Reviewed, UniProtKB/Swiss-Prot P18280 (NTF3_RAT)

Names and origin

Protein names

Recommended name:
    Neurotrophin-3
      Short name=NT-3
Alternative name(s):
    Neurotrophic factor
    HDNF
    Nerve growth factor 2
      Short name=NGF-2

Gene names

Name:	Ntf3
Synonyms:	Ntf-3

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Seems to promotes the survival of visceral and proprioceptive sensory neurons.
Subcellular location	Secreted.
Tissue specificity	Brain and peripheral tissues.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	myelination Inferred from direct assay. Source: RGD positive regulation of glial cell differentiation Inferred from direct assay. Source: RGD regulation of synaptic transmission Inferred from direct assay. Source: RGD
Cellular component	extracellular region Inferred from Experiment. Source: Reactome plasma membrane Ref.1 Inferred from mutant phenotype. Source: RGD
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW nerve growth factor binding Ref.1 Inferred from mutant phenotype. Source: RGD neurotrophin receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 139	121			PRO_0000019663
	Chain	140 – 258	119	Neurotrophin-3		PRO_0000019664
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Disulfide bond	153 ↔ 218		By similarity
	Disulfide bond	196 ↔ 247		By similarity
	Disulfide bond	206 ↔ 249		By similarity
Experimental info
	Sequence conflict	218	1	C → R in AAH70504. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P18280-1 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: 74D557CF8518A1CE	FASTA	258	29,645
	10 20 30 40 50 60 MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 70 80 90 100 110 120 STLPKAEAPR EPEQGEATRS EFQPMIATDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 130 140 150 160 170 180 EDYVGNPVVT NRTSPRRKRY AEHKSHRGEY SVCDSESLWV TDKSSAIDIR GHQVTVLGEI 190 200 210 220 230 240 KTGNSPVKQY FYETRCKEAR PVKNGCRGID DKHWNSQCKT SQTYVRALTS ENNKLVGWRW 250 IRIDTSCVCA LSRKIGRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain." Ernfors P., Ibanez C.F., Ebendal T., Olson L., Persson H. Proc. Natl. Acad. Sci. U.S.A. 87:5454-5458(1990) [PubMed: 2164684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Neurotrophin-3: a neurotrophic factor related to NGF and BDNF." Maisonpierre P.C., Belluscio L., Squinto S., Ip N.Y., Furth M.E., Lindsay R.M., Yancopoulos G.D. Science 247:1446-1451(1990) [PubMed: 2321006] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations." Maisonpierre P.C., le Beau M.M., Espinosa R. III, Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D. Genomics 10:558-568(1991) [PubMed: 1889806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." Hallboeoek F., Ibanez C.F., Persson H. Neuron 6:845-858(1991) [PubMed: 2025430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 195-237. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M34643 mRNA. Translation: AAA41313.1. M33968 Genomic DNA. Translation: AAA41727.1. M61179 Genomic DNA. Translation: AAA63497.1. BC070504 mRNA. Translation: AAH70504.1.
IPI	IPI00189937.
PIR	A35781.
RefSeq	NP_112335.2.
UniGene	Rn.9715
3D structure databases
HSSP	HSSP built from PDB template 1NT3 based on UniProtKB P20783.
SMR	P18280. Positions 147-254.
ModBase	Search...
Genome annotation databases
Ensembl	ENSRNOG00000019716. Rattus norvegicus. [Contig view]
GeneID	81737.
KEGG	rno:81737.
Organism-specific databases
RGD	619728. Ntf3.
Phylogenomic databases
HOVERGEN	P18280.
OMA	P18280. QRRYSSP.
Gene expression databases
ArrayExpress	P18280.
GermOnline	ENSRNOG00000019716. Rattus norvegicus.
Family and domain databases
InterPro	IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. IPR015578. Neurotrophin-3. [Graphical view]
PANTHER	PTHR11589:SF4. Neurotrophin-3. 1 hit. PTHR11589. NGF. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR00268. NGF.
ProDom	PD002052. NGF. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	615426.

Entry information

Entry name

NTF3_RAT

Accession

Primary (citable) accession number: P18280
Secondary accession number(s): Q6NS33

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)