P18271 (8513_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sialidase 85-1.3
EC=3.2.1.18

Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name=NA
SA85-1.3 protein

Gene names

Name:

SA85-1.3

Organism

Trypanosoma cruzi

Taxonomic identifier

5693 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	175 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.
Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Developmental stage	Mammalian stage of parasite.
Miscellaneous	The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.
Sequence similarities	Belongs to the glycosyl hydrolase 33 family.

Ontologies

Keywords
Domain	Repeat
Molecular function	Glycosidase Hydrolase
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Molecular_function	exo-alpha-(2->3)-sialidase activity Inferred from electronic annotation. Source: EC exo-alpha-(2->6)-sialidase activity Inferred from electronic annotation. Source: EC exo-alpha-(2->8)-sialidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 175	›175	Sialidase 85-1.3		PRO_0000208912
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P18271 [UniParc]. Last modified November 1, 1990. Version 1. Checksum: E90DD13274B75B8F	FASTA	175	19,552
	10 20 30 40 50 60 LCLNATVRNA TKVKDGFQLT EPDSGVMWPV NIPDYNKRHV FLNHNFTLVA SVTIEEAPSG 70 80 90 100 110 120 NTPLLIAVLA NTEPTHTMRI LYTADNKWMT MLKDEKKPTT ESGTWEPKKE HQVALMLQGN 130 140 150 160 170 KASVYVDGEL LGEEEVPLTG EKPLELFAFC FGACGEENPS QESHVTVTNV FLYNR

References

[1]

"The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes." Kahn S., van Voorhis W., Eisen H. J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53547 mRNA. Translation: CAA37619.1.
PIR	S11294.
3D structure databases
ProteinModelPortal	P18271.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR008377. Sialidase_trypan. [Graphical view]
PRINTS	PR01803. TCSIALIDASE.
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
ProtoNet	Search...

Entry information

Entry name

8513_TRYCR

Accession

Primary (citable) accession number: P18271

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1990
Last sequence update:	November 1, 1990
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)