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P18280

- NTF3_RAT

UniProt

P18280 - NTF3_RAT

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Protein
Neurotrophin-3
Gene
Ntf3, Ntf-3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
  2. nerve growth factor binding Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. activation of Ras GTPase activity Source: Ensembl
  3. activation of protein kinase B activity Source: Ensembl
  4. axon guidance Source: Ensembl
  5. brain development Source: Ensembl
  6. enteric nervous system development Source: Ensembl
  7. epidermis development Source: Ensembl
  8. glial cell fate determination Source: Ensembl
  9. induction of positive chemotaxis Source: Ensembl
  10. mechanoreceptor differentiation Source: Ensembl
  11. myelination Source: RGD
  12. negative regulation of neuron apoptotic process Source: Ensembl
  13. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  14. nerve development Source: Ensembl
  15. nervous system development Source: RGD
  16. neuromuscular synaptic transmission Source: Ensembl
  17. peripheral nervous system development Source: Ensembl
  18. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  19. positive regulation of cell migration Source: Ensembl
  20. positive regulation of cell proliferation Source: Ensembl
  21. positive regulation of glial cell differentiation Source: RGD
  22. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  23. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  24. positive regulation of receptor internalization Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. regulation of synaptic transmission Source: RGD
  27. smooth muscle cell differentiation Source: Ensembl
  28. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiREACT_219269. PLC-gamma1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi619728. Ntf3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: Ensembl
  2. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 139121
PRO_0000019663Add
BLAST
Chaini140 – 258119Neurotrophin-3
PRO_0000019664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi153 ↔ 218 By similarity
Disulfide bondi196 ↔ 247 By similarity
Disulfide bondi206 ↔ 249 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

GenevestigatoriP18280.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026685.

Structurei

3D structure databases

ProteinModelPortaliP18280.
SMRiP18280. Positions 144-254.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiQ6NS33.
KOiK04356.
OMAiYAEHKSH.
OrthoDBiEOG7RBZ8Z.
PhylomeDBiP18280.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18280-1 [UniParc]FASTAAdd to Basket

« Hide

MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK    50
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN 100
SPRVLLSDST PLEPPPLYLM EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY 150
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR 200
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA 250
LSRKIGRT 258
Length:258
Mass (Da):29,645
Last modified:November 1, 1990 - v1
Checksum:i74D557CF8518A1CE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181C → R in AAH70504. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34643 mRNA. Translation: AAA41313.1.
M33968 Genomic DNA. Translation: AAA41727.1.
M61179 Genomic DNA. Translation: AAA63497.1.
BC070504 mRNA. Translation: AAH70504.1.
PIRiA35781.
RefSeqiNP_001257797.1. NM_001270868.1.
NP_001257798.1. NM_001270869.1.
NP_001257799.1. NM_001270870.1.
NP_112335.3. NM_031073.3.
UniGeneiRn.9715.

Genome annotation databases

EnsembliENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
GeneIDi81737.
KEGGirno:81737.
UCSCiRGD:619728. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34643 mRNA. Translation: AAA41313.1 .
M33968 Genomic DNA. Translation: AAA41727.1 .
M61179 Genomic DNA. Translation: AAA63497.1 .
BC070504 mRNA. Translation: AAH70504.1 .
PIRi A35781.
RefSeqi NP_001257797.1. NM_001270868.1.
NP_001257798.1. NM_001270869.1.
NP_001257799.1. NM_001270870.1.
NP_112335.3. NM_031073.3.
UniGenei Rn.9715.

3D structure databases

ProteinModelPortali P18280.
SMRi P18280. Positions 144-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000026685.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000026685 ; ENSRNOP00000026685 ; ENSRNOG00000019716 .
GeneIDi 81737.
KEGGi rno:81737.
UCSCi RGD:619728. rat.

Organism-specific databases

CTDi 4908.
RGDi 619728. Ntf3.

Phylogenomic databases

eggNOGi NOG39844.
GeneTreei ENSGT00390000007725.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi Q6NS33.
KOi K04356.
OMAi YAEHKSH.
OrthoDBi EOG7RBZ8Z.
PhylomeDBi P18280.
TreeFami TF106463.

Enzyme and pathway databases

Reactomei REACT_219269. PLC-gamma1 signalling.

Miscellaneous databases

NextBioi 615426.
PROi P18280.

Gene expression databases

Genevestigatori P18280.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain."
    Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.
    Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
    Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
    Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 195-237.
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiNTF3_RAT
AccessioniPrimary (citable) accession number: P18280
Secondary accession number(s): Q6NS33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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