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P18270 (8512_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialidase 85-1.2

EC=3.2.1.18
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name=NA
SA85-1.2 protein
Gene names
Name:SA85-1.2
OrganismTrypanosoma cruzi
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length240 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Developmental stage

Mammalian stage of parasite.

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 240›240Sialidase 85-1.2
PRO_0000208911

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P18270 [UniParc].

Last modified November 1, 1990. Version 1.
Checksum: 8B73A9F7EE19ED9C

FASTA24026,601
        10         20         30         40         50         60 
EHSGDNVRHV FLNHNFTLVA SVTIEEAPSE KTPLLTALLG DAEPPYFMRL SYTADNKWET 

        70         80         90        100        110        120 
ISKGDKKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES LGEEAPLTVE TPLEPFGFCF 

       130        140        150        160        170        180 
GACDFDDDDD GGDDDDEEDS QEESSPKESS PEKIGKKPHV TVTNVFLYNR PLNPTEMRAI 

       190        200        210        220        230        240 
KDRIPVSTRA PEPQVKIAPK PVAPAAPGSL RCLAHGKYQQ HRGGQLWGEP PIPNMRQRDA 

« Hide

References

[1]"The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
Kahn S., van Voorhis W., Eisen H.
J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53546 mRNA. Translation: CAA37618.1.
PIRS11293.

3D structure databases

ProteinModelPortalP18270.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
[Graphical view]
PRINTSPR01803. TCSIALIDASE.
SUPFAMSSF49899. SSF49899. 2 hits.
ProtoNetSearch...

Entry information

Entry name8512_TRYCR
AccessionPrimary (citable) accession number: P18270
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries