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Protein

Sialidase 85-1.2

Gene

SA85-1.2

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase 85-1.2 (EC:3.2.1.18)
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name:
NA
SA85-1.2 protein
Gene namesi
Name:SA85-1.2
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 240›240Sialidase 85-1.2PRO_0000208911Add
BLAST

Expressioni

Developmental stagei

Mammalian stage of parasite.

Structurei

3D structure databases

ProteinModelPortaliP18270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR008377. Sialidase_trypan.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Fragment.

P18270-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EHSGDNVRHV FLNHNFTLVA SVTIEEAPSE KTPLLTALLG DAEPPYFMRL
60 70 80 90 100
SYTADNKWET ISKGDKKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES
110 120 130 140 150
LGEEAPLTVE TPLEPFGFCF GACDFDDDDD GGDDDDEEDS QEESSPKESS
160 170 180 190 200
PEKIGKKPHV TVTNVFLYNR PLNPTEMRAI KDRIPVSTRA PEPQVKIAPK
210 220 230 240
PVAPAAPGSL RCLAHGKYQQ HRGGQLWGEP PIPNMRQRDA
Length:240
Mass (Da):26,601
Last modified:November 1, 1990 - v1
Checksum:i8B73A9F7EE19ED9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53546 mRNA. Translation: CAA37618.1.
PIRiS11293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53546 mRNA. Translation: CAA37618.1.
PIRiS11293.

3D structure databases

ProteinModelPortaliP18270.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR008377. Sialidase_trypan.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
    Kahn S., van Voorhis W., Eisen H.
    J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CL.

Entry informationi

Entry namei8512_TRYCR
AccessioniPrimary (citable) accession number: P18270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.