ID   NTF3_RAT                Reviewed;         258 AA.
AC   P18280; Q6NS33;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   24-JAN-2024, entry version 170.
DE   RecName: Full=Neurotrophin-3;
DE            Short=NT-3;
DE   AltName: Full=HDNF;
DE   AltName: Full=Nerve growth factor 2;
DE            Short=NGF-2;
DE   AltName: Full=Neurotrophic factor;
DE   Flags: Precursor;
GN   Name=Ntf3; Synonyms=Ntf-3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2164684; DOI=10.1073/pnas.87.14.5454;
RA   Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.;
RT   "Molecular cloning and neurotrophic activities of a protein with structural
RT   similarities to nerve growth factor: developmental and topographical
RT   expression in the brain.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2321006; DOI=10.1126/science.247.4949.1446;
RA   Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E.,
RA   Lindsay R.M., Yancopoulos G.D.;
RT   "Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.";
RL   Science 247:1446-1451(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1889806; DOI=10.1016/0888-7543(91)90436-i;
RA   Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L.,
RA   de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.;
RT   "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene
RT   structures, distributions, and chromosomal localizations.";
RL   Genomics 10:558-568(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE OF 195-237.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain and peripheral tissues.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; M34643; AAA41313.1; -; mRNA.
DR   EMBL; M33968; AAA41727.1; -; Genomic_DNA.
DR   EMBL; M61179; AAA63497.1; -; Genomic_DNA.
DR   EMBL; BC070504; AAH70504.1; -; mRNA.
DR   PIR; A35781; A35781.
DR   RefSeq; NP_001257797.1; NM_001270868.1.
DR   RefSeq; NP_001257798.1; NM_001270869.1.
DR   RefSeq; NP_001257799.1; NM_001270870.1.
DR   RefSeq; NP_112335.3; NM_031073.3.
DR   AlphaFoldDB; P18280; -.
DR   SMR; P18280; -.
DR   STRING; 10116.ENSRNOP00000070420; -.
DR   GlyCosmos; P18280; 1 site, No reported glycans.
DR   GlyGen; P18280; 1 site.
DR   PhosphoSitePlus; P18280; -.
DR   PaxDb; 10116-ENSRNOP00000026685; -.
DR   Ensembl; ENSRNOT00000026685.6; ENSRNOP00000026685.3; ENSRNOG00000019716.6.
DR   Ensembl; ENSRNOT00000115703.1; ENSRNOP00000090293.1; ENSRNOG00000019716.6.
DR   Ensembl; ENSRNOT00055017824; ENSRNOP00055014347; ENSRNOG00055010520.
DR   Ensembl; ENSRNOT00060027904; ENSRNOP00060022430; ENSRNOG00060016294.
DR   Ensembl; ENSRNOT00065057359; ENSRNOP00065047200; ENSRNOG00065033366.
DR   GeneID; 81737; -.
DR   KEGG; rno:81737; -.
DR   UCSC; RGD:619728; rat.
DR   AGR; RGD:619728; -.
DR   CTD; 4908; -.
DR   RGD; 619728; Ntf3.
DR   eggNOG; ENOG502R4FK; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   HOGENOM; CLU_059942_1_1_1; -.
DR   InParanoid; P18280; -.
DR   OMA; ILLYVMF; -.
DR   OrthoDB; 5399313at2759; -.
DR   PhylomeDB; P18280; -.
DR   TreeFam; TF106463; -.
DR   Reactome; R-RNO-9034013; NTF3 activates NTRK3 signaling.
DR   Reactome; R-RNO-9034793; Activated NTRK3 signals through PLCG1.
DR   Reactome; R-RNO-9603381; Activated NTRK3 signals through PI3K.
DR   PRO; PR:P18280; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000019716; Expressed in kidney and 19 other cell types or tissues.
DR   ExpressionAtlas; P18280; baseline and differential.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISO:RGD.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR   GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR   GO; GO:0048406; F:nerve growth factor binding; IMP:RGD.
DR   GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; ISO:RGD.
DR   GO; GO:0007420; P:brain development; ISO:RGD.
DR   GO; GO:0048484; P:enteric nervous system development; ISO:RGD.
DR   GO; GO:0008544; P:epidermis development; ISO:RGD.
DR   GO; GO:0048699; P:generation of neurons; ISO:RGD.
DR   GO; GO:0007403; P:glial cell fate determination; ISO:RGD.
DR   GO; GO:0050930; P:induction of positive chemotaxis; ISO:RGD.
DR   GO; GO:0042490; P:mechanoreceptor differentiation; ISO:RGD.
DR   GO; GO:0007613; P:memory; IBA:GO_Central.
DR   GO; GO:0050804; P:modulation of chemical synaptic transmission; IDA:RGD.
DR   GO; GO:0042552; P:myelination; IDA:RGD.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR   GO; GO:0021675; P:nerve development; ISO:RGD.
DR   GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; IMP:RGD.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; ISO:RGD.
DR   GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
DR   GO; GO:0048666; P:neuron development; ISO:RGD.
DR   GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR   GO; GO:0007422; P:peripheral nervous system development; ISO:RGD.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0045687; P:positive regulation of glial cell differentiation; IDA:RGD.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR   GO; GO:0002092; P:positive regulation of receptor internalization; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0043523; P:regulation of neuron apoptotic process; ISO:RGD.
DR   GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR   GO; GO:0035902; P:response to immobilization stress; IEP:RGD.
DR   GO; GO:0051145; P:smooth muscle cell differentiation; ISO:RGD.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISO:RGD.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
DR   Genevisible; P18280; RN.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..139
FT                   /id="PRO_0000019663"
FT   CHAIN           140..258
FT                   /note="Neurotrophin-3"
FT                   /id="PRO_0000019664"
FT   REGION          60..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        153..218
FT                   /evidence="ECO:0000250"
FT   DISULFID        196..247
FT                   /evidence="ECO:0000250"
FT   DISULFID        206..249
FT                   /evidence="ECO:0000250"
FT   CONFLICT        218
FT                   /note="C -> R (in Ref. 4; AAH70504)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   258 AA;  29645 MW;  74D557CF8518A1CE CRC64;
     MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
     STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
     EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI
     KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW
     IRIDTSCVCA LSRKIGRT
//