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P18269

- 8511_TRYCR

UniProt

P18269 - 8511_TRYCR

Protein

Sialidase 85-1.1

Gene

SA85-1.1

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialidase 85-1.1 (EC:3.2.1.18)
    Alternative name(s):
    Major 85 kDa surface antigen
    Neuraminidase
    Short name:
    NA
    SA85-1.1 protein
    Gene namesi
    Name:SA85-1.1
    OrganismiTrypanosoma cruzi
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 752729Sialidase 85-1.1PRO_0000012039Add
    BLAST

    Expressioni

    Developmental stagei

    Mammalian stage of parasite.

    Structurei

    3D structure databases

    ProteinModelPortaliP18269.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati274 – 28512BNR 1Add
    BLAST
    Repeati319 – 33012BNR 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 33 family.Curated
    Contains 2 BNR repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    IPR021287. Trans-sialidase_CS.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    PfamiPF11052. Tr-sialidase_C. 1 hit.
    [Graphical view]
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P18269-1 [UniParc]FASTAAdd to Basket

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    MSRRVFASAV LLLIVVTMCC GGAATAQVGS NADASTPGSA LTGAIAGEGS    50
    SSGGVEGLQR VDLFVPQKTQ VLPKKGPDSS RRDSFFSPSL VSAGGVIAAF 100
    AEGHINTKNP HNESAKPFSD VVAGYIDSAW EWPTLVEKVS ESTWQAHTVL 150
    GKAEGKKSLD VVLRPTTTTK GNKVFLLAGS TDLSYVNWSW REGSLELKLV 200
    VGDVTKPTSS EPTERIKWGE IKSLLNESTI AAQKGKLTEF LASGGSGVVM 250
    EDGTIVFSLM AVNEKKDGVF SLIIYSKDNG STWSLSEGIS PAKCGAPRIT 300
    EWEGSLLMIV DCENDQRVYV SRDMGTTWTE AIGTLSGVGS THNWETIGRR 350
    LAVEALITVT IEGRKVMLYT QRGYALGETE TTSPLYLWVT DNNRSFFVGP 400
    VGMDNAVKGE LAGALLYSDG GLHLLQRRDS GEDSVMSLSR LTEELKEIKS 450
    VLSTWSQKDV FFSSLSIPTV GLVAVLSDAA GDGRWYDEYL CLNATVTNAT 500
    KVKDGFQLTE PDSRAVWSVN IPDGNVRHIS LSHNFTLVAS VIIEEAPSGN 550
    TPLLTAVLVD AGPEYFMRLS YTADNKWMTM LKDEKKPTTE SRPWEAGKEH 600
    QVALMLQGNK ASVYVDGELL GEEEVPLTGE KPLEIFAFCF GACKIDGDEE 650
    ESSPKEIGKK PRVTVTNVFL YNRPLNSTEM RAIKDRIPVP TRAPEPQVKI 700
    APKPAAPAAP AGNEETARET GDGGANGDAV SAYGRVLLPL LFLLGLWGLA 750
    TA 752
    Length:752
    Mass (Da):80,847
    Last modified:October 1, 1996 - v2
    Checksum:iBDC33F3EF2DC6859
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62735 mRNA. Translation: AAA30245.1.
    X53545 mRNA. Translation: CAA37617.1.
    PIRiA39378.
    S11292.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62735 mRNA. Translation: AAA30245.1 .
    X53545 mRNA. Translation: CAA37617.1 .
    PIRi A39378.
    S11292.

    3D structure databases

    ProteinModelPortali P18269.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR026856. Sialidase_fam.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    IPR021287. Trans-sialidase_CS.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    PTHR10628:SF5. PTHR10628:SF5. 1 hit.
    Pfami PF11052. Tr-sialidase_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases."
      Kahn S., Colbert T.G., Wallace J.C., Hoagland N.A., Eisen H.
      Proc. Natl. Acad. Sci. U.S.A. 88:4481-4485(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CL.
    2. "The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
      Kahn S., van Voorhis W., Eisen H.
      J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 520-752.
      Strain: CL.

    Entry informationi

    Entry namei8511_TRYCR
    AccessioniPrimary (citable) accession number: P18269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3