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Reviewed, UniProtKB/Swiss-Prot P18280 (NTF3_RAT)

Last modified June 16, 2009. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Neurotrophin-3
      Short name=NT-3
Alternative name(s):
    Neurotrophic factor
    HDNF
    Nerve growth factor 2
      Short name=NGF-2
Gene names
Name: Ntf3
Synonyms: Ntf-3
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Seems to promotes the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted.

Tissue specificity

Brain and peripheral tissues.

Sequence similarities

Belongs to the NGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 139121
PRO_0000019663
Chain140 – 258119Neurotrophin-3
PRO_0000019664

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond153 ↔ 218 By similarity
Disulfide bond196 ↔ 247 By similarity
Disulfide bond206 ↔ 249 By similarity

Experimental info

Sequence conflict2181C → R in AAH70504. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P18280-1 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 74D557CF8518A1CE

FASTA25829,645
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 

       190        200        210        220        230        240 
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 

       250 
IRIDTSCVCA LSRKIGRT 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain."
Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.
Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed: 2164684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Neurotrophin-3: a neurotrophic factor related to NGF and BDNF."
Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D.
Science 247:1446-1451(1990) [PubMed: 2321006] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
Genomics 10:558-568(1991) [PubMed: 1889806] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Hallboeoek F., Ibanez C.F., Persson H.
Neuron 6:845-858(1991) [PubMed: 2025430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 195-237.
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

M34643 mRNA. Translation: AAA41313.1.
M33968 Genomic DNA. Translation: AAA41727.1.
M61179 Genomic DNA. Translation: AAA63497.1.
BC070504 mRNA. Translation: AAH70504.1.
IPIIPI00189937.
PIRA35781.
RefSeqNP_112335.2.
UniGeneRn.9715

3D structure databases

HSSPHSSP built from PDB template 1NT3 based on UniProtKB P20783.
SMRP18280. Positions 147-254.
ModBaseSearch...

Genome annotation databases

EnsemblENSRNOG00000019716. Rattus norvegicus. [Contig view]
GeneID81737.
KEGGrno:81737.

Organism-specific databases

RGD619728. Ntf3.

Phylogenomic databases

HOVERGENP18280.
OMAP18280. QRRYSSP.

Gene expression databases

ArrayExpressP18280.
GermOnlineENSRNOG00000019716. Rattus norvegicus.

Family and domain databases

InterProIPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589:SF4. Neurotrophin-3. 1 hit.
PTHR11589. NGF. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR00268. NGF.
ProDomPD002052. NGF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio615426.

Entry information

Entry nameNTF3_RAT
AccessionPrimary (citable) accession number: P18280
Secondary accession number(s): Q6NS33
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents