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P18270

- 8512_TRYCR

UniProt

P18270 - 8512_TRYCR

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Protein

Sialidase 85-1.2

Gene
SA85-1.2
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase 85-1.2 (EC:3.2.1.18)
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name:
NA
SA85-1.2 protein
Gene namesi
Name:SA85-1.2
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 240›240Sialidase 85-1.2PRO_0000208911Add
BLAST

Expressioni

Developmental stagei

Mammalian stage of parasite.

Structurei

3D structure databases

ProteinModelPortaliP18270.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Fragment.

P18270-1 [UniParc]FASTAAdd to Basket

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EHSGDNVRHV FLNHNFTLVA SVTIEEAPSE KTPLLTALLG DAEPPYFMRL    50
SYTADNKWET ISKGDKKLTT ESRPWVPKKE HQVALMLQGN KASVYIDGES 100
LGEEAPLTVE TPLEPFGFCF GACDFDDDDD GGDDDDEEDS QEESSPKESS 150
PEKIGKKPHV TVTNVFLYNR PLNPTEMRAI KDRIPVSTRA PEPQVKIAPK 200
PVAPAAPGSL RCLAHGKYQQ HRGGQLWGEP PIPNMRQRDA 240
Length:240
Mass (Da):26,601
Last modified:November 1, 1990 - v1
Checksum:i8B73A9F7EE19ED9C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53546 mRNA. Translation: CAA37618.1.
PIRiS11293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53546 mRNA. Translation: CAA37618.1 .
PIRi S11293.

3D structure databases

ProteinModelPortali P18270.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
[Graphical view ]
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
    Kahn S., van Voorhis W., Eisen H.
    J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CL.

Entry informationi

Entry namei8512_TRYCR
AccessioniPrimary (citable) accession number: P18270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: November 1, 1990
Last modified: October 16, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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