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P18269

- 8511_TRYCR

UniProt

P18269 - 8511_TRYCR

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Protein

Sialidase 85-1.1

Gene

SA85-1.1

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialidase 85-1.1 (EC:3.2.1.18)
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name:
NA
SA85-1.1 protein
Gene namesi
Name:SA85-1.1
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 752729Sialidase 85-1.1PRO_0000012039Add
BLAST

Expressioni

Developmental stagei

Mammalian stage of parasite.

Structurei

3D structure databases

ProteinModelPortaliP18269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati274 – 28512BNR 1Add
BLAST
Repeati319 – 33012BNR 2Add
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 33 family.Curated
Contains 2 BNR repeats.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
IPR021287. Trans-sialidase_CS.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
PfamiPF11052. Tr-sialidase_C. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P18269-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSRRVFASAV LLLIVVTMCC GGAATAQVGS NADASTPGSA LTGAIAGEGS
60 70 80 90 100
SSGGVEGLQR VDLFVPQKTQ VLPKKGPDSS RRDSFFSPSL VSAGGVIAAF
110 120 130 140 150
AEGHINTKNP HNESAKPFSD VVAGYIDSAW EWPTLVEKVS ESTWQAHTVL
160 170 180 190 200
GKAEGKKSLD VVLRPTTTTK GNKVFLLAGS TDLSYVNWSW REGSLELKLV
210 220 230 240 250
VGDVTKPTSS EPTERIKWGE IKSLLNESTI AAQKGKLTEF LASGGSGVVM
260 270 280 290 300
EDGTIVFSLM AVNEKKDGVF SLIIYSKDNG STWSLSEGIS PAKCGAPRIT
310 320 330 340 350
EWEGSLLMIV DCENDQRVYV SRDMGTTWTE AIGTLSGVGS THNWETIGRR
360 370 380 390 400
LAVEALITVT IEGRKVMLYT QRGYALGETE TTSPLYLWVT DNNRSFFVGP
410 420 430 440 450
VGMDNAVKGE LAGALLYSDG GLHLLQRRDS GEDSVMSLSR LTEELKEIKS
460 470 480 490 500
VLSTWSQKDV FFSSLSIPTV GLVAVLSDAA GDGRWYDEYL CLNATVTNAT
510 520 530 540 550
KVKDGFQLTE PDSRAVWSVN IPDGNVRHIS LSHNFTLVAS VIIEEAPSGN
560 570 580 590 600
TPLLTAVLVD AGPEYFMRLS YTADNKWMTM LKDEKKPTTE SRPWEAGKEH
610 620 630 640 650
QVALMLQGNK ASVYVDGELL GEEEVPLTGE KPLEIFAFCF GACKIDGDEE
660 670 680 690 700
ESSPKEIGKK PRVTVTNVFL YNRPLNSTEM RAIKDRIPVP TRAPEPQVKI
710 720 730 740 750
APKPAAPAAP AGNEETARET GDGGANGDAV SAYGRVLLPL LFLLGLWGLA

TA
Length:752
Mass (Da):80,847
Last modified:October 1, 1996 - v2
Checksum:iBDC33F3EF2DC6859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62735 mRNA. Translation: AAA30245.1.
X53545 mRNA. Translation: CAA37617.1.
PIRiA39378.
S11292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62735 mRNA. Translation: AAA30245.1 .
X53545 mRNA. Translation: CAA37617.1 .
PIRi A39378.
S11292.

3D structure databases

ProteinModelPortali P18269.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR026856. Sialidase_fam.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
IPR021287. Trans-sialidase_CS.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
PTHR10628:SF5. PTHR10628:SF5. 1 hit.
Pfami PF11052. Tr-sialidase_C. 1 hit.
[Graphical view ]
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases."
    Kahn S., Colbert T.G., Wallace J.C., Hoagland N.A., Eisen H.
    Proc. Natl. Acad. Sci. U.S.A. 88:4481-4485(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CL.
  2. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
    Kahn S., van Voorhis W., Eisen H.
    J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 520-752.
    Strain: CL.

Entry informationi

Entry namei8511_TRYCR
AccessioniPrimary (citable) accession number: P18269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3