Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P18269 (8511_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sialidase 85-1.1

EC=3.2.1.18
Alternative name(s):
Major 85 kDa surface antigen
Neuraminidase
Short name=NA
SA85-1.1 protein
Gene names
Name:SA85-1.1
OrganismTrypanosoma cruzi
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length752 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Developmental stage

Mammalian stage of parasite.

Miscellaneous

The parasite mammalian stage surface antigen exhibits extensive antigenic diversity.

Sequence similarities

Belongs to the glycosyl hydrolase 33 family.

Contains 2 BNR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 752729Sialidase 85-1.1
PRO_0000012039

Regions

Repeat274 – 28512BNR 1
Repeat319 – 33012BNR 2

Sequences

Sequence LengthMass (Da)Tools
P18269 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: BDC33F3EF2DC6859

FASTA75280,847
        10         20         30         40         50         60 
MSRRVFASAV LLLIVVTMCC GGAATAQVGS NADASTPGSA LTGAIAGEGS SSGGVEGLQR 

        70         80         90        100        110        120 
VDLFVPQKTQ VLPKKGPDSS RRDSFFSPSL VSAGGVIAAF AEGHINTKNP HNESAKPFSD 

       130        140        150        160        170        180 
VVAGYIDSAW EWPTLVEKVS ESTWQAHTVL GKAEGKKSLD VVLRPTTTTK GNKVFLLAGS 

       190        200        210        220        230        240 
TDLSYVNWSW REGSLELKLV VGDVTKPTSS EPTERIKWGE IKSLLNESTI AAQKGKLTEF 

       250        260        270        280        290        300 
LASGGSGVVM EDGTIVFSLM AVNEKKDGVF SLIIYSKDNG STWSLSEGIS PAKCGAPRIT 

       310        320        330        340        350        360 
EWEGSLLMIV DCENDQRVYV SRDMGTTWTE AIGTLSGVGS THNWETIGRR LAVEALITVT 

       370        380        390        400        410        420 
IEGRKVMLYT QRGYALGETE TTSPLYLWVT DNNRSFFVGP VGMDNAVKGE LAGALLYSDG 

       430        440        450        460        470        480 
GLHLLQRRDS GEDSVMSLSR LTEELKEIKS VLSTWSQKDV FFSSLSIPTV GLVAVLSDAA 

       490        500        510        520        530        540 
GDGRWYDEYL CLNATVTNAT KVKDGFQLTE PDSRAVWSVN IPDGNVRHIS LSHNFTLVAS 

       550        560        570        580        590        600 
VIIEEAPSGN TPLLTAVLVD AGPEYFMRLS YTADNKWMTM LKDEKKPTTE SRPWEAGKEH 

       610        620        630        640        650        660 
QVALMLQGNK ASVYVDGELL GEEEVPLTGE KPLEIFAFCF GACKIDGDEE ESSPKEIGKK 

       670        680        690        700        710        720 
PRVTVTNVFL YNRPLNSTEM RAIKDRIPVP TRAPEPQVKI APKPAAPAAP AGNEETARET 

       730        740        750 
GDGGANGDAV SAYGRVLLPL LFLLGLWGLA TA 

« Hide

References

[1]"The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases."
Kahn S., Colbert T.G., Wallace J.C., Hoagland N.A., Eisen H.
Proc. Natl. Acad. Sci. U.S.A. 88:4481-4485(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CL.
[2]"The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
Kahn S., van Voorhis W., Eisen H.
J. Exp. Med. 172:589-597(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 520-752.
Strain: CL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62735 mRNA. Translation: AAA30245.1.
X53545 mRNA. Translation: CAA37617.1.
PIRA39378.
S11292.

3D structure databases

ProteinModelPortalP18269.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
IPR021287. Trans-sialidase_CS.
[Graphical view]
PfamPF11052. Tr-sialidase_C. 1 hit.
[Graphical view]
PRINTSPR01803. TCSIALIDASE.
SUPFAMSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry name8511_TRYCR
AccessionPrimary (citable) accession number: P18269
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries