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P18280 (NTF3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrophin-3

Short name=NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name=NGF-2
Neurotrophic factor
Gene names
Name:Ntf3
Synonyms:Ntf-3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted.

Tissue specificity

Brain and peripheral tissues.

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

activation of Ras GTPase activity

Inferred from electronic annotation. Source: Ensembl

activation of protein kinase B activity

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

enteric nervous system development

Inferred from electronic annotation. Source: Ensembl

epidermis development

Inferred from electronic annotation. Source: Ensembl

glial cell fate determination

Inferred from electronic annotation. Source: Ensembl

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

mechanoreceptor differentiation

Inferred from electronic annotation. Source: Ensembl

myelination

Inferred from direct assay PubMed 15139015. Source: RGD

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

nerve development

Inferred from electronic annotation. Source: Ensembl

nervous system development

Inferred from mutant phenotype Ref.1. Source: RGD

neuromuscular synaptic transmission

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of glial cell differentiation

Inferred from direct assay PubMed 15139015. Source: RGD

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor internalization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of synaptic transmission

Inferred from direct assay PubMed 14507970. Source: RGD

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

nerve growth factor binding

Inferred from mutant phenotype Ref.1. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 139121
PRO_0000019663
Chain140 – 258119Neurotrophin-3
PRO_0000019664

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond153 ↔ 218 By similarity
Disulfide bond196 ↔ 247 By similarity
Disulfide bond206 ↔ 249 By similarity

Experimental info

Sequence conflict2181C → R in AAH70504. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P18280 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 74D557CF8518A1CE

FASTA25829,645
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 

        70         80         90        100        110        120 
STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 

       130        140        150        160        170        180 
EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 

       190        200        210        220        230        240 
KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 

       250 
IRIDTSCVCA LSRKIGRT 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain."
Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H.
Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Neurotrophin-3: a neurotrophic factor related to NGF and BDNF."
Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D.
Science 247:1446-1451(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations."
Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D.
Genomics 10:558-568(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Hallboeoek F., Ibanez C.F., Persson H.
Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 195-237.
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34643 mRNA. Translation: AAA41313.1.
M33968 Genomic DNA. Translation: AAA41727.1.
M61179 Genomic DNA. Translation: AAA63497.1.
BC070504 mRNA. Translation: AAH70504.1.
PIRA35781.
RefSeqNP_001257797.1. NM_001270868.1.
NP_001257798.1. NM_001270869.1.
NP_001257799.1. NM_001270870.1.
NP_112335.3. NM_031073.3.
UniGeneRn.9715.

3D structure databases

ProteinModelPortalP18280.
SMRP18280. Positions 144-254.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000026685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026685; ENSRNOP00000026685; ENSRNOG00000019716.
GeneID81737.
KEGGrno:81737.
UCSCRGD:619728. rat.

Organism-specific databases

CTD4908.
RGD619728. Ntf3.

Phylogenomic databases

eggNOGNOG39844.
GeneTreeENSGT00390000007725.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidQ6NS33.
KOK04356.
OMAYAEHKSH.
OrthoDBEOG7RBZ8Z.
PhylomeDBP18280.
TreeFamTF106463.

Enzyme and pathway databases

ReactomeREACT_212996. Signal Transduction.

Gene expression databases

GenevestigatorP18280.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615426.
PROP18280.

Entry information

Entry nameNTF3_RAT
AccessionPrimary (citable) accession number: P18280
Secondary accession number(s): Q6NS33
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families