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P18271

- 8513_TRYCR

UniProt

P18271 - 8513_TRYCR

Protein

Sialidase 85-1.3

Gene

SA85-1.3

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase 85-1.3 (EC:3.2.1.18)
    Alternative name(s):
    Major 85 kDa surface antigen
    Neuraminidase
    Short name:
    NA
    SA85-1.3 protein
    Gene namesi
    Name:SA85-1.3
    OrganismiTrypanosoma cruzi
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 175›175Sialidase 85-1.3PRO_0000208912Add
    BLAST

    Expressioni

    Developmental stagei

    Mammalian stage of parasite.

    Structurei

    3D structure databases

    ProteinModelPortaliP18271.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P18271-1 [UniParc]FASTAAdd to Basket

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    LCLNATVRNA TKVKDGFQLT EPDSGVMWPV NIPDYNKRHV FLNHNFTLVA    50
    SVTIEEAPSG NTPLLIAVLA NTEPTHTMRI LYTADNKWMT MLKDEKKPTT 100
    ESGTWEPKKE HQVALMLQGN KASVYVDGEL LGEEEVPLTG EKPLELFAFC 150
    FGACGEENPS QESHVTVTNV FLYNR 175
    Length:175
    Mass (Da):19,552
    Last modified:November 1, 1990 - v1
    Checksum:iE90DD13274B75B8F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53547 mRNA. Translation: CAA37619.1.
    PIRiS11294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53547 mRNA. Translation: CAA37619.1 .
    PIRi S11294.

    3D structure databases

    ProteinModelPortali P18271.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
      Kahn S., van Voorhis W., Eisen H.
      J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CL.

    Entry informationi

    Entry namei8513_TRYCR
    AccessioniPrimary (citable) accession number: P18271
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3