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Protein

Neurotrophin-3

Gene

Ntf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • chemoattractant activity Source: Ensembl
  • growth factor activity Source: GO_Central
  • nerve growth factor binding Source: RGD
  • neurotrophin p75 receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_277317. ARMS-mediated activation.
REACT_285557. NRAGE signals death through JNK.
REACT_285987. Signalling to STAT3.
REACT_301225. Frs2-mediated activation.
REACT_316581. Signalling to RAS.
REACT_322024. PLC-gamma1 signalling.
REACT_323780. Signalling to p38 via RIT and RIN.
REACT_333661. Retrograde neurotrophin signalling.
REACT_351596. TRKA activation by NGF.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619728. Ntf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 139121PRO_0000019663Add
BLAST
Chaini140 – 258119Neurotrophin-3PRO_0000019664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 218By similarity
Disulfide bondi196 ↔ 247By similarity
Disulfide bondi206 ↔ 249By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

GenevestigatoriP18280.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026685.

Structurei

3D structure databases

ProteinModelPortaliP18280.
SMRiP18280. Positions 144-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP18280.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP18280.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA

LSRKIGRT
Length:258
Mass (Da):29,645
Last modified:November 1, 1990 - v1
Checksum:i74D557CF8518A1CE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181C → R in AAH70504 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34643 mRNA. Translation: AAA41313.1.
M33968 Genomic DNA. Translation: AAA41727.1.
M61179 Genomic DNA. Translation: AAA63497.1.
BC070504 mRNA. Translation: AAH70504.1.
PIRiA35781.
RefSeqiNP_001257797.1. NM_001270868.1.
NP_001257798.1. NM_001270869.1.
NP_001257799.1. NM_001270870.1.
NP_112335.3. NM_031073.3.
UniGeneiRn.9715.

Genome annotation databases

EnsembliENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
GeneIDi81737.
KEGGirno:81737.
UCSCiRGD:619728. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34643 mRNA. Translation: AAA41313.1.
M33968 Genomic DNA. Translation: AAA41727.1.
M61179 Genomic DNA. Translation: AAA63497.1.
BC070504 mRNA. Translation: AAH70504.1.
PIRiA35781.
RefSeqiNP_001257797.1. NM_001270868.1.
NP_001257798.1. NM_001270869.1.
NP_001257799.1. NM_001270870.1.
NP_112335.3. NM_031073.3.
UniGeneiRn.9715.

3D structure databases

ProteinModelPortaliP18280.
SMRiP18280. Positions 144-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
GeneIDi81737.
KEGGirno:81737.
UCSCiRGD:619728. rat.

Organism-specific databases

CTDi4908.
RGDi619728. Ntf3.

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP18280.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP18280.
TreeFamiTF106463.

Enzyme and pathway databases

ReactomeiREACT_277317. ARMS-mediated activation.
REACT_285557. NRAGE signals death through JNK.
REACT_285987. Signalling to STAT3.
REACT_301225. Frs2-mediated activation.
REACT_316581. Signalling to RAS.
REACT_322024. PLC-gamma1 signalling.
REACT_323780. Signalling to p38 via RIT and RIN.
REACT_333661. Retrograde neurotrophin signalling.
REACT_351596. TRKA activation by NGF.

Miscellaneous databases

NextBioi615426.
PROiP18280.

Gene expression databases

GenevestigatoriP18280.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain."
    Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.
    Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
    Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
    Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 195-237.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiNTF3_RAT
AccessioniPrimary (citable) accession number: P18280
Secondary accession number(s): Q6NS33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: April 29, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.