P18280 (NTF3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurotrophin-3
Short name=NT-3

Alternative name(s):
HDNF
Nerve growth factor 2
Short name=NGF-2
Neurotrophic factor

Gene names

Name:	Ntf3
Synonyms:	Ntf-3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Seems to promotes the survival of visceral and proprioceptive sensory neurons.
Subcellular location	Secreted.
Tissue specificity	Brain and peripheral tissues.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	myelination Inferred from direct assay. Source: RGD positive regulation of glial cell differentiation Inferred from direct assay. Source: RGD regulation of synaptic transmission Inferred from direct assay. Source: RGD
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW nerve growth factor binding Inferred from mutant phenotype Ref.1. Source: RGD neurotrophin receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 139	121			PRO_0000019663
	Chain	140 – 258	119	Neurotrophin-3		PRO_0000019664
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	153 ↔ 218		By similarity
	Disulfide bond	196 ↔ 247		By similarity
	Disulfide bond	206 ↔ 249		By similarity
Experimental info
	Sequence conflict	218	1	C → R in AAH70504. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P18280 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 74D557CF8518A1CE	FASTA	258	29,645
	10 20 30 40 50 60 MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 70 80 90 100 110 120 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 130 140 150 160 170 180 EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 190 200 210 220 230 240 KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 250 IRIDTSCVCA LSRKIGRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain." Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H. Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed: 2164684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Neurotrophin-3: a neurotrophic factor related to NGF and BDNF." Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D. Science 247:1446-1451(1990) [PubMed: 2321006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D. Genomics 10:558-568(1991) [PubMed: 1889806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." Hallboeoek F., Ibanez C.F., Persson H. Neuron 6:845-858(1991) [PubMed: 2025430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 195-237. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34643 mRNA. Translation: AAA41313.1. M33968 Genomic DNA. Translation: AAA41727.1. M61179 Genomic DNA. Translation: AAA63497.1. BC070504 mRNA. Translation: AAH70504.1.
IPI	IPI00189937.
PIR	A35781.
RefSeq	NP_112335.2. NM_031073.2.
UniGene	Rn.9715.
3D structure databases
ProteinModelPortal	P18280.
SMR	P18280. Positions 144-254.
ModBase	Search...
Protein-protein interaction databases
STRING	P18280.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
GeneID	81737.
KEGG	rno:81737.
UCSC	NM_031073. rat.
Organism-specific databases
CTD	4908.
RGD	619728. Ntf3.
Phylogenomic databases
eggNOG	maNOG04548.
GeneTree	ENSGT00390000007725.
HOVERGEN	HBG006494.
InParanoid	P18280.
OMA	AANRTSR.
OrthoDB	EOG46HGBB.
PhylomeDB	P18280.
Enzyme and pathway databases
Reactome	REACT_111984. Signal Transduction.
Gene expression databases
ArrayExpress	P18280.
Genevestigator	P18280.
GermOnline	ENSRNOG00000019716. Rattus norvegicus.
Family and domain databases
InterPro	IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. IPR015578. Neurotrophin-3. [Graphical view]
KO	K04356.
PANTHER	PTHR11589:SF4. Neurotrophin-3. 1 hit. PTHR11589. NGF. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01914. NEUROTROPHN3. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615426.

Entry information

Entry name

NTF3_RAT

Accession

Primary (citable) accession number: P18280
Secondary accession number(s): Q6NS33

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	November 16, 2011
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program