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P18271

- 8513_TRYCR

UniProt

P18271 - 8513_TRYCR

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Protein

Sialidase 85-1.3

Gene
SA85-1.3
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase 85-1.3 (EC:3.2.1.18)
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name:
NA
SA85-1.3 protein
Gene namesi
Name:SA85-1.3
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 175›175Sialidase 85-1.3PRO_0000208912Add
BLAST

Expressioni

Developmental stagei

Mammalian stage of parasite.

Structurei

3D structure databases

ProteinModelPortaliP18271.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Fragment.

P18271-1 [UniParc]FASTAAdd to Basket

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LCLNATVRNA TKVKDGFQLT EPDSGVMWPV NIPDYNKRHV FLNHNFTLVA    50
SVTIEEAPSG NTPLLIAVLA NTEPTHTMRI LYTADNKWMT MLKDEKKPTT 100
ESGTWEPKKE HQVALMLQGN KASVYVDGEL LGEEEVPLTG EKPLELFAFC 150
FGACGEENPS QESHVTVTNV FLYNR 175
Length:175
Mass (Da):19,552
Last modified:November 1, 1990 - v1
Checksum:iE90DD13274B75B8F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53547 mRNA. Translation: CAA37619.1.
PIRiS11294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53547 mRNA. Translation: CAA37619.1 .
PIRi S11294.

3D structure databases

ProteinModelPortali P18271.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF49899. SSF49899. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
    Kahn S., van Voorhis W., Eisen H.
    J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CL.

Entry informationi

Entry namei8513_TRYCR
AccessioniPrimary (citable) accession number: P18271
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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