNA.
DR   IPI; IPI00189937; -.
DR   PIR; A35781; A35781.
DR   RefSeq; NP_112335.2; -.
DR   UniGene; Rn.9715; -.
DR   HSSP; P20783; 1NT3.
DR   SMR; P18280; 147-254.
DR   STRING; P18280; -.
DR   Ensembl; ENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716; Rattus norvegicus.
DR   GeneID; 81737; -.
DR   KEGG; rno:81737; -.
DR   UCSC; NM_031073; rat.
DR   CTD; 81737; -.
DR   RGD; 619728; Ntf3.
DR   HOVERGEN; P18280; -.
DR   OMA; QRRYSSP; -.
DR   NextBio; 615426; -.
DR   ArrayExpress; P18280; -.
DR   Genevestigator; P18280; -.
DR   GermOnline; ENSRNOG00000019716; Rattus norvegicus.
DR   GO; GO:0005576; C:extracellular region; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; IMP:RGD.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0048406; F:nerve growth factor binding; IMP:RGD.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   GO; GO:0042552; P:myelination; IDA:RGD.
DR   GO; GO:0045687; P:positive regulation of glial cell different...; IDA:RGD.
DR   GO; GO:0050804; P:regulation of synaptic transmission; IDA:RGD.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR020409; Neurotrophin-3_N.
DR   PANTHER; PTHR11589:SF4; Neurotrophin-3; 1.
DR   PANTHER; PTHR11589; NGF; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   ProDom; PD002052; NGF; 1.
DR   SMART; SM00140; NGF; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Secreted; Signal.
FT   SIGNAL        1     18       Potential.
FT   PROPEP       19    139
FT                                /FTId=PRO_0000019663.
FT   CHAIN       140    258       Neurotrophin-3.
FT                                /FTId=PRO_0000019664.
FT   CARBOHYD    131    131       N-linked (GlcNAc...) (Potential).
FT   DISULFID    153    218       By similarity.
FT   DISULFID    196    247       By similarity.
FT   DISULFID    206    249       By similarity.
FT   CONFLICT    218    218       C -> R (in Ref. 4; AAH70504).
SQ   SEQUENCE   258 AA;  29645 MW;  74D557CF8518A1CE CRC64;
     MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
     EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI
     KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW
     IRIDTSCVCA LSRKIGRT
//