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P18280

- NTF3_RAT

UniProt

P18280 - NTF3_RAT

Protein

Neurotrophin-3

Gene

Ntf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Seems to promote the survival of visceral and proprioceptive sensory neurons.

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl
    2. nerve growth factor binding Source: RGD

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. activation of Ras GTPase activity Source: Ensembl
    4. axon guidance Source: Ensembl
    5. brain development Source: Ensembl
    6. enteric nervous system development Source: Ensembl
    7. epidermis development Source: Ensembl
    8. glial cell fate determination Source: Ensembl
    9. induction of positive chemotaxis Source: Ensembl
    10. mechanoreceptor differentiation Source: Ensembl
    11. myelination Source: RGD
    12. negative regulation of neuron apoptotic process Source: Ensembl
    13. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    14. nerve development Source: Ensembl
    15. nervous system development Source: RGD
    16. neuromuscular synaptic transmission Source: Ensembl
    17. peripheral nervous system development Source: Ensembl
    18. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    19. positive regulation of cell migration Source: Ensembl
    20. positive regulation of cell proliferation Source: Ensembl
    21. positive regulation of glial cell differentiation Source: RGD
    22. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    23. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    24. positive regulation of receptor internalization Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. regulation of synaptic transmission Source: RGD
    27. smooth muscle cell differentiation Source: Ensembl
    28. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_219269. PLC-gamma1 signalling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-3
    Short name:
    NT-3
    Alternative name(s):
    HDNF
    Nerve growth factor 2
    Short name:
    NGF-2
    Neurotrophic factor
    Gene namesi
    Name:Ntf3
    Synonyms:Ntf-3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi619728. Ntf3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: Ensembl
    2. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 139121PRO_0000019663Add
    BLAST
    Chaini140 – 258119Neurotrophin-3PRO_0000019664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 218By similarity
    Disulfide bondi196 ↔ 247By similarity
    Disulfide bondi206 ↔ 249By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Brain and peripheral tissues.

    Gene expression databases

    GenevestigatoriP18280.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026685.

    Structurei

    3D structure databases

    ProteinModelPortaliP18280.
    SMRiP18280. Positions 144-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39844.
    GeneTreeiENSGT00390000007725.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiQ6NS33.
    KOiK04356.
    OMAiYAEHKSH.
    OrthoDBiEOG7RBZ8Z.
    PhylomeDBiP18280.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
    QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN 100
    SPRVLLSDST PLEPPPLYLM EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY 150
    SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR 200
    PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA 250
    LSRKIGRT 258
    Length:258
    Mass (Da):29,645
    Last modified:November 1, 1990 - v1
    Checksum:i74D557CF8518A1CE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti218 – 2181C → R in AAH70504. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34643 mRNA. Translation: AAA41313.1.
    M33968 Genomic DNA. Translation: AAA41727.1.
    M61179 Genomic DNA. Translation: AAA63497.1.
    BC070504 mRNA. Translation: AAH70504.1.
    PIRiA35781.
    RefSeqiNP_001257797.1. NM_001270868.1.
    NP_001257798.1. NM_001270869.1.
    NP_001257799.1. NM_001270870.1.
    NP_112335.3. NM_031073.3.
    UniGeneiRn.9715.

    Genome annotation databases

    EnsembliENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
    GeneIDi81737.
    KEGGirno:81737.
    UCSCiRGD:619728. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34643 mRNA. Translation: AAA41313.1 .
    M33968 Genomic DNA. Translation: AAA41727.1 .
    M61179 Genomic DNA. Translation: AAA63497.1 .
    BC070504 mRNA. Translation: AAH70504.1 .
    PIRi A35781.
    RefSeqi NP_001257797.1. NM_001270868.1.
    NP_001257798.1. NM_001270869.1.
    NP_001257799.1. NM_001270870.1.
    NP_112335.3. NM_031073.3.
    UniGenei Rn.9715.

    3D structure databases

    ProteinModelPortali P18280.
    SMRi P18280. Positions 144-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000026685 ; ENSRNOP00000026685 ; ENSRNOG00000019716 .
    GeneIDi 81737.
    KEGGi rno:81737.
    UCSCi RGD:619728. rat.

    Organism-specific databases

    CTDi 4908.
    RGDi 619728. Ntf3.

    Phylogenomic databases

    eggNOGi NOG39844.
    GeneTreei ENSGT00390000007725.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi Q6NS33.
    KOi K04356.
    OMAi YAEHKSH.
    OrthoDBi EOG7RBZ8Z.
    PhylomeDBi P18280.
    TreeFami TF106463.

    Enzyme and pathway databases

    Reactomei REACT_219269. PLC-gamma1 signalling.

    Miscellaneous databases

    NextBioi 615426.
    PROi P18280.

    Gene expression databases

    Genevestigatori P18280.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain."
      Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.
      Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
      Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
      Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
      Hallboeoek F., Ibanez C.F., Persson H.
      Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 195-237.
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiNTF3_RAT
    AccessioniPrimary (citable) accession number: P18280
    Secondary accession number(s): Q6NS33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3