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P18270

- 8512_TRYCR

UniProt

P18270 - 8512_TRYCR

Protein

Sialidase 85-1.2

Gene

SA85-1.2

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase 85-1.2 (EC:3.2.1.18)
    Alternative name(s):
    Major 85 kDa surface antigen
    Neuraminidase
    Short name:
    NA
    SA85-1.2 protein
    Gene namesi
    Name:SA85-1.2
    OrganismiTrypanosoma cruzi
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 240›240Sialidase 85-1.2PRO_0000208911Add
    BLAST

    Expressioni

    Developmental stagei

    Mammalian stage of parasite.

    Structurei

    3D structure databases

    ProteinModelPortaliP18270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR008377. Sialidase_trypan.
    [Graphical view]
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 2 hits.

    Sequencei

    Sequence statusi: Fragment.

    P18270-1 [UniParc]FASTAAdd to Basket

    « Hide

    EHSGDNVRHV FLNHNFTLVA SVTIEEAPSE KTPLLTALLG DAEPPYFMRL    50
    SYTADNKWET ISKGDKKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES 100
    LGEEAPLTVE TPLEPFGFCF GACDFDDDDD GGDDDDEEDS QEESSPKESS 150
    PEKIGKKPHV TVTNVFLYNR PLNPTEMRAI KDRIPVSTRA PEPQVKIAPK 200
    PVAPAAPGSL RCLAHGKYQQ HRGGQLWGEP PIPNMRQRDA 240
    Length:240
    Mass (Da):26,601
    Last modified:November 1, 1990 - v1
    Checksum:i8B73A9F7EE19ED9C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53546 mRNA. Translation: CAA37618.1.
    PIRiS11293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53546 mRNA. Translation: CAA37618.1 .
    PIRi S11293.

    3D structure databases

    ProteinModelPortali P18270.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR008377. Sialidase_trypan.
    [Graphical view ]
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
      Kahn S., van Voorhis W., Eisen H.
      J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CL.

    Entry informationi

    Entry namei8512_TRYCR
    AccessioniPrimary (citable) accession number: P18270
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3