Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurotrophin-3

Gene

Ntf3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • nerve growth factor binding Source: RGD
  • neurotrophin p75 receptor binding Source: GO_Central

GO - Biological processi

  • modulation of chemical synaptic transmission Source: RGD
  • myelination Source: RGD
  • negative regulation of neuron apoptotic process Source: GO_Central
  • nervous system development Source: RGD
  • neuron projection morphogenesis Source: GO_Central
  • positive regulation of glial cell differentiation Source: RGD
  • regulation of neuron differentiation Source: GO_Central
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:Ntf3
Synonyms:Ntf-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi619728 Ntf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001966319 – 139Add BLAST121
ChainiPRO_0000019664140 – 258Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 218By similarity
Disulfide bondi196 ↔ 247By similarity
Disulfide bondi206 ↔ 249By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP18280

Expressioni

Tissue specificityi

Brain and peripheral tissues.

Gene expression databases

BgeeiENSRNOG00000019716
ExpressionAtlasiP18280 baseline and differential
GenevisibleiP18280 RN

Interactioni

GO - Molecular functioni

  • growth factor activity Source: GO_Central
  • nerve growth factor binding Source: RGD
  • neurotrophin p75 receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026685

Structurei

3D structure databases

ProteinModelPortaliP18280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP18280
KOiK04356
PhylomeDBiP18280
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK
60 70 80 90 100
QMVDVKENYQ STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN
110 120 130 140 150
SPRVLLSDST PLEPPPLYLM EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY
160 170 180 190 200
SVCDSESLWV TDKSSAIDIR GHQVTVLGEI KTGNSPVKQY FYETRCKEAR
210 220 230 240 250
PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW IRIDTSCVCA

LSRKIGRT
Length:258
Mass (Da):29,645
Last modified:November 1, 1990 - v1
Checksum:i74D557CF8518A1CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti218C → R in AAH70504 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34643 mRNA Translation: AAA41313.1
M33968 Genomic DNA Translation: AAA41727.1
M61179 Genomic DNA Translation: AAA63497.1
BC070504 mRNA Translation: AAH70504.1
PIRiA35781
RefSeqiNP_001257797.1, NM_001270868.1
NP_001257798.1, NM_001270869.1
NP_001257799.1, NM_001270870.1
NP_112335.3, NM_031073.3
UniGeneiRn.9715

Genome annotation databases

EnsembliENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716
GeneIDi81737
KEGGirno:81737
UCSCiRGD:619728 rat

Similar proteinsi

Entry informationi

Entry nameiNTF3_RAT
AccessioniPrimary (citable) accession number: P18280
Secondary accession number(s): Q6NS33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health